Topics for partial examination First semester 2014 2015

The examination will be written on next week (9-13 March) when we have
lecture (I am still not sure, but I think it will be Thursday) and will consist of:
-10 or 15 multiple choice questions from subjects 1-49, and 10 or 15 multiple
choice questions from subjects 50-82 in total 20 or 30 questions
-one subject of practice - probably a case study - you will also be able to argue
orally this subject
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Concept of Disease (ILLNESS)

Concept of Health
Etiology of disease
Etiological factors (agents)
Predisposing factors
Pathogenesis of disease
Reactivity
Outcome of disease (THE END OF THE DISEASE)
Brain Death (WHO criteria )
Essential characteristics of the state of sickness (Disease / ILLNESS)
The onset of the disease (physiopathologicical onset vs clinical onset)
Primary Parameters of disease
Phase status and disease primary parameters
Secondary parameters of disease
Classification of diseases
Normal body temperature
Types of the elevation of body temperature (Physiological vs Pathological)
Types of fever
Fever (Def, Causes and mechanisms of fever)
Hyperthermia
Pyrogenic activator (def, Category of pyrogenic activator )
Concept of endogenous pyrogen (EP)
EP generating cells
Category of endogenous pyrogen
Pathways for EP signal transduction to the thermoregulation center
Pathogenesis of fever
Phases of fever
Inflammation (def)
Inflammation Causes (agents)
Cardinal Signs of Inflammation (pathophysiological underling process)
Mechanism of Inflammation
Chemical Mediators of Inflammation
Types of Inflammation
Inflammation Outcome
Concept of Pain
Purpose of pain
First Order Neurons
Neurotransmitters
Descending Neurons
Pain fibers
Pain Threshold
Pain Tolerance
Pain transmission
Pain Control Theories (Specificity theory, Pattern theory, Gate control theory)
The pain response - NociceptorsModulation of Pain
Central control and descending inhibition of pain

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The main categories of pain (acute vs chronic)

Analgesia
Anemia Definition
Anemia Mechanism
Significance of anemia and compensatory mechanisms
Anemia Diagnosis, Lab evaluation
Classification of anemias (morphologically)
Iron Deficiency Anemia
Megaloblastic anemia
Differential diagnosis of Anemia
Aplastic anemia
Hemolytic anemia
Leukemia def, Diagnosis, Pathogenesis
Classification of leukemias
Principles of leukemogenesis
Leukemia Clincal manifestations
Leukemia Lab evaluation
Acute lymphoblastic leukemia
Chronic myelogenous (granulocytic) leukemia
Chronic lymphocytic leukemia
Polycythemia Vera
Pathophysiology of Secondary Polycythemia
Main effects of insulin
Hypoglycemic state
Hyperglicemia
Diabetes mellitus
Lipoproteins
Plasma lipid disorders
Lipid storage disease
Atherosclerosis physiopathology
Atherogenic factors
Obesity physiopathology
Dehydration
Hyperhydration
Hypernatremia Hyponatremia

Prof. MD PhD Suzana Danoiu

Head of Pathophysiology
Department of Functional Disciplines
Faculty of Medicine
University of Medicine and Pharmacy of Craiova
Romania