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Documente Profesional
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EDUCATION
RESEARCH
INDUSTRY/ TREATMENT
Aims
Understand
components
and
functions of the two types of
lymphoid organs.
Haematopoiesis
Haematopoiesis
2. IMMUNE CELLS
EDUCATION
RESEARCH
INDUSTRY/ TREATMENT
2.1. B lymphocyte
Origin: Bone marrow
Maturation: Bone marrow
CD molecule
B lymphocyte differentiation
Stem cell
Pro-B
Pre-B
Immature B
Mature B
B lymphocyte differentiation
B cell function:
produce antibody
2.2. T lymphocyte
Origin: Bone marrow
Maturation: Thymus
T cell markers
CD2:
Involve
in cell signaling
Natural
CD3:
Specific
Part
for T lymphocyte
CD8,
Similar in structures
Unique specificity - both formed by gene arrangement
T cell differentiation
Bone marrow
Thymus
T cell differentiation
During differentiation
(maturation) process,
genes are rearranged to
form molecules that
contribute to the
functions of the cell.
Some molecules
appear, some disappear
during the maturation of
the cell
T cell functions
TC
Note:
Without T helper,
macrophage can eat the
bacteria but can not kill
them.
With T helper,
macrophage can kill the
bacteria which have been
eaten but survive inside
the cell).
OK,
macrophage
kill them!
Figure 1-25
signaling
CD3:
Either:
NK produces IFN- to
activate macrophage
to kills more bacteria.
Abbas A. K and Lichtman A. H
Basic Immunology 3rd Ed Saunders 2011
Notes
2.4. Phagocytes
Mast cells
membrane.
are
under
skin
and
mucous
Mast cell
Basophil
2.6. Eosinophil
APCs include:
Macrophage
Dendritic
cell
B lymphocyte
APCs
3. LYMPHOID ORGANS
Two type of lymphoid organs:
EDUCATION
RESEARCH
INDUSTRY/ TREATMENT
Lymphoid organs/tisue
Central/primary
lymphoid organs:
Peripheral/secondary
lymphoid organs:
Where lymphocyte
encounter antigen and
growth strongly after
stimulation by antigen.
Maturation/differentiation process of
lymphocytes in central lymphoid organs
Bone marrow and thymus stromal cells educate prelymphocyte to mature lymphocyte.
3.2.2. Spleen
To capture antigens which enter
blood stream
4. Circulation of lymphocytes
Circulation of lymphocytes
SUMMARY
Lymphocytes
B
Lymphoid organs
Central:
Review Questions
1.
2.
3.
4.
What are
properties.
5.
APCs
and
their
common