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TuberculosisMCQsforAIPGMEE,MCCEE,
JIPMER,FMGE

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Tuberculosis(TB)
1.AntiTBdrugthathasbacteriociddalandsterilizingeffectontissueis:
A)Rifampicin
B)INH
C)Ethambutol
D)Pyrazinamide
2.FollowingtypeofpulmonaryTBismostlikelytobeassociatedwithAFB
sputumpositivity:
A)Primarycomplex
B)Fifronodular
C)Cavitary
D)Pleuraleffusion
3.FollowingantiTBdrugisassociatedwithmajorvisualsideeffects:
A)INH
B)Rifampicin
C)Ethambutol
D)Pyrazinamide
4.Empyemanecessitansis:
A)CommonmanifestationofpostprimaryTB:
B)Extensionofempyematothethoraciccage
C)Empyemaassociatedwithpneumonia
D)PartofPrimarycomplex
5.Fibrocavitarylunglesiononxrayisafeatureof:
A)PrimaryTB
B)PostprimaryTB
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C)Metastaticlungdisease
D)Lungabscess
6.MiliaryTBonCTscanhas:
A)Peribronchialdistributionoflesions
B)Lesionsrandomlydistributedmeasuring12mm
C)Smallgranulomaswithsatellitelesions
D)Smallnoduleswithcaseation

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TuberculosisMCQs(1)

7.Gohnsfocusisusually:
A)Subpleural
B)Peribronchial
C)Apical
D)Inlyphnode
8.Mantouxtest:
A)Iscarriedoutbyintradermalinoculationofliveattenuatedbacilli.
B)PositivityindicatespriorexposureoftheindividualtoM.Tuberculosis.
C)PositivityindicatesgoodimmunityagainstTB
D)Isameasureofindividualshumoralimmunity
9.AntiTBdrugswithmaximumCNSpenetrationare:
A)INHandRifampicin
B)INHandStreptomicin
C)INHandEthambutol
D)INHandPyrazinamide
10.WhenTBisassociatedwithAIDS:
A)Mantaoxreadingisaffected
B)CSFparametersareaffected
C)Firstlinemanagementisaffected
D)TBiscausedbyatypicalmycobacteria

Answersanddiscussions:
Answer:1A
RifampicinisabacteriocidalantiTBdrugthatkillsbothmultiplyingand
dormantbacteriahenceitsterilizesthetissue.INHiseffectiveagainst
multiplyingbacilli.Ethambutolinlowdoseisbacteriostaticandinhigh
dosages,isbacteriocidal.Pirazinamideisamildbacteriocidaldrugbuthas
apropertyofkillingbacilliinacidicenvironmentsuchas,inmacrophages
andareasofacuteinflammation.Itcancrossbloodbrainbarrieringood
concentration.
Answer:2C
Cavitiesrepresentnecrosisoftissueresultingincommunicationofthe
infectedmaterialwiththeairways.Thebacteriaarethusdischargedinthe
bronchialtreefromwheretheycanbecoughedoutwithsputum.The
infectedmaterialcancausetubercularbronchopneumoniainhostby
spreadtootherpartsoflungsorgastrointestinaltuberculosisbymeansof
swallowedsecretions.Theriskofspreadtootherindividualisveryhigh
withcavitarytuberculosis.
Answer:3C
HepatotoxicityisthemostcommonsideeffectofantiTBtreatment.INH,
rifampicinandpyrazinamideatehepatotoxic.INHmaycausesensory
neuropathy.Rifampicinmaycauseitchinginfirsttwoweeksandmay
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causethrombocytopenia.Ethambutolcancauseretrobulbarneuritis
which,insomecases,maybeirreversible.
Answer:4B
EmpyemanecessitanceisanuncommonmanifestationofTBwhenTB
empyemaextendstothethoraciccage.
Answer:5B
Primarycomplexisasmallareaofconsolidationinsubpleural
parenchyma.PostprimaryTBoccursinimmunocompetenthostsand
causescaseatinggranulomas.Thecaseousmaterialgetsdrainedout
throughbronchiresultinginsmallcavitiessurroundedbyfibrosis.Lung
abscessisathickwalledcavityonXray.
Answer:6B
MiliaryTBiscausedbyhematogenousspreadofTBbacilliandhas
characteristicappearanceonCTscanofchestwithrandomlydistributed
lesionsmeasuring12mm.

Answer:7A

Answer:8B
Mantouxtestiscarriedoutbyintradernmalinjectionofpurifiedprotein
derivativeextractedfromtubercularbacilliculture.Itisasterilesolution
anddoesnotcontainlivebacteria.Positivemantouxtestindicatesprior
exposuretoTB.Itisameasureofcellmediatedimmunityandnotof
humoralimmunity.Positivetestdoesnotnecessarilymeangood
immunity.
Answer:9D
INHandpyrazinamidehave100%CNSpenetrationandareimportantin
treatmentofTBmeningitis.
Answer:10A
Inanimmunodeficientpersonsuchas,acaseofAIDS,cellmediated
immunityisdeficient.Mantaoxtestdetectscellmediatedresponseofan
individualtotuberculinantigen.Hencethetestwillshowlowerinduration
orlesspositivity.Restoftheparametersarenotaffected.
PostedbyMcMediat07:22 Nocomments:
Labels:AIPGMEE,FMGE,JIPMER,MCCEE,PGIEE,StatePGentrance,TuberculosisMCQs

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