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Name: _________________________________

(Last)
(First)

SID: ___________________________
Section: _________________________

INTRODUCTION TO GENETICS
LS4 Spring 2009
04/20/09
MIDTERM I
Please circle your TAs name:
EMILY

YI

BLAKE

EDDIE

RYAN

SATORU

Instructions:
1. This exam has 9 pages. Before starting, make sure you have all the pages.
2. Clearly write your name on every page. Be sure to write clearly. Only legible answers
will be graded.
3. Do not write on the backs of pages. We will not grade them.
4. All books, notes, and cell phones (turned off) must be put in zipped backpacks.
5. Calculators may be used. NO GRAPHING CALCULATORS ARE ALLOWED!
6. On the last page are the Critical Values for the Chi-Square Test.

Page 2

______________

Page 6

______________

Page 3

______________

Page 7

______________

Page 4

______________

Page 8

______________

Page 5

______________
Total:

_____________/100

Respond to the following questions and statements to the best of your ability.
Please note that you should limit your responses to the space provided. Points
will be taken off if you go beyond the limit and provide incorrect responses in the
presence of correct responses.

Name: _________________________________
(Last)
(First)

SID: ___________________________
Section: _________________________

1. Mitosis/Meiosis (12 points)


A diploid organism has three pairs of chromosomes (2n = 6). The lines in the figures
below represent the metaphase plate that is perpendicular to this page. The circles
represent centromeres.

A
.

B
.

C
.

D
.

E
.

F
.

G
.

H
.

I
.
A. Which one of the above represents Metaphase during Meiosis I? ___________
B. Which one of the above represents Metaphase during Mitosis? ____________
C. Which one of the above represents Metaphase during Meiosis II? _____________

Name: _________________________________
(Last)
(First)

SID: ___________________________

Section: _________________________
2. Lethal allele and Independent Assortment (12 points)
Heterozygous Cp cp chickens express a condition called creeper, in which the leg and wing
bones are shorter than normal (cp cp). The dominant Cp allele is lethal when
homozygous. Two alleles of an independently segregating gene determine white (W-)
versus yellow (ww) skin color. From mating between chickens heterozygous for both of
these genes, what phenotypic classes will be represented among the viable progeny, and
what are their expected relative frequencies?

Name: _________________________________
(Last)
(First)

SID: ___________________________
Section: _________________________

3. Linkage (12 points)


In wheat, normal plant height required the presence of either or both of two dominant
alleles, A and B. Plants homozygous for both recessive alleles (ab/ab) are dwarfed but
otherwise normal. The two genes are on the same chromosome, 16 map units apart. From
the cross Ab/aB x AB/ab, what is the expected frequency of dwarfed plants among the
progeny? Show your work and CIRCLE YOUR ANSWER.

4. Pedigree (12 points)


Consider the following pedigree.
I

II

III
(A) What is the mode of inheritance of this RARE condition?

(B) If individuals II-2 and II-3 have three children, what is the probability that
exactly two of them will be affected? CIRCLE YOUR ANSWER.

Name: _________________________________
(Last)
(First)

SID: ___________________________
Section: _________________________

5. Gene Interaction (12 points)


Sometimes one gene may have the effect of suppressing an abnormal (mutant) allele of
another gene, resulting in the normal phenotype. For instance, in Drosophila there is a
gene called suppressor of hairy wing. Homozygous recessive for that gene restores the
normal wing phenotype in flies homozygous recessive for the target gene hairy wing.
The following questions refer to offspring ratios after the mating of individuals
heterozygous for both genes: the suppressor (gene A) and the gene it suppresses (gene B).
a) What phenotypic ratio of offspring would you expect if suppression occurs when gene
A possesses a dominant allele and the target gene produces a mutant phenotype when
gene B possesses a dominant allele. Show your work and CIRCLE YOUR ANSWER.

b) What phenotypic ratio of offspring would you expect if both the suppressor allele is
recessive and the mutant it suppresses is recessive, too? Show your work and CIRCLE
YOUR ANSWER.

Name: _________________________________
(Last)
(First)

SID: ___________________________
Section: _________________________

6. Complementation Analysis (14 points)


To understand the genetic basis of locomotion in the diploid nematode C elegans, recessive
mutations were obtained, all making the worm wiggle ineffectually instead of moving
with its usual smooth gliding motion. These mutations presumably affect the nervous or
muscle systems. Nine homozygous mutants were intercrossed, and the F1 hybrids were
examined to see if they wiggled. The results were as follows, where a plus sign means
that the F1 hybrid was wild type (gliding) and w means that the hybrid wiggled.
1
2
3
4
5
6
7
8
9

1
w

2
+
w

3
w
+
w

4
+
+
+
w

5
+
+
+
+
w

6
+
+
+
w
+
w

7
w
+
w
+
+
+
w

8
+
+
+
+
+
+
+
w

9
+
+
+
+
w
+
+
+
w

a) Explain what this experiment was designed to test.

b) Explain why the phenotype of the F1 hybrids between mutants 1 and 2 differed from
that of the hybrids between mutants 1 and 3.

c) How many genes are represented by the mutations, and which mutations belong to each
gene?

Name: _________________________________
(Last)
(First)

SID: ___________________________
Section: _________________________

7.
analysis (12 points)
You are an undergrad working in a plant lab here at UCLA. The professor wants you to
determine if two genes responsible for flower color and flower blooming in Arabidopsis are
linked or unlinked. In the P generation, you cross a red-flowered, late-blooming plant with
a white-flowered, early-blooming plant. The resulting F1 (all red and late blooming) is
crossed with a white-flowered, early-blooming plant. You find:
403 red, late
395 white, early
143 red, early
151 white, late
If each of these traits is produced by a single gene, test if these two genes are
linked. Use chi-square analysis in your determination. Include in your answer:
your hypothesis in the 2 analysis, predicted values, 2 calculation, and your
conclusion. (Table on very last page)

Name: _________________________________
(Last)
(First)

SID: ___________________________
Section: _________________________

8. Interference (14 points)


The genes for vermilion (v) eyes, sable (s) body color, and forked (f) bristles are on
the X-chromosome of Drosophila. They map in the order vsf, with 10 map units
between v and s and 14 map units between s and f. Suppose that you cross a
wildtype male with a vsf female and then testcross the F1 females. Indicate the
progeny classes and their numbers among 2000 total progeny, assuming that the
Interference I = 0.5