Code No: RR412303 Set No.

1
IV B.Tech I Semester Supplimentary Examinations, February 2008
BIO PHARMACEUTICAL TECHNOLOGY
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
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1. State the offences and penalties relating to

(a) External dealings in narcotic drugs and psychotropic substances.

(b) Psychotropic substances act.
(c) Import, export, transshipment of narcotic drugs & psychotropic substances.
(d) Name five drugs, which should be stored “in a well closed container, protected
from light, in a cool place”. [4+4+4+4]

2. What are the various mechanisms for drug-drug interactions in the GIT (Gastro
Interstinal Track)? Describe in detail. [16]

3. Describe about the biological effects of radiations? [16]

4. What are the different types of purification techniques used in the case of bulk drug
manufacturing process? [16]

5. Write the operation of rotary tablet press. [16]

6. What is quality assurance and how does it control the quality of drug product?
[16]

7. What are saline laxatives? How they are differ from stimulant laxatives? Explain
with examples? [16]

8. (a) What are the conjugated estrogens and describe about conjugated estrogens
with examples?
(b) Describe about the therapeutic importance of non-steroidal contraceptives?
[8+8]

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Code No: RR412303 Set No. 2
IV B.Tech I Semester Supplimentary Examinations, February 2008
BIO PHARMACEUTICAL TECHNOLOGY
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆

1. What are antimalarial drugs? Give structure and uses of the following: [4]

(a) Quinine
(b) Trimethoprim
(c) Chloroquine
(d) Amodiaquine. [3+3+3+3]

2. List the factors influencing protein binding of drugs? [16]

3. What are the limitations in calculating Km and Vmax by assuming one -compartment
model and a single capacity - limited process Define those dependent kinetics? [16]

4. What are the types of mixer equipment’s used in the bulk drug manufacturing
process. [16]

5. Write the method of manufacture of Soft gelatin capsules. [16]

6. Write about different glass containers used for the packing of dosage forms. [16]

7. Write the synthesis properties and uses of ascorbic acid. [16]

8. Differentiate between non-steroidal and steroidal contraceptives? Write about non-

steroidal (or) synthetic Estrogens. [16]

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Code No: RR412303 Set No. 3
IV B.Tech I Semester Supplimentary Examinations, February 2008
BIO PHARMACEUTICAL TECHNOLOGY
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆

1. (a) Define the term “Antidepressant”. Briefly describe the chemical classification
of antidepressants. [8]
(b) Write structures and uses of the following drugs.
i. Penicilline
ii. Phenelzine sulfate (Nordil)
iii. Antriptyline hydro chloride(Enovil) [2+3+3]
2. Which physiochemical properties of the drug limit its distribution, describe in de-
tail? [16]
3. What is organ imaging technique? How the radioisotopes are useful in the organ
imaging technique? [16]
4. (a) What are the factors influencing milling techniques in the bulk drug manufac-
turing process
(b) Write about the different techniques of milling in the bulk drug manufacturing
process. [8+8]
5. (a) Write about different methods of film coating.
(b) What are the objectives of the tablet coating and list out different stages of
sugar coating. [8+8]
6. Write about the following quality control test for the evaluation of parenteral dosage
form.

(a) Leaker test

(b) Clarity test
(c) pyrogeins test. [5+5+6]

7. What are opioid analgesics? Describe the structure, properties and uses of Mor-
phine sulphate. [16]
8. (a) Explain about drug interaction in the case of non-steroidal contraceptives like
estrogens.
(b) Write the structure, preparation and uses of chlorotrianisene (non-steroidal
contraceptive) [8+8]

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Code No: RR412303 Set No. 4
IV B.Tech I Semester Supplimentary Examinations, February 2008
BIO PHARMACEUTICAL TECHNOLOGY
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆

1. (a) Describe the prevention of food Adulteration Act and Rules. [8]
(b) Answer any Two of the following.
i. Central food on laboratory
ii. Standards of quality.
iii. Preservative in food article
iv. Coloring matter in food articles. [4+4]

2. Why oxidative reactions are predominant in comparison to other phase - II reactions

in the case of drug metabolism? Explain. [16]

3. (a) Define Pharmacokinetics. Name and define the three pharmacokinetic para-
meters that describe a typical plasma level - time curve.
(b) What are the various pharamcodynamic parameters? [8+8]

4. What are the different reactors used in the case of bulk drug manufacturing process?
[16]

5. Write about different coating techniques for the manufacture of coated tablets?
[16]

6. Write about different analytical methods used for the testing of drugs. [16]

7. What are opioid analgesics? Describe the structure, properties and uses of Mor-
phine sulphate. [16]

8. Why some of the sulpha drugs are called as antibiotics? Describe the structure of
tetracyclines. [16]

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