PATHOPHYSIOLOGY

Modifiable Factors:
-

Non- Modifiable Factors:

Lifestyle
Diet
Occupation

Age
Race

Exposure to carcinogens
(Initiation)

Mutation in the Genetic

material (DNA)

Activation of growth
promoting oncogenes

Inactivation of tumor
suppressor genes (p53)

Alteration in mechanism that

control

Unregulated cell
differentiation and growth

S/Sx:

Neoplasm in the Thyroid

gland
Metastasis
Brain

Tumor
ArrestAngiogenesis
cells
in capillary
transport
bedwith
of
other blood
organs
elements

Mass, nonmovable at
right lateral
Papillary
neck area
adrenocarcinoma
- Dysphagia
-

Lungs

S/Sx:

S/Sx:
Multiple brain
metastases (frontal,
left temporal, right
cerebral, and left
cerebellar)
Right sided weakness
Decrease in sensorium

Pulmonary
nodules,
bilateral