02 ADAP, Vielka Angela V.

2A-PH
LEC

Maam Ngo
PHARDOSE

TABLET DEFECTS

NAME OF
TABLET DEFECT

1. CHIPPING

2. STICKING

REASON
FOR DEFECT

REMEDY FOR
DEFECT

involves
increased
brittleness of the
tablet
breaking
of
tablet edges

- excessive use
of fillers and
pigments
- low amount of
polymers
too
dry
granules
- sticking on
punch faces

- tablets sticking
to other tables
and onto the pan
faces

- granules not
dried properly
too
little
lubrication
too
much
binders
- too soft or
weak granules

- add hygroscopic
substances
moisten
the
granules
increase
lubrication
increase
hardness of the
film
- dry the granules
properly;
make
moisture analysis.
- increase or swap
lubricants
reduce
the
amount of binders
used
- optimize amount
of
binder
and
granulation
technique used

DEFINITION

ILLUSTRATION

3. BLISTERING

4. BRIDGING

the
local
detachment
of
film
from
the
substrate forming
blisters

- Over heating - use mild/proper

during spraying drying conditions
coating solution when spraying the
coat solution

- the shrinking or
pulling away of
the coating of a
tablet

-improper
application
of
the solution.
- poor design of
the
tablet
embossing
- high coating
viscosity
improper
atomization
pressure.

- a defect wherein
5.
COLOUR a
variation
VARIATION
happens in the
color of the film

improper
mixing,
- uneven spray
pattern,
insufficient
coating

control
of
spraying
of
coating solution
- changing of font
for the logo and
monogram
adjust
the
concentration
of
coating material

- utilization of lake
dyes
eliminates
dye migration
reformulation
with a different
plasticizer
and
additives

- surface defect
which
results
from
the
film
6. ORANGE PEEL being rough and
EFFECT
nonglossy;
texture resembles
the surface of an
orange

- Use mild drying

conditions
- rapid drying
- Use additional
- high solution
solvents
to
viscosity
decrease viscosity
of solution

complete
or
partial loss of top
or bottom crowns
of the tablet

utilize
flat
punches
instead
- improper use
using
deep
or
of punches
overly
concaved
punches

unequal
distribution
of
color
on
the
tablet,
causing
lighter or darker
areas to appear

- utilization of a
drug
whose
color
differs
from
tablet
excipients.
- utilization of a
drug
whose
dehydration
products
are
colored

7. CAPPING

8. MOTTLING

controlling
humidity
conditions.
monitoring
of
the
temperature when
formulation
is
happening

9. CRACKING

10. LAMINATION

small,
fine
cracks
are
observed on the
tablet, especially
on the upper and
lower surfaces of
the tablet

- absorption of
moisture
excess
concentration of
coating material
present in the
tablet
- large size of
granules
too
dry
granules
- granulation is
too cold

- the separation
of a tablet into
two
or
more
distinct layers

- pre-compression
- reduction of final
compression force
- air entrapment
- utilization of flat
- utilization of
punches
deep
concave
utilization
of
punches
hygroscopic
materials
to
maintain
proper
moisture levels

- reduce granule
size
moisten
the
granules properly
and add proper
amount of binder
improve
granulation
- adjustment of
the concentration
of
the
coating
solution