Tumor Marker

ALK gene
Alpha-fetoprotein (AFP)

Types of Cancer
Non-small cell lung cancer and anaplastic large cell
lymphoma
Liver cancer and germ cell tumors

Beta-2-microglobulin (B2M)

Multiple myeloma, chronic lymphocytic leukemia, and some

lymphomas

Beta-human chorionic
gonadotropin (Beta-hCG)

Choriocarcinoma and testicular cancer

BCR-ABL fusion gene

Chronic myeloid leukemia

BRAF mutation V600E

Cutaneous melanoma and colorectal cancer

CA15-3/CA27-29

Breast cancer

CA19-9

Pancreatic cancer, gallbladder cancer, bile duct cancer, and

gastric cancer

CA-125

Ovarian cancer

Calcitonin

Medullary thyroid cancer

Calretinin

mesothelioma, sex cord-gonadal stromal tumour,

adrenocortical carcinoma, synovial sarcoma

Carcinoembryonic antigen
(CEA)

Colorectal cancer and breast cancer

CD20

Non-Hodgkin lymphoma

CD34

hemangiopericytoma/solitary fibrous tumor, pleomorphic

lipoma, gastrointestinal stromal tumor, dermatofibrosarcoma
protuberans

CD99

Ewing sarcoma, primitive neuroectodermal tumor,

hemangiopericytoma/solitary fibrous tumor, synovial
sarcoma, lymphoma, leukemia, sex cord-gonadal stromal
tumour

CD117

gastrointestinal stromal tumor, mastocytosis, seminoma[6]

Chromogranin

neuroendocrine tumor

Chromogranin A (CgA)

Neuroendocrine tumors

Chromosomes 3, 7, 17, and

Bladder cancer

9p21
Cytokeratin fragments 21-1

Lung cancer

Desmin

smooth muscle sarcoma, skeletal muscle sarcoma,

endometrial stromal sarcoma

Epithelial membrane

many types of carcinoma, meningioma, some types of

antigen(EMA)

sarcoma

Factor VIII, CD31 FL1

vascular sarcoma

Glial fibrillary acidic

glioma (astrocytoma, ependymoma)

protein(GFAP)
Gross cystic disease fluid

breast cancer, ovarian cancer, salivary gland cancer

protein (GCDFP-15)
HMB-45

melanoma, PEComa (for example angiomyolipoma), clear

cell carcinoma, adrenocortical carcinoma

EGFR mutation analysis

Estrogen receptor
(ER)/progesterone receptor
(PR)

Fibrin/fibrinogen

Non-small cell lung cancer

Breast cancer

Bladder cancer

HE4

Ovarian cancer

HER2/neu

Breast cancer, gastric cancer, and esophageal cancer

Human chorionic

gestational trophoblastic disease, germ cell tumor,

gonadotropin(hCG)

choriocarcinoma

Immunoglobulins

Multiple myeloma and Waldenstrm macroglobulinemia

KIT

Gastrointestinal stromal tumor and mucosal melanoma

KRAS mutation analysis

Colorectal cancer and non-small cell lung cancer

Lactate dehydrogenase

Germ cell tumor

Nuclear matrix protein 22

Bladder cancer

Prostate-specific antigen (PSA)

Prostate cancer

Thyroglobulin

Thyroid cancer

Urokinase plasminogen
activator (uPA) and
plasminogen activator inhibitor
(PAI-1)

Breast cancer

5-Protein signature (Ova1)

Ovarian cancer

21-Gene signature (Oncotype

DX)

Breast cancer

70-Gene signature
(Mammaprint)

Breast cancer

inhibin

sex cord-gonadal stromal tumour, adrenocortical carcinoma,

hemangioblastoma

keratin (various types)

carcinoma, some types of sarcoma

lymphocyte marker (various

lymphoma, leukemia

types
MART-1 (Melan-A)

melanoma, steroid-producing tumors (adrenocortical

carcinoma, gonadal tumor)

Myo D1

rhabdomyosarcoma, small, round, blue cell tumour

muscle-specific actin (MSA)

myosarcoma (leiomyosarcoma, rhabdomyosarcoma)

neurofilament

neuroendocrine tumor, small-cell carcinoma of the lung

neuron-specific enolase (NSE)

neuroendocrine tumor, small-cell carcinoma of the lung,

breast cancer

placental alkaline

seminoma, dysgerminoma, embryonal carcinoma

phosphatase(PLAP)
PTPRC (CD45)

lymphoma, leukemia, histiocytic tumor[6]

smooth muscle actin (SMA)

gastrointestinal stromal tumor, leiomyosarcoma, PEComa[6]

S100 protein

melanoma, sarcoma (neurosarcoma, lipoma,

chondrosarcoma), astrocytoma, gastrointestinal stromal
tumor, salivary gland cancer, some types ofadenocarcinoma,
histiocytic tumor (dendritic cell, macrophage)[6]

synaptophysin

neuroendocrine tumor[6]

thyroid transcription factor-1

all types of thyroid cancer, lung cancer[6]

Tumor M2-PK

colorectal cancer,[14] Breast cancer,[15][16] renal cell

carcinoma[17][18] Lung cancer,[19][20] Pancreatic cancer,[21]
Esophageal Cancer,[22] Stomach Cancer,[22]Cervical Cancer,
[23]

vimentin

Ovarian Cancer,[24]

sarcoma, renal cell carcinoma, endometrial cancer, lung

carcinoma, lymphoma, leukemia, melanoma[6]

NMP22

Prostatic acid
phosphatase (PAP)
S-100

Soluble mesothelinrelated peptides

Bladder cancer
prostate cancer

Melanoma
type of lung cancer called mesothelioma.