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at Global Hospitals
Hyderabad: Currently there are About 200,000 patients suffering from end stage renal
disease (ESRD) in India. Approximately 7,000 patients suffer from ESRD in Telangana and
16,800 patients suffer from ESRD in Andhra Pradesh, so approximately there are about
23,000 to 24,000 patients are suffering from ESRD in both the states.
The treatment options for ESRD include renal (kidney) transplantation, hemodialysis,
and CAPD (Home Dialysis). Out of these, renal transplantation is the treatment of
choice. But unfortunately only 5-10% of patients are getting renal transplantation, rest
of them are on one or the other forms of dialysis.
Kidney transplantation is the treatment of choice because transplanted kidney performs
100% of the native kidney function and the person can lead almost a normal life.
Whereas, Dialysis can replace 50-60 per cent of the native kidney functions and the
quality of life on dialysis is poor. Cost of renal transplantation is also lower compared to
long term cost of Dialysis over a period of time.
Even though the transplantation is the best option available, only 5-10% opt for it and
remaining 90-95% are on dialysis. The reason for this is lack of donors. Source of the
kidney for transplantation is either cadaver donor or live related donor. But, most
patients on cadaver list die waiting for a kidney. For successful renal transplant the
routine protocol is that the blood group matching between donor and the recipient is
must, otherwise, it leads to rejection of the graft immediately. In some families, even
though the related donor is willing to donate kidney and is deemed to be medically fit,
they are rejected because their blood groups do not match. This happens in
approximately 30% cases. Dr. Gandhe Sridhar, Chief Consultant Nephrologist and
Kidney Transplant Physician, Global Hospitals said while addressing a press conference.
One of the answers to address this problem is to promote paired (swap) renal
transplantation and transplantation with no blood group matching. Recent advances in
transplantation has lead to the successful outcome of transplantation even without
blood group matching by method of plasmapharesis and using medications like
rituximab. Renal transplantation without blood group matching has been very successful
in Japan and few European countries. In India, very few centers are doing incompatible
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