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*Correspondence:
S.R.C.J. Santos
Laboratrio de Farmacologia
Teraputica, Departamento de
Farmcia
FCF/USP
Av. Prof. Lineu Prestes, 580 05508-900
- Sao Paulo, Brazil.
Uniterms
Obesity
Propranolol
Pharmacokinetics
Hypothermic
cardiopulmonary bypass
E-mail: pharther@usp.br.
INTRODUCTION
Propranolol, a nonselective beta-adrenergic
blocking agent, is an usual drug prescribed for treatment
of arterial hypertension, angina pectoris, and cardiac
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FIGURE 1 - Propranolol plasma levels (means) at the pre-operative period in patients: obeses, n = 9 versus non-obeses,
n = 6.
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0.0625
0.1563
0.8438
0.0039
0.0391
0.0039
Statistics: Wilcoxons Test, post- versus pre-operative periods; significance level: p< 0.05; 1* Reference values, Hardman
J.G. et al. (1996).
FIGURE 2 - Propranolol plasma levels (means) at the post-operative period in patients: obeses, n = 9 versus non-obeses,
n = 6.
RESUMO
Influncia da obesidade na farmacocintica do
propranolol em pacientes submetidos
revascularizao do miocrdio com circulao
extracorprea
As concentraes plasmticas e a disposio cintica do
propranolol podem ser alteradas pela circulao
extracorprea (CEC). Investigou-se a influncia da obe-
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ACKNOWLEDGEMENTS
To the University of Sao Paulo/Pro-Reitoria de Pesquisa: (1) PROJECT 1: 96.1.27884.1.0 and
97.1.27884.1.0, (2) PROJECT 3/PROINTER
96.1.36042.1.0 and to the Brazilian Foundations for
Research: FAPESP 00/02707-4 CNPq: 306205/88/96-98,
Scientific Cooperation Programme: 99.1.524.9.9
E.J.Zerbini Foundation/InCor-University of Sao Paulo,
for the financial support to this project.
REFERENCES
BABKA, R.; PIFARR, R. Potassium replacement during
cardiopulmonary bypass. J. Thorac. Cardiovasc. Surg.,
St. Louis, v.73, n.2, p.212-215, 1977.
BELFRAGE, E. Vasodilatation and modulation of
vasoconstriction in canine subcutaneous adipose tissue
caused by activation of -adrenoceptors. Acta Physiol.
Scand., Stockholm, v. 102, p. 459-468, 1978.
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