Near Horizons Collaborative Grant for Basic, Translational, and Clinical Scientists

Application Instructions
For grant year January 1, 2016 December 31, 2016
DEADLINES
Submission Deadline: December 15, 2015
Funds available: January 1, 2016
For questions regarding these instructions, please contact Christy K. Holland, Ph.D., Director of Research, UC Heart Lung and Vascular Institute, at: Christy.Holland@uc.edu or (513) 558-5675.
1. Funding Pool/s: Funding for this program is derived from the University of Cincinnati Heart, Lung,
and Vascular Institute and the UC College of Medicine Office of Research. The Principal Investigator must hold a faculty appointment in the College of Medicine. To be eligible and responsive to this
RFP, faculty must develop basic or translational collaborative research proposals from 2 or more
divisions or departments at the University of Cincinnati College of Medicine, Cincinnati Childrens
Hospital Medical Center, and the Veterans Affairs Medical Center. Up to $25,000 per proposal may
be requested. It is anticipated that four awards will be made for the 2016 funding cycle, one of
which must be specifically tied to a Comparative Effectiveness Research/Patient Centered Outcomes project.
2. Purpose: The purpose of the proposed program is to promote basic and translational research collaborations that involve more than one participating division or department within the Heart, Lung,
and Vascular Institute. The goal is to bring together expertise, scientific resources, patient populations, and core resources that are not all readily available within the separate divisions and departments. Additionally, funds can be targeted to the acquisition of preliminary data that is responsive
to a critique of a prior extramural grant proposal.
3. Eligible Research: Collaborative research may include any types within the spectrum of basic and
translational research ranging from bench research to projects that seek to apply basic research
knowledge in an identifiable pathway towards the development of trials and studies in humans.
4. Collaborations: The UCHLVI encourages interactions between basic scientists and clinicians to
foster the development of basic and clinical investigations for patients with serious cardiovascular
and pulmonary diseases. Thus, studies that include the participation of both basic scientists and clinicians will be given high priority. Projects involving interdisciplinary collaborations will be given
priority during the administrative review. An individual investigator can participate in only one proposal.
5. Timeline: These grants are for one year of support. Funds will be available January 1, 2016 and
will need to be spent prior to December 31, 2016. The number of awardees will be determined by
the quality of the proposals, the total amounts of the requested budgets of sufficiently meritorious
proposals, and available funds. A brief progress report will be due 12 months after the funds are
awarded.
6. Eligibility: Applications will be accepted from any faculty member with an appointment of 100%
FTE in the University of Cincinnati College of Medicine who is a member of a department or division
currently participating in the Heart, Lung and Vascular Institute, specifically, Cardiovascular Health
and Disease, Pulmonary Critical Care and Sleep Medicine, Vascular Surgery and the HLVI Cardio-

vascular Research Center of Excellence. Eligible applicants can be basic scientists, physicians,
nurses, and other health care faculty with advanced degrees (M.D., Ph.D., M.D.-Ph.D., or equivalent). Clusters of investigators spanning disciplines and programs made up of basic and clinical
faculty are strongly encouraged to apply. The Near Horizons Collaborative Grant program is intended to support 1-year projects that will lead to R01-type applications. The budget may include
funds for equipment, supplies, salary for technical help particularly from students, and support for
use of core facilities. Importantly, faculty salary is excluded.
7. Overview of Review Process: The review of applications is performed in two phases: (1) Scientific Review, and (2) Administrative Review. The 3-page applications will be reviewed by 2 scientific
reviewers with relevant background from the participating divisions and departments, and a biostatistician. The 2-3 reviewers will provide written critiques in a format similar to an NIH scoring system and include an assessment of sustainability of the project after completion of the 1-year funding. Administrative review will consist of UCHLVI leadership (Richard C. Becker, M.D.; Christy K.
Holland, Ph.D., Andrew D. Friedrich, M.D., David Feldman, M.D., Ph.D.; Frank McCormack, M.D.,
and George Meier, M.D.) who will review the merit scores of the review committee and make final
funding decisions based on available resources in the Heart, Lung, and Vascular Institute. Critiques
from the review will be provided to the applicants after award decisions are made.
8. Letter of Support: Applications must include a letter of support from the primary applicants Division Director or Department Chair. Included in the letter of support must be a statement regarding
the priority of the research proposal for the division or department, particularly as it relates to patient
resources.
9. Required format: Applications must be submitted electronically. Send the application as one collective PDF file of assembled elements in the required order to UCHeart@UCHealth.com. Application forms (modified from PHS 398) are attached. Proposals must be submitted in single spaced
text, one-half inch margins, and no smaller than an 11-point font. Arial typeface is preferred. The
primary applicants name must appear in the upper right hand corner of each page, and each page
must be numbered in the order of the required elements. Invited proposals are limited to no more
than 3 pages (including figures but excluding animal and human subject protections and references). Standard PHS 398 forms for budget, biosketch, other support, and resources should be
used.
10. Supplemental items: Supplemental items are not allowed, other than the animal and human subject protections, references, letters of collaboration and contracts.
11. Components: Research proposals require the following elements in the order specified:
1. Face page (check all appropriate IBC, IACUC, IRB, or Radiation Safety approvals or indicate
pending if submitted)
2. Abstracts (scientific and lay)
3. Detailed Budget (1 year; use PHS 398 form provided)
4. Budget justification
5. Biosketch(es) (include PI and co-investigators; use PHS 398 form)
6. Other support (PHS 398 form)
7. Hypothesis and Specific Aims (1 page)
8. Background and Significance
9. Preliminary Results
10. Research Design and Methods
11. Statements regarding human subjects and/or animals
12. Literature cited
13. Consortium/Contractual Arrangements
14. Letters of support from the PIs department head and collaborators or consultants

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NOTE: SECTIONS 7-11 MUST NOT EXCEED 3 PAGES.

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Near Horizons Collaborative Grant Program

Grant Application
1. TITLE OF PROJECT (Do not exceed 56 characters, including spaces and punctuation.)
2. PRINCIPAL INVESTIGATOR/PROGRAM DIREC- New Investigator
TOR
2a. NAME (Last, first, middle)
2b. DEGREE(S)
2c. POSITION TITLE

No

Yes

2d. MAILING ADDRESS (Street, city, state, zip code)

2e. DIVISION
2f. DEPARTMENT, SERVICE, LABORATORY, OR
EQUIVALENT
2g. TELEPHONE AND FAX (Area code, number) and E-MAIL ADDRESS:
TEL:
FAX:
extension)
New Investigator
3. CO-INVESTIGATOR

No

Yes

3b. DEGREE(S)

3a. NAME (Last, first, middle)

3c. POSITION TITLE

3d. MAILING ADDRESS (Street, city, state, zip code)

3e. DIVISION

3f. DEPARTMENT, SERVICE, LABORATORY, OR

EQUIVALENT
3g. TELEPHONE AND FAX (Area code, number) and
TEL:
FAX:
extension)
E-MAIL ADDRESS:
4. Human Subjects
Research
No
Yes

6. Vertebrate Animals
No
Yes
6a. If Yes, IACUC
Approval Date

4a. Research
Exempt
No
Yes
If Yes, Exemption No.

4b. Human Subjects Assurance No.

4c. NIH-Defined Phase I
Clinical Trial
No
Yes

7. IBC Protocol
No
Yes
7a. If Yes, Approval Date:

8a. If Yes,
Approval Date

7b. Approval Number:

6b. Animal Welfare
Assurance No.
9. DATES OF PROPOSED PERIOD
OF SUPPORT (month, day, year MM/DD/YY)

From
04/01/2014

8. Radiation
No
Yes

10. COSTS
REQUESTED
Direct Costs ($)

Through
3/31/2015

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5. Human Subjects
Protection Certification:
No
Yes
5a. Certification Date:

Near Horizons Collaborative Grant Program

Grant Application, p. 2
12. The undersigned reviewed this application for a CCTST research award and are familiar with the policies,
terms, and conditions of CCHMC concerning research support and accept the obligation to comply with all
such policies, terms, and conditions.
Primary Applicant:

Signature of Primary Applicant

Affiliate applicant:
Signature of Affiliate Applicant:

Date Application Received by UCHLVI:

Dept. or Div. Chair of Primary Applicant:

Date:
Date:

Signature of Division Chair

of Primary Applicant
Date:
Dept./Div. Chair:
Chair of Affiliate
Applicant: Date:
Signature
of Dept./Div.
Chair of Affiliate Applicant:

Received By:

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Principal Investigator/Program Director

(Last, First, Middle):

Scientific Abstract: Using technical language, briefly describe the proposed project in 200 words or less.

Lay Abstract: Using non-technical language, briefly describe the proposed project in 100 words or less.

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Principal Investigator/Program Director

(Last, First, Middle):
FROM
01/01/2014

DETAILED BUDGET FOR BUDGET PERIOD

DIRECT COSTS ONLY
PERSONNEL (salary support provided
only for students or technicians)
NAME

TYPE
ROLE ON
APPT.
PROJECT
(month
Principal
s)
Investigator

%
EFFORT
ON
PROJ.

INST.
BASE
SALARY

THROUGH
12/31/2014

DOLLAR AMOUNT REQUESTED

(omit cents)
SALARY
FRINGE
REBENEFITS
TOTAL
QUESTED

SUBTOTALS
CONSULTANT COSTS
EQUIPMENT (Itemize)

SUPPLIES (Itemize by category)

TRAVEL
PATIENT CARE
COSTS

INPATIENT
OUTPAALTERATIONS ANDTIENT
RENOVATIONS (Itemize by category)
OTHER EXPENSES (Itemize by category)

SUBTOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD

$
DIRECT COSTS

CONSORTIUM/CONTRACTUAL COSTS

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FACILITIES AND
ADMINISTRATIVE COSTS
TOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD (Item 10, Face Page)
Principal Investigator/Program Director (Last, First, Middle):
BUDGET JUSTIFICATION

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Principal Investigator/Program Director (Last, first, middle):

BIOGRAPHICAL SKETCH
Provide the following information for the key personnel in the order listed for Form Page 2.
Follow the sample format for each person. DO NOT EXCEED FOUR PAGES.
NAME

POSITION TITLE

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing,
and include postdoctoral training.)
INSTITUTION AND LOCATION

DEGREE
(if applicable)

YEAR(s)

FIELD OF STUDY

NOTE: The Biographical Sketch may not exceed four pages. Items A and B (together) may not exceed two of the four-page limit. Follow the formats and instructions on the attached sample.
A. Positions and Honors. List in chronological order previous positions, concluding with your present position. List any honors. Include present membership on any Federal Government public advisory committee.

B. Selected peer-reviewed publications (in chronological order). Do not include publications submitted or in preparation.

C. Research Support. List selected ongoing or completed (during the last three years) research projects
(federal and non-federal support). Begin with the projects that are most relevant to the research proposed in this application. Briefly indicate the overall goals of the projects and your role (e.g. PI, CoInvestigator, Consultant) in the research project. Do not list award amounts or percent effort in projects.

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Principal Investigator/Program Director (Last, first, middle):

OTHER SUPPORT
Provide active support for all key personnel. Other Support includes all financial resources, whether Federal, non-Federal, commercial or institutional, available in direct support of an individual's research
endeavors, including but not limited to research grants, cooperative agreements, contracts, and/or institutional awards. Training awards, prizes, or gifts do not need to be included.
There is no "form page" for other support. Information on other support should be provided in the format shown
below, using continuation pages as necessary. Include the principal investigator's name at the top and
number consecutively with the rest of the application. The sample below is intended to provide guidance
regarding the type and extent of information requested. Refer to the specific instructions in Section I.
For information pertaining to the use of and policy for other support, see Policy and Additional Guidance.
Format
NAME OF INDIVIDUAL
ACTIVE/PENDING
Project Number (Principal Investigator)
Source
Title of Project (or Subproject)

Dates of Approved/Proposed Project

Annual Direct Costs

The major goals of this project are

OVERLAP (summarized for each individual)
ACTIVE
PENDING
OVERLAP

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Percent Effort

Principal Investigator/Program Director (Last,

First, Middle):
RESOURCES
FACILITIES: Specify the facilities to be used for the conduct of the proposed research. Indicate the performance sites and describe capacities, pertinent capabilities, relative proximity, and extent of availability to the
project. Under Other, identify support services such as machine shop, electronics shop, and specify the
extent to which they will be available to the project. Use continuation pages if necessary.
Laboratory:

Clinical:

Animal:

Computer:

Office:

Other:

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MAJOR EQUIPMENT: List the most important equipment items already available for this project, noting the
location and pertinent capabilities of each.

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