Breaking:

Sleep Loss Impedes Decision Maki

Food Security at Risk Due to Soil L
How Many Bacteria Fight Off Invad
Ileostomy Reversal
Enjoy the Freedom Of Being Bagless. Lean More About Ileostomy
Options
Strong
Statin-Diabetes Link Obser
'Whispering Gallery' Effect Confine
Supernova Mystery: Lopsided Star
Vision Restored in Blind Mice
SD
Health
Tech
Enviro
Society
Quirky
Resolution
Full View of Protein
Near-Atomic
Mercury's Magnetic Field Secrets
Brain's Emotional Reactions Influe
Science News
from research organizations

Your source for the latest research news

Cancer drugs approved quickly but not to

patient's benefit, researcher says
Date:
Source:
Summary:

Tubeless Insulin Pump

Experience More Freedom
With The OmniPod! Get A
Free Demo Kit.

May 7, 2015
York University
Highly priced cancer drugs get rushed approvals despite
poor trial methodology and little effect on the longevity of
patients, cautions one expert, who adds that drug reviewers
don't look at the long term survival of patients who take
them.

open in browser PRO version

Are you a developer? Try out the HTML to PDF API

Related Stories
Trial Results Reveal First Targeted
Treatment to Boost Survival for
pdfcrowd.com

Share:

Total shares:

FULL STORY

Highly priced cancer drugs get rushed approvals

despite poor trial methodology and little effect on
the longevity of patients, cautions York University
Professor Dr. Joel Lexchin in the School of Health
Policy and Management.
"Patients and their doctors should demand that regulators require pharma
companies to provide clear evidence of clinical effectiveness of the drugs,
resulting from rigorous methodology," suggests Lexchin. "Drug agencies
like the Food and Drug Administration (FDA) and the European Medicine
Agency (EMA) don't actually look at whether people live longer."
In an article in the British Medical Journal, titled "Why do cancer drugs get
such an easy ride?," Lexchiin and co-author Donald Light, a professor in
the School of Osteopathic Medicine, Rowan University in New Jersey, note
that accelerated approval and shortened review times also make it a
smooth sail for cancer drugs.
Lexchin cites earlier research reviewing solid cancer drugs within 10 years
of EMA approval to point out that these drugs improved survival by just
over a month.
"Similarly 71 drugs approved by the FDA from 2002 to 2014 for solid
open in browser PRO version

Are you a developer? Try out the HTML to PDF API

Treatment to Boost Survival for

Esophageal Cancer
Nov. 4, 2014 Patients with a
specific type of esophageal cancer
survived longer when they were
given the latest lung cancer drug,
according to trial results. This is the
first treatment for advanced
esophageal ... read more
All FDA Drug Approvals Not
Created Equal
Jan. 21, 2014 Many patients and
physicians assume that the safety
and effectiveness of newly
approved drugs is well understood
by the federal Food and Drug
Administration -- but a new study
shows that the clinical ...
read more
Avastin, Sutent Increase Breast
Cancer Stem Cells, Study Suggests
Jan. 25, 2012 Cancer
treatments designed to block the
growth of blood vessels were found
to increase the number of cancer
stem cells in breast tumors in mice,
suggesting a possible explanation
for why these drugs ...
read more
pdfcrowd.com

tumours have resulted in median gains in progression-free and overall

survival of only 2.5 and 2.1 months, respectively," he says adding, "Also,
only 42 per cent met the American Society of Clinical Oncology Cancer
Research Committee's criteria for meaningful results for patients."

Story Source:
The above story is based on materials provided by York University. Note:
Materials may be edited for content and length.

Journal Reference:
1. D. W. Light, J. Lexchin. Why do cancer drugs get such an easy
ride? BMJ, 2015; 350 (apr23 1): h2068 DOI: 10.1136/bmj.h2068

Cite This Page:

MLA

APA

read more
Women, Elderly, Minorities Poorly
Represented in Lung Cancer Drug
Trial Data Submitted to US FDA
July 6, 2011 Women, older
people and minorities are enrolled
less frequently in lung cancer drug
trials and the numbers do not
reflect the prevalence of lung
cancer in these populations,
according to new ... read more
Patient support
programs
Improve adherence to treatment
with personalised support
programs

Chicago

York University. "Cancer drugs approved quickly but not to patient's

benefit, researcher says." ScienceDaily. ScienceDaily, 7 May 2015.
<www.sciencedaily.com/releases/2015/05/150507135917.htm>.

Strange & Offbeat

HEALTH & MEDICINE

Share This Page:

Viagra to Prevent
Transmission of the
Malaria Parasite?

RELATED TOPICS

open in browser PRO version

Are you a developer? Try out the HTML to PDF API

pdfcrowd.com

Health & Medicine

Antioxidant Effects of Coffee byProducts 500 Times Greater Than

Vitamin C

Colon Cancer

Mapping App Turns

Art Into a Sharable
Walking Route

Lung Cancer
Cancer
Science & Society
Public Health

Study Shows

Scientific Conduct

MIND & BRAIN

Educational Policy
RELATED TERMS

Rewards
Clinical trial
Esophageal cancer
Insulin
Longevity

Blocking ObesityAssociated Protein

Stops Dangerous Fat
Formation, Mouse

Carrot or Stick?
Punishments May
Guide Behavior More
Effectively Than

Popular Electric Brain

Stimulation Method
Used to Boost
Brainpower Is
Detrimental to IQ Scores
Late-Night Snacking:
Is It Your Brain's
Fault?

Lymphoma
Anti-obesity drug

Real Stereotypes Continue to Exist

in Virtual Worlds
LIVING & WELL

open in browser PRO version

Are you a developer? Try out the HTML to PDF API

pdfcrowd.com

Recommended Content

Sounds

First Evolutionary
History of 50 Years of
Music Charts Using
Big Data Analysis of
Social Factors May
Not Be Necessary to
Produce or Explain
Conformity

Framing Time in Days Instead of

Years Could Spur Action Toward
Goals
sciencedaily.com

sciencedaily.com

sciencedaily.com

FDA approves
clinical trial of
auditory brainstem
implant...

Stopping HIV in its

tracks: New
subdermal implant
delivers potent...

Babies born with

drug withdrawal
symptoms on the
rise, study shows

Breast Milk Sharing Among

Friends, Relatives Likely
Light Increasing,
-- not pain-but Still Risky
killing drugs -- used
to activate brain's
News from NewsDaily
opioidOther
receptors
sciencedaily.com

NEXT

Health & Medicine News

May 8, 2015

SCIENCE

Failed Russian spacecraft falls

from orbit, burns up
Huffing and puffing won't blow
these straw homes down
SpaceX puts Dragon passenger
spaceship through test run
Deep-sea microbes called missing
link for complex cellular life
Brain technology patents soar as

open in browser PRO version

Are you a developer? Try out the HTML to PDF API

pdfcrowd.com

Sleep Loss Impedes Decision

Making in Crisis

How Many Bacteria Fight Off

Invaders

Brain technology patents soar as

companies get inside people's
heads
HEALTH

Novartis says lung cancer drug

Zykadia gains EU approval
Hepatitis C rates jump in four
central Appalachian states: CDC

Strong Statin-Diabetes Link

Observed

Vision Restored in Blind Mice

Latest Headlines

Novartis 'biosimilar' drug blocked

by U.S. appeals court
Healthy diet tied to lower risk of
cognitive decline

updated 12:56 pm ET

Walking or Cycling to Work Could Help You Lose Weight

Deviated noses may be harder to

correct than first thought
ENVIRONMENT

May 7, 2015 Leaving your car at home could help shed pounds
Australian MP's adviser says U.N.
according to new research. Given that car use is high, the findings strengthen using climate change for 'new world
the case for incentivising walking or cycling to boost population ...
order'
read more
Sub-tropical storm Ana forms off
southeast U.S. coast: NHC

Hip Strengthening Might Ease Pain of Clogged Leg Arteries

China optimistic on reaching 2015

energy-saving goals: China Daily

May 7, 2015 Exercise to strengthen hip flexor muscles may increase how
far some patients can walk without calf pain. Gait analysis reveals that people California environmentalists sue
over oil industry water practices
with clogged leg arteries use calf muscles to compensate for ... read more
NHC says 90 percent chance of
cyclone near southeast coast
open in browser PRO version

Are you a developer? Try out the HTML to PDF API

pdfcrowd.com

Ebola Virus in Patients Eye Fluid 10 Weeks After It Was Undetectable

in Blood

TECHNOLOGY

New Intervention Helps Mothers Address Depression

Weak PC sales, strong dollar hurt

Nvidia's second-quarter forecast

May 7, 2015 A new intervention has been developed that identifies

potentially depressed mothers and encourages them to seek treatment. The
Motivating our Mothers (MOM) program takes a unique approach, relying on
... read more

Uber bids for Nokia's mapping

service: NYT

Hillary Clinton woos technorati,

May 7, 2015 Researchers are reporting a case study in which viable Ebola draws comparison to Eleanor
virus was present in the eyes aqueous humor the clear fluid in the front of Roosevelt
the ... read more
Exclusive: Microsoft has no plans to
pursue Salesforce sources

Ecologist Warns of Bamboo Fueling Spread of Hantavirus

Fitness tracking device maker Fitbit

files for IPO

May 7, 2015 The popularity of bamboo landscaping could increase the

spread of hantavirus, researchers say, with the plant's prolific seed
production creating a population boom among seed-eating deer mice that ...
read more

'Fracture' Prints, Not Fingerprints, Help Solve

Child Abuse Cases

May 7, 2015 Much like a finger leaves its own unique print to help identify
a person, researchers are now discovering that skull fractures leave certain
signatures that can help ... read more
open in browser PRO version

Are you a developer? Try out the HTML to PDF API

pdfcrowd.com

The Opioid Epidemic and Its Impact on Orthopaedic Care

May 7, 2015 The United States makes up less than five percent of the
world's population but consumes 80 percent of the global opioid supply and
approximately 99 percent of all hydrocodone -- the most commonly ...
read more

Viagra to Prevent Transmission of the Malaria

Parasite?

May 7, 2015 By increasing the stiffness of erythrocytes infected by the

causal agent of malaria, Viagra favors their elimination from the blood
circulation and may therefore reduce ... read more

Researchers Hack a Teleoperated Surgical

Robot to Reveal Security Flaws

May 7, 2015 How safe is that robot doing your surgery? Researchers
easily hacked a next generation teleoperated surgical robot to test how easily
a malicious attack could hijack ... read more

Fragments of tRNA Suggest a Novel Mechanism for Cancer

Progression
open in browser PRO version

Are you a developer? Try out the HTML to PDF API

pdfcrowd.com

May 7, 2015 Researchers discover that particular genetic fragments, of a

type of RNA known as transfer RNA, or tRNA, appear to be capable of
reducing the growth and spread of breast cancer ... read more

more stories

Latest Videos

from news services

Millennials More Open To

Premarital Sex, Fewer Partners

Allergy Sufferers, Beware Of

The 'Pollen Tsunami'

Afghan Runaways Fight Heroin

Addiction in Pakistan

U.S. One Of The Worst Places

For Mothers, Europe The Best

open in browser PRO version

Are you a developer? Try out the HTML to PDF API

pdfcrowd.com

more videos

Free Subscriptions

Follow Us

Get the latest science news with ScienceDaily's free

email newsletters, updated daily and weekly. Or view
hourly updated newsfeeds in your RSS reader:

Keep up to date with the latest news from ScienceDaily

via social networks:

Email Newsletters
RSS Feeds

Facebook

Twitter
Google+
LinkedIn

Mobile Apps

Have Feedback?

Get the latest news from ScienceDaily via our free

mobile apps, available for download on the following
platforms:

Tell us what you think of ScienceDaily -- we welcome

both positive and negative comments. Have any
problems using the site? Questions?

iPhone/iPad

Leave Feedback

Android

Contact Us

About This Site | Editorial Staff | Awards & Reviews | Contribute | Advertise | Privacy Policy | Terms of Use
open in browser PRO version

Are you a developer? Try out the HTML to PDF API

pdfcrowd.com

Copyright 2015 ScienceDaily or by third parties, where indicated. All rights controlled by their respective owners.
Content on this website is for information only. It is not intended to provide medical or other professional advice.
Views expressed here do not necessarily reflect those of ScienceDaily, its staff, its contributors, or its partners.

open in browser PRO version

Are you a developer? Try out the HTML to PDF API

pdfcrowd.com