Documente Academic
Documente Profesional
Documente Cultură
2013,
4 (5)
If you data
needofto protect your active from the gastric fluid
Collected
Suitable
for
multiparticulate
tablet
and will provide a deep and current knowledge for further researchers to conduct study regarding Pulsatile
polymers
drug delivery system.
preparation.
Keywords:
Pulsatile
drug delivery
Polymers, Controlled
release,
Eudragit,
properties.
would like
to improve
drugsystem,
effectiveness
EUDRAGIT
Eudragit
RLPhysicochemical
1003
L
It is a copolymer of Ethyl acrylate, methyl methacrylate
and S Pharma
polymers
are your
preferred
intestine.
Polymers
offers
a broad choice
productofportfolio
low content of methacrylic acid ester with
and a
coating
quaternary
ofpolymers.
anionicIn
EUDRAGIT
They enable
grades
targeting
which
dissolve
specific
areas
pH andammonium
groups. The ammonium groups are
values.
addition,
the
different
grades
can at
berising
salts
make the polymers
present
of theas with
combined
permeable.
each
other,
making the
it possible
the forProduct
Form-Targeted
GranulesDrug Release Area- Time controlled
and
thus
to achieve
required toGIadjust
targeting
the drug.
dissolution
pH,
release,
pH
Targeted drug release in the colon is requiredindependent
for
local
Characteristicstreatment of intestinal disorders such as Crohns
Insoluble
disease,
High permeability
ulcerative colitis or intestinal cancer. It is also
pH independent swelling
required for
Customized release profile by combination of RL and
drugs that are poorly soluble in the upper
RS
gastrointestinal
grades in different ratios.
Moreover, the gastroresistance of the coating
tract.
Aqueous
Suitable for matrix structures
ensures
processing
that
the
oral
dosage
form
is
patient
compliant.
The
Structure
preferred
coating is EUDRAGIT FS 30 D, which combines release
in
the colon with the following technical advantages:
Nonproprietary
Names
Category
Description
Solubility
Film formation
Dry substance / Residue on
evaporation
Loss on drying
Storage
Stability
Incompatibilities
Page 71
Nonproprietary
Names
Category
Description
Solubility
Film formation
Dry substance /
Residue on
evaporation
Loss on drying
Storage
Stability
Incompatibilities
Page 72