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BLUEPRINT of LIFE
What is this topic about?
To keep it as simple as possible, (K.I.S.S.) this topic involves the study of:
1. EVOLUTION OF LIFE
2. MENDELIAN GENETICS
3. CHROMOSOMES & DNA STRUCTURE
4. MOLECULAR GENETICS & MUTATION
5. REPRODUCTIVE TECHNOLOGIES &
GENETIC DIVERSITY
Chromosomes
Part of a DNA
molecule
Genetics
In
section
on
Genetics
the
Molecular
Dominant-R
Recessive
inheritance.
Monohybrid crosses
Divergent
&
Convergent
Evolution
Mendels
experiments
Evolution
of Life
Pedigrees
(Family trees)
Mendelian
Genetics
Chromosomes,
genes & DNA
THE
BLUEPRINT
OF LIFE
Meiosis &
gamete
formation
Chromosomes
&
DNA
Sex-llinkage
&
Codominance
Reproductive
Technologies
&
Genetic Diversity
Molecular Genetics
&
Mutations
DNA
Replication
Transcription &
Translation
Effects on
genetic
diversity
Genetic
Engineering
Punctuated
Equilibrium
The link to
evolution
Artificial insemination
and pollination.
Cloning
HSC Biology Topic 2 Blueprint of Life
copyright 2005-2
2009 keep it simple science
www.keepitsimplescience.com.au
Mutation
&
mutagens
1. EVOLUTION OF LIFE
The Evidence for Evolution
Palaeontology
Fossil
Pa
atterns of Cha
ange
Ancient Life
Modern Life
Simple types
Less variety
Less like
present-d
day life
Bony jaw
with teeth
youngest
oldest
Reconstruction
Bony tail
covered in
feathers
Clawed wings
It is very unlikely that Archaeopteryx could fly like a
modern bird. It may have climbed trees & glided
down on insect & lizard prey
These fossils
correlate to
each other.
The
coresponding
rock layers
(in different
places)
must be the
same age.
Biogeography
Comparative Embryology
...and
what they develop into
OZ
All these
Sth America
animals are
relatively
large, fastrunning,
Africa
with flat
grinding
teeth, and all lead pretty much the same lifestyle.
So why is there not just one type of large grazer
in the world, living on every continent?
Comparative Anatomy
When the body structures of different
organisms are compared, it is often obvious that
they share common features, even though those
body parts might be used in different ways.
2 bones
in forearm
5 sets
of finger
bones
Ancestral Finch
Why?
Island 1
Island 2
Human
arm
Whale
flipper
Bat
wing
Island 3
Not
to
same
scale
(Penta= 5, dactyl=fingers)
Biochemistry
Selective Breeding
Selective Breeding
proves that a species can be changed.
Humans can do it artificially,
in the wild it happens by Natural Selection
For
example,
the
evolutionary
relationship
between
LIZARDS,
CROCODILES and BIRDS.
TRADITIONAL CLASSIFICATION
Based on DNA
studies, which
show
evolutionary
relatedness
BIRD is
DIFFERENT
Croc & Lizard in SAME GROUP
Based on body
structure
HSC Biology Topic 2 Blueprint of Life
copyright 2005-2
2009 keep it simple science
www.keepitsimplescience.com.au
Origin of a Theory
Meanwhile, another Englishman, Alfred
Wallace (1823-1913) came up with
exactly the same idea after his journeys
in the 1840s and 1850s. We often give
Darwin most of the credit for this major
scientific
theory,
but
Wallaces
contribution should not be forgotten.
Charles
Darwin
The Darwin-Wallace
Theory of Evolution
Natural Selection
Natural Selection refers to the way that
the conditions of nature constantly select
who survives and who dies. If survival
depends on speed to run from a predator,
then the faster individuals survive and the
slower ones get eaten. In a drought those
plants with slightly thicker cuticle on their
leaves conserve water and survive, while
others die.
hairy
long
neck
long
legs
light
colour
Natturral
Selecttion
n
hairy survives
Surrvival
of the
Fitttestt
big
ears
squat
body
Squat survives
Survivors breed
over many generations
Even
ntually itt chan
nges so much thatt itt
becom
mes a differren
nt species.
The Species ha
as Evolved.
A Change in the
Physical Environment
In unpolluted
forests, the lightercoloured moths are
camouflaged... They
are fittest for
survival and
breeding.
Population ratio.
The black form
is rare.
In polluted forests,
the dark-c
coloured
moths are better
camouflaged...
They are fittest for
survival and
breeding.
Population ratio.
The lighter form
is rare.
New competitor
enters ecosystem
ER
N
IN
W
LO
SE
R
TIME (years)
Reproduction is the
true measure of survival.
An animal which does not live long, but
manages to produce many, viable offspring is an
evolutionary success!
a change of climate.
a new disease, predator or competitor.
a change in availability of a food.
Directions of Evolution
It is easy to imagine that evolution has a target that it aims for.
Looking back at fossil ancestors of a modern species, its easy to think that those
ancestors were deliberately evolving to become the modern, final species.
Ancestors always look primitive compared to their modern descendants.
Of course, the modern species is NOT the final outcome at all.
Evolution has no targets. It is an on-going process which continues to cause changes.
In 100 million years time, the fossils of todays creatures will seem primitive.
Divergent Evolution
Convergent Evolution
(Converge=come together)
on
the
Ancestral Finch
More
Island 1
Island 2
Island 3
`Name....................................
Biogeography is the study of p).............................
............... It gives indirect evidence for evolution.
Comparative Embryology reveals that vertebrate
embryos are all q)............................... to each
other, even though each animal grows up to be
r)..................................... This is explained by
evolution as being due to these animals all
evolving from a s)...................................................
Similarly, the study of Comparative Anatomy
shows much the same. For example, the
forelimbs of vertebrates have the same
t)................................ even though each animal
uses the limb u).................................................
This 5-digit limb structure is called
v).....................................
Name....................................
10
Worksheet 3
Test Questions
Section 1
Name....................................
Multiple Choice
1.
The fossil record shows a pattern, from ancient
times to recent times, of:
A. more complexity to less complexity.
B. greater diversity to less diversity.
C. increasing complexity and diversity.
D. no distinct pattern of change.
8. (4 marks)
Explain the difference between relative dating
of fossils and absolute dating, by outlining
how each is achieved and what each can tell you
about fossils.
9. (3 marks)
Comparative Anatomy can give evidence
supporting the idea of evolution.
a) Outline an example of comparative anatomy
that gives such evidence.
3.
Two types of evidence which both suggest
descent from a common ancestor are:
A. embryos of vertebrates & the pentadactyl limb.
B. convergent evolution and biochemistry.
C. DNA structure and the biogeography.
D. natural selection and survival of the fittest.
4.
Natural Selection refers to
A. those organisms best suited to the
environment survive and reproduce.
B. factors of the environment determining which
organisms survive and which do not.
C. the changes to living things over generations.
D. the way that not all organisms can survive
because too many offspring are produced.
10. ( 3marks)
Briefly discuss, using an example, how
advances in
technology have changed
scientific
thinking
about
evolutionary
relationships.
5.
The really important part of Survival of the
Fittest is:
A. being very well adapted to the environment.
B. living a long and healthy life.
C. being chosen to survive.
D. reproducing many offspring.
11. (5 marks)
Outline the Darwin-Wallace Theory of Evolution.
6.
A species has a better chance of long-term
survival during changes to the environment if:
A. it reproduces asexually.
B. most individuals are similarly adapted.
C. the species has a lot of genetic variation.
D. there are many large, strong individuals.
12. (4 marks)
Differentiate between convergent and
divergent evolution, giving examples of each.
7.
An example of microevolution that has
actually been observed to happen, is:
A. the extinction of the dodo.
B. divergence of Darwins finches on the
Galapagos Islands.
C. convergence of the shark and dolphin.
D. change in the population of Pepper Moths.
HSC Biology Topic 2 Blueprint of Life
copyright 2005-2
2009 keep it simple science
www.keepitsimplescience.com.au
11
2. MENDELIAN GENETICS
Next, he self-pollinated the plants of the F1.
TALL F1 plant
SELF
SELF
POLLINATED
TALL
DWARF
PURPLE
FLOWER
WHITE
FLOWER
X is shorthand for
crossed with
12
Mendels Pure-B
Breeding
parent plants were
homozygous for each
trait... 2 genes the same
PARENT
PLANTS
Tall
TT
These are
Genotypes
the actual
genes
present
Self-p
pollinating
the F1 plants is
the same as
crossing with
the same
genotype
Dwarf
tt
Only 1
gene is
passed
into
gametes
GAMETES
Fertilisation
All the F1
offspring
receive this
combination
of genes
ALL THE F1
OFFSPRING ARE
TALL, BUT
HETEROZYGOUS
Tt
Tall
Possible
GAMETES
Tall
Tt
possible
fertilisations
TT
TALL
Tt
TALL
Ratio of Phenotypes
Tt
TALL
tt
DWARF
3 Tall : 1 Dwarf
13
bb
Bb
bb
bb
tt
Phenotypes of Offspring
Tall : Dwarf
3:1
75% : 25%
ll
LL x
L only
l only
and
b&b
Bb
Tt
Solution
Gametes possible:
Tt
Parents genotypes:
Sample Problem 1
TT
Solution
To work out the F1, a punnett square is not really
needed.
gametes
B&b
Sample Problem 2
T&t
gametes
phenotypes of
offspring should be
shown as a ratio or
percentage
Monohybrid Crosses
Bb
Tt
T&t
Parents are
Tt
parent
genotypes
List of all
possible
gametes
Punnett Square
table shows all
the possible
offspring
genotypes
Phenotypes of Offspring
Black : Albino
1:1
50% : 50%
The phenotypes
of offspring are
written as a ratio
or percentage
L&
gametes
L&
LL
l
l
ll
Phenotypes of Offspring
Long Wing : Short Wing
3:1
75% : 25%
Male
with trait being studied
Therefore,
dominant.
Female
without trait
Horizontal connections are marriage lines.
Vertical lines lead to children of that couple.
Each generation is numbered by Roman
Numerals.
Individuals may be numbered for identification.
tongue-rolling
ability
must
be
tongue-rolling = R non-rolling = r
...and work out most peoples genotypes:
1
2
3
4
5
6
7
8
Rr
Rr
?
rr
?
Rr
rr
rr
Example
In humans, some people can roll their tongue
while others cannot. This is passed on by
simple Mendelian Inheritance. Here is a
pedigree of a family showing how this trait was
passed on.
1
Generations
II
III
8
9
rr
Sarah can...
Nathan cant
Worksheet 4
Mendelian Genetics
Name....................................
Worksheet 5
1.
In pea plants, green seed pods (G) is a dominant
trait over yellow seed pods (g)
a) What is the phenotype of a plant, if the
genotype is:
i) GG?
ii) gg?
iii) Gg?
Name....................................
2.
In rats, black fur (B) is dominant to brown (b).
a) If a pure-breeding black rat mated with a purebreeding brown rat, what would be the
i) genotypes of the offspring?
ii) phenotypes of the offspring?
iii) gg x GG
iv) Gg x gg
16
Worksheet 6
Pedigrees
II
5
III
10
11
Name....................................
6. (5 marks)
In pea plants, green seed pods(G) is dominant to
yellow pods (g).
A pure breeding green pod plant was crossed
with a pure-breeding yellow pod plant.
a) Explain why all the offspring will have green
pods.
7. (8 marks)
a) Use the following information to construct a
pedigree diagram.
Inheritance of red-hair in the Meggs family.
Fred and Mary both have blonde-brown hair.
They have 4 children, a daughter and 3 sons.
Their daughter and one son are red-heads, the
other 2 sons are similar to their parents. The redheaded son married a red-headed girl and they
have a son and a daughter.
5. (5 marks)
Outline the reasons why:
a) Mendels experiments were successful in
discovering the fundamentals of how
inheritance works.
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copyright 2005-2
2009 keep it simple science
www.keepitsimplescience.com.au
17
a
A
Chromatids
separate
Cell Divides
in 2
Homologous
pairs have
separated, and
cell divides in 2.
Now cells divide
again, and
separate the
chromatids.
Homologous pair of
Double chromosomes
Chromosomes
line up in their
homologous
pairs
Chromosomes
line up in a
single line
The chromatids in a
double chromosome are
Indentical Chromatids in
identical... (look at the
each chromosome
genes in the diagram)
but the homologous partners are not
identical... merely corresponding.
HSC Biology Topic 2 Blueprint of Life
copyright 2005-2
2009 keep it simple science
www.keepitsimplescience.com.au
DIPLOID CELLS
2n = 4
2 Daughter cells
18
HAPLOID CELLS
n=2
Meiosis
In BOTH
processes, the
chromosomes
are first
duplicated, to
form double
chromosomes
Homologous pair
In this case,
2n = 4
Mitosis
4 Gamete cells
Mendels
Genes
Begin in homologous
pairs
Pairs separate
in meiosis
At fertilisation, each
gamete supplies one
chromosome, so the
zygote gets back to
having paired chromosomes (Diploid)
At fertilisation, each
gamete supplies one
gene, so the offspring
gets back to having
two genes per
characteristic
A NUCLEOTIDE
Phosphate
group
Base molecule
There are 4 different
bases, so 4 nucleotides
are in DNA
Sugar
(Deoxyribose)
A
Bases
Bases
A-T
T bonded
G
C-G
G bonded
A
Notice that the only
base combinations are
A-T
T and C-G
G
Chromosomes
One Nucleotide
Part of a DNA
molecule
Each
chromosome
contains 1000s of DNA
molecules
(wrapped
in
protein) each one specifying
one of the organisms many
hereditary traits.
HSC Biology Topic 2 Blueprint of Life
copyright 2005-2
2009 keep it simple science
www.keepitsimplescience.com.au
19
Notice that
X&y
females can
only pass on
an X chromosome
in their eggs.
Males sperm
cells can either
carry an X or a y.
XX
X&X
gametes
XX
XX
Xy
Xy
Girls
Boys
Phenotypes of Offspring
Which type of
Girls : Boys
1:1
sperm fertilises
50% : 50%
the egg
determines the sex of the baby.
Non-Mendelian Inheritance
Gregor Mendel discovered the basics of Genetics, but it was found early in the 20th century
that genes dont always work in that simple Mendelian fashion.
Thomas Morgan began experimenting with
Drosophila fruit flies and quickly found they
were ideal for genetics experiments.
The Explanation:
The genes for eye colour are carried on the X
chromosome.
The dominant (Red) gene can be designated as
XR. The recessive (White) gene is Xr
The male y chromosome does NOT carry one
of these alleles at all.
Sex-Linkage Inheritance
The common and normal eye colour in the flies
is red. Morgan discovered a male fly with white
eyes. He set out to do a Mendel-type breeding
experiment:
PARENTS
White-e
eyed
Male
Red-e
eyed
Female
XRXR
XRXr
XrXr
(XX)
genotypes
&
F1 generation
All have red eyes.
Morgan concluded
(correctly)
Red is DOMINANT,
White RECESSIVE
F2 generation
Females 100%
red eyed.
20
Morganss Sex-Linkage
Experiment (continued...)
Xry
F1
Xr & y
F2
XRXR
gametes
XR & XR
XR
XR
Xr
XRXr
XRXr
XRy
XRy
XRy
XR & y
The F2 are
red : white
3:1
just like
Mendels
results, but
the sexes are
different.
XRXr
XR & Xr
gametes
XR
Xr
XR
XRXR
XRXr
XRy
Xry
Phenotypes of Offspring
FEMALES
MALES
Red : White
Red : White
100% : 0
50% : 50%
There are a number of genes in humans that are sex-linked. The best-known are 2 genetic disorders:
Red-Green Colour Blindness, is where a person cannot distinguish between certain colours.
Haemophilia, is a condition in which the blood does not clot properly, putting the person at constant
risk of internal bleeding. It was always a fatal condition, but in modern times people with
haemophilia are treated with clotting factors from donated blood.
Both conditions are sex-linked, inherited as recessive genes on the X chromosome.
They occur much more often in males than females.
Inheritance by Co-Dominance
Another example of Non-Mendelian Inheritance is known as Co-Dominance. This is a fairly
common situation in which the 2 alleles for a characteristic do not show a Dominant-Recessive
pattern, but when both genes are present (heterzygous) they are both expressed,
and may result in an in-between phenotype.
Here is what happens in a Mendel-type cross:
Example: In Shorthorn cattle, there is gene (R)
that causes the hair of the animals coat to be
red (actually a rustyPARENTS
X
brown colour). To be red,
the animal must be
RR
WW
homozygous for this gene.
Genotype RR
gametes: R only
W only
The other allelic gene (W) causes
the coat to be white,
if the animal is homozygous.
RW
RW
Genotype WW
RW
F1 100% Roan
If an animal is heterozygous,
with both alleles present,
neither gene dominates the other.
Both genes are expressed,
producing mottled patterns
of red and white hair which
is called roan.
gametes: R or W
RW
RR
F2
Phenotypes:
Genotype RW
Note that it is best to use
2 different CAPITAL letters as
symbols in this case, since neither gene is
recessive.
HSC Biology Topic 2 Blueprint of Life
copyright 2005-2
2009 keep it simple science
www.keepitsimplescience.com.au
RW
F1 breed among
themselves
RW
WW
IN GOOD SOIL
Genotype TT
Phenotype TALL
Genotype tt
Phenotype
DWARF
Genotype tt
Phenotype DWARF
Phenotype
DWARF
Crossing-Over
MEIOSIS
B
Possible gene
combinations
in gametes
AB
or ab
WITH CROSSING-O
OVER
a
b
MEIOSIS
Possible gene
combinations
in gametes
AB
aB
Ab
ab
Variation Caused by
Sexual Reproduction
The simple fact that sexual reproduction
involves TWO parents, creates a lot of variation.
The offspring receives genes from 2 different
individuals, thereby getting a new mix of
traits.
Summary
Worksheet 8
Chromosomes
are
thread-like
structures in the a).................... of a cell.
They
are
only
visible
during
b).......................................
Chromosomes come in pairs, referred to
as c).............................. The members of
a c)............................... pair are not
identical, but correspond with each
other
because
they
carry
d)....................................
genes
in
corresponding locations. Before a cell
division,
each
chromosome
is
e)............................ to make a double
chromosome. The 2 parts are called
f)................................ and they are
g)................................. to each other.
Sexual
reproduction
produces
variations in a population because:
WHEN COMPLETED,
WORKSHEETS BECOME SECTION SUMMARIES
HSC Biology Topic 2 Blueprint of Life
copyright 2005-2
2009 keep it simple science
www.keepitsimplescience.com.au
Name....................................
Worksheet 9
1.
Refer to Morgans experiment with fruit flies.p20
a) Why are there 3 genotypes for female flies,
but only 2 for males?
Name...............................
4.
In a particular breed of chickens, the feather
colour is controlled by 2 alleles B and W.
Genotype BB produces black feathers.
Genotype WW produces white feathers. The
heterozygous genotype BW results in black &
white speckled feathers.
ii)
XRy
crossed with
XrXr
2.
In humans, a recessive gene (Xn) carried on the X
chromosome causes colour-blindness. The
normal vision gene can be symbolized by XN.
Use these symbols to write the genotype of:
a) a homozygous normal-vision female.
b) a normal-vision male.
c) a colour-blind male.
d) a colour-blind female.
e) a carrier female (heterozygous)
f) A man with normal vision married a woman
who is colour blind. Use a Punnett Square to
predict the pattern of inheritance in their
children.
24
Worksheet 10
Test Questions
Multiple Choice
section 3
Name....................................
1.
A pair of homologous chromosomes:
A. are identical to each other.
B. carry totally different genes
C. will line up as a pair during mitosis.
D. carry alleles in corresponding locations.
7. (6 marks)
a)
Sketch
one
pair
of
homologous
chromosomes, just before a cell was to undergo
a cell division.
If the organism is heterozygous for allelic genes
Q and q, show on your diagram the
positions of all copies of these genes.
2.
Meiosis produces:
A. 4 haploid gamete cells.
B. 2 diploid body cells.
C. 4 identical gametes.
D. 4 non-identical body cells.
3.
A nucleotide contains:
A. sugar, phosphate and 1 of 4 possible bases.
B. a base, phosphate, & 1 of 4 possible sugars.
C. amino acids in a polypeptide chain.
D. base pairs A-T and C-G.
4.
In human sperm cells you would expect to find:
A. 46 chromosomes including an Xy pair.
B. 46 chromosomes including either an X or a y.
C. 23 chromosomes, including an X.
D. 23 chromosomes, including either an X or a y.
8. (5 marks)
In Drosophila fruit flies, the normal eye colour is
red. A recessive, sex-linked gene causes white
eyes.
Using symbols XR, Xr and y, predict the
phenotypes (separately for each sex) of the
cross between a white-eye male and a
heterozygous red-eye female.
Show your
working.
5.
If a recessive gene is sex-linked you would
expect:
A. males and females to show the
phenotype equally.
B. a heterozygous female will show
the recessive phenotype.
C. males may inherit the trait only from
their mother.
D. males will pass the recessive gene on
to their sons.
9. (5 marks)
A certain species of African rodent was
described in Multiple Choice Question 6.
Using appropriate (declared) symbols, predict
the outcome of a mating between a grey and
black animal of this species.
6.
In a species of small African rodents it was
noticed that 2 grey coloured animals produced a
litter of babies that were about 25% white, 25%
black and about 50% grey. It seems likely that:
10. (3 marks)
a) Explain, with the help of simple diagrams if
you wish, the process of crossing over with
chromosomes.
25
DNA Replication
Bases
DNA
REPLICATION
C
A
A T
G C
C G
G C
A T
T A
C G
G C
CG
Spare nucleotides
CG
C
AT
G
A
C
T
Nucleotides
match up with
complementary
base on original
strand.
Enzymes
connect them in
place, forming
a new strand.
G
G
T
AT
GC
CG
T
T
C
G A
T
GC
AT
T A
CG
GC
When
completed,
each new DNA
molecule is
twisted back
into a doublehelix shape.
old strand
New strand
TA
G T
A
Double-s
stranded Helix
C-G
G
GC
Molecule is untwisted
and unzipped by
enzymes
Pairs of Bases
and
A-T
T
DNA Strand
Bases
Protein Structure
has been covered briefly in previous topics.
Heres a quick revision:
Codon
Protein
with precise
3-D
D shape
Protein Functions
Proteins have many functions within an
organism:
Enzymes are all protein molecules
Structural Molecules, such as in muscle fibres,
skin, hair and bone matrix are proteins.
Many Special Molecules are proteins, such
as haemoglobin, (the oxygen carrier in blood)
chlorophyll (absorbs light for photosynthesis)
antibodies (which help fight disease)
... and many more.
Enzyme 1
Enzyme 2
Enzyme 3
27
TRANSLATION
TRANSCRIPTION
DNA
m-R
RNA
RNA is a polymer of
nucleotides, similar to
DNA, but
single strand only
different sugar
one different
nucleotide
gr
ow
in
g
Each
3-b
base codon
in m-R
RNA
specifies
one amino acid
in the
polypeptide chain
mfro RNA
m
m
the ove
nu s
ou
cle
t to
us
ar
ibo
som
e
P
by oly
ad pep
di ti
tio de
n ch
of a
Am in
in
o
Amino
Acids
Ac
id
s
m-R
RNA
Ribosome
moves along
m-R
RNA
then,
Part 2. From Polypeptide to Phenotype
Perhaps its a
structural protein,
used to build
muscle or skin
Possibly it is combined
with other polypeptides
or special chemical
groups to form...
Substrates
Maybe it becomes a
molecule of
Haemoglobin, used
to carry oxygen in
the blood
a functional
PROTEIN
molecule
It could be an
ENZYME, able to
catalyse a chemical
reaction
STARTING
CHEMICALS
(Substrates)
t-R
RNAs
Ribosome enzymes
connect the amino
acids to form a
polypeptide chain
It could be a Hormone,
which controls some
aspect of Homeostasis
Enzyme
Product;
a Coloured
Pigment
The gene(s) for eye colour are present in every cell of your body, but are only expressed in your iris cells.
Similarly, the genes for liver functions are only expressed in your liver cells, and genes to make taste buds are
only expressed in your tongue. What controls which genes are expressed is still unknown in most cases.
HSC Biology Topic 2 Blueprint of Life
copyright 2005-2
2009 keep it simple science
www.keepitsimplescience.com.au
28
Mutation
Codon
Causes of Mutation
Bases
Codon
Blue
original
Enzyme
Pigment
in iris
Original
Phenotype
(Blue eyes)
Substrate
Chemical
New
Mutated
Enzyme
Colour
Pigment
Effects of Mutation
Mutation during Meiosis
Affects a Gamete
Mutation
might
have no
effect on
cell.
Cell might
not be able
to function
properly.
Cell dies.
No effect on
multicellular
organism.
Changed base
Mutant
Phenotype
(new colour)
Gamete NOT
involved in
reproduction.
No effect.
29
Evidence for
Punctuated Equilibrium
EVOLUTION by
STABLE AGAIN
NO CHANGE...
Studies on living
populations (eg snails in
grasslands) show that if
the environment
changes suddenly
(e.g. because
of humans
clearing
the land)
the species can
respond with
...THEN A RAPID BURST
a very rapid
OF CHANGES
genetic shift
within 20 years or so.
This does not prove that a
new species can evolve
quickly, but lends support
to the idea of rapid change.
The debate continues...
30
Name....................................
Cloning
Artificial Pollination
Body Cell
Diploid Nucleus
Extracted
Unfertilised
Egg
Nucleus
removed
Surrogate
Mother
EGG DONOR
PARENT of CLONE
Fertilized egg
placed in uterus
Normal pregnancy
and birth
32
Reproductive Technologies
& Genetic Diversity
Transgenic Species
As well as reproductive technologies, humans
are altering the gene pools of species in
another way...
Gene Transfer
Purpose / Benefits
33
Human Insulin
Type I Diabetes is a killer disease in which a
persons pancreas stops making the hormone
insulin. Without insulin their cells cannot absorb
glucose and they lapse into a coma and die.
Early treatments relied on extracting insulin from
animals at an abbatoir, but there were many
side-effects and supplies were uncertain.
Human DNA,
extracted from a
human cell
chemically
chopped-u
up
into fragments
chemically
cut open
Mixed
together
section 4 & 5
Name....................................
1.
Which of the following is NOT a source of
increased genetic diversity in a species?
6. (6 marks)
Use a simple flow chart diagram to outline the
process by which DNA controls the production
of a polypeptide.
7. (5 marks)
a) What is a mutagen?
3.
The factor least likely to be mutagenic is:
A. nuclear radiation.
B. herbicide chemicals like agent orange.
C. ultra-violet light.
D. low temperatures.
4.
The base sequence on a part of a DNA chain is
...ATTCGAGGCTAC...
Which of the following statements is correct?
8. (4 marks)
Compare and contrast the idea of Gradualism
in Evolution, with the theory of Punctuated
Equilibrium.
9. (5 marks)
a) Outline the process that can be used to make
a clone of a mammal.
b) Explain the effect that cloning could have on
the genetic diversity of the cloned species.
10. (5 marks)
a) Give an example of the use of a transgenic
species, stating:
i) precisely which species are involved,
and
ii) the benefit or purpose achieved.
b) State an ethical concern that some people
might have with the use of this transgenic
species.
35
THE
BLUEPRINT
OF LIFE
36
9.
a) An example is the Pentadactyl Limb
structure in vertebrate animals. The bone
structures in the fore-limb of a whale, bat, dog,
human, lizard, etc. are all essentially the same,
even though each looks very different on the
outside, and each is used for very different
purposes... swimming, flying, walking, etc.
b) This is evidence of descent from a common
ancestor which had that bone structure.
Answer Section
Worksheet 1
a) Palaeontology
b) fossils
c) less
d) more
e) less
f) more
g) present-day organisms
h) millions (billions)
i) relative
j) correlating
k) Radiometric
l) transitional
m) Archaeopteryx
n) dinosaur
o) bird
p) how living things are distributed
q) very similar
r) very different
s) common ancestor
t) bone structure
u) for different purposes v) Pentadactyl limb
w) DNA
x) enzymes
y) common ancestry
z) species can be changed
10.
Sequencing the DNA of different species allows
their degree of relatedness to be determined
very precisely, since closely related species
have very similar DNA.
This has revealed some surprises that have
changed the thinking on evolutionary
relationships. For example, it has previously
been thought that lizards and crocodiles (both
classified as reptiles) are more closely related to
each other than to birds. DNA analysis reveals
that birds are more closely related to crocodiles
than either is to the lizards.
Worksheet 2
a) Charles Darwin & Alfred Wallace
b) more offspring than can possibly survive
c) variation (genetic diversity)
d) Natural Selection
e) best suited
f) reproduce / breed
g) Survival of the Fittest h) evolves / changes
i) predators, food, supply
j) who are best suited
k) reproduce
l) survive
m) reproduce
n) Pepper
o) industrial
p) black to light moths
q) DDT
r) selection
s) resistant
t) extinct
u) Partitioning
v) using slightly different
resources
w) evolves into several / more than one
x) isolated
y) selection
z) Convergent
aa) resemble
ab) similar / same
ac) characteristics / adaptations
ad) dolphin
ae) features / adaptations
af) closely related
11.
(Best in 5 numbered points)
1. All species produce more offspring than can
survive.
2. There is variation within each species... not all
the same.
3. Natural Selection: the factors of the
environment choose which individuals survive.
4. Survival of the Fittest: those best suited to
the environment survive and reproduce.
5. The survival characteristics get passed on
to offspring so each generation is slightly
different than before. Over many generations
the species changes... it evolves.
12.
Divergent evolution is when one ancestral species
evolves into 2 or more different species. An
example is the finches of the Galapagos islands,
where a different species of finch has evolved on
each separate island, all from a single ancestral
species.
Convergent evolution is when different species
evolve to resemble each other, even though they
are not closely related. An example is the shark &
dolphin which are both streamlined, fastswimming look-alikes, but are not related in an
evolutionary sense.
Worksheet 3
1. C
2. B
3. A
4. B
5. D
6. C
7.D
8.
Relative Dating is done by correlating fossils
from one place with those elsewhere. It allows
scientists to put things in order, from oldest to
youngest, but the actual ages cannot be
determined.
Absolute Dating involves measuring the
radiation from naturally occurring radioisotopes. These decay at known rates, so the
amount of radiation remaining in a rock or fossil
allows the actual age in years to be determined.
37
Worksheet 6
Worksheet 4
a) Mendel
c) inherited
e) pure-breeding
g) F1
i) self
k) 3:1
m) alleles
o) 2
q) heterozygous
s) fertilization
u) recessive
w) homozygous
y) actual genes present.
aa) pure-breeding
ac) statistically
ae) German
b) pea
d) pure
f) dwarf
h) tall
j) 2nd generation
l) genes
n) allelic
p) the same
r) gametes
t) parent
v) dominant
x) phenotype
z) simple, easily identified
ab) large
ad) a recognised scientist
b) S = Straight, s = curved.
c) 1=ss, 2=SS, 3=ss, 4=SS, 5=Ss, 6=Ss, 7=Ss,
8=Ss, 9=Ss, 10=SS or Ss(uncertain), 11=ss
d) No chance of curved-finger children, because
all children must receive a S gene from
mother who is SS.
e) Ss x ss would give 50% curved, 50% straight.
f) It is quite possible. Prediction is not wrong.
In small samples, random chance can result in
offspring ratios that are not in agreement with
the prediction. (In a large sample of offspring
there should be approximately 50-50)
Worksheet 5
1. a) i) green
b) i) GG
c)
i)
ii) yellow
ii) Gg
iii) green
iii) gg
Gg
Gg
G&g
Worksheet 7
G&g
gametes
GG
Gg
Gg
gg
1. B
2. A
3. C
4.
a) Dominant gene will always be expressed.
Recessive gene can only be expressed when no
other allele is present (i.e. if homozygous for the
recessive gene)
b) Homozygous means having 2 copies of the
same allele for a particular trait. eg, AA, or bb.
Heterozygous means to have 2 different alleles
for the trait. eg, Aa
Phenotypes of Offspring
Green : Yellow
3:1
75% : 25%
5.
a) Mendels experiments were successful
because:
he chose to study simple traits that occurred in
just 2 alternative forms, such as Tall v. Dwarf.
he began with pure-breeding parent plants.
he bred large numbers of offspring so the
results could be interpreted statistically.
b&b
gametes
Bb
Bb
bb
bb
Phenotypes of Offspring
Black : Albino
50% : 50%
ii)Not surprising.
In such small samples, random chance can give
results not exactly in the expected ratio.
38
Worksheet 7
Worksheet 8 (cont)
z) DNA
aa) polymer
ab) nucleotides
ac) sugar, phosphate & base
ad) A,C,G & T
ae) helix
af) 2
ag) A-T and C-G
ah) genes from 2 different parents
ai) Independent Segregation
aj) Crossing-over
(cont)
6.
a) Each of the offspring will receive a gene from
each parent and so all will have genotype Gg.
Since G is dominant, it will be expressed so all
offspring will have green pods.
b)
Gg
gg
G&g
g&g
gametes
Gg
Gg
gg
gg
Worksheet 9
1. a) Males cannot be heterozygous because
they only have one X chromosome. The y
chromosome doesnt carry an allele.
b) From his mother, who gives him his X
chromosome. Father gives y, which doesnt
carry an allele.
Phenotypes of Offspring
Green pod : Yellow pod
1:1
50% : 50%
c) i) XRXr
ii) Red-eyed
iii) She carries the recessive gene and passes it
to her children, but does not show the
phenotype of it herself.
Generations
Xr & y
II
Xry
d) i)
Mary
III
8
XR
Xr
Xr
XRXr
XrXr
XRy
Xry
Worksheet 8
XR & Xr
gametes
Phenotypes of Offspring
FEMALES
MALES
Red:White
Red : White
50% : 50%
50% : 50%
XRXr
b) XNy
e) XNXn
c) Xny
XNy
f)
XN & y
XnXn
Xn & Xn
gametes
Xn
Xn
XN
XNXn
XNXn
Xny
Xny
Phenotypes of Offspring
FEMALES
MALES
100% normal
100% colour blind
vision
the
39
Worksheet 9
Worksheet 10
(cont)
RW
3.
a)
RR
R&W
1. D
RR
RR
RW
RW
3. A
4. D
5. C
6. B
Homologous pair of
Double chromosomes
7. a)
R&R
gametes
2. A
b)
i) in a single line
Phenotypes of Offspring
Red : Roan
1:1
50% : 50%
ii)
b) WW x RW.
Phenotypes of offspring
50%White, 50% Roan.
BW
4.
a)
BW
B&W
iii) in pairs
iv)
B&W
gametes
BB
BW
BW
WW
Xry
8.
Xr & y
Phenotypes of Offspring
Black : Speckled : White
1 :
2
: 1
25% : 50%
: 25%
XRXr
XR & Xr
gametes
XR
Xr
Xr
XRXr
XrXr
XRy
Xry
Phenotypes of Offspring
FEMALES
MALES
Red : White
Red : White
50% : 50%
50% : 50%
ii) RW
RR x WW
R only
W only
F1:
GREY
BLACK
BW
BB
100% RW (Pink)
RW
F2
9.
Gene symbols: B= Black, W=White
iii) WW
R&W
B&W
RW
R&W
gametes
B&B
gametes
BB
BB
RR
RW
BW
BW
RW
WW
Phenotypes of Offspring
Black : Grey
1 : 1
50% : 50%
Phenotypes of Offspring
Red : Pink : White
1
1
: 2 :
25% : 50% : 25%
40
Worksheet 10
Worksheet 12
(cont)
10.
a) Crossing-over is when
homologous chromosomes
exchange corresponding
parts of a chromatid with
each other.
1. B
6.
2. C
DNA
3. D
4. A
5. C
TRANSCRIPTION
m-R
RNA
Moves to a
Ribosome
TRANSLATION
Polypeptide
m-R
RNA controls
sequence of
amino acids
joined together
Worksheet 11
a) communication
b) collaboration
c) Wilkins
d) Franklin
e) Watson
f) Crick
g) base
h) double
i) replicated
j) division
k) unzip / untwist
l) template
m) A & T
n) C & G
o) identical
p) amino acids
q) polypeptide
r) 3-D shape
s) sequence
t) 20
u) repel
v) enzymes
w) structural
x) shape
y) amino
z) DNA
aa) 3
ab) codon
ac) Transcription
ad) m-RNA
ae) template
af) single
ag) sugar
ah) base
ai) nucleus
aj) mitochondria
ak) synthesis
al) Translation
am) polypeptide
an) t-RNA
ao) mitochondria
ap) protein
aq) catalyses
ar) pigment
as) change
at) mutation
au) mutagens
av) temperature
aw) chemicals
ax) X-rays
ay) nuclear radiation az) Ultra-violet U.V.
ba) DNA
bb) amino
bc) polypeptide
bd) shape
be) enzyme
bf) pigment
bg) Evolution
bh) variation / genetic diversity
bi) Punctuated Equilibrium
bj) remain unchanged
bk) rapid bursts
Altered
DNA
Change in
cells activity
Altered
m-R
RNA
Altered
Polypeptide
Altered
Enzyme
causes different
chemical
product to form
8.
Similarity: both are models describing
evolution of a species.
Difference:Gradualism = evolution occurring
slowly and steadily over relatively long time
periods. Punctuated Equilibrium = species
remains unchanged for long periods, then
evolves in a rapid burst.
9.
a) Body cell taken from parent, and nucleus
extracted. Egg cell obtained and nucleus
replaced with nucleus from parent cell.
Egg cell implanted in uterus of surrogate
mother, where normal pregnancy and birth
occur. Baby is clone of parent individual.
b) If used on a large scale, cloning would
reduce genetic diversity because less parents
are involved and more offspring would be
identical.
41
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