Pepito, Kirtia Mae C.

DRUG

CLASSIFICATION

ACTION

INDICATION

CONTRAINDICATION

ADVERSE
REACTION

NURSING
RESPONSIBILITIES

Generic
name:
Tobramycin



Brand name:
AK-Tob
- Solution
0.3%
TOBI
Tobramycin
Tobrex
Sandoz
Tobramycin (
Canada)





Inhibits
bacterial
protein
synthesis,
causing cell
death

Tobramycin
acts by binding
to 30S
ribosomal
subunits thus
interfering with
bacterial protein
synthesis. It is
active against
many aerobic
gram-negative
bacteria and
some aerobic
gram-positive
bacteria but
inactive against
Chlamydia,
fungi, viruses,
and most
anaerobic
bacteria.


Treatment of
serious infections
caused by
susceptible
strains of gram-
negative bacteria;
treatment of
serious
susceptible
staphylococcal
infections when
other, less toxic
drugs are
contraindicated.

Hypersensitivity to
aminoglycosides;
pregnancy.

Nausea,
vomiting,
dizziness or
vertigo, acute
renal failure,
interstitial
nephritis, acute
tubular necrosis,
electrolyte
imbalances,
purpura,
encephalopathy,
convulsions,
mental
depression,
hallucinations,
ototoxicity, blood
dyscrasias,
increased LFT
and bilirubin
concentrations.

>Administer
separately. Do not
mix with other drugs.
>For IV
administration dilute
in 50 to 100 mL of
0.9% sodium chloride
injection or 5%
dextrose injection.
Use less diluent for
children. Administer
at least 20 min to 60
min.
>Administer IM
injection deep into
large muscle.
.




Pepito, Kirtia Mae C.


DRUG

CLASSIFICATION

ACTION

INDICATION

CONTRAINDICATI
ON

ADVERSE
REACTION

NURSING
RESPONSIBILITIES


Generic
name:
(Co-
amoxiclav
)

Brand
name:
Augmentin,
Clavamox,
Co-
amoxicl av


Antibiotic,
Aminopeni ci l
lin, Beta-
lactam
(Beta-
Lactam and
Beta-
Lactamase
Inhibitor
Combination
)


Augmentin
is
bactericidal
and works
by
inhibiting
the
synthesis of
bacterial
cel l walls..



- Known or
suspected
amoxici l li n-
resistant
infections
including
respiratory
tract, skin and
soft tissue,
genitourinary,
and ear, nose
and throat
infections.
- Effective
against strains
of Escherichia
col i, Proteus
mirabi lis,
Haemophil us
influenzae,
Streptococcus
faecalis,
Streptococcus
pneumoniae
and some
beta-
lactamase-


- Penicil l in
hypersensiti vity
- History of co-
amoxicl av-
associ ated or
penici ll in-
associ ated
j aundice or
hepatic
dysfunction


- History of
all ergy.
- Renal
impairment.
- Erythematous
rashes common
in glandul ar
fever.
-
Cytomegaloviru
s infection.
- Acute or
chronic
l ymphocytic
leukaemia.
- Hepatic
impairment.
- Pregnancy.
- Cholestatic
j aundice.




- Assess bowel
pattern before and
during treatment as
pseudomembranou
s colitis may occur.
- Report
haematuria or
oliguri a as high
doses can be
nephrotoxic.
- Assess
respiratory status.
- Observe for
anaphylaxis.
- Ensure that the
patient has
adequate fluid
intake during any
diarrhoea attack.