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by Massimo Pigliucci
NEWS FEATURE
Beyond genes
Insights from ecology, developmental biology,
and genomics in particular are nudging evolutionary biology away from a focus on population geneticshow the distribution of genes
changes across groups of individualsand
toward an understanding of the molecular
underpinnings of these changes. Better family
trees that give researchers greater confidence
about the relatedness among organisms have
helped promote a credible, comparative
approach to these mechanisms, says invitee
Gnter Wagner, an evolutionary developmental biologist at Yale University.
Some studies, for example, indicate that
development constrains evolution. From the
modern synthesis perspective, Wagner
explains, the body plan is a historical residue
of evolutionary time, the afterglow of the evo-
Postmodern evolution?
the middle of the twentieth century. And in Darwins ideas about natural selection and Greeveryday speech, it is pretty clear what comes gor Mendels insights into how traits pass from
after the modern.
parents to offspring which many biologists
Whats more, some of this work sounds of the time believed antithetical and fused
as though it fits the term quite nicely. Over them into a mathematical description of the
dinner at the meetings end, Pigliucci expresses genetic makeup of populations and how it
his hope of moving from a gene-centric view changes. That fusion was the modern synthesis.
of causality in evolution to a pluralist, multi- It treats an organisms form, or phenotype, as a
level causality. Postmodernists in the humani- readout of its hereditary information, or genoties call this decentering, and they are all for it. type. Change is explained as one version of a
Over the course of the meeting,
gene being replaced by another.
its fairly clear that the means
Natural selection acts by changThe modern
to this pluralist end are being
ing the frequency of genes in
synthesis is good
sought through mixing and
the next generation according
matching neglected ideas and at modelling the
to the fitness of phenotypes in
old problems from biologys
this one. In this world view, the
survival of the
gene is a black box, its relationpast with the latest experimenfittest,
but
not
the
tal and analytical techniques.
ship to phenotype is a one-way
Apply that sort of bricolage to arrival of the fittest. street, and the environment,
both cellular and external, is a
architecture and you get the
Scott Gilbert
selective filter imposed on the
sort of brutalist-right-angle
readout of the genes, rather
here, classical-column-there,
swirling-titanium-ceiling-above-it-all look than something that can influence an organthat is normally pigeonholed, for better or isms form directly.
worse, as postmodern.
Whats wrong with this picture, say the
would-be extenders at Altenberg and elsewhere, is what it leaves out. Molecular biolEvolution of ideas
Leaving aside the troublesome adjective, what ogy, cell biology and genomics have provided
is the modernism that the Altenburg meeting a much richer picture of how genotypes make
is meant to move beyond or to use Pigliuc- phenotypes. The extenders claim that enough
cis preferred term, extend1? Between about insights have now come from this and other
1920 and 1940, researchers such as the Ameri- research for it to be time to re-examine probcan Sewall Wright and the Englishmen Ron- lems that the modern synthesis doesnt address.
ald Fisher and J. B. S. Haldane took Charles These problems include some of the key turning
281
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11 JULY 2008
VOL 321
SCIENCE
Published by AAAS
www.sciencemag.org
ILLUSTRATION BY J. TAYLOR
CREDITS: (TOP AND BOTTOM RIGHT) COURTESY OF GERD B. MLLER; (BOTTOM LEFT) COURTESY OF MASSIMO PIGLIUCCI
Massimo Pigliucci is no Jimi Hendrix. This passing genes from parent to offspring, as the
soft-spoken evolutionary biologist from Stony environment, chemical modification of DNA,
Brook University in New York state looks and other factors come into play as well. Organnothing like that radical hard-rock musician isms vary not only in how they adapt to changwhose dramatic guitar solos helped revolution- ing conditions but also in how they evolve.
ize rock nroll. But to Suzan Mazur, a veteran
Evolution is much more nuanced than the
journalist who occasionally covers science, founders of the modern synthesis fully appreciPigliucci is the headliner this week at a small ated, says Pigliucci. That doesnt mean that the
meeting she believes will be the equivalent of overall theory of evolution is wrong, as some
Woodstock for evolutionary biology. The invi- intelligent design proponents have tried to
tation-only conference, being held in assert using Mazurs story as support, but rather
Altenberg, Austria, promises to be far more that the modern synthesis needs to better incortransforming for the world than the 1969 porate modern science and the data revealed by
music festival, Mazur wrote online in March it. More than genes pass on information from
for Scoop.co.nz, an independent
news publication in New Zealand.
That hyperbole has reverberated throughout the evolutionary
biology community, putting
Pigliucci and the 15 other participants at the forefront of a debate
over whether ideas about evolution need updating. The mere
mention of the Altenberg 16, as
Mazur dubbed the group, causes
some evolutionary biologists to
roll their eyes. Its a joke, says
Jerry Coyne of the University of Daring duo. Massimo Pigliucci (right) and Gerd Mller want to
Chicago in Illinois. I dont think update the modern synthesis.
theres anything that needs fixing. Mazurs attention, Pigliucci admits, one generation to the next, for example, and
frankly caused me embarrassment.
development seems to help shape evolutions
Yet Pigliucci and others argue that the so- course. Many things need fixing, emphasizes
called modern synthesis, which has guided evo- one invited speaker, Eva Jablonka of Tel Aviv
lutionary thought and research for about University in Israel. I think that a new evolu70 years, needs freshening up. A lot has hap- tionary synthesis is long overdue.
pened in the past half-century. DNAs structure
was revealed, genomes were sequenced, and Modern tradition
developmental biologists turned their sights on The modern synthesis essentially represents a
evolutionary questions. Researchers have come marriage of the 19th century concept of evoto realize that heredity is not simply a matter of lution with Mendelian genetics, which was
rediscovered at the beginning of the 20th century; the birth of population genetics in the
1920s added to the intellectual mix. By the
1940s, biologists had worked out a set of ideas
that put natural selection and adaptation at
evolutions core. Julian Huxleys 1942 book,
Evolution: The modern synthesis, brought
together this work for a broad audience.
Simply put, the modern synthesis holds
that organisms have a repertoire of traits that
are passed down through the generations.
Mutations in genes alter those traits bit by bit,
and if conditions are such that those alterations make an individual more fit, then the
altered trait becomes more common over
time. This process is called natural selection.
In some cases, the new feature can replace an
old one; in other instances, natural selection
also leads to speciation.
However, several concepts have arisen
since then that make the modern synthesis
seem too simplistic to some, Pigliucci
among them. In a 2007 Evolution paper, he
called for the development of an extended
evolutionary synthesis. His plea coincided
with a similar one made that year by Gerd
Mller, a theoretical biologist at the University of Vienna. Together, with support from
the Konrad Lorenz Institute for Evolution
and Cognition Research in Altenberg, they
organized this weeks conference, inviting
many who share the view that the modern
synthesis is incomplete. Whats happening
now in evolutionary theory is as exciting and
foundational as during the early days, says
David Wilson of Binghamton University in
New York, another attendee.
Common descent
Natural selection
Rejection of Lamarckism
Separation of soma and germ
Wallace
Weissman
Fisher
Haldane
Wright
Dobzhansky
Huxley
Mayr
Simpson
Stebbins
Doug Futuyma
John Beatty
Sergey Gavrilets
collective
level
particle
level
Michael Purugganan
Genomic networks
(less emphasis on
role of
individual genes)
Gunter Wagner
Modularity,
Evolvability and
evolutionary Robustness
Genetic
Epigenetic (methylation, iRNA,
histone conformation)
Behavioral (mimicking)
Cultural (traditions, memes)
Eors Szathmary
John Odling-Smee
Gerd Muller
Marc Kirschner
Stuart Newman
David Jablonski
Phenotypic
plasticity can catalyze
fast phenotypic shifts via
phenotypic / genetic
accommodation
Werner Kallebaut
Alan Love
Thomas Kuhn
paleonto
genomics,
networks theory
complexity
epigenetic theory
Mendelism common
inheritance
descent
plasticity &
populationnatural
accommodation
statistical
selection
genetics
multilevel contingency
selection theory
paleontology
niche
construction
evolvability &
ecology
modularity
www.platofootnote.org