Documente Academic
Documente Profesional
Documente Cultură
PRINCIPLES OF IMMUNOLOGY
Le Van Dong MD., PhD
Deputy Head, Department of Immunology
Vietnam Military Medical University
levandong@vmmu.edu.vn;
g@
levandong@yahoo.com
g@y
EDUCATION
RESEARCH
INDUSTRY/ TREATMENT
Text books
2011
2011
Syllabus
y
[1] Topic 1: Introduction to Immunity and Immune Systems
[2] Topic 2: Cells and Organs of the Immune System
[3] Topic 3: Innate Immunity
[4] Topic 4: Antigen
[5] Topic 5: Antibody
[6] Topic 6: Humoral Immune Responses
[7] Topic 7: Cell-Mediated Immune Responses
[8] Topic 8: Immune Responses Against Tumors and Transplants
[9] Tutorial/ Practice
[10] Topic 9: Hypersensitivity Diseases, Immunodeficiencies and Autoimmunity
[11] Topic 10: Immunotherapy
[12] Topic 11: Common immunological techniques
[13] Tutorial/ Practice
[14] Lab work
INTRODUCTION TO IMMUNITY
AND IMMUNE SYSTEMS
Le Van Dong MD., PhD
Deputy Head, Department of Immunology
Vietnam Military Medical University
levandong@vmmu.edu.vn;
g@
levandong@yahoo.com
g@y
EDUCATION
RESEARCH
INDUSTRY/ TREATMENT
Contents
Brief
e history
sto y o
of Immunology
u o ogy
Classification of immunity
No infectious diseases
Infectious diseases
Immune system:
y
Bodys
y arm forces
Immune system = Ministry of Defence + Ministry of Public Security
Surveillance and
destroy cancer (fight
against internal crimes).
Notes
immune
Milestones in Immunology
Before 1900
Louis
L
i P
Pasteur
t
(1885) used
d rabies
bi
vaccine for the first time on human
Eli M
Metchnikoff.
t h ik ff Phagocyte
Ph
t is
i
important to kill bacteria
1900-1959
1960-1979
1980-1990
1990-2000
Passive immunity:
y immunityy conferred on an individual
by transfer of antibodies from an actively immunized
individual (i.e., protection of newborns from infection by
acquiring antibodies from their mothers through the
placenta and in milk).
BK
No systemic TB;
surmised (Has
immunity after BK
i f ti )
infection)
Mouse survived
after infected with BK
Mouse has
passive
immunity
Transfer
Immune cells
Mouse has
adoptive
immunity
Mouse surmised
after infected with BK
(Has active immunity)
Primed
immune cells
><
Adaptive
Ad
ti iimmune response
(Specific)
Phagocytosis
g y
><
Epithelial
p
barriers ((and the
specialized cells and natural
antibiotics present in epithelia)
Phagocytes
g y
lymphocytes; Antibodies
(eliminate microbes in
extracellular fluids)
Cell-mediated immune
Dendritic cells
Natural killer cells
Complement
C
l
t ((and
d other
th plasma
l
proteins)
response: T lymphocytes;
Effector T cells ((eliminate
microbes living inside cells)
Adaptive
p
((specific)
p
) immunity
y
Specificity: ensures
Specificit
ens res that distinct antigens elicit
specific responses
Diversity:
Di
it enables
bl immune
i
system
t
t respond
to
d to
t
a large variety of antigens
Memory: leads
M
l d to
t enhanced
h
d responses to
t
repeated exposures to the same antigens
The process of
clonal selection
(often referred to as
signal
1)
and
molecules
produced during the innate
immune response (signal 2)
function cooperatively to activate
antigen-specific
antigen
specific lymphocytes.
The
Antigen elimination
(i) via humoral immunity; B cells proliferate and
diff
differentiate
ti t iinto
t plasma
l
cells
ll th
thatt secrete
t antibodies;
tib di
antibodies then bind to microbes and prevent them
from infecting cells and eliminate them
(ii) via
i cell-mediated
ll
di t d immunity;
i
it h
helper
l
T cells
ll (CD4
(CD4+))
produce cytokines promoting macrophage killing of
microbes; CTLs (CD8+) directly kill cells harbouring
y p
]
microbes in the cytoplasm]
Homeostasis
H
t i iis
achieved by
apoptosis
Memory
(surviving
from the
initial
activation)
Over
O
er response cell and tiss
tissue
e inj
injuries
ries
(hypersensitivity).
Over
O
er response cell and tiss
tissue
e inj
injuries
ries
(hypersensitivity).
Under response Immunodeficiency.
Immunodeficiency
Congenital:
no antibody, no thymus
Acquired: malnutrition,
malnutrition pregnancy
pregnancy, infection
infection,
HIV/AIDS
Immunodeficiency
Over
O
er response cell and tiss
tissue
e inj
injuries
ries
(hypersensitivity).
Under response Immunodeficiency.
Immunodeficiency
Congenital:
no antibody, no thymus
Acquired: malnutrition,
malnutrition pregnancy
pregnancy, infection
infection,
HIV/AIDS
Autoimmune diseases
Over
O
er response cell and tiss
tissue
e inj
injuries
ries
(hypersensitivity).
Under response Immunodeficiency.
Immunodeficiency
Congenital:
no antibody, no thymus
Acquired: malnutrition,
malnutrition pregnancy
pregnancy, infection
infection,
HIV/AIDS
SUMMARY
The Immune system comprises of tissues, cells,
molecules participating in defending the body.
The physiologic function of the immune system
is to prevent infections and to eradicate
established infections. The major
j roles of the
immune system include:
1) Defense against infections.
2) Recognition and response to newly introduced
proteins and cells such as tumours and tissue grafts.
Summary (cont.)
Clinical implications of these roles include:
1) Deficient immunity results in increased susceptibility to
infection ((exemplified
p
byy AIDS)) .
2) Vaccination boosts immune defenses and protects
against infections.
3) Immune responses are barriers to transplantation and
gene therapy.
4) Potential for immunotherapy of cancer.
Summary (cont.)
Innate immunity:
y mediates the initial p
protection against
g
infections; is always present in healthy individuals and
prepared to block the entry of microbes and to rapidly
eliminate microbes that do succeed in entering host tissues.
tissues
Adaptive
Adapti
e immunity:
imm nit develops
de elops more slowly
slo l and mediates
the later, even more effective, defense against infections; is
the type of host defense that is stimulated by microbes that
invade tissues (in other words, it adapts to the presence of
microbial invaders)
Summary (cont.)
Active immunity: immunity induced in an individual by
infection or vaccination.
Passive immunity: immunity conferred on an individual by
transfer of antibodies from an actively immunized
individual.
Adoptive immunity: immunity conferred on an individual
by transfer of primed lymphocytes from an actively
immunized individual.
Review questions
q
1.
2.
3.
4.
5.
Review questions
q
6.
7.
8.