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a.
b.
c.
d.
4. -adrenergic agents
38.one of the following statements is true about epinephrine
1. it is synthesized from norepinephrine by side chain hydroxylation
2. the enzyme responsible for the conversion is norepinephrine hydroxylase
3. it activates both alpha and beta adrenergic receptors
4. it iscatabolized by MAO and COMT to homovanilic acid
39.tyrosine is converted to L-DOPA by which reaction
1. ring hydroxylaytion
2. hydroxylation of the side chain
3. decarboxylation
4. methylation
40.the concentration of this metabolite is elevated in the urine on patients with tumor of the
adrenal medulla
1. DOPA
2. Vanillylmandelic acid
3. Dopamine
4. Homovanillic acid
41.The following adrenergic receptor subgroups are coupled to the adenylyl system except
1. -1
2. -1
3. -2
4. -2
42.the following P450 group of enzymes is located in the endoplasmic reticulum except
1. P450 scc
2. P450 c17
3. P450 c21
4. P450 arom
43.Which of the following enzymes catalyze conversion of 17-hydroxyprogesterone to
dehydroepiandrosterone
1. 17 a-hydroxylase
2. 17, 20 lyase
3. 17 ketoreductase
4. 17 -isomerase
44.Mutation of this enzyme can lead to male pseudohermaphroditism
1. 17 20 lyase
2. 18 hydroxylase
3. 3 B hydroxysteroid dehydrogenase
4. 17 ketoreductase
45.The region or domain that confers specificity to a steroid hormone receptor
1. Ligand binding region
2. DNA binding region
3. Variable region
4. Zinc fingers binding region
46.Which steroid hormone receptor is located on the x-chromosome
1. Thyroid hormone receptor
2. Retinoic acid receptor
3. Estrogen receptor
4. Androgen receptor
47.Membrane receptors for oxytocin in uterine smooth muscle are increased by
1. Estrogen
2. Progesterone
3. Testosterone
4. Cortisol
48.This steroid hormone is the end product of the corpus luteum in the ovary
1. Estradiol
2. Testosterone
3. Dehydroepiandosterone
4. Progesterone
49.Predominant type of estrogen in non pregnant reproductive age women is
1. Estriol
2. Estradiol
3. Estrone
4. Estrin
50.This hormone is structurally related to proactin
1. Human placental lactogen
2. Human chorionic gonadotropin
3. Follicle stimulating hormone
4. Leutenizing hormone
51.Which hormone is responsible for the milk ejection or milk let doen reflex
1. Prolactin
2. Oxytocin
3. Estrogen
4. Progesterone
52.The checkpoint complex that regulates progeression from the growth phase to DNA
synthesis
1. CDK1:D
2. CDK2:E
3. CDK6:D
4. CDK1:B
53.The processivity of DNA synthesis refers to the activity of
1. Dna ligase
2. Topoisomerase I
3. DNA polymerase
4. Helicase
54.Which statement best describes the function of the gene?
1. It encodes the primary sequence of a polypeptide
2. Regulatory sequences are located within the coding sequence
3. Te entire chromosome contains coding sequences
4. Its expression involves a complement of cytosolic enzymes
55.The structure of the dna molecule is described as
1. The backbone is stabilized by hydrogen bonds
2. The nitrogenous bases account for the polarity of the molecule
3. The antiparallel stands are complementary
4. The ribose component participates in base pairing
56.The themes that govern human dna replication includes
1. The information in the parent molecule is completely conserved in one new DNA
2. The antiparallel strands undergo simultaneous unwinding
3. The initial step involves the random nicking of an adenine-thymine rich sequence
4. All of the above
57.Which protein is not involved in the formation of the replication fork
1. Dam methylase 1
2. Dna polymerase 4
3. Rna polymerase 3
4. Dna gyrase 2
58.The subunit of the e. coli dna polymerase that attaches the enzyme to the template
1.
2.
3.
4.
59.the catalytic effect of dna gyrase during replication is to
2. 3 B-hydroxysteroid dehydrogenase
3. 17 B-hydroxysteroid dehydrogenase
4. Aromatase
80.Sex hormone binding globulin is decreased by which of the following
1. Estrogen
2. Androgen
3. Liver disease
4. Hypothyroidism
81.The following conversion reactions require P450arom (aromatase) enzyme
1. Androstendione to estrone
2. DHEA to androstenedione
3. Testosterone to estradiol
4. Estrone to estradiol
82.Ketosteroid metabolites of testosterone include which of the following
1. Pregnanediol
2. Androsterone
3. Dihydrotestosterone
4. Etiocholanolone
83.Dihydrotestosterone specific actions include
1. Spermatogenesis
2. Prostate development
3. Sexual differentiation into wolffian ducts
4. Sexual maturation at puberty
84.In the A cells of the pancreas, the products of preproglucagon include
1. Glucagon
2. GLP1
3. MPGF
4. Glicenin
85.Which of the following GI hormones inhibit secretion of insulin
1. GIP
2. CGRP
3. GLP-1
4. Galanin
86.Which of the following affect the amount of hormone within target cells
1. Dilution effect
2. Conversion to active form
3. Dissociation constant
4. Clearance rate
87.The following are features of group 1 hormones
1. Lipophilic
2. Receptors as proteins
3. Have long half life in circulation
4. Require intermediary molecules for activity
88.The proportion of bound and free hormones depends on the transport proteins
1. Rate of synthesis and secretion
2. Binding affinity
3. Solubility and polarity
4. Binding capacity
89.Hormone-receptor complex formation involves
1. Specificity\sensitivity to antagonist
2. Sensitivity to antagonist
3. Saturation
4. Bioavailabiliy
90.Which enzyme;reaction pair is observed during post translational modification of mRNA
1. Methyltransferase; 3-5 attachment of guanine
Column B
A. cAMP
B. kinase/phosphate cascade
C. Ca2+/PIP2
D. cGMP
E. NO
LABORATORY
106.In blood glucose determination using Horizon procedure
a. d-gluconic acid is measured at 405nm
b. at 405nm, the color intensity correlates well with blod glucose levels
c. quinonenimine formation is stabilized by addition of of hydrogen peroxide
d. p-hydroxybenzene sulfate enhances the formation of a stable red dye
107.this is the best indicator of basal metabolic rate
a. random blood sugar
b. oral glucose tolerance test
c. fasting blood sugar
d. glycohemoglobin test
108.measures of fuel metabolism in the body includes
a. lipid profile
b. FBS
c. BMI
d. All of the above
109.The variable stability of specimen for blood glucose determination is due to
a. Rbc lysis in the stiored specimens
b. Bacteria contamination of specimens
c. Glycolytic activity in RBC
d. All of the above
110.Eliminating the influence of physical activity and diet, this blood determination indicates
fuel source status
a. Serum lipid profile
b. BMI
c. FBS
d. All of the above
111.This is true of glycohemoglobin
a. It is a measure of an average blood glucose levels in 2-3 months duration
b. Glucose attaches to the NH3 terminus of the 4 globin chains
c. Its levels correlate well with life expectancy in DM type 2 patients
d. All of te above
112.Impaired glucose tolerance correlates with
a. FBS = 70-110mg/dL
b. 2o OGTT = 140-< 200 mg/dL
c. RBS = 110-125 mg/dL
d. B and C only
113.To document an increase of blood glucose after a meal by a physiologic means, this/
these tests are requested
a. RBS
b. Pos prandial BS
c. OGTT
d. B and C only
114.The following is true of gestational DM
a. The most reliable screening test is OGTT
b. GDM is established if blood glucose levels are elevated at 2 hours post glucose
intake
c. Only pregnant women with family history of DM should be screened for the
condition at 24-28 weeks
d. A and B only
115.GDM occurs because of a defect in
a. Insulin action
b. Insulin receptor substrate -1 (IRS-1) expression
c. Tyrosine kinase activity
d. A and B only
Answers
1. C
2. D
3. B
4. A
5. B
6. A
7. A
8. B
9. D
10.B
11.B
12.B
13.C
14.D
15.B
16.A
17.D
18.D
19.A
20.B
21.B
22.B
23.B
24.D
25.B
26.A
27.B
28.D
29.A
30.D
31.B
32.B
33.C
34.C
35.A
36.B
37.C
38.C
39.A
40.B
41.D
42.A
43.B
44.D
45.C
46.D
47.A
48.B
49.D
50.A
51.B
52.C
53.C
54.A
55.C
56.B
57.B
58.C
59.C
60.A
61.A
62.C
63.C
64.B
65.D
66.D
67.B
68.D
69.C
70.B
71.C
72.B
73.B
74.B
75.E
76.A
77.E
78.B
79.A
80.C
81.B
82.C
83.C
84.B
85.C
86.E
87.A
88.C
89.A
90.D
91.A
92.E
93.A
94.C
95.D
96.B
97.A
98.A
99.B
100.D
101.A
102.B
103.B
104.B
105.A
106.D
107.C
108.D
109.B
110.D
111.D
112.B
113.D
114.B
115.B