Henoch-Schnlein purpura

Henoch-Schnlein purpura (HSP) is an inflammatory disorder characterized by a generalized

vasculitis involving the small vessels of the skin, GI tract, kidneys, joints, and, rarely, the lungs
and CNS. It is the most common vasculitis in children.
Pathophysiology

It is thought to be multifactorial with genetic, environmental, and antigenic components.

75% of patients report antecedent upper-respiratory, pharyngeal, or GI infections
Multiple bacterial and viral infectious agents
drug ingestions and vaccinations.
thought to be an immunoglobulin A (IgA)mediated autoimmune phenomenon.

Symptoms

Abdominal pain
Joint pain
Purple spots on the skin (purpura), usually over the buttocks, lower
legs, and elbows
Bloody stools
Hives or angioedema

Nausea

Diarrhea

Painful menstruation

Vomiting