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The role of
milk components
on skin health
Introduction
SKIN
Composition of skin
Roles of skin
Skin aggression factors
Skin disorders: risk factors
Milk components
and skin disorders
Vitamins and minerals
from milk
Specific proteins
and peptides from milk
Lipids and phospholipids
from milk
2
Conclusion
Human skin is the largest organ of the body (Furukawa et al., 2008) and has the particularity to be in
perpetual interaction with environmental factors (Dubertret, 2000). Thus, it is important to know and
understand its structure and roles, as well as its factors of aggressions. Some micronutrients, proteins
or peptides from milk have demonstrated beneficial effect in some skin disorders.
SKIN
The most important function of skin is to form an effective barrier between the inside and
the outside of the organism.
1.1
Composition of skin
Three types of
aggressions:
Physical
Chemical
Biological
1.2
Roles of skin
1.3
The main role of skin is to protect the organism against biological, mechanical, and physical aggressions,
as it is represented in figure 2 (Proksch et al., 2008). Depending on the environmental aggressions,
skin is able to develop a proper mechanism of defense. For instance, in case of light aggressions, skin
is able to secrete melanin, a pigment which can protect skin cells from UV radiations. In case of rubs,
skin is also able to develop callosity (Dubertret, 2000).
Here three types of aggressions can be distinguished
(Dubertret, 2000):
Physical aggressions: There are two types of
physical aggressions: mechanical and light. For
the first, it is mainly the dermis which ensures
this function due to its high content in collagen
and elastin which induce its good resistance. For
the second, in response to sun exposure, skin
is able to synthesize melanin by photoprotective
cells from UV exposure (Miyamura et al., 2007).
Chemical aggressions: Skin is able to prevent
the penetration of chemical substances thanks to
its low permeability. In addition, this permeability
can regulate gas exchange in the organism.
Biological aggressions: Skin possesses immune cells which are able to counteract the invasion
of micro-organisms. These are the Langerhans
cells, which are the equivalent of macrophages.
It seems that skin can induce potent immune
responses.
Risk factors
of skin
disorders
1.4
Which milk components can play a role in the improvement of skin disorders?
Milk is mainly composed of water (about 87%). The other 13% consist of carbohydrates
with lactose, lipids with saturated, mono-unsaturated and poly-unsaturated fatty
acids, and proteins like caseins and whey proteins. Moreover, milk is an important
source of micronutrients, necessary for the infant development. Beside fat-soluble
and water-soluble vitamins, minerals and trace elements are also present in milk.
A lot of vitamins
and minerals
present in milk
have an interest
in skin health
2.1
2.2
Alpha-lactalbumin
and Alpha
S1-casein can
reduce stress &
anxiety that are
two of risk factors
of skin disorders
2. A
nti-fungal and anti-viral actions
Lactoferrin can
reduce the
Herpes Simplex
Virus 1 and 2
Alpha-lactalbumin,
associated
with oleic acid,
can reduce
the lesions
of skin
papillomas
Lactoferrin
A specific
whey protein
extract can
significantly
improve the
psoriasis
symptoms
3. A
nti-psoriasis action
Whey protein fraction enriched
with growth factors
Two double-blind, placebo-controlled, randomized
studies and one open-label trial have been carried
out to assess the effect of a whey protein extract. The
most recent study, in 16 persons suffering from mild
to moderate psoriasis, demonstrated that 800 mg of
this whey protein extract for 56 days significantly improved the Dermatology Life Quality Index and the
Psoriasis Area and Severity Index scores (p<0.05)
at the end of the study (Drouin et al., 2008). The
previous trials have demonstrated the efficacy of this
whey protein extract at a more important dose (5g
per day for at least 56 days) in people with mild to
moderate psoriasis too (Poulin et al., 2007; Drouin et
al., 2007; Poulin et al., 2006; Poulin et al., 2005). All
these studies showed that this whey protein fraction
significantly improved the symptomatic scores of psoriasis and the quality of life of the participants.
4. W
ound healing actions
Mitogenic Bovine
Whey proteins can
improve wound
healing
Alpha-Lactalbumin
can reduce
oxidative stress.
Suppressing
oxidative stress
can accelerate
wound healing
process
Day 1
2.3
Day 56
Conclusion
Cows milk, and particularly proteins of milk, belongs
to the first allergen of food, which manifested itself by
atopic dermatitis for instance. However, some macro and
micro-nutrients from milk demonstrate a real effectiveness
against some skin disorders. Vitamins and minerals play an
important role in skin health and some of them are used to
treat some skin disorders, as for instance vitamins B9 and
B12, in combination, against vitiligo or zinc and acne.
Milk is also a source of proteins and peptides. Indeed; some
milks peptides are able to attenuate stress, which is one
of the risk factors of skin disorders. Then, lactoferrin and
alpha-lactalbumin demonstrated a certain efficiency against
Herpes simplex virus-1 and -2 and cutaneous papilloma
virus respectively. In addition to anti-viral and anti-fungal
Main references
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de Haan EE. Am J Clin Nutr. 2000 Jun;71(6):1536-44.
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Poulin Y, Bissonnette R, Juneau C, Cantin K, Drouin R, Poubelle PE. J Cutan Med Surg. 2006 Sep-Oct;10(5):241-8.
Poulin Y, Pouliot Y, Lamiot E, Aattouri N, Gauthier SF. J Cutan Med Surg. 2005 Dec;9(6):271-5.
Varelias A, Cowin AJ, Adams D, Harries RH, Cooter RD, Belford DA, Fitridge RA, Rayner TE. Wound Repair Regen. 2006
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Previous issues
# 01 Proteins and Satiety
# 02 Alphalactalbumin and Human Nutrition
# 03 Proteins and Sport
# 04 Hydrolysates and Peptides
# 05 Dairy Calcium and Health
# 06 Magnesium and Potassium
# 07 Why are Sulfur amino acids so important?
# 08 Hyperprotein diet: are they useful or dangerous?
# 09 Evaluation of protein quality.
Overview of current and future methods
# 10 Special report from Congrilait 2002
The 26th World Dairy Congress
# 11 Lactoferrin: General review and
opportunities for the future
# 12 Bioactives components in milk
and their physiological function
# 13 Lactose intolerance : the medical point of view
# 14 Allergy: myths and realities
# 15 The soy saga: trying to understand the wave.
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