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RESEARCH ARTICLE
Development and Evaluation of Fast Dissolving Tablets of Flurbiprofen
1
ABSTRACT
The aim of the investigation is to prepare the fast dissolving tablet of flurbiprofen. Flurbiprofen,
a widely prescribed anti inflammatory analgesic drug belongs to BCS class II and exhibit low
and variable oral bioavailability due to its poor solubility and dissolution rate. The objective of
the present study is to develop flurbiprofen fast dissolving tablet formulations by direct
compression method by forming its inclusion complex with -cyclodextrin. The 9 batches were
prepared by using super disintegrants. The tablet weight is 350mg.The clathrate is having 1:1
proportion. Inclusion complex of BCD with drug enhance its dissolution and also improve the
taste Different super disintegrating agent like cross carmellose sodium, kyron T-314 and SSG in
different proportion to enhance solubility of flurbiprofen. The method used was direct
compression and directly compressible vehicle used was avicel PH 102, Mannitol was used to
fill up the tablet volume and was also acts as sweetener. All the evaluations were performed to
check the efficacy and effectiveness of tablet like disintegration time, hardness, friability,
wetting time and in-vitro dissolution test. From all the evaluations data batch B6 which contain
kyron T-314 as super disintegrating agent with 15mg in each tablet was evaluated as optimized
formula for the preparation of fast dissolving tablet of flurbiprofen.
KEYWORDS
Flurbiprofen, Fast dissolving tablet, Inclusion complex, kyron T-314
INTRODUCTION1,2
76
provide
common
cold,
allergic
condition
instantaneous
disintegration
of
and
bronchitis.
The bioavailability of some drugs may be
increased due to absorption of drug in oral
For these reason, tablets that can rapidly
standard tablet.
with
eventually
bioavailability of drug
greater
than
those
is significantly
observed
from
slow
drug
to
absorption
inadequate
and
leading
variable
non-steroidal
anti
inflammatory
agent
carboxymethyl
cellulose
its poor
water
77
to
increase
flurbiprofen
using
the
and
solubility
of
complexation
These
oligosaccharides
are
derived
cyclic
from
and
starch
Flurbiprofen
clatherate(1:1)5
with
-cyclodextrin
BCD/flurbiprofen clathrate.
which gives it
a relatively lipophilic
Fast
dissolving
tablets
containing
Flurbiprofen
78
Ingredients
(mg)
Drug + cyclodextrin
Cross
carmellose
sodium
Kayron
SSG
Mannitol
Avicel pH 102
Talc
Magnesium
stearate
Total weight
in (mg)
F1
F2
F3
F4
F5
F6
F7
F8
F9
284
284
284
284
284
284
284
284
284
10
15
10
15
30.5
20
7
25.5
20
7
20.5
20
7
30.5
20
7
25.5
20
7
20.5
20
7
5
30.5
20
7
10
25.5
20
7
15
20.5
20
7
3.5
3.5
3.5
3.5
3.5
3.5
3.5
3.5
3.5
350
350
350
350
350
350
350
350
350
and
flurbiprofen
clatherate
and
other
parameters
of
FDT
of
100 mg of Flurbiprofen was weighed
flurbiprofen10,16
and
disintegration
time
and
was
friabilator.
determined
Disintegration
in
a
time
Roche
using
UV-Visible
was
79
6.4.
analyzed.
Compatibility
Study
of
Drug
and
Excipients3
1b respectively.
the
physical
and
chemical
interaction
Infrared
spectra
of
Flurbiprofen
and
polymer.
80
70
%T
60
50
40
30
4
5
7
.1
4
7
0
7
.9
0
8
40
.9
9
8
1
5
.9
2
7
6
7
.6
9
87
9
.57
9
2
5
.8
6
1
2
6
5
.3
5
13
6
1
.7
9
69
8
.25
4
1
8.5
7
1
4
1
1
.9
4
1
4
19
.66
15
0
6
.4
6
1
4
73
.6
6
15
3
3
.4
6
3
3
1
9
.6
0
3
35
4
.32
10
3
3
3
8
.8
9
20
-10
4000
A
3600
3200
2800
2400
2000
1800
1600
1400
1200
1000
800
600
400
1/cm
4
0
1
.2
1
7
2
9
.1
2
6
9
4
.4
0
7
6
5
.7
7
1
0
0
4
.9
5
1
0
2
6
.1
6
1
1
5
7
.3
3
1
0
8
0
.1
7
1
4
1
9
.6
6
3
1
7
3
.0
1
3
1
8
2
.6
5
3
2
0
0
.0
1
3
2
4
0
.5
2
3
2
7
7
.1
7
3
2
8
4
.8
8
3
3
3
3
.1
0
3
4
8
9
.3
4
3
3
4
6
.6
1
15
7.5
-7.5
-15
4000
B
3600
3200
2800
2400
2000
1800
1600
1400
1200
1000
800
600
400
1/cm
4
0
1
.2
1
4
8
9
.9
4
4
2
0
.5
0
6
1
3
.3
8
6
8
6
.6
8
6
9
4
.4
0
1
0
0
3
.0
2
1
0
2
8
.0
9
1
1
3
0
.3
2
1
0
7
4
.3
9
1
1
5
3
.4
7
1
3
3
8
.6
4
1
3
6
1
.7
9
1
4
0
8
.0
8
3
1
6
5
.2
9
3
2
1
1
.5
9
3
2
2
8
.9
5
3
2
5
4
.0
2
3
3
9
6
.7
6
7.5
3
2
7
9
.1
0
15
0
-7.5
4000
C
3600
3200
2800
2400
2000
1800
1600
1400
1200
1000
800
600
400
1/cm
81
Formulations
F1
F2
F3
F4
F5
F6
F7
F8
F9
Formula
F1
F2
F3
F4
F5
F6
F7
F8
F9
Hausners
Ratio*
1.1600.010
1.1610.015
1.1580.020
1.1770.020
1.1630.015
1.1510.005
1.158 0.025
1.1830.015
1.1710.010
Thickness
Hardness
Weight
Friability %***
(mm)***
(Kg/cm2)**
variation(mg)***
5.1 0.1
4.7 0.25
0.94 0.08
351 3.6
5.03 0.05
4.3 0.26
0.95 0.05
349 3.0
5.13 0.05
4.8 0.49
0.95 0.03
346 4.0
5.13 0.1
4.5 0.25
0.98 0.08
346.66 4.72
5.16 0.5
4.2 0.5
0.94 0.02
353.33 2.08
5.03 0.5
4.5 0.25
0.86 0.1
351 1.0
5.2 0.1
5.1 0.1
0.95 0.6
353.7 3.78
5.06 0.5
5.2 0.2
0.98 0.05
352 3.46
5.2 0.5
5.03 0.15
0.97 0.02
348.7 3.51
Table 2b: Evaluation Parameters FDT of flurbiprofen
Formulation
F1
F2
F3
F4
F5
F6
F7
F8
F9
Bulk Density
(gm/ml)*
Diameter(mm)
(n=3)
10.4 0.06
10.5 0.05
10.5 1.00
10.4 1.00
10.4 0.05
10.3 0.02
10.5 1.00
10.4 1.10
10.4 1.254
In vitro Disintegration
time (seconds)(n=3)
143 4.58
135 4.08
129 3.49
120 3.21
112 4.85
88 3.56
136 4.04
138 4.69
131 5.73
Wetting time
(seconds)(n=3)
62 4.46
58 5.67
55 4.48
52 6.64
49 5.23
42 3.15
67 5.69
64 6.82
60 6.71
82
F1
0.0
64.550.341
74.280.256
80.220.145
86.570.358
91.460.257
93.060.412
94.650.373
95.960.246
0
5
10
15
20
30
40
50
60
F6
0.0
79.140.124
83.700.187
88.53 .210
92.850.319
94.460.147
96.690.264
98.330.371
99.360.259
dissolution
medium
and
analyzed
Time
F7
0
5
10
15
20
30
40
50
60
57.25 0.218
62.11 0.369
67.62 0.258
78.090.149
82.58 0.347
89.25 0.420
90.20 0.396
91.77 0.278
58.43 0.394
69.11 0.342
74.06 0.267
81.28 0.263
86.72 0.319
90.39 0.289
93.18 0.356
94.47 0.239
64.85 0.297
70.66 0.346
79.21 0.326
83.71 0.379
88.36 0.297
91.47 0.283
95.45 0.372
96.72 0.277
17.14 0.176
19.58 0.249
21.83 0.153
24.21 0.168
25.93 0.148
28.09 0.129
30.23 0.167
32.69 0.134
83
20
40
60
Time (min.)
80
%
cumulative Drug
release F1
%
cumulative Drug
release F2
%
cumulative Drug
release F3
%
cumulative Drug
release F4
CONCLUSION
-cyclodextrin
by
direct
compression
84
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