A Comparative Study of Effectiveness of Antacids

Chemistry
Project

A
Compa
rative
Study
of
Effecti
veness
of
Antaci
ds

Copyright Kaushal and Omkar (2014)

A Comparative Study of Effectiveness of Antacids

CERTIFICATE
This is to certify that the work entered in this
project file is of Master Kaushal Nerkar of
class XII Science Roll no.09 has satisfactorily
completed the Required Project in Chemistry
Copyright Kaushal and Omkar (2014)

A Comparative Study of Effectiveness of Antacids

for the Academic year 2014-2015 in Kendriya

Vidyalaya Lab as laid down by CBSE Board.

Principals
Internal

External

Signature
Examiner

Examiner

Date:

ACKNOWLEDGEMENT

Copyright Kaushal and Omkar (2014)

A Comparative Study of Effectiveness of Antacids

I would like
gratitude to

to

express

my

sincere

Mr. , Chemistry teacher, for his

expert, valuable & sincere guidance &
encouragement extended to me for doing
this project on antacids.
Also I would like to thank Mr. , Lab
Assistant, who provided us all necessary
apparatus.
I certify that all sources of information
used in this project have been fully
acknowledged.
Thank you
Kaushal Nerkar

INDEX
Copyright Kaushal and Omkar (2014)

A Comparative Study of Effectiveness of Antacids

Introduction
Antacids
Classifications of antacids
Experiments
Aim
Apparatus
Procedure
Observations
Result& Inference
Precautions
Difficulties
Bibliography
Photos

INTRODUCTION
Copyright Kaushal and Omkar (2014)

A Comparative Study of Effectiveness of Antacids

This project is aimed at analyzing some of the

commercially available antacids to determine
their ability to neutralize hydrochloric acid
and hence to determine the best of brands
which has the highest ability to neutralize
acids.
The Project can provide important information
about
the
various
antacids
available
commercially.
We all know that the food we eat undergoes
various biochemical reactions resulting in
digestion. In this process various enzymes
working at different conditions are required.
The enzymes of stomach require an acidic pH
to function, hence dilute HCl is produced in
stomach.
However, sometimes the stomach starts
producing excess of HCl .this condition is
called Gastric Hyperacidity and is usually
caused by over eating highly spiced food.

Copyright Kaushal and Omkar (2014)

A Comparative Study of Effectiveness of Antacids

In an uncontrolled condition this HCl can

destroy the Mucous lining of the stomach and
result in peptic ulcer.

Antacids
Antacids are commercially available products
which neutralize the excess HCl secreted in
the stomach.
The action of antacids is based on the fact
that base can neutralize an acid forming salt
and water.
The antacid should not contain excess alkali
that may lead to an alkaline medium in the
stomach and make the enzyme inactive.
Thus some additional compounds are added
to the antacids to keep the pH optimum. The
action of an acid is for a short time,
irrespective of dose; hence it is required to
take an antacid at frequent intervals.

Copyright Kaushal and Omkar (2014)

A Comparative Study of Effectiveness of Antacids

Commercially Available
Antacids

Copyright Kaushal and Omkar (2014)

A Comparative Study of Effectiveness of Antacids

Classification of Antacids
Absorbable Antacids:NaHCO3 mixture is commonly used for giving
relief from indigestion.
It has moderate neutralizing power.
However, it releases CO2 gas in the stomach
and causes swelling of deep Ulcers and hence
it is not generally used.
Non Absorbable Antacids:These are available in three broad groups
1.
Aluminium salts: All these drugs have
common buffering action and reduce
acidity in the stomach .Eg-Al(OH)3,AlPO4.
2.
Magnesium salts: Their action is slow
and these cause a purgative action.EgMgCo3, MgO, Mg(OH)2.
3.
Calcium salts: These are powerful
antacids. They have no buffering action

Copyright Kaushal and Omkar (2014)

A Comparative Study of Effectiveness of Antacids

10

and can therefore neutralize the acid

completely in stomach.

EXPERIMENT
Aim:- A comparative study of effectiveness of
different commercially available antacids .
Apparatus:- burrete, pipette, conical flask
,glass rod, mortar and pastel, weighing
machine, measuring flask, beaker.
Chemical required :- HCl 0.1N solution, NaOH
0.1N solution ,phenolphthalein , methyl
orange, antacids.

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A Comparative Study of Effectiveness of Antacids

11

PROCEDURE
1.
Prepare 0.1N NaOH solution by
dissolving 0.2 Gram of NaOH in 50 ml of
water.
2.
Take 50ml of 0.1N HCl in conical flask.
3.
Add 2-3 ml of phenolphthalein or
methyl orange to the conical flask which
serves as an indicator.

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A Comparative Study of Effectiveness of Antacids

12

4.
Add 1 gram of finely powered antacid
to the conical flask. Use mortar and pastel
to powder it.
5.
Shake well and now titrate the solution
by taking NaOH in the burette, and HCl in
conical flask.
6.
Observe the end point a pink or
yellow colored solution.
7.
Repeat this with other antacids and
note the readings.

Copyright Kaushal and Omkar (2014)

A Comparative Study of Effectiveness of Antacids

Take 50
ml of
0.1N HCl

Add 1gm
of
antacid

13

Titrate
against
0.1N
NaOH

Copyright Kaushal and Omkar (2014)

A Comparative Study of Effectiveness of Antacids

14

OBSERVATIONS
Tablet/sam
ple
antacid
(1gm)

Volume
of NaOH
used
(ml)

Digine
Eno
Omez
Gelusil
Ulgel

30.6
22.3
21.2
32.6
26.8

Volume of
HCl
neutralize
d
(ml)
19.4
27.7
28.8
17.4
23.2

Volume of
HCl
neutralize
d /gm of
antacid
19.4
27.7
28.8
17.4
23.2

35
30
Volume of NaOH used
25
20
15

Volume of HCl neutralized

10
5
Volume of HCl neutralized /gm of antacid
0
Digine

Eno

Omez

Gelusil

Ulgel

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A Comparative Study of Effectiveness of Antacids

15

RESULT
Among the five different antacids tested,
OMEZ has highest acid neutralizing capacity
per gram of the antacid.

INFERENCE
OMEZ is better antacid amongst the five we
tested because it could neutralize more
amount of HCl (0.1 N) than any other antacid.

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A Comparative Study of Effectiveness of Antacids

16

PRECAUTIONS
1.
The weighing should be accurate.
2.
Powder should be fine to promote
maximum dissolution.
3.
Should not add much of indicator.
4.
The amount of HCl should be
sufficiently in excess so as to neutralize
every bit of antacid.
5.
Should keep the eye in level with the
Meniscus of the solution.
6.
Should read the lower meniscus in
case of colorless solutions.

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A Comparative Study of Effectiveness of Antacids

17

DIFFICULTIES
While carrying out above experiment some
antacid salts like solution of rabicip,
Eno(orange) and Zantac, the color of salt
solution was red, orange and red respectively,
so while titration of these antacids the
indicator did not show any significant change
in color, so finding end point of titration was
very difficult .
Due to pink colour of antacid gelusil,
phenolphthalein was not used as indicator
and methyl orange was used.

Copyright Kaushal and Omkar (2014)

A Comparative Study of Effectiveness of Antacids

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BIBLIOGRAPHY
Following sources of information have been
referred for this project: Together with Chemistry lab manual.
Wikipedia
Chem4kids.com

PHOTOS

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A Comparative Study of Effectiveness of Antacids

19

Copyright Kaushal and Omkar (2014)

A Comparative Study of Effectiveness of Antacids

20

Copyright Kaushal and Omkar (2014)