in spite of / despite / although

In spite of, despite and although are all used to show a contrast but there are differences in the structures used with them.
In spite of / despite
After in spite of and despite we use a noun or a pronoun.

We enjoyed our camping holiday in spite of the rain.

Despite the pain in his leg he completed the marathon.

Despite having all the necessary qualifications, they didnt offer me the job.

Remember that the gerund (-ing form) is the noun form of a verb.
The only difference between in spite of and despite is the of.

Despite of the bad weather, there was a large crowd at the match.

Although
After although we use a subject and a verb.

We enjoyed our camping holiday although it rained every day.

Although he worked very hard, he didnt manage to pass the exam.

The holiday was great although the hotel wasnt very nice.

We can use in spite of and despite with a subject and verb if we include the expression the fact that.

In spite of the fact that he worked very hard, he didnt manage to pass the exam.

Despite the fact that he worked very hard, he didnt manage to pass the exam.

Even though
Even though is a slightly stronger form of although.

We decided to buy the house even though we didnt really have enough money.

You keep making that stupid noise even though Ive asked you to stop three times.

Like although, even though is followed by a subject and a verb.

https://learnenglish.britishcouncil.org/en/grammar-reference/spite-despitealthough

15/02/15
They are similar in meaning, yes. They all serve to record
something that is surprising or unexpected. But the difference in
usage is that although, though and even though are all
conjunctions, whilst in spite of and despite are both prepositions.
So usage requires:
in spite of + noun
although + clause
despite + noun
though + clause
even though + clause

Although and though can be used in the same way. Though is

perhaps more common in informal speech and writing, whereas
although can be used in a wide variety of styles. Compare:

'Our new neighbours are quite nice, though their dog is a

bit of a nuisance.'

'She insisted on keeping her coat on, although it was

extremely warm in the house as the central heating was
on.'

'Although she was commended for completing the

Millennium Dome project on time and within budget,
management felt that it was now time for a new person
with different talents to take over.'

Though is often used with even in order to give emphasis:

'I managed to get good results in my exams, even though

I went out four times a week when I was supposed to be
revising.'

Whilst despite might be thought more formal than in spite of it is, after all, one word rather than three - there is really very
little difference in usage between the two:

'Despite the appalling weather, they succeeded in

walking to the top of Ben Nevis.'

'They decided to get married in spite of the huge

differences in their ages.'

So, to summarise: despite and although: similar meanings,

but different syntax required. Compare:

'Although it was raining heavily, we finished the game of

football.'

'We finished the game of football in spite of the heavy

rain.'

'Despite his strong Welsh accent, we understood most of

what he was saying.'

'Even though he had a strong Welsh accent, we

understood most of what he was saying.'

One further word. Although, despite and in spite of are

normally used as prepositions, they can also be used in adverbial
constructions with -ing, thus:

'I managed to pass my exams, despite going out four

times a week during the revision period.'

'In spite of feeling terribly sick, I went to work every day

that week.'

'Despite being severely handicapped, he managed to

complete the race.'

http://www.bbc.co.uk/worldservice/learningenglish/grammar/learnit/learnitv41.s
html
15/02/15