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38 (2005) 12791299
University of Pittsburgh, 200 Lothrop Street, PUH D132, Pittsburgh, PA 15213, USA
b
Oregon Health Sciences University, Portland, Oregon, USA
In the past decade, imaging of the paranasal sinuses has progressed from
the realm of conventional radiographs (plain lms) almost exclusively into
the realms of computed tomography (CT) and magnetic resonance (MR)
imaging. Technological advances in these two modalities have provided
more precise dierential diagnoses and greater detail about the anatomic extent of disease. It might seem that, with modern imaging techniques, either
CT or MR could provide sucient information for diagnosis and surgical
planning in the sinuses. However, CT and MR provide complementary information; each has advantages and potential drawbacks.
Clinicians who understand the relative strengths and weaknesses of CT
and MR are able to pursue a more directed approach to imaging. Understanding the most common diagnostic errors associated with each modality
is critical to such decision making.
There are several important considerations when deciding whether to order CT or MR (or both) to evaluate abnormalities of the paranasal sinuses.
The remainder of this article focuses on 10 concepts that can be helpful in
tailoring an imaging approach to sinus disease (Box 1).
* Corresponding author.
E-mail address: branstetterbf@upmc.edu (B.F. Branstetter).
0030-6665/05/$ - see front matter 2005 Elsevier Inc. All rights reserved.
doi:10.1016/j.otc.2005.08.013
oto.theclinics.com
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be appreciated on CT because the surrounding air and bone are of such different radiodensities (Fig. 1). This concept is particularly evident in the evaluation of the expanded sinus. A thin rim of remodeled bone may be present
and yet dicult to assess on MR (Fig. 2).
MR can provide useful information in the setting of mucocele, but CT
provides the best assessment of the bony remodeling and dehiscence [1].
MR imaging of mucoceles is complicated by the variable signal intensity
Fig. 1. CT is highly sensitive for mucosal thickening. Coronal reformatted CT in a patient with
mild chronic rhinosinusitis shows minimal mucosal disease of the ethmoid air cells (arrows) and
maxillary sinus (arrowheads).
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Fig. 2. CT is preferred over MR for ne bone detail. (A) Axial T2-weighted MR image demonstrates a sphenoid mucocele (m) but cannot determine whether bone is intact around the margins of the expanded sinus. (B) Corresponding CT image demonstrates a thin rim of intact bone
anteriorly (arrow) but dehiscent bone posteriorly and laterally (arrrowheads).
Fig. 3. Mucopyocele. Axial T1-weighted image without contrast shows an expanded right frontal sinus (s) with inherently high T1 signal. This indicates high protein content and may be seen
with superinfection of a mucocele.
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Fig. 4. Utility of MR for soft tissue analysis. Postcontrast coronal T1-weighted image reveals
surgical material (m) lling the superior nasal cavity after surgical removal of an esthesioneuroblastoma. Small amounts of linear enhancement are consistent with scar (arrow).
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Fig. 5. Encephalocele. Coronal T2-weighted images show extension of brain tissue (arrow)
through a gap in the right cribiform plate. MR is useful for distinguishing scar from meningocele or encephalocele.
the other paranasal sinuses (Fig. 6). In the authors opinion, if the sinuses
are worth imaging, it is worth using CT.
Even as a screening tool for acute rhinosinusitis, conventional radiographs are falling out of favor. Because CT has become ubiquitous, and
modern techniques allow for lower patient radiation dose and more comfortable patient positioning, CT is now a more reasonable choice for
Fig. 6. Insensitivity of conventional radiographs. (A) Frontal projection radiograph of the sinuses shows only minimal asymmetry in the density of the maxillary sinuses. (B) MR obtained
the same day demonstrates mucosal disease (arrows) and dependent secretions (s) in the right
maxillary sinus.
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Fig. 7. Acute bacterial sinusitis. (A) Axial T2-weighted image from a patient with acute bacterial sinusitis shows uid levels in the right maxillary sinus (arrow) and the sphenoid sinus
(arrowhead ). Note that the uid level is horizontal except where it forms a meniscus against
the walls of the sinuses. (B) Axial T2-weighted image from another patient demonstrates a
mucus retention cyst (arrow) mimicking a uid level. Note that the edge of the cyst is not truly
horizontal, and it does not form a meniscus on the lateral margin.
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Fig. 8. Aerated mucus. Axial CT image shows a reticulated (frothy) pattern (arrows) within the
sphenoid sinuses. This pattern does not necessarily indicate acute sinusitis; aerated mucus may
also appear frothy.
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Fig. 9. MR demonstrates tumor extent. Enhanced coronal T1-weighted image shows a lung
carcinoma metastasis (m) lling the superior left nasal cavity. Although the mass invades surrounding structures, a fat plane is preserved between the mass and the medial rectus muscle (arrow), and a CSF plane is preserved between the mass and the brain parenchyma (arrowhead ).
Neither the rectus muscle nor the brain was involved at surgery.
Squamous cell carcinoma of the nasal cavity usually has no specic imaging characteristics that distinguish it from other malignancies. Heterogeneous enhancement, with central areas of necrosis, are usually present
[10]. Melanoma of the nasal cavity may appear as a well-dened nonaggressive mass, similar to a polyp, or it may be aggressive with extensive invasion
of surrounding structures (Fig. 10). There are usually no specic imaging
clues to this diagnosis, but melanotic melanomas may show intrinsically
high T1 signal, without gadolinium enhancement, from melanin content
[11]. Melanomas are often vascular, so extensive enhancement is expected
when gadolinium agents are administered. Sinonasal undierentiated carcinoma (SNUC) also has an aggressive, destructive appearance that may be
indistinguishable radiographically from other nasal malignancies.
The diagnosis of esthesioneuroblastoma can usually be suggested by its
characteristic pattern of spread (Fig. 11). This diagnosis should be considered for any mass that crosses the cribiform plate [12]. Extension across
the cribiform plate may be seen with other aggressive tumors, and esthesioneuroblastomas may be conned to the nasal cavity or cranial vault, but
there is nonetheless a close association between esthesioneuroblastoma
and erosion of the cribiform plate. Also characteristic is the presence of cysts
along the intracranial margin of the tumor [13]. Involvement of surrounding
structures, such as the orbit, is often noted. Esthesioneuroblastoma enhances briskly, but may show areas of central necrosis when large. Involvement of dura, brain, and orbital contents is better assessed with MR than
with CT, making MR the preferred modality for staging and follow-up.
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CT and MR are frequently employed together as complementary examinations during diagnostic evaluation [14].
The inverted papilloma, a benign neoplasm, may have an aggressive radiographic appearance. These lesions usually extend from the lateral nasal
wall into the antrum and the nasal cavity and remodel or erode the
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Fig. 12. Inverted papilloma. Coronal CT reformatted image shows a mass (m) centered on the
medial wall of the right maxiallary sinus, with extent into the sinus and into the nasal cavity.
This location is characteristic of inverted papilloma.
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Fig. 13. Chondrosarcoma. Contrast-enhanced axial CT image shows a destructive mass (arrows) arising from the right sphenoid sinus. Irregular central calcications (arrowheads) are
characteristic of chondrosarcoma.
Osteoma
There are two radiographic categories of sinonasal osteoma: cortical (ivory)
osteomas and brous osteomas. Cortical osteomas are uniformly as dense
as cortical bone (Fig. 14). Fibrous osteomas have an irregular internal
matrix of calcication, usually with a rim of denser calcication. Enhancement patterns are usually obscured by the inherent density of the lesion [19].
Cortical osteomas produce a complete signal void on all MR sequences, so
Fig. 14. Sinus osteomas. (A) Cortical (ivory) osteoma. Axial CT image shows a mass (arrow) of
uniform high density lling the right frontal sinus. (B) Fibrous osteoma. Axial CT shows a mass
(arrows) of heterogenous high-density lling the left frontal sinus. Fibrous osteoma is distinguished from brous dysplasia by the presence of normal sinus walls surrounding the osteoma.
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they are often indistinguishable from the surrounding air in the paranasal
sinuses and are thus overlooked. Fibrous osteomas have low to absent signal
intensity on all MR sequences.
Subcentimeter osteomas are a frequent incidental nding, particularly in
the frontal and ethmoid sinuses. Multiple osteomas suggest the diagnosis of
Gardners syndrome, a disease also known for gastrointestinal polyps.
Ossifying broma
Ossifying bromas may be dicult to distinguish from brous osteomas
radiographically. Demographics are sometimes more helpful than radiographic appearance; ossifying bromas are more frequently diagnosed in
children [20]. The calcication pattern seen on CT varies. Ossifying bromas
may have ground-glass calcication similar to brous dysplasia, or a mottled appearance. A calcication pattern of central radiations with a dense
rim may suggest ossifying broma.
Ossifying bromas frequently invade their bone of origin as well as other
bones that they come into contact with. When evaluating the extent of an
ossifying broma, CT is preferred over MR because the margins of the lesion can be more reliably dened for complete surgical resection, and the
likelihood of recurrence can thus be minimized.
Fibrous dysplasia
There are three radiographic forms of brous dysplasia, dened by their
CT appearance: ground glass, cystic, and Pagetoid [21]. These three forms
are frequently seen in combination within a single lesion. The aected
bone is expanded, and the lesion has ill-dened borders (Fig. 15). CT is
Fig. 15. Fibrous dysplasia. (A) Contrast-enhanced fat-suppressed axial T1-weighted image
shows a heterogeneously enhancing mass (arrows) in the posterior nasal cavity. The ndings
could be mistaken for malignancy. (B) Unenhanced axial CT in the same patient demonstrates
uniform ground-glass density throughout the mass (m), characteristic of brous dysplasia.
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Fig. 16. Distinguishing entrapped secretions from tumor. (A) Contrast-enhanced axial CT image shows a tumor (m) eroding the medial wall of the left maxillary sinus. Entrapped secretions
(s) in the sinus are of lower density and are distinguished from the mass by a rim of enhanced
tissue (arrows). (B) Axial T2-weighted image of the same patient more easily distinguishes the
mass (m) from the secretions (s).
Fig. 17. Pterygopalatine fossa invasion. (A) Contrast-enhanced axial CT image demonstrates
a normal amount of low-density fat in the right pterygopalatine fossa (arrow). The fat of the
left pterygopalatine fossa has been replaced (arrowhead ) by squamous cell carcinoma originating in the maxilla. (B) Unenhanced axial T1-weighted image of a dierent patient shows normal
high signal from fat in the right pterygopalatine fossa (arrow). The fat of the left pterygopalatine
fossa (arrowhead ) has been replaced by adenoid cystic carcinoma originating in the left parotid
gland. Unenhanced T1-weighted images are useful to evaluate tumor extent into structures that
normally contain fat.
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Fig. 18. Allergic fungal sinusitis. (A) Axial T2-weighted MR image shows heterogeneous signal
in slightly expanded ethmoid air cells (arrows) and in the left sphenoid sinus. There is no signal
in the right sphenoid sinus (arrowhead ), which might be interpreted as aeration. (B) Corresponding contrast-enhanced T1-weighted image demonstrates that the right sphenois sinus (arrow) is not aerated. Fungal diseases may have low T2 signal that mimics aeration on T2weighted images.
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Fig. 19. Invasive fungal sinusitis. Contrast-enhanced coronal CT reformatted image shows
a mass extending from the maxillary sinus (white arrow) into the medial orbit (arrowhead ). Cortical erosions are present in the orbital oor (black arrow).
imaging ndings are similar to the other forms of fungal sinusitis (eg, dense
secretions on CT and low T2 signal on MR) [33]. Unlike the other forms of
fungal sinusitis, however, mycetomas tend to be more masslike and to aect
a single sinus. Calcication is more common in mycetomas than in other
forms of fungal sinusitis, as is bony thickening of the sinus walls.
Highly inspissated secretions from long-standing chronic sinusitis may
become so proteinaceous that their T2 signal falls, and the secretions become less evident on MR. There may also be an increase in T1 signal as protein content increases. This increased T1 signal is similar to that seen in
mucopyoceles (see Fig. 3). The distinction is made by assessing for expansion of the aected air cell, which is seen in pyomucoceles but is unexpected
in uncomplicated chronic sinusitis.
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Fig. 20. Antronasal polyp. Coronal inversion recovery MR image shows a well-circumscribed
mass (m) lling the left maxillary sinus and extending into the nasal cavity (arrows). The smooth
margins of the mass, and the characteristic location, suggest the diagnosis of antronasal polyp.
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Fig. 21. Nasal polyposis. Unenhanced axial CT image shows the characteristic cascading pattern of dense secretions (arrows) amid low-density thickened mucosa.
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Fig. 22. Sagittal CT reformatted image provides a novel means of evaluating sinonasal anatomy.
The basal lamina of the middle turbinate (arrows) and the frotnonasal recess (arrowheads)
are well seen in this plane. The drainage pathways of the ethmoid air cells (small arrowheads)
are more evident in this plane than in coronal or axial planes.
for the evaluation of the paranasal sinuses. Although there are few studies
evaluating the benets of sagittal plane imaging, there is potential for surgical planning and for better dening the highly variable anatomy of the nasal
cavity and the ethmoid air cells (Fig. 22).
The frontonasal recess is well evaluated in the sagittal plane, and the relationship of the recess to the ethmoid bulla and the agar nasi cells is more
clearly delineated than in coronal or axial planes. The drainage patterns of
the ethmoid cells are more readily established, which may help to guide surgical procedures. Also, the conguration of the base of the turbinates can be
characterized.
As CT technology continues to advance, three-dimensional sinus imaging
may evolve additional capacities, such as y-through imaging that mimics
the point of view of an endoscopist. Three-dimensional renderings with robust clinician interfaces may also help surgeons visualize their entire procedure digitally, before ever taking the patient to the operating room.
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