Documente Academic
Documente Profesional
Documente Cultură
Opinion
Mesh in prolapse surgery: an imaging perspective
Introduction
Recurrence after female pelvic organ prolapse surgery is
common, with up to a third of all procedures performed
for recurrence1 . Anterior compartment recurrence seems
to be a particular problem2 . It is not surprising, therefore,
that there is constant striving to improve outcomes.
While mesh implants have been used for decades in an
attempt to reduce recurrence rates, it was only after the
worldwide success of midurethral slings made of wideweave polypropylene mesh, developed in the early 1990s,
that surgeons became more comfortable with using such
implants3 . The introduction of transobturator slings4 set
off a new wave of innovation when anterior vaginal wall
meshes anchored via the transobturator route (Perigee
and Anterior Prolift) were developed in 20032004.
At the same time, posterior meshes anchored through the
ischiorectal fossa were introduced (Posterior Prolift and
Apogee). Essentially, all current commercial meshes
sold and used specifically for prolapse repair are derivatives of those mesh devices. Biological meshes, on the
other hand, are often not properly anchored, and there
are no solid data on outcomes. Sonographically they are
invisible, and owing to the lack of available information
they will not be considered any further in this review. At
present, the use of biological meshes has to be regarded as
experimental.
Synthetic prolapse meshes are commonly used in conjunction with suburethral slings to treat concomitant
urodynamic stress incontinence. Ultrasound has played
a major role in the evaluation of sling function and placement, since such implants are as echogenic as polypropylene meshes used for prolapse surgery5 9 . Initially there
was some concern about simultaneous insertion, especially if both implants use a transobturator path. However, there are generally no technical difficulties, and the
two different procedures (suburethral sling and anterior
compartment mesh) seem to have very little, if any, effect
on each other, as shown in a paper published in this issue
of the journal10 . The only exception seems to be cases
where both mesh and sling are inserted through the same
anterior vaginal incision, which can either be deliberate
or a result of inadvertent extension of one incision to the
other. This can result in a mechanical union between sling
and mesh, making dynamic compression of the urethra
less likely and potentially leading to sling failure. Such
an effect is easily demonstrable on translabial ultrasound,
since the sling is directly adjacent to the mesh implant
and shows no mobility relative to the mesh on Valsalva
maneuver.
Methodology
Pelvic floor assessment by imaging is best performed
by translabial or transperineal ultrasound, which has a
number of advantages over magnetic resonance imaging
(MRI), as it is cheaper and more easily available, and
provides information in real time at 30 Hz or higher11 .
Even with four-dimensional (4D) imaging using systems
originally developed for fetal assessment, temporal
resolution is higher than for single-plane dynamic MRI.
The advantages of ultrasound are particularly obvious
when it comes to assessing mesh implants, since modern
wide-weave polypropylene meshes are highly echogenic,
but invisible on plain X-ray or MRI12,13 . As a result, both
intravaginal and perineal ultrasound have been introduced
for the imaging of mesh implants14 18 .
Modern 4D ultrasound systems designed for prenatal
diagnosis are perfectly suited for pelvic floor assessment.
A 7090 aperture and an 8090 acquisition angle
allow visualization of the entire levator hiatus with
levator ani, urethra, vagina, rectal ampulla and anal
canal at the same time, in real time, requiring very little
transducer manipulation (Figure 1). The method has
been comprehensively described in two recent review
articles11,19 . Its main limitation in terms of implant imaging is that cranial aspects of prolapse meshes are difficult
or impossible to visualize, especially if there is recurrent
posterior prolapse. However, these limitations are rarely
relevant clinically, since suspension failure will invariably
make the mesh descend and become clearly visible.
This article will be limited to those applications of pelvic
floor ultrasound that are useful for surgeons contemplating the use of mesh in pelvic reconstructive surgery, and
for those dealing with patients after mesh implantation.
The imaging of suburethral slings is covered elsewhere11 .
OPINION
Dietz
496
compartment mesh seems to be associated with substantially reduced recurrence rates20 , it is probable that the
risk : benefit ratio of mesh use vs traditional surgery in
some women should favor the use of mesh, regardless of
mesh-related complications. This is most likely in women
at high risk for prolapse recurrence after conventional
surgery. Hence, it seems prudent to consider individual
recurrence risk prior to prolapse surgery.
A number of authors have investigated risk factors
for recurrence. Younger age21,22 , a family history of
prolapse23 , prolapse grade21 24 , poor pelvic floor muscle contractility25 , previous hysterectomy, body mass
index21 , previous prolapse surgery, a larger genital
hiatus25 , levator avulsion (Figure 2)23,26 28 and hiatal
ballooning29 , that is, excessive distensibility of the levator
hiatus (Figure 3)30 , all seem to be associated with recurrence. Whiteside et al.22 , in a series of 176 women seen
1 year after prolapse surgery, found stage 2+ prolapse in
58%, associated with younger age and higher preoperative stage. In 292 women seen on average 5 months after
prolapse repair, Vakili et al.25 found recurrent stage 2+
prolapse in 35%, and this occurred more commonly in
women with a large genital hiatus and poor levator contractility. More recently, levator avulsion, a major defect
Figure 2 Right-sided levator avulsion ( ) after normal vaginal delivery at term (as seen from caudally) on: (a) a rendered ultrasound volume
similar to that in Figure 1d, (b) magnetic resonance imaging (axial plane) and (c) tomographic ultrasound imaging, 3 months postpartum.
Figure 3 Ultrasound images showing different degrees of hiatal distensibility on maximal Valsalva maneuver. The limit of normality
(mean + 2 SD in nulliparae60 , or as predictor of symptoms of prolapse30 ) is 25 cm2 .
Opinion
497
Probability
(a) 1.0
0.8
0.6
0.4
0.2
0.0
10
20
30
40
50
60
70
Probability
(b) 1.0
0.8
0.6
0.4
0.2
0.0
10
20
30
40
50
60
70
ballooning, but both these main predictors of recurrence can be obtained on clinical examination35,36 . In
view of the acrimonious discussion regarding the use of
mesh and the increasing medicolegal relevance of mesh
complications it seems prudent to limit mesh use to the
anterior compartment, and to patients at high risk of
prolapse recurrence. Unfortunately, the need for better
patient selection and identification of those at a high risk
of recurrence is being ignored by bureaucrats and senior
clinicians involved in this debate37 39 .
498
Dietz
Figure 5 Identification of transobturator armed mesh on Valsalva maneuver in midsagittal (a), coronal (b) and axial (c) planes. Arrows show
mesh length. Horizontal line in (a) is a line of reference placed through the inferior symphyseal margin; vertical line illustrates maximum
descent of caudal mesh margin on Valsalva maneuver. B, bladder; L, levator ani; R, rectum; S, symphysis.
Figure 7 Typical appearance on ultrasound of transobturator mesh (M) in a case of dislodgment of superior transobturator anchoring arms,
resulting in a high cystocele as observed after colposuspension or fascial sling: midsagittal views at rest (a), on half Valsalva (b) and on
maximum Valsalva maneuver (c). The cranial aspect of the mesh is unsupported and highly mobile. B, bladder; S, suburethral sling;
SP, symphysis pubis.
Opinion
maximal Valsalva (c), demonstrating apical failure, i.e.
dislodgment of apical anchoring structures, resulting in
excessive mobility of cranial aspects of the implant.
In a single midsagittal slice it is possible to document
both prolapse recurrence and mesh anchoring failure.
Patterns of failure vary substantially between different
mesh kits and anchoring methods. The most solid form of
lateral anchoring seems to be provided by transobturator
arms. Dislodgment of inferior arms seems to be least
likely. Sidewall fixation by plastic anchors may be less
effective51 . Just placing a mesh and expecting it to scar
into place over a few weeks with some form of vaginal
splinting seems unlikely to provide anything but increased
complication rates compared with traditional anterior
colporrhaphy. The effectiveness of apical anchoring seems
to vary between implants, with barbed anchors adding less
support than expected51 .
It is likely that some anchoring methods are better
than others, and that some anchors are at increased risk
of being dislodged. In a series of 296 women, seen on
average 1.8 years after anchored anterior compartment
mesh (Perigee, Prolift, Anterior Elevate), we found a
large percentage of anatomical situations indicative of
anchoring failure52 . A recurrent cystocele was found in
38% of patients. Three different patterns of cystocele
recurrence were observed, associated with distinctive
mesh mobility on Valsalva: (1) anterior failure (3%):
cystocele ventral and caudal to well supported mesh; (2)
apical failure (8%): high cystocele dorsal and caudal to
mesh with high mobility of the cranial mesh aspect; and
(3) global failure (27%): cystocele with high mobility of
the entire mesh on Valsalva (Figure 8). Anterior failures
occur because of dislodgment of the bladder base from a
well supported mesh (Figure 8a). Apical failures are not
uncommon in armed transobturator meshes, implying
dislodgment of superior arms, as seen in Figures 7 and
8b. Most common are global failures (Figure 8c) in which
the entire mesh has become highly mobile, implying a
complete absence of effective mesh anchoring. A global
recurrence may occur after placement of any of the five
different mesh types we have audited to date, but it
seems particularly common after non-anchored meshes
and Anterior Elevate. Apical and global anchoring failures
499
Figure 8 Ultrasound images showing types of mesh anchoring/cystocele recurrence after application of anterior compartment meshes: (a)
anterior recurrence, (b) apical recurrence and (c) global recurrence. Dots indicate outline of meshes, with arrows indicating cranial and
caudal mesh margins. A, anal canal; B, bladder; R, rectum; SP, symphysis pubis; U, urethra.
Dietz
500
80
70
60
Force (N)
50
40
30
20
10
0
0
10
20
30
40
50
60
70
Opinion
501
Acknowledgment
I would like to thank Mr Poul Nielsen, Auckland
Bioengineering Institute, for help with the modeling of
pelvic floor loading as shown in Figure 9.
Disclosures
Within the last 2 years, Dr Dietz has received an
educational grant from GE Medical (value USD 9000)
and has received equipment support from GE Medical
and Siemens for workshops. He also acted as consultant
for Materna Medical (San Francisco, USA).
Conclusions
The current debate surrounding the use of mesh in pelvic
reconstructive surgery has to date largely missed the
point. Accurate diagnosis has to come before surgery,
and much of the confusion at present is due to a lack of
diagnostic effort, both before and after mesh surgery. Any
further attempts at optimizing prolapse surgery should
be preceded by a conscious effort to first improve the
assessment of such patients, and imaging has a major role
to play in this regard.
Anchored anterior compartment meshes do seem to
lower recurrence rates, but owing to substantial meshrelated complications they are probably only indicated in
women at high risk of prolapse recurrence. Such patients
can be identified on clinical examination and pelvic floor
imaging. Women with a highly abnormal levator ani
muscle are unlikely to be permanently cured of their
prolapse by conventional means, and should probably be
offered mesh surgery.
Even with mesh use, however, recurrence rates
(while substantially lower than without mesh) are still
unacceptably high, suggesting that current implant design
is suboptimal. Imaging shows distinct patterns of mesh
failure and suggests equally distinct surgical approaches,
as well as improvements in implant design. Imaging also
allows entirely new surgical approaches, such as levator
H. P. Dietz
Discipline of Obstetrics, Gynaecology and Neonatology,
Sydney Medical School Nepean, Penrith,
New South Wales, Australia
(e-mail: hpdietz@bigpond.com)
REFERENCES
1. Olsen AL, Smith VJ, Bergstrom JO, Colling JC, Clark AL.
Epidemiology of surgically managed pelvic organ prolapse and
urinary incontinence. Obstet Gynecol 1997; 89: 501506.
2. Fialkow M, Newton K, Weiss N. Incidence of recurrent
pelvic organ prolapse 10 years following primary surgical
management: a retrospective cohort study. Int Urogynecol J
Pelvic Floor Dysfunct 2008; 19: 14831487.
3. Ulmsten U, Henriksson L, Johnson P, Varhos G. An ambulatory
surgical procedure under local anesthesia for treatment of
female urinary incontinence. Int Urogynecol J Pelvic Floor
Dysfunct 1996; 7: 8185; discussion 8586.
4. Delorme E, Droupy S, de Tayrac R, Delmas V. Transobturator
tape (Uratape): a new minimally-invasive procedure to treat
female urinary incontinence. Eur Urol 2004; 45: 203207.
5. Dietz HP, Wilson PD. The iris effect: how two-dimensional
and three-dimensional ultrasound can help us understand antiincontinence procedures. Ultrasound Obstet Gynecol 2004; 23:
267271.
6. Dietz HP, Barry C, Lim YN, Rane A. Two-dimensional and
three-dimensional ultrasound imaging of suburethral slings.
Ultrasound Obstet Gynecol 2005; 26: 175179.
7. Chantarasorn V, Shek KL, Dietz HP. Sonographic appearance
of transobturator slings: implications for function and
dysfunction. Int Urogynecol J 2011; 22: 493498.
8. Yang Y, Yang S, Huang W. Correlation of morphological
alterations and functional impairment of the tension-free
vaginal tape obturator procedure. J Urol 2009; 181: 211218.
9. Shek KL, Chantarasorn V, Dietz HP. The urethral motion
profile before and after suburethral sling placement. J Urol
2010; 183: 14501454.
10. Huang WC, Yang SH, Yang JM, Tzeng CR. Impact
of concomitant anterior vaginal reconstructive surgery on
transobturator suburethral tape procedures. Ultrasound Obstet
Gynecol 2012; 40: 562569.
502
11. Dietz HP. Pelvic floor ultrasound: a review. Am J Obstet
Gynecol 2010; 202: 321334.
12. Fischer T, Ladurner R, Gangkofer A, Mussack T, Reiser
M, Lienemann A. Functional cine MRI of the abdomen for
the assessment of implanted synthetic mesh in patients after
incisional hernia repair: initial results. Eur Radiol 2007; 17:
31233129.
13. Schuettoff S, Beyersdorff D, Gauruder-Burmester A, Tunn
R. Visibility of the polypropylene tape after tension-free
vaginal tape (TVT) procedure in women with stress urinary
incontinence: comparison of introital ultrasound and magnetic
resonance imaging in vitro and in vivo. Ultrasound Obstet
Gynecol 2006; 27: 687692.
14. Tunn R, Picot A, Marschke J, Gauruder-Burmester A.
Sonomorphological evaluation of polypropylene mesh implants
after vaginal mesh repair in women with cystocele or rectocele.
Ultrasound Obstet Gynecol 2007; 29: 449452.
15. Letouzey V, Deffieux X, Levaillant J, Faivre E, de Tayrac R,
Fernandez H. Ultrasound evaluation of polypropylene mesh
contraction at long term after vaginal surgery for cystocele
repair. Int Urogynecol J Pelvic Floor Dysfunct 2009; 20:
S205S206.
16. Svabik K, Martan A, Masata J, El-Haddad R, Hubka P,
Pavlikova M. Ultrasound appearances after mesh implantation
evidence of mesh contraction or folding? Int Urogynecol J
2011; 22: 529533.
17. Shek KL, Dietz HP, Rane A, Balakrishnan S. Transobturator
mesh for cystocele repair: a short- to medium-term follow-up
using 3D/4D ultrasound. Ultrasound Obstet Gynecol 2008; 32:
8286.
18. Shek KL, Rane A, Goh J, Dietz HP. Stress urinary incontinence
after transobturator mesh for cystocele repair. Int Urogynecol
J Pelvic Floor Dysfunct 2009; 20: 421425.
19. Santoro GA, Wieczorek AP, Dietz HP, Mellgren A, Sultan
AH, Shobeiri SA, Stankiewicz A, Bartram C. State of the
art: an integrated approach to pelvic floor ultrasonography.
Ultrasound Obstet Gynecol 2011; 37: 381396.
Dietz
30. Dietz H, De Leon J, Shek K. Ballooning of the levator hiatus.
Ultrasound Obstet Gynecol 2008; 31: 676680.
31. Shek KL, Dietz HP. Intrapartum risk factors of levator trauma.
BJOG 2010; 117: 14851492.
32. Dietz HP, Bernardo MJ, Kirby A, Shek KL. Minimal criteria
for the diagnosis of avulsion of the puborectalis muscle
by tomographic ultrasound. Int Urogynecol J 2011; 22:
699704.
33. Zhuang RR, Song YF, Chen ZQ, Ma M, Huang HJ, Chen JH,
Li YM. Levator avulsion using a tomographic ultrasound and
magnetic resonance-based model. Am J Obstet Gynecol 2011;
205: 232.e18.
34. Morgan DM, Larson K, Lewicky-Gaupp C, Fenner DE,
DeLancey JO. Vaginal support as determined by levator ani defect status 6 weeks after primary surgery for
pelvic organ prolapse. Int J Gynaecol Obstet 2011; 114:
141144.
35. Dietz HP, Shek C. Validity and reproducibility of the digital
detection of levator trauma. Int Urogynecol J Pelvic Floor
Dysfunct 2008; 19: 10971101.
36. Khunda A, Shek KL, Dietz HP. Can ballooning of the levator
hiatus be determined clinically? Am J Obstet Gynecol 2012;
206: 246.e14.
37. UPDATE on Serious Complications Associated with Transvaginal Placement of Surgical Mesh for Pelvic Organ Prolapse.
http://www.fda.gov/medicaldevices/safety/alertsandnotices/ucm
262435.htm.
38. Brubaker L, Shull B. A perfect storm. Int Urogynecol J 2012;
23: 34.
39. Haylen B, Sand PK, Swift SE, Maher C, Moran PA, Freeman
RM. Transvaginal placement of surgical mesh for pelvic organ
prolapse: more FDA concerns positive reactions are possible.
Int Urogynecol J 2012; 23: 1113.
40. Feiner B, Maher C. Vaginal mesh contraction. Obstet Gynecol
2010; 115: 325330.
41. Bako A, Dhar R. Review of synthetic mesh-related complications in pelvic floor reconstructive surgery. Int Urogynecol J
Pelvic Floor Dysfunct 2009; 20: 103111.
42. Poujade O, Reyal F, Alves K, Dhainaut C, Thoury A, Madelenat
P. Mesh erosion after anterior prosthetic reinforcement by
vaginal route: risk factors and management. J Gyn Surg 2008;
24: 110.
43. Savasneh A, Johnson H. Risk factors for mesh erosion
complicating vaginal reconstructive surgery. J Obstet Gynaecol
2010; 30: 721724.
44. Lowman JK, Woodman PJ, Nosti PA, Bump RC, Terry CL,
Hale DS. Tobacco use is a risk factor for mesh erosion after
abdominal sacral colpoperineopexy. Am J Obstet Gynecol
2008; 198: 561.e14.
45. Feiner B, Jelovsek J, Maher C. Efficacy and safety of transvaginal
mesh kits in the treatment of prolapse of the vaginal apex: a
systematic review. BJOG 2009; 116: 1524.
MA, Vega Ruiz V, Daz Godoy A, Baez
Perea
46. Garca-Urena
Opinion
52. Shek K, Wong V, Rane A, Goh J, Krause H, Lee J, et al.
How common is fixation failure after mesh kit surgery?. Int
Urogynecol J 2012; 23: S154S155.
53. Dietz H, Franco A, Shek K, Kirby A. Avulsion injury and levator
hiatal ballooning: two independent risk factors for prolapse?
An observational study. Acta Obstet Gynecol Scand 2012; 91:
211214.
54. Dietz H, Gillespie A, Phadke P. Avulsion of the pubovisceral
muscle associated with large vaginal tear after normal vaginal
delivery at term. Aust NZ J Obstet Gynaecol 2007; 47:
341344.
55. Dietz H, Shek K, Korda A. Can levator avulsion be corrected
surgically? Neurourol Urodyn 2011; 30: 877879.
56. Dietz HP, Vancaillie P, Svehla M, Walsh W, Steensma
AB, Vancaillie TG. Mechanical properties of urogynecologic
implant materials. Int Urogynecol J Pelvic Floor Dysfunct 2003;
14: 239243; discussion 243.
503
57. Shepherd JP, Feola AJ, Abramowitch SD, Moalli PA. Uniaxial
biomechanical properties of seven different vaginally implanted
meshes for pelvic organ prolapse. Int Urogynecol J 2012; 23:
613620.
58. Zacharin RF, Hamilton NT. Pulsion enterocele: long-term
results of an abdominoperineal technique. Obstet Gynecol
1980; 55: 141148.
59. Dietz HP, Korda A, Benness C, Wong V, Shek KL, Daly O.
Surgical reduction of the levator hiatus. Neurourol Urodyn
2012 (in press).
60. Dietz H, Shek K, Clarke B. Biometry of the pubovisceral muscle and levator hiatus by three-dimensional pelvic
floor ultrasound. Ultrasound Obstet Gynecol 2005; 25:
580585.
61. Mulder FE, Shek KL, Dietz HP. Whats a proper push? The
Valsalva manoeuvre revisited. Aust NZ J Obstet Gynaecol
2012; 52: 282285.