SYNCHRONOUS OCCURRENCE OF PRIMARY NEOPLASM BETWEEN

SQUAMOUS CELL CARCINOMA OF THE CERVIX AND CYSTADENOCARCINOMA

OF THE OVARY : CASE REPORT
Febrianty Paulina1, Laihad Bismarck J2, Tendean Hermi M.M3
1

Residents, Dept of Obstetrics and Gynecology, Prof. dr. R. D Kandou Medical College Hospital, Manado, Indonesia

Oncology Consultant, Dept of Obstetrics and Gynecology, Prof. dr. R. D Kandou Medical College Hospital, Manado, Indonesia

Professor, Dept of Obstetrics and Gynecology, Prof. dr. R. D Kandou Medical College Hospital, Manado, Indonesia

ABSTRACT
Objective: Cervical cancer is the most common gynecologic malignancy1, while ovarian
cancer is commonly diagnosed and particularly deadly gynecologic malignancy worldwide. It
ranks among top ten diagnosed cancers and top five deadliest cancers in most countries.2
Synchronous multiple primary tumors of the female genital tract are relatively rare, comprising
only 1-6% of all genital neoplasms3. Synchronous primary neoplasm between cervical squamous
cell carcinoma and ovarian cystadenocarcinoma are rare.
Case Report: P1A0 47-years-old complained of lower abdomen discomfort with
difficulty in urinating. After having pap test, cervical biopsy, CT scan, gynecologic examination ,
she was diagnosed with cervical cancer stage IIA2. CT scan showed tumor extend from cervix to
uterus, left parametrial and perirectal fat, subserosum myoma in uterine fundus, normal multiple
bilateral ilio-pelvic lymph nodes. Patient received NAC (cisplatin, vincristine, bleomycine) 3
times before radical hysterectomy.
During operation, we found 11x9x6 cm tumor originating from left ovary. Histopathology
conclusion : non-keratinizing squamous cell carcinoma of the cervix, chronic vaginitis,
cystadenocarcinoma musinous et serous papiliferum of the ovary, squamous cell carcinoma
metastasis in right iliac nodes. Patient then having post operative carboplatin-paclitaxel
chemotherapy for 6 times.
Conclusion: Synchronous tumors of cervix and ovary with different histopathology are
rarely reported. The underlying phenomenon responsible for these is not identified yet.
Determination whether it is synchronous primary tumor or metastasis is essential for prognosis

and further treatment. The synchronous tumors with different histology deserve further studies to
enhance our knowledge of these rare though potential occurrences.
Keywords : synchronous primary malignancies, cervical cancer, ovarian cancer

REFERENCES
1. Mohar A, Frias-Mendivil M. Epidemiology of cervical cancer. Cancer Invest 2000;18 :584590.
2. Ferlay J.; Shin H.R.; Bray F.; Forman, D., Mathers, C. & Parkin, D.M. Cancer Incidence and
Mortality Worldwide: IARC Cancer Base No. 10. Lyon, France: International Agency for
Research on Cancer; 2010.
3. Schoenberg BS, Greenberg RA, Eisenberg H. Occurrence of certain multiple primary cancers
in females. J Natl Cancer Inst 1969;43:1532.
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