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Innate
Goal: prevent organism establishing
Inherited by mother
Born with
First to response
Consistent response
Nonspecific
Adaptive
Acquired
Develops (breast feeding contributes for small
amount)
Antigen specific
Has memory through exposure
Diverse
Rapidly adaptive
Specific, but it turns of
2 main classes
Humoral
antibody
Cell
mediated
Secreted protein: Ig
Mechanism of action:
Eosinophil
1.
Recognition
Neutrophil (PMN)
2.
Activation
Dendrite cells
3.
Efector stage
4.
Decline
5.
Memory of exposure
Blymphocytes
TLymphocytes
KEY FEATURES:
-
KEY FEATURES:
-
Monocytes
Macrophages
Lysosome presence
APC
Present antigen to T cells
Name depends on the location
Examples:
Follicular cells
Granulocytes
epidermal: Langerhans
Special class
Multinuclear:
Eosinophils
PMNs
75% (most)
Eosin
5%
Basophil 1%
1. Parasites
2. Allergic reaction
3. Phagocytosis
4. Release Lytotoxin
5. Controls inflammation
6. Increase with asthma, Addisons disease
Basophiles
Mass cells
Natural killer
cells
B cells
T Cells
IgE (Allergy)
Do not phagocytose
Late Efect
Release of histamine
Origin: Lymphocyte
Recognize antigens
Produce antibody
4. 3 steps of phagocytosis
a. ID
b. INGEST (MICROTUBULE IS NEEDED)
c. DESTROY
7. Diff cells, diff lines: myeloid and lymphoid lines and what cells are in each.
Stem cell
Pluripotent
a) A)
Lymphoid
a. B cells
b. T cells
b) Myeloid
a. Granucy
te
shift to myeloid
b. Basophil
e
c. RBC
d. Eosinop
hil
e. Platelet
8. Specific characteristics of the each cells. Major characteristics of the cells. And their major
function and how they are regulated.
11.What each organ does. Liver as a neonate has a diff function as liver in adults. So diff
functions like that. Ex lung flat lung in the neonates and diff in adults. Neonate vs adults.
Neonate
Adult
Liver
Shifts to Filtering
Thym
us
shrinks
IL1/TNF
IL-2
IL-3
IL-4
IL-6
IL-7
IL-10
IL-11
Stimulate megakaryocytes
IFN-
TGF-
GMCSF
13.5 diff types of receptor. Type 1 and type 2 , Ig and transmembrane domains
a. Type I
b. Type II
c. TNF
d. Ig Superfamily
e. -Helical receptors (7- transmembrane)
JAKs phosphorylate the receptor, providing binding sites for STAT proteins
15.Diff categories for cytokines: 3main categories and major cytokines of the each system.
( innate and adaptive)
Innate
IL-1/TNF
IL-2
IL-10
Adaptive
IL-2
IL-4
Hematopoiesis
IL-3
IL-7
IL-11
IFN-
IFN-
GM-CSF
TGF-
16. The clinical application of cytokine: INF alpha has a diff application, just the cytokine class.
What the cytokines are used for. ( this might not be that important)
IL-1
IL-2
IL-3
IL-11
IFN-
IFN-
GM-CSF