ANEMIA IS TYPE OF HEREDITARY DISEASE. IT IS DESCRIBED AS THE
CONDITION IN WHICH THE NUMBER OF RED BLOOD CELLS OR HAEMOGLOBIN IS LOWER. NORMAL LEVEL OF HAEMOGLOBIN GENERALLY DIFFERENT IN MALES AND FEMALES.FOR MEN, TYPICALLY DEFINED AS HAEMOGLOBIN LEVEL OF LESS THAN 13.5GRAM/100ML AND IN WOMAN AS HAEMOGLOBIN OF LESS THAN 12.0GRAM/100ML. A PERSON WHO HAS ANEMIA (HAVING A LOW BLOOD COUNT) IS CALLED ANEMIC. ANY PROCESS THAT CAN DISRUPT THE NORMAL LIFE SPAN OF RED BLOOD CELLS MAY CAUSE ANEMIA. RED BLOOD CELLS ARE MADE IN BONE MARROW. THE LIFE SPAN OF RED BLOOD CELLS ARE TYPICALLY AROUND 120 DAYS. HEREDITARY DISORDER CAN SHORTEN THE LIFE SPAN OF RED BLOOD CELLS AND LEAD TO ANEMIA. FOR EXAMPLE, SICKLE CELL ANEMIA. HEREDITARY DISORDER CAN ALSO CAUSE ANEMIA BY IMPAIRING THE PRODUCTION OF HAEMOGLOBIN. FOR EXAMPLE, ALPHA THALLASEMIA AND BETA THALLASEMIA. HEREDITARY DISORDER ALSO CAUSE ANEMIA CHANGING THE SHAPE OF RED BLOOD CELLS. DEPENDING ON DEGREE OF GENETIC ABNORMALITY, HEREDITARY ANEMIAS MAY CAUSE MILD, MODERATE OR SEVERE ANEMIA. IN FACT, SOME MAY BE TOO SEVERE TO BE COMPATIBLE WITH LIFE AND MAY RESULT IN DEATH OF FOETUS(UNBORN INFANT). ON THE OTHER HAND, SOME OF THESE ANEMIAS ARE SO MILD THAT THEY ARE NOT NOTICEABLE AND ARE INCIDENTALLY REVEALED DURING A ROUTINE BLOOD WORK. SICKLE CELL IS A TYPICALLY HEREDITARY. CERTAIN HEREDITARY VARIATIONS IN A PERSONS GENES CAN LEAD TO INCORRECT OR DECREASED PRODUCTION OF RED BLOOD CELLS. THIS CAN CAUSE RED BLOOD CELLS TO NOT LAST AS LONG IN THE BLOOD,NOT BE AS EFFECTIVE TRANSPORTING OF OXCGEN FROM THE LUNGS TO DIFFERENT PARTS OF THE BODY, OR NOT BE CREATED AT ALL. THALLASEMIA IS ANOTHER GROUP OF HAEMOGLOBIN-RELATED CAUSES OF ANEMIA. THERE ARE MANY TYPES OF THALASSEMIA, WHICH VARY IN SEVERITY.TESE IS ALSO HEREDITARY, BUT THEY CAUSE QUANTITATIVE HAEMOGLOBIN ABNORMALTIES,MEANING AN INSUFFICIENT NUMBER OF HAEMOGLOBIN MOLECULE IS MADE. HEMOCHROMATOSIS IS AN IRON RELATED HEREDITARY CONDITION IN WHICH THE BODY ABSORBS MORE IRON MORE FROM THE FOOD THAT IN NEEDS. BECAUSE THERE IS NO WAY FOR THE BODY TO GET RID OF THE EXCESS IRON, IT IS STORED IN VARIOUS ORGANS LIKE THE LIVER, HEARTS, AND PANCREAS. IF UNTREATED, THE HIGHER LEVEL OF STORED IRON CAN CAUSE ORGANS TO BECAME DISEASED. ALSO KNOWN AS IRON AS IRON OVERLOADED DISEASE, HEMOCHROMATOSIS IS ONE OF COMMON GENETIC DISORDER. IN HAEMOLYTIC ANEMIA, THE NORMAL RED BLOOD CELLS SHAPE IS IMPORTANT FOR ITS FUNCTION. HEMOLYTIC ANEMIA IS ATYPE OF ANEMIA IN WHICH THE RED BLOOD CELLS RUPTURE(KNOWN AS HAEMOGLOBIN) AND BECOME DYSFUNCTIONAL. THIS COULD HAPPEN DUE TO VARIETY OF REASONS. SOME FORMS OF HEMOLYTIC ANEMIA CAN BE HEREDITARY WITH CONSTANT DESTRUCTION AND RAPID REPRODUCTION OF RED BLOOD CELLS. THIS DESTRUCTION MAY ALSO HAPPEN TO NORMAL RED BLOOD CELLS IN CERTAIN CONDITION. FOR EXAMPLE, WITH ABNORMAL HEART VALVES DAMAGING THE BLOOD CELLS. BECAUSE A LOW RED BLOOD CELLS COUNT DECREASES OXYGEN DELIVERY TO EVERY TISSUE IN BODY, ANEMIA MAY CAUSE MANY SIGNS AND SYMPTOMS. IT CAN ALSO MAKE ALMOST ANY OTHER UNDERLYING MEDICAL CONDITION WORSE. IF ANEMIA IS MILD, IT MAY NOT CAUSE ANY SYMPTOMS.IF ANEMIA IS SLOWLY ONGOING(CHRONIC) , THE BODY MAY ADAPT AND COMPENSATE FOR THE CHANGE; IN THIS CASE THERE MAY NOT BE ANY SYMPTOMS UNTIL BECOME MORE SEVERE. SYMPTOMS OF ANEMIA MAY INCLUDE THE FOLLOWING:FATIGUE, WEAKNESS, SHORTNESS OF BREATH, LIGHTHEADEDNESS, APPEAR PALE, DEVELOP PALPITATIONS(FEELING OF HEART RACING), HAIR LOSS, MALAISE(GENERAL SENSE OF FEELING UNWELL), CHEAST PAIN, ANGINA, HEART ATTACK, DIZZINESS, FAINTING, PASSING OUT AND RAPID HEART RATE. THERE SOME SIGNS THAT MAY INDICATE ANEMIA IN AN INDIVIDUAL. THERE ARE CHANGE IN STOOL COLOR, INCLUDING BLACK AND TARRY STOOL(STICKY AND FOUL SMELLING), MAROON-COLORED OR VISIBLY BLOODY STOOLS, LOW BLOOD PRESSURE, RAPID BREATHING, PALE/COLD SKIN, YELLOW SKIN CALLED JAUNDICE.HEART MURMUR AND ENLARGEMENT OF SPLEEN. AS MENTIONED EARLIER, HAEMOGLOBIN HAS THE IMPORTANT ROLE OF DELIVERING OXYGEN TO ALL PARTS OF BODY OF CONSUMPTION AND CARRIES BACK CARBON DIOXIDE BACK TO LUNG TO EXHALE IT OUT OF THE BODY. IF HAEMOGLOBIN LEVEL IS TOO LOW, THIS PROCESS MAY BE IMPAIRED, RESULTING IN BODY HAVING LOW OXYGEN LEVEL(HYPOXIA). THERE ARE WAYS TO DIAGNOSE ANEMIA. ANEMIA IS USUALLY DETECTED OR AT LEAST CONFIRMED BY A COMPLETE BLOOD CELL(CBC) COUNT. CBC TEST MAY BE ORDERED BY A PHYSICIAN AS A PART OF ROUTINE GENERAL CHECK-UP AND SCREENING OR BASED ON CLINICAL SIGNS AND SYMPTOMS THAT MAY SUGGEST ANEMIA AND OTHER BLOOD ABNORMALTIES. A COMPLETE BLOOD CELL(CBC)COUNT IS ATEST FOR COUNTING AND EXAMINING THE DIFFERENT TYPES OF CELLS IN THE BLOOD. SI COMPONENTS MEASUREMENT MAKE UP A CBC TEST ARE RED BLOOD CELL(RBC)COUNT, HEMATOCRIT, HAEMOGLOBIN, WHITE BLOOD CELL(WBC)COUNT, DIFFERENTIAL BLOOD COUNT(THE ³DIFF´) AND PLATELET COUNT. ONLY THE FIRST THREE OF THESE TESTS: THE RBC COUNT, THE HEMATOCRIT AND THE HAEMOGLOBIN ARE RELEVANT TO THE DIAGONESE OF ANEMIA. ADDITIONALLY,MEAN CORPUSCULAR VOLUME(MCV) IS ALSO OFTEN REPORTED IN A CBC, WHICH BASICALLY WE MEASURE THE AVERAGE VOLUME OF RED BLOOD CELLS IN ABLOOD SAMPLE. THIS IS IMPORTANT IN DISTINGUISHING THE CAUSES OF ANEMIA. UNITS OF MCV ARE REPORTED IN TEMTOLITERS, A FRACTIONOF ONE MILLION OF A LITER . OTHER USEFUL CLUES TO CAUSES OF ANEMIA THAT ARE REPORTED IN A CBC ARE THE SHAPE AND COLOR OF RBC. THERE ARE WAYS TO SCREEN AND TREAT HEREDITARY ANEMIA. BECAUSE HEREDITARY ANEMIA IS DETERMINED BY THE MAKE- UP OF YOUR GENES,THERE ARE VARIOUS WAYS IN WHICH YOUR DOCTOR CAN DETECT IF YOU HAVE ONE OF THESE GENETIC VARIATIONS. THE PRESENCE OF ANEMIA, AS DETERMINED BY A BELOW NORMAL HAEMOGLOBIN LEVEL, IS ONE IMPORTANT INDICATOR THAT YOU MAY HAVE A HEREDITARY OR CHRONIC CONDITION THAT CAUSES ANEMIA. THESE METHODS OF DETECTIONS ARE USUALLY REFERRED TO AS GENETIC SCREENING TESTS AND INVOLVE PRECISE ANALYSIS OF STRUCTURE OT YOUR GENES, BUT AREW NOT AVAILABLE YET FOR ALL HEREDITARY ANEMIAS. TO HELP YOUR DOCTOR DIAGNOSE YOUR ANEMIA, BE SURE TO TELL HIM/HER IF YOUR FAMILY HISTORY OF ANY OF THE HEREDITARY CONDITION. THIS HISTORY CAN INDICATE IF YOU ARE AT RISK FOR CARRYING ONE OF THE GENETICS VARIATIONS WHICH CAN CAUSE ANEMIA. THERE ARE MANY DIFFERENT TYPES OF TREATMENT FOR HEREDITARY ANEMIAS WHICH COUNTS THE BODIES INABILITY TO SUSTAIN HEALTHY LEVEL OF RED BLOOD CELLS AND MINIMISE THE ANEMIA RELATED SYMPTOMS TO PATIENCE OFF EXPERIENCE. THERE ARE NO SPECIFIC SURGICAL INTERVENTIONS FOR THE TREATMENT OF ANEMIA. HOWEVER, DEPENDING ON THE CASE OF THE ANEMIA SURGERY MAY BE A TREATMENT OPTION.