Documente Academic
Documente Profesional
Documente Cultură
115
Copyright @2013
ISSN: 2319-5886
Accepted: 15th Aug 2013
Research article
COMPARATIVE STUDY ON EFFICACY & SAFETY OF INTRAVENOUS IRON SUCROSE
VERSUS INTRAMUSCULAR IRON SORBITOL THERAPY IN ANEMIA DURING
PREGNANCY
*Lomte DB1, Bhosale RS2, Jambdade V3, Gore PR4
1
2,4
Aims and Objectives: To compare the efficacy, safety, and rate of response of intravenous iron sucrose
and intramuscular iron Sorbitol therapy for anemia during pregnancy. Material and Methods: 100
antenatal cases of gestational age 16-32 weeks were included in this prospective study. Cases were
randomly divided into two groups. Group A, having 50 cases received intravenous iron sucrose, and
50cases in group B received intramuscular iron sorbitol. Response to therapy in both groups was studied
and compared. Results: The mean pretherapy hemoglobin in group A was 6.49 g/dl and in group B was
6.48 g/dl. The rise in hemoglobin after 4 weeks of starting therapy was 3.52 g/dl in group A and 2.33
g/dl in group B The difference was Statistically significant (P<0.01) The mean time taken to achieve
target hemoglobin (>11 g/dl) was 6.37 weeks in group A and 9.04 weeks in group B. In group A, 8%
(four) cases had grade I adverse effects. In group B, 24% (12) cases had grade I adverse effects. The
difference was statistically significant (P=0.027). In both the groups no case discontinued the therapy.
Conclusion: Intravenous iron sucrose is safe, convenient, more effective, and faster acting therapy than
intramuscular iron sorbitol therapy for treating moderate to severe anemia during pregnancy.
Keywords: Iron sucrose, Iron sorbitol, Pregnancy, Iron deficiency.
INTRODUCTION
Lomte DB et al.
RESULTS
Table 1: Demographic distribution of cases
Group A
(n=50)
26.46
24.48
68
76
Group B
(n=50)
26.62
23.94
56
80
720
Lomte DB et al.
Group B
%
12
16
72
No.
3
12
35
6.48
%
6
24
70
>0.05
Group B
No.
5
21
24
8.81
%
10
42
48
-
Time period
(weeks)
Group A
2-4
>4-8
>8-12
>12
No.
3
42
5
-
Mean
P value
6.37
<0.01
Group B
%
6
84
10
-
No.
17
28
5
%
34
56
10
9.4
Group A
Group B
No.
No.
Local phlebitis
Shivering and weakness
Moderate abdominal pain
Local pain
2
1
1
-
4
2
2
-
12
Skin staining
12
Headache
Total
12
24
721
Lomte DB et al.
Lomte DB et al.
723
Lomte DB et al.
DOI: 10.5958/j.2319-5886.2.4.116
Copyright @2013
ISSN: 2319-5886
Accepted: 16th Aug 2013
Dept of Physiology, Narayana Medical College, Nellore Currently affiliated with JIPMER, Puducherry,
India.
2
Department of Physiology, JIPMER, Puducherry, India
3
Dept of Physiology, Meenakshi Medical College Hospital & Research Institute, Kancheepuram,
Tamilnadu, India
4
Department of Physiology, Narayana Medical College, Nellore, Andhra Pradesh, India
*Corresponding author email: res.publications@gmail.com
ABSTRACT
Objectives: we found only effects of at least a short term practice extended over a period of a few days
to weeks of pranayama (alternate nostril breathing) rather than acute effects of unilateral right nostril
breathing (suryanadi pranayama). Keeping this in mind the present study was designed to test the
hypothesis that 10 min. of right nostril breathing have any immediate effect on ventilatory volumes and
capacities in healthy volunteers. Methodology: Forced vital capacity (FVC), Forced expiratory volume
in the first second (FEV1), Forced expiratory volume percent (FEV1/FVC%), Peak expiratory flow rate
(PEFR), Forced expiratory flow25-75% (FEF25-75%), Maximum voluntary ventilation (MVV), Slow vital
capacity (SVC), Expiratory reserve volume (ERV), Inspiratory reserve volume (IRV) and Tidal volume
(TV) were recorded before and after Surya Nadi Pranayama. Results & Conclusion: There was a
significant increase in FVC (p<0.0001), FEV1 (p<0.0007), PEFR (p<0.0001), FEF25-75% (p<0.0001),
MVV (p<0.0001), SVC (p<0.0001), ERV (0.0006), IRV (p<0.0001) and TV (0.0055) after suryanadi
pranayama. The immediate effect of suryanadi pranayama practice showed alleviation of ventilatory
capacities and volumes. Any practice that increases PEFR and FEF2575% is expected to retard the
development of COPDs. The increase in PEFR, vital capacities and flow rates by suryanadi pranayama
practice obviously offers an increment in respiratory efficiency and it can be advocated to the patients of
early bronchitis and as a preventive measure for COPD.
Keywords: Pulmonary function, Suryanadi pranayama, immediate effect, ventilatory volumes and
capacities
INTRODUCTION
(exercise),
pranayama
(breathing),
and
1.
meditation Pranayama, the fourth step of astang
724
Shravya etal.,
Shravya etal.,
725
Shravya etal.,
S.no
1.
Parameter
Age (Yrs)
Mean SD
21.03 4.43
2.
Weight (Kgs)
54.911.56
3.
Height (m)
1.62 0.09
4.
BMI (kg/m2)
20.72 3.28
5.
BSA ( m2)
1.57 0.18
S.no
Parameter
Mean SD
P value
Before
After
1.
FVC(L)
2.45 0.49
2.75 0.59
0.0001*
2.
FEV1(L)
2.09 0.49
2.30 0.55
0.0007*
3.
FEV1/FVC%
83.82 10.59
84.29 9.38
0.79
4.
PEFR(L/S)
4.14 1.32
4.32 1.06
0.0001*
5.
FEF25-75%(L/S)
2.62 0.79
2.67 0.62
0.0001*
6.
SVC(L)
3.61 1.93
4.47 2.81
0.0001*
7.
ERV(L)
1.22 1.18
1.70 1.54
0.0006*
8.
IRV(L)
2.09 1.85
2.87 2.62
0.0001*
9.
TV(L)
0.92 0.49
1.07 0.43
0.0055*
10.
MVV(L)
69.39 17.10
77.98 19.65
0.0001*
FVC: Forced Vital capacity, FEV1: Forced Expiratory Volume in 1 sec, PEFR: Peak Expiratory Flow
rate, FEF25-75%: Forced Expiratory Volume, SVC: Slow vital capacity, ERV: Expiratory Reserve
Volume, IRV: Inspiratory Reserve Volume, TV: Tidal Volume and MVV: Maximal Voluntary
Ventilation. * signifies p< 0.001 which shows values are statistically significant.
DISCUSSION
Shravya etal.,
727
Shravya etal.,
CONCLUSION
1. Roopa
BA, Anita
Herur, Shailaja
Patil, Shashikala GV, Surekharani Chinagudi.
Effect of Short-Term Pranayama and
Meditation on Cardiovascular Functions in
Healthy
Individuals.
Heart
Views.
2011;12(2): 5862.
2. Madanmohan. Effect of slow and fast
pranayamas
on
reaction
time
and
cardiorespiratory variables. Indian J Physiol
Pharmacol 2005; 49(3): 313-18.
3. Upadhyay Dhungel K, Malhotra V, Sarkar
D, Prajapati R. Effect of alternate nostril
breathing exercise on cardiorespiratory
functions. Nepal Med Coll J 2008; 10(1): 2527.
4. Shivraj P. Manaspure, Ameet Fadia,
Damodara Gowda KM. Effect of selected
breathing techniques on respiratory rate and
breath holding time in healthy adults.
IJABPT.2011; 2(3): 225-29.
5. Sukhdev Singh. Effects of a 6-week nadishodhan
pranayama
training
on
cardiopulmonary parameters. Journal of
Physical Education and Sports Management.
2011; 2(4): 44-47.
6. Chanavirut R. Yoga exercise increases chest
wall expansion and lung volumes in young
healthy thais. Thai journal of Physiological
sciences 2008; 19(1): 1-7.
7. Subbalakshmi NK, Saxena SK, Urmimala,
Urban JA, DSouza. Immediate effect of
Nadi-Shodhana pranayama on some selected
parameters of cardiovascular, pulmonary, and
higher
functions
of
brain.
TJPS.
2005;18(2):10-16.
8. Madanmohan. Effect of six week yoga
training on weight loss following step test,
respiratory pressures, handgrip strength and
handgrip endurance in young healthy
subjects. Indian J Physiol Pharmacol 2008;
52 (2): 164-70.
9. Pal GK, Velkumary S, Madanmohan. Effect
of short-term practice of breathing exercises
on autonomic functions in normal human
volunteers. Indian J Med Res.2004;120:115121.
10. Ravinder Jerath, John WE, Vernon AB,
Vandna Jerath. Physiology of long
pranayamic breathing: Neural respiratory
elements may provide a mechanism that
explains how slow deep breathing shifts the
autonomic nervous system.Med Hypotheses.
2006;67(3):566-71.
Shravya etal.,
DOI: 10.5958/j.2319-5886.2.4.117
Assistant Professor of Ophthalmology, Meenakshi Medical College and Research Institute, Enathur,
Kanchipuram, Tamilnadu, India
*Corresponding author email: elangovansuma@hotmail.com
ABSTRACT
Purpose: Optical coherence tomography (OCT) and Scanning LASER polarimetry (GDX-VCC) are
newer techniques to analyse retinal nerve fibre loss in glaucoma. This study aims to evaluate the
relationship between the Retinal Nerve Fibre Layer(RNFL) parameters measured using Stratus-OCT and
GDx-VCC and visual field loss by Octopus interzeag perimetry in established glaucoma patients in South
Indian Population. Materials and methods: Prospectively planned cross sectional study of 67 eyes of 34
established glaucoma patients on medical management. The mean age of patients was 46.911 years
(SD+13.531). A complete ophthalmic examination, automated perimetry with octopus interzeag 1-2-3
perimeter, retinal nerve fibre analysis with GDx VCC and Stratus OCT was done. The differences
between the mean RNFL parameters in the presence or absence of field defects were evaluated. Results:
The data analysed were mean deviation, loss variance, OCT total average nerve fibre thickness, GDX
VCC- TSNIT average and Nerve fibre indicator (NFI).The data were split into two subgroups on the basis
of presence or absence of visual field defect and analysed. The difference between the mean value of NFI
between the subgroups was highly significant with a p value < 0.01.The OCT parameter Total average
nerve fiber layer thickness differed significantly between the two subgroups (p value <0.05). The mean
GDx TSNIT average did not differ significantly between the two subgroups. Conclusion: The total
average nerve fibre thickness by OCT correlated better with visual field loss than the GDX TSNIT
average .Among the GDx parameters, the NFI was found to be a better indicator of visual field damage
than the average thickness.
Key words: Retinal nerve fibre analysis, OCT, GDX-VCC
INTRODUCTION
Suma etal.,
Suma etal.,
Table: 1. Analysis of the visual field indices obtained from octopus perimetry ( mean defect (MD) and loss
variance (LV)and OCT and GDX VCC parameters in the 67 study eyes:
Parameter
MD
LV
OCT Total average thickness(microns)
GDX-VCC TSNIT average thickness
(microns)
GDX-VCC Nerve fibre indicator
Min
-1.4
1.8
Max
24.9
88.4
87.7422.21
20
129
48.216 9.02
24.160
64.710
32.463 25.36
98
732
Suma etal.,
Table 2: Analysis of the RNFL parameters on the basis of presence or absence of visual field loss:
Parameter
Group
Normal fields
Abnormal fields
MD
Mean SD
-0.100.90
MeanSD
6.285.85
Significance of
difference between the
means (Students t Test) P
value
0.000**
LV
3.481.32
26.71 20.73
0.000**
85.75 23.48
47.579.59
34.9527.13
0.023*
0.075***
0.003**
Fig 1: Bar chart showing the difference between the mean values among the two subgroups
Suma etal.,
Suma etal.,
736
Suma etal.,
DOI: 10.5958/j.2319-5886.2.4.118
Student, final year, 2Lecturer in the Department of Physiology, Sathyabama University Dental College
and Hospital, Jeppiar Nagar, Rajiv Gandhi Salai, Chennai, Tamilnadu, India
3
Professor of Physiology, Madha Medical College and Research Institute, Kuntrathur Main Road, Kovur,
Thandalam near Porur, Chennai, Tamilnadu, India
* Corresponding author email: prema_sembu@yahoo.com
ABSTRACT
Introduction: Men and women are similar in their cognitive appraisal of a stress. But their behavior is
different when exposed to stress. As stress responses and cognitive abilities are closely associated with
autonomic nervous system, an attempt had been made to evaluate the behavioral pattern of autonomic
functional status in males and females under stressed conditions. Methodology: 30 normal young male
and female students (15 each) participated in this study. Systolic blood pressure (SBP), diastolic blood
pressure (DBP), heart rate (HR) and heart rate variation (HRV) were recorded before and after postural
change, Valsalva maneuver and cold exposure. Results: SBP and DBP decreased and HR increased
after standing from lying posture (p < 0.000) in both the genders. But the changes were less in males
than in females (SBP and HR non significant, DBP p < 0.008,) 30:15 ratio was higher in males (p <
0.001) upon standing. After Valsalva maneuver, SBP decreased (p < 0.05) and DBP increased (p <
0.000) with a higher Valsalva ratio (p < 0.002) in females than in males. After exposure to cold, males
showed more decrease in SBP and DBP and less increase in HR (non-significant) than females.
Discussion: Results reveal more sympathetic activity in males than in females when exposed to stress.
This may be because of the altered baroreceptor mechanism, male-female type of fat distribution,
difference in vascular bed resistance, influence of cortisol and hypothalamus-pituitary-adrenal axis.
Conclusion: The fact that females have less tolerance to stress may help us in understanding the sex
linked pathophysiology of cardiovascular diseases and developing a different approach in treating the
similar cardiovascular disease in men and women.
Key words: Blood pressure, Heart rate, Heart rate variation, Postural change, Valsalva
maneuver, Cold pressor test
INTRODUCTION
739
Int J Med Res Health Sci. 2013;2(4):737-744
variables
Gender
Mean SD
Mean difference
P value
Age (years)
Male
18.73 0.70
0.40 0.91
0.111
Female
18.33 0.62
Male
Female
165.83 8.44
Male
69.07 8.44
Female
57.73 5.15
Male
22.37 3.09
Female
20.98 1.43
Height (cm)
Weight (kg)
BMI
0.002*
11.33 10.11
0.001*
1.39 3.31
0.127
Table 2: Effect and the difference in the effect of postural change on BP and HR in males and females
Posture
Parameters
SBP
(mm HG)
DBP
(mm HG
HR
(beats/min)
Sahera etal.,
Gender
Lying
Standing
P value
Male
Female
Male
109.60 10.21
92.27 9.39
72.53 5.24
92.60 7.60
71.40 6.28
60.60 5.15
0.000*
0.000*
0.000*
Mean difference:
Lying to standing
- 17.00 11.15
- 20.87 11.29
- 10.27 5.08
Female
65.27 6.76
48.40 6.27
0.000*
- 16.87 7.09
Male
Female
76.80 7.10
69.60 10.25
93.67 6.16
89.33 9.08
0.000*
0.000*
16.87 8.95
19.73 8.21
P Vlaue
0.168
0.008*
0.354
740
Int J Med Res Health Sci. 2013;2(4):737-744
Table 3: Effect and the difference in the effect of Valsalva maneuver on BP and HR in males &
females
VM
Gender
Parameters
SBP
(mm HG)
DBP
(mm HG
p
value
Mean
difference
Before VM
After VM
109.53 8.65
91.40 7.89
71.93 8.81
69.47 7.11
51.07 8.01
0.000*
- 10.27 5.08
78.07 7.36
0.000*
- 16.87 7.09
87.47 9.24
0.319
3.40 11.09
63.27 5.54
0.000*
11.13 14.28
Male
p value
0.05*
0.000*
0.002*
VM - Valsalva maneuver
Table 4: Effect and the differences in the effect of cold pressor test on BP and HR in males and females
CPT
Parameters
SBP
(mm HG)
DBP
(mm HG
HR
(beats/min)
Gender
Before CPT
Male
Female
Male
Female
Male
110.13 10.21
96.53 8.54
64.87 6.63
61.87 8.24
76.87 7.96
94.27 12.04
Female
CPT Cold pressor test
After CPT
82.80 8.82
69.80 6.38
50.53 5.36
51.33 7.06
54.73 8.11
69.87 5.91
p
value
0.000*
0.000*
0.000*
0.007*
0.000*
Mean
difference
after CPT
- 27.33 12.92
- 26.73 15.32
- 14.33 8.56
- 10.53 13.01
- 22.13 10.63
p
value
0.878
0.389
0.640
Parameter
30:15 ratio
Valsalva ratio
Male
1.52 0.24
2.06 0.51
Female
1.26 0.16
2.35 0.44
Sig
0.001*
0.002*
DISCUSSION
Sahera etal.,
Sahera etal.,
744
Int J Med Res Health Sci. 2013;2(4):737-744
DOI: 10.5958/j.2319-5886.2.4.119
Background and Objectives: Hypertension and dyslipidemia are two major risk factors for
cardiovascular disease and they commonly occur together. Management of dyslipidemia in a
hypertensive patient significantly reduces the total cardiovascular risk .Telmisartan is an Angiotensin
receptor blocker with a partial agonistic action on PPAR-. In the present study, the effect of
Telmisartan on serum Lipid Profile was evaluated in hypertensive patients who also have associated
Dyslipidemia and also the efficacy of Telmisartan in reducing systolic and diastolic BP was assessed in
these patients. Materials and Methods: A total of 50 outpatients from the medical outpatient
department of Gandhi Hospital, Secunderabad, were enrolled into the study. These patients had grade
essential Hypertension and mild dyslipidemia. After the study period of 24 weeks, the efficacy of
Telmisartan in reducing serum lipid profile was evaluated apart from its effect on reducing systolic and
diastolic BP. Results: Telmisartan was very effective in reducing serum triglycerides (27 %, P<0.01),
VLDL-C (27 %, P<0.01), LDL-C (22%, P<0.01). It also decreased serum cholesterol by 16%
(P<0.01). HDL-C increased by 14% (P<0.05). Telmisartan in a dose of 40-80 mg/day, significantly
reduced both systolic BP by 18 %( P<0.01) and diastolic BP by 12 %( P<0.01) Conclusion: In our
study, Telmisartan proved to be effective not only in controlling BP, but had a favorable effect on lipid
profile also So, in conclusion, all the patients with uncomplicated Hypertension and mild dyslipidemia
can be effectively treated with Telmisartan.
Key words: Telmisartan, Hypertension, Dyslipidemia, Serum lipid profile
INTRODUCTION
hypertension,
dyslipidemia
substantially
increases the cardiovascular risk. So, there is a
need for disciplined diet plan and appropriate
pharmacological therapy in these patients. The
exact pathophysiology by which dyslipidemia
may be involved in the development of
hypertension is not well established. Lipid
disorders cause endothelial dysfunction and this
may become manifest as hypertension
edication therapy for hypertension and
dyslipidemia is becoming more complicated, as
over two-thirds of patients require two or more
anti-hypertensive agents and at least one lipid
lowering agent. The mechanism of action of
majority of anti-hypertensive drugs in use today
is to primarily target the factors which contribute
to development of increased blood pressure.
They do not in any way modify the
pathophysiological
mechanisms
causing
dyslipidemia. Angiotensin II receptor blockers
(ARB) are efficient anti hypertensive agents that
act through inhibition of AT1 receptors. In
experimental models, as well as in some clinical
trials, ARBs have been found to significantly
affect lipid metabolism .More precisely; ARBs
improved the overproduction and accumulation
of TGL in the liver, in experimental models,
through mechanisms independent of their
hypotensive action2. Furthermore, there are
preclinical studies showing that telmisartan
exerts a favourable effect on lipid abnormalities,
due to its partial activation of peroxisome
proliferator-activated receptor-gamma (PPAR-).
The finding that Telmisartan acts as both an
ARB and a partial agonist of PPAR- has
important implications in the prevention of
atherosclerosis and cardiovascular disease.
Moreover, it has been shown that activation of
PPAR-, downregulates the expression of
angiotensin II type I receptor and modifies the
effects of angiotensin II on intracellular signaling
pathways3.Telmisartan
is
a
potent,
insurmountable and highly selective antagonist
of AT1 receptors, with a long terminal
elimination half-life, Telmisartan is capable of
Vanitha et al.,
After 24 weeks
% of
P value
185.065.29
123.860.52
112.56.11
47.53.12
25.061.42
15%
27%
22%
- 14%
27%
< 0.01
< 0.01
< 0.01
< 0.05
< 0.01
Parameters
Initial
149.96 1.0
92.88 0.52
After
24 % of
weeks
122.723.4 18%
81.922.33 12%
P value
< 0.01
< 0.01
DISCUSSION
Vanitha et al.,
ACKNOWLEDGEMENT
Vanitha et al.,
749
Int J Med Res Health Sci. 2013;2(4):745-749
DOI: 10.5958/j.2319-5886.2.4.120
Copyright @2013
ISSN: 2319-5886
Accepted: 20th Aug 2013
Background: Obesity is one of the common significant health hazards and is associated with autonomic
dysfunction. Aims and objectives: The present study was designed to assess the underlying autonomic
neuropathy in obese subjects and to compare it with age-matched controls. Material and Methods:
Thirty obese subjects in the age group of 21-40 years were recruited for the study. Six non-invasive
autonomic function tests were performed out of which four were based mainly on parasympathetic
control (Heart rate response to standing (30:15 ratio), The S:L (standing to lying) ratio, The Valsalva
ratio, Heart rate response to deep breathing ) and the other two were mainly sympathetic (Isometric
Handgrip Exercise Test and Cold Pressor Test). Statistical Analysis: Results were analysed by ANOVA
with SPSS version 17.0 using unpairedt test. Results: Results showed that Heart rate response to
standing(30:15 ratio), The S:L (standing to lying) ratio, The Valsalva ratio, Heart rate response to deep
breathing, Isometric Handgrip Exercise Test and Cold Pressor Test were significantly lower (p <0.05)
in obese subjects as compared to control subjects. Conclusions: Latent autonomic neuropathy may be
present in otherwise healthy obese individuals. Early and regular screening of obese individuals is
necessary to prevent any future complications.
Keywords: Obesity, Autonomic nervous system, Cold pressor test
INTRODUCTION
750
Garg et al.,
BMI
<18.5
18.5-24.9
25-29.9
30-39.9
>40
Category
Underweight
Healthy
Overweight
Obese
Morbid obese
751
RESULTS
Group I(Controls)
33.084.8
1.620.42
58.114.3
22.111.04
Group II(Obese)
32.125.4
1.510.56
81.134.9
35.132.08
1.14 0.11
1.20.03
1.650.28
23.464.31
Group II
(BMI >30)
P value
1.060.02
1.110.02
1.450.11
16.462.11
<0.05
<0.05
<0.05
<0.05
12.21.2
12.11.4
12.21.6
13.11.8
8.31.3
8.11.2
8.21.4
9.11.4
<0.05
<0.05
<0.05
<0.05
Garg et al.,
752
DISCUSSION
Garg et al.,
CONCLUSIONS
753
Garg et al.,
754
Garg et al.,
755
DOI: 10.5958/j.2319-5886.2.4.121
Copyright @2013
ISSN: 2319-5886
Accepted: 20th Aug 2013
Background & Objectives: Diabetes mellitus (DM) is a significant public health problem worldwide
which is associated with hormonal, metabolic and micro vascular abnormalities. The angiopathic
complications affect eyes, kidneys, nervous, cardiovascular and respiratory system, which are primarily
due to biochemical alterations in connective tissue. Materials & Methods: In this study, we included
100 subjects, 50 Diabetic (25 Male and 25 Female) and 50 (25 Male and 25 Female) healthy
individuals aged 30-55 years. The pulmonary function tests were performed by the computerized
spirometer in the Clinical Physiology Lab, Department of Physiology, Dr. PSIMS & RF,
Chinnavutapalli. Results: The results of our study showed a statistically significant reduction in
FEF50%, FEF75% & FEV1 /FVC ratio in diabetic male subjects when compared with control male
subjects (p< 0.0001) and diabetic female subjects showed a reduction in FEV1/FVC which is not
statistically significant (p = 0.0004) but we observed a statistically significant reduction in FEF50% &
FEF75% in diabetic female subjects when compared with control female subjects (p< 0.0001). On
spirometry, Diabetic subjects showed a significant reduction in FEV1/ FVC ratio, FEF 50%, FEF 75%
relative to non diabetic controls. Conclusion: We conclude from our study that diabetic subjects
showed impairment in lung function. We found a decrease in FEV1/FVC ratio, FEF50% and FEF75%
in diabetic subjects as compared to control subjects.
Keywords: Diabetes, Forced Vital capacity, Forced expiratory Volume, Forced Expiratory Flow
INTRODUCTION
756
757
RESULTS
Table: 1. Comparison of Mean Values of FEV1/FVC, FEF50% and FEF75% in Male, female subjects
PARAMETER
FEV1/ FVC
FEF50%
(L/sec)
FEF75%
(L/sec)
Male
Fe male
CONTROL
DIABETIC
P-value
CONTROL
DIABETIC
P-value
82.4 1.63
79.5 1.87
0.0001
80.4 1.35
78.9 1.40
0.0004
3.8 0.31
3.0 0.50
0.0001*
3.8 1.24
2.60.33
0.0001*
1.26 0.13
1.02 0.20
0.0001*
1.2 0.12
0.9 0.11
0.0001*
Srikanth et al.,
758
759
760
761
DOI: 10.5958/j.2319-5886.2.4.122
Copyright @2013
ISSN: 2319-5886
Accepted: 22nd Aug 2013
Objective: The aim of the present study is to evaluate the anti-ulcer activity of Ethanolic extract of
Momordica Dioica in pylorus ligation and ibuprofen induced gastric ulcers in rats. Methods: Gastric
ulcer was induced by giving ibuprofen (200mg/Kg) and by pylorus ligation method. The animals used
for the experiment were divided into 4 groups for each model, 6 rats in each group. In pylorus ligation
model, all groups of rats were pre-treated with test drugs, Group-I (control) received 2%gum acacia2ml/100g, Group-II (standard) received Ranitidine (60mg/kg.) and group-III, IV were treated with
Ethanolic extracts 150mg/kg, 300mg/kg. respectively orally 30mins prior to pylorus ligation. The
Antiulcer activity of Momordica Dioica was assessed by determining and comparing gastric volume,
free acidity, total acidity, pH, percentage of ulcer protection, ulcer index. In ibuprofen induced ulcer
model, all groups of rats were treated with test drugs for 7 days prior to ibuprofen induced ulcer.
Animals were divided into 4 groups and treated with drugs as in above model. After 7 days of treatment,
animals were fasted for 24 hrs. Ulcers were produced by giving ibuprofen (200mg/Kg) on the day of
sacrifice. The animals were sacrificed 4 hours later and stomachs were open along the greater curvature
and ulcers were graded. Percentage of ulcer protection, ulcer index were observed and calculated.
Results: The extract of Momordica Dioica in pylorus ligation model, it decreased the ulcer index (1.66)
and there was a decrease in total gastric acid and free acid (p<0.0001), and increases the pH value
(p<0.0001) and also reduces the total gastric volume (p<0.0003), increases the percentage of ulcer
protection (61.66%). In ibuprofen induced ulcer model, it decreases the ulcer index (10.66) and
increases the ulcer protection (72.09%). Conclusion: The Ethanolic extract of Momordica Dioica was
clearly shows a protective effect against total acid, free acid, gastric volume and ulcer index and also
increases pH and percentage of protection against ulcers in both models.
Key words: Momordica Dioica, Gastric protection, Ibuprofen, Ulcer Index
762
Raveendra et al.,
INTRODUCTION
vegetable. The Fruits are reported to show antiinflammatory, anti-ulcer, anti-oxidant, and
hepatoprotective6. Traditionally this fruit was
used in ulcer but scientifically not proved. Hence
the present study was aimed to investigate the
anti ulcer effect of Momordica Dioca in
experimental animal models
MATERIALS AND METHODS
Raveendra et al.,
Raveendra et al.,
Table 1: Effect of Momordica Dioica on pylorus ligation ulcer model (n=6, MeanSEM)
Grou
p
Treatment
Control-2%
GA
StandardRanitidine
Test-T1extract
Test-T2extract
2
3
4
Dose
Vol. of
gastric juice
pH
Ulcer
index
% of ulcer
protection
2ml/100g
4.700.34
94.333.59
32.331.56
2.030.12
4.33
0%
60mg/kg
2.980.15**
53.334.07
191.36*
4.790.14
0.33
92.37%
**
4.150.27*
79.834.14
27.830.98*
3.460.26
2.8
35.33
632.54**
25.501.89*
3.980.13
1.66
61.66
150mg/kg
300mg/kg
3.180.21**
**
**
Treatment
Dose
Control-2% GA
2ml/100g
2
Standard-ranitidine
60mg/kg
3
Test-T1-extract
150mg/kg
4
Test-T2-extract
300mg/kg
*
**
***
P<0.05, P<0.01, P<0.001 compared to Control.
Ulcer grade
(MeanSEM)
33.333.33
Ulcer index
38.2
% of ulcer
protection
0
1.661.66**
26.662.10*
104.47*
1.66
27.99
10.66
95.65
26.72
72.09
DISCUSSION
In spite of tremendous development in the field
of synthetic drugs during recent era, they are
found to have some or other side effects, whereas
plant products or homeo drugs still hold their
own unique place by the way of having no side
effects. Peptic ulcer disease is a chronic
inflammatory disease characterized by ulceration
in the upper GI.14 The pathophysiology of ulcers
is due to an imbalance between aggressive
factors (acid, pepsin, H.pylori and NSAIDs) and
local mucosal defensive factors (mucous,
bicarbonate, blood flow and prostaglandins). The
integrity of gastro duodenal mucosa is
Raveendra et al.,
Raveendra et al.,
gastritis
and
peptic
ulcer
Lancet
1984:1(8390):1311-1315.
5. Kumar A, Nirmala V. Gastric anti ulcer
activity of the leaves of Caesalpinia
pulcherrima. Indian J. Pharm.1992;(4)67-68
6. Shreedhara CS, Vaidya VP. Screening of
Momordica dioica for hepatoprotective, antiinflammatory, anti oxidant activities. Natural
product science. 2006; 12(3):157-61
7. Asli Semiz, Alaattin SEN. Antioxidant and
chemoprotective properties of Momordica
charantia L. (bitter melon) fruit extract.
African Journal of Biotechnology. 2007;
6(3): 273-277.
8. Ramesh L Londonkar. Studies on activity on
various extracts of Mentha arvensis Linn.
Against drug induced gastric ulcer in
mammals,
World
J
gastrointestinal
Oncology. 2009; 1(1): 82-88.
9. Hegde DA, Khosa RL, Goel RK. Antiulcer
and cytoprotective action of Wedelia
calendulace Less. Ancient Sci. Life. 1994;
14:7781.
10. Sastri BN. The wealth of India-raw materials.
CSIR, New Delhi.1962;.2:408.
11. Nwinyl FC, Binda L, Ajoku GA. Evaluation
of aqueous extract of Boswollia dalzielii stem
bark for anti microbial activities and
gastrointestinal effects. African J of
Biotechnol.2004;3;284-88
12. Antonial J, Sertie A. Anti ulcer activity of
ethanol extract of Sesbania grandiflora.
Brazilian J Pharm Sci. 2007;37:20-26.
13. Khayaei M, Salehi H, Protective effect of
falcaria vulgaris extract on ethanol induced
gastric ulcer in rats. Iranian J Pharmacol Ther
2006;5:43-46.
14. Cola- Miranda M. Anti-ulcerogenic activity
Indigo for a truxillensis kunth. Biota
neotropico 2006; 6 available from URL:
http:// www.biotaneotropica.org.br
767
Raveendra et al.,
DOI: 10.5958/j.2319-5886.2.4.123
Copyright @2013
ISSN: 2319-5886
th
Accepted: 24 Aug 2013
Background: Oral cancer is most common in males and also in females. Betel quid (BQ) is the main
causative agent of oral cancer. Areca catechu, a major component of BQ, contains certain alkaloids that
give rise to nitrosamines. Mitotic index (MI) and Micronuclei (MN) were studied among the studied
population. Methods: In this present study subjects were screened from Department of E.N.T. &
Department of Oral and Facio maxillary of RKMSP hospital, and different areas of Eastern and North
Eastern states of India. For mitotic index (MI) blood leukocyte cultures were analyzed and for
micronuclei (MN) buccal mucosa were examined. Results: Some of them had more than one addiction.
Micronuclei percentage and mitotic index both higher than normal. Conclusion: Betel quid play a role
in changing the oral pathology and thus causes oral cancer.
Keywords: Oral cancer, betel quid, micronuclei, mitotic index
INTRODUCTION
Aniket et al.,
RESULTS
Table 1: Detailed history of subjects of different areas
31-40
41-50
51-60
61-70
Above 70
Smoking
Alcohol
Betel Quid
No BQ Addiction
Tea Drinker
Addiction
Below 30
AGE GROUP
( in years)
56
12
24
11
33
23
40
16
34
20
16
14
19
15
34
East Midnapur,
Bibhisanpur
North, Atghara
46
22
13
28
29
36
10
40
89
28
18
21
15
27
56
33
73
16
Narrah, Bankura
51
13
12
14
22
29
49
RKMSP hospital
35
11
20
24
11
29
TOTAL
311
66
73
64
65
32
11
114
65
190
121
265
46
PLACE
NO
PLACE
Micronuclei (%)
Mitotic Index
(Mean SE)
(Mean SE)
Dhulai, Bankura
26.29 1.95
3.94 0.23
Bibisanpur, East Midnapore
12. 31 2.75
8.66 0.67
Atghara
4.76 1.26
5.07 0.60
RKMSP Hospital
----- *
4.54 0.33
Narrah, Bankura
4.61 2.82
4.28 0.62
(Normal values of MI are < 4% and MN is < 1%)
*Study of micronuclei of oral cancer cases was not possible due to severe ulceration and bleeding and
cases were unable to open their mouth. Mean value of mitotic index of all cases having betel quid
chewing habit was 5.29 0.49 and mean percentage of micronuclei were 12 2.19
Aniket et al.,
770
Int J Med Res Health Sci. 2013;2(4): 768- 772
DISCUSSION
ACKNOWLEDGEMENTS
Aniket et al.,
CONCLUSION
771
Int J Med Res Health Sci. 2013;2(4): 768- 772
Aniket et al.,
772
Int J Med Res Health Sci. 2013;2(4): 768- 772
DOI: 10.5958/j.2319-5886.2.4.124
Copyright @2013
ISSN: 2319-5886
Accepted: 27th Aug 2013
WITH
ESSENTIAL
Asso. Prof Dept, 2Undergraduate Student, 3Lecturer, 4Professor & HOD, 5Professor, 6Post Graduate
Student, Dept. of Anatomy, Shri B M Patil Medical College Hospital and Research Centre BLDE
University Bijapur, Karnataka India
*Corresponding author email: gavish.hadimani@yahoo.com
ABSTRACT
773
Rudragouda et al.,
INTRODUCTION
Rudragouda et al.,
775
Rudragouda et al.,
Male
Female
Study Group
Control Group
Study Group Control Group
Right
Left
Right
Left
Right Left Right Left
Hand
Hand
Hand
Hand
Hand Hand Hand Hand
25
18
04
07
22
19
0
4
Arch
26
30
11
21
31
32
23
21
LoopRadial
115
116
131
120
100
113
129
118
Loop Ulnar
84
86
104
102
97
86
88
112
Whorl
Simian Line absent in right and left hands of both male & female hypertensive individuals
Table 2: Presence of Sydney Line in Right Hand
Male
Female
14
36
15
35
0
50
0
50
22
28
14
36
0
50
0
50
Control (Normal)
Inference
80.3 1.4*
84.7 1.6
84.3 1.4
83.8 1.2
Significant
Not significant
Male
Female
Study Group
Male
Female
103.9 14
112.6 18.4
Control
109.9 18
110 14.6
t
p
Inference
1.00 0.32 not significant
0.03 0.977 not significant
1.10 0.275 not significant
0.03 0.979 not significant
hands of male and female study and
Rudragouda et al.,
777
Rudragouda et al.,
CONCLUSION
Rudragouda et al.,
01-09
12. Kumar S, Kumar N, Mangal BD.
Dermatoglyphics in healthy Indian children:
An analysis of finger prints, palm prints,
axial triradii, and atd angle, sole and toe
prints. Indian J Pediatric 1974; 41:249-56.
13. Babu SS, Powar BP, Khare ON, Palmar
Dermatoglyphics in Pulmonary Tuberculosis.
J. Anat Soc.India 2005; 54:64-6.
14. Pour Jafari H, Farhed DD, Yazdani A, Hashe
Mzadeh CM. Dermatoglyphics in patients
with eczema, psoriasis and alopecia areata.
Skin Res Technol 2003; 9:240-44.
15. Oladipo GS, Osogba IG, Bobmanuel I,
Ugboma HAA, Sapira MK, Ekeke ON.
Palmar Dermatoglyphics in Essential
Hypertension Amongst Rivers Indigenes.
Australian J of Basic and Applied Sci.
2010;4(12): 6300-05
779
Rudragouda et al.,
DOI: 10.5958/j.2319-5886.2.4.125
Copyright @2013
ISSN: 2319-5886
Accepted: 1st Sep 2013
Assistant Professor, Department of Anatomy, Gujarat Adani Institute of Medical Sciences, Bhuj, Gujarat
Assistant Professor, 4Associate Professor, Department of Anatomy, Smt.N.H.L.Municipal Medical College,
Ellisbridge, Ahmedabad, Gujarat, India
3
Tutor, Department of Anatomy, GCS Medical College, Naroda road, Ahmedabad, Gujarat, India
5
Assistant Professor, Department of Anatomy, GCS Medical College, Naroda road, Ahmedabad, Gujarat
6
Associate Professor, Department of Anatomy, B.J.Medical College, Asarwa, Ahmedabad, Gujarat
2
Aims: To study the various positions of vermiform appendix, and its relation to various diseases of the
vermiform appendix, and average length and external diameter of the vermiform appendix.
Materials & Methods: This study was conducted on 200 cases 100 cadavers from the dissection
laboratory with an age range of 50 90 years. The dissection was performed in the dissection hall of Smt.
N.H.L. Municipal Medical College, Ahmedabad, B. J. Medical College, Ahmedabad, A.M.C.M.E.T.
Medical College, Ahmedabad, and 100 cases from postmortum room of V. S. Hospital from August 2009 to
December 2012. Result and Observation: classic coeliac trunk with emission of the left gastric, splenic and
hepatic arteries was found in 76(76 %) cadavers. Haller's tripod, in which the three arteries originated at the
same level and in the terminal portion of the coeliac trunk was observed in 18(18%) cadavers. In 16 cadavers
inferior phrenic arteries originated from coeliac trunk was observed. In 8 cadavers variations regarding
disposition of the left gastric, splenic and hepatic arteries also regarding the number of emitted arteries
observed. Conclusion: Appendix is only organ in our body which has not constant anatomical position.
From various positions of vermiform appendix we can understand the possible outcome of the appendicitis
specifically location of site of pain.
Manisha et al.,
Serial number
1
2
3
4
5
6
Total
Position
Retrocaecal
Pelvic
Postileal
Subcaecal
Paracaecal
Subhepatic
Male
75
32
14
07
07
01
136
Female
36
15
04
06
03
00
64
Total
111
047
018
013
010
001
200
Percentage
55.5 %
23.5 %
9%
6.5 %
5%
0.5 %
100 %
781
Manisha et al.,
MALE
External
Diameter (mm)
15
3
7.3014
7
2.8029
Maximum
Minimum
Mean
Median
SD
FEMALE
Length
(Cm)
9
2
5.5647
5.6
1.3348
External
Diameter (mm)
14
4
6.5000
6
2.2253
Length
(Cm)
7
2.4
5.1625
5.4
1.1086
Table 3: Comparison of different positions of the vermiform appendix of present study with other studies
Author
No.of
Retro- Pelvic
specimen caecal
125
38.4% 31.2%
Solanke TF8
Paracaecal
2.4%
Subhepatic
-
Varshney S et 600
al.9
Golalipour MJ2 117
19%
53%
1%
2%
7%
18%
32.4%
33.3%
2.6%
18.8%
12.8%
Cecil P G10
65.28% 31.1%
0.40%
1.00%
2.26%
67.3%
21.6%
3.8%
4.9%
2.4%
62%
31%
0.4%
11%
2%
74%
21%
0.5%
1%
1.5%
2%
55.5%
23.5%
9%
6.5%
5.0%
0.5%
10,000
13
0.5%
Table 4: Comparison of length of the vermiform appendix of present study with other studies
Year
Author
Shortest
Centimeters
Longest
Centimeters
Mean
Length (cm)
Mean External
Diameter (mm)
1891
1895
1913
1918
1923
Ferguson14
Berry15
Deaver16
Lewis17
Arthur
Robinson18
2.2
3.1
1.0
2.0
1.8
13.3
23
20
23
10.13
8.3
8-9
8.3
9.2
8
3-5
1927
1932
Royster19
2.5
Donald C. Collins20
29.4
24.5
7.5
8.2
2012
Present
Study
5.436
7.035
782
Manisha et al.,
DISCUSSION
Manisha et al.,
784
Manisha et al.,
785
Manisha et al.,
DOI: 10.5958/j.2319-5886.2.4.126
Coden: IJMRHS
nd
Copyright @2013
ISSN: 2319-5886
Objectives: Individuals engage in strenuous physical activity to which they are unaccustomed usually
land up in a phenomenon called Delayed Onset of Muscle Soreness (DOMS) and results in pain, muscle
stiffness and swelling. The current study was aimed to see the effect of cryo, ultrasound and its
combination therapies on the reduction of symptoms of DOMS. Materials and Methods: A total of 30
subjects with the mean age of 22.1 5.9 years participated in the study. Subjects were randomly
allocated to three groups A, B and C (n=10) and induced DOMS by a standard exercise protocol. Each
group received different treatment application i.e. ultrasound (US), cryotherapy (CT) and combination
(C) of both. Study outcomes were measured by Perceived Muscle Soreness (PMS), Relaxed-Elbow
flexion angle (rEFA), Plasma Creatine Kinase (CK) level at 0 hours (pre-exercise), 24hrs, 48hrs, 72hrs
and at 92hrs. Results: All three groups showed improvement with respect to their interventions, whereas
the C group, after 96 hours of post-exercise the rEFA return to its near normal range as compared to the
other two groups. Although there was a rise in the plasma CK level in all three groups, however the C
group was effective in minimizing the rising level of CK and also in the reduction of muscle soreness at
successive time intervals and reaches to baseline after 96 hours of post-exercise. Conclusion: The
combined application of cryotherapy and pulsed ultrasound immediately after exercise induced muscle
damage is a better choice of treatment, It is also observed that cryotherapy was more effective than
pulsed ultrasound alone treatment in reduction of symptoms.
Key words: Muscle soreness, Cryotherapy, Ultrasound, Range of motion, Creatine Kinase
INTRODUCTION
Shaji et al.,
786
Shaji et al.,
787
72Hrs.
2.60.51
1.40.48
1.10.31
72Hrs.
18.41.5
16.21.0
14.81.1
96Hrs.
2010.688.7
1796.290.0
1547.096.4
96Hrs.
1.60.69
0.50.52
0.30.48
96Hrs.
16.41.5
15.21.2
13.91.1
788
Shaji et al.,
Sig.
9.00
.001
51.63
.000
Plasma CK
2500
1500
G-A
1000
G-B
Axis Title
2000
G-C
500
4
3.5
3
2.5
2
1.5
1
0.5
0
G-A
G-B
G-C
0
0Hrs. 24 Hrs. 48Hrs. 72Hrs. 96Hrs.
rEFA
25
20
15
G-A
10
G-B
G-C
5
0
0Hrs.
24 Hrs.
48Hrs.
72Hrs.
96Hrs.
DISCUSSION
Shaji et al.,
REFERENCES
791
Shaji et al.,
792
Shaji et al.,
DOI: 10.5958/j.2319-5886.2.4.127
Copyright @2013
ISSN: 2319-5886
th
Accepted: 5 Sep 2013
AND
SUPERIOR
Department of Anatomy, Subbaiah Institute of Medical Sciences & Research Centre, Shimoga,
Karnataka, India
2
Department of Anatomy, Melmaruvathur Adiparasakthi Institute of Medical Sciences and Research,
TamilNadu, India
*Corresponding author email: tkvasudha75@gmail.com
ABSTRACT
Background: The scapula is a flat triangular bone situated on the posteroleteral aspect of thoracic wall
between second and seventh rib. The coracoid process of scapula projects upward and, medial to the
base of coracoid process is the Suprascapular Notch (SSN). Morphology of SSN is considered to be a
risk factor for Suprascapular Nerve (SN) entrapment in combination with an anomalous Superior
Transverse Scapular Ligament (STSL). Aim: To review and document the morphology of suprascapular
notch, degree of ossification of superior transverse scapular ligament and its clinical correlation.
Materials and Methods: The study was carried out by visual observation on 115 dried human scapulae.
Result: It was observed that 115 scapulae showed different shapes with symmetrical U, the most
common type (34.78%). There was a unique variation in one left scapula, where SSN was replaced by a
narrow groove (0.86%). Conclusion: This study will help to correlate suprascapular nerve entrapment
with a specific type of SSN.
Keywords: Suprascapular notch, Superior transverse scapular ligament, suprascapular nerve
entrapment.
INTRODUCTION
Vasudha et al.,
Shape of SSN
Symmetrical U shaped
Shallow U
J shape
Wide notch
Indented
Hockey stick
Deep U
Absence
Groove
No. of Scapulae
[Right & Left]
39
[22 & 07]
07
[03 & 04]
22
[10 & 12]
08
[04 & 04]
09
[04 & 05]
06
[04 & 02]
07
[04 & 03]
07
[05 & 02]
01
[00 & 01]
Percentage (%)
34.78
6.08
19.13
6.95
7.82
5.21
6.08
6.08
0.88
Degree of Ossification
Complete
Partial
Notch with foramen
No. of Scapulae
05
02
01
Percentage (%)
[Right & left]
[ 02 & 03 ]
[ 01 & 01 ]
[ 00 & 01 ]
4.34
1.73
0.86
794
Vasudha et al.,
Table.3: Comparison of different shapes of SSN and degree of ossification of STS of previous studies with
present study.
Shapes
SSN
Present study
(%)
al
34.78
6.08
19.13
6.95
7.82
5.21
6.08
6.08
0.88
-
Fig 1: Different Shapes of SSN. a) Width and breadth of SSN equal, b) Width is greater than breadth,
c) One edge of SSN was longer, d) Width is more wider,
e) Almost like a shape of hockey stick, f)
SSN was absent, g) slight notch was present, h) a groove replacing SSN,
i) breadth is greater than
the width.
795
Vasudha et al.,
a) Complete
b) Partial
c) Notch with foramen
Fig 2: Different degrees of ossification of STSL a) STSL was completely calcified, b) partially calcified
STSL c) Ossified band of STSL dividing the SSN into foramen below and notch above
DISCUSSION
Vasudha et al.,
Vasudha et al.,
798
Vasudha et al.,
DOI:10.5958/j.2319-5886.2.4.128
Objectives: Cerebrovascular diseases are the leading illness affecting the modern world with a high
mortality rate. The posterior circulation of the brain consists of vertebrobasilar system, shows a high
incidence of anomalies in the form of hypoplasia, fenestrations and asymmetry of the vessels, which
precipitate the development of vertebrobasilar insufficiency and posterior circulation stroke. A detailed
knowledge of the vertebrobasilar variants is essential in the diagnosis, treatment as well as in educating
the patients suffered from posterior circulation stroke. The present study is aimed to analyze the size,
asymmetry and anomalies of the vertebrobasilar system and their implications in posterior circulation
infarcts. Materials and methods: Fifty adult brains were studied during routine dissection of the
cadavers. The base of the brain with intact vertebral, basilar and posterior cerebral arteries were
dissected, preserved in 10% formalin and analyzed for the variations in the size, length and asymmetry
in the configuration. The dimensions of the vessels were measured using graduated calipers. Results:
Anomalies of the basilar artery were found in 14% of the brains, in the form of hypoplasia, fenestration
and terminal expansion at its bifurcation. The vertebral arteries showed asymmetry with right vertebral
were hypoplastic in majority of the brains. Conclusions: The variations of the vertebrobasilar system
increase the risk of vertebrobasilar insufficiency and posterior circulation stroke. Anomalies of the
vertebrobasilar arteries were also found to be associated with aneurysms. The right vertebral artery has
been frequently hypoplastic and there was no consistent correlation between the left vertebral
dominance and right handedness of the person. Hypoplastic vessels were frequently associated with
vertebrobasilar territory ischemic stroke.
Keywords: Hypoplasia, Fenestration, Dolichoectasia, Asymmetry, Dimensions, Infarction.
INTRODUCTION
Iqbal et al.,
Length (mm)
Range
Average
Diameter (mm)
Range
Average
Basilar artery
18-37
30
2.8-5.1
3.9
Vertebral artery
1.6-3.9
2.1
20 - 40
31.42
2.5 - 5.5
3.82
2.98
Present study
18 - 37
30
2.8 - 5.1
3.9
1.6 - 3.9
2.1
Fig.1: A-Progressive narrowing of (hypoplastic) basilar artery, B-Cobra-hood like terminal expansion of
the basilar artery at its bifurcation, C-Partial duplication (Fenestration) of the basilar artery at its
proximal portion, D-Hypoplastic left vertebral artery & E-Hypoplastic right vertebral artery.
801
Iqbal et al.,
DISCUSSION
1.
2.
3.
4.
5.
6.
806
Iqbal et al.,
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
Iqbal et al.,
808
Iqbal et al.,
DOI:10.5958/j.2319-5886.2.4.129
Copyright @2013
ISSN: 2319-5886
th
Accepted: 12 Sep 2013
Background: Alterations in the sleep-wake cycle leads to decreased melatonin secretion and it may be
associated with sleep disorders and cancer risk. Exposure of light at night and rotating night shift
decrease the melatonin production due to acute suppression of pineal melatonin secretion during night
work has been suggested to increases cancer risks. Aims & Objectives: The objectives of the present
study were to investigate the effect of light exposure at night on circadian pattern of 6-Sulfatoxy
melatonin levels in night shift nursing professionals. Material and Methods: 62 healthy nursing
professionals of both genders performing day and night shifts (continuous 9 days night shift with
alternate day shifts) were recruited. Urine samples were collected at around 8 hour intervals (afternoon
sample: between 13:00 to 15:00, night samples between 22:00 to 01:00 and morning samples between
05:00 to 08:00) while they were performing night duties and repeated when they were assigned day
duties. Night melatonin level was decreased as compared to morning melatonin. Results: Night
melatonin level was found declined as compared to morning level and this pattern was significant when
compared night melatonin between night (16.71 11.98) vs day shift (22.71 13.25) and morning
melatonin level between night (20.07 14.13) vs day shifts (28.26 14.14) (p<0.001). Conclusion:
Light exposure at night disrupts the circadian rhythm of melatonin secretion during night shift leads to
internal desynchronization.
Key words: Rotating night shift; Light at Night; Circadian rhythm; 6-Sulfatoxy melatonin.
INTRODUCTION
Anjum et al.,
Anjum et al.,
RESULTS
Baseline Characteristics
Age (years)
Weight (kg)
Height (cm)
Body mass index (BMI)
Marital Status
Married
Unmarried
Diet
Vegetarian
Non-Vegetarian
Data are presented as means SD.
( n=62 )
Afternoon Melatonin: NS vs DS
r =0.13ns
Night Melatonin: NS vs DS
Morning Melatonin:NS vs DS
r =0.51***
r =0.18ns
811
Anjum et al.,
Fig 1: Mean Afternoon, Night and Morning melatonin during night and day shift
(AML: Afternoon Melatonin level; NML: Night Melatonin level; MML: Morning Melatonin level),
(*p<0.05, ***p<0.001; By paired t test; - Bar of the standard deviation).
Melatonin hormone also shows diurnal variation,
its level increases from midnight to early
morning and decreases in the late morning and in
day hours. This pattern was found altered in
rotating night shift workers during night shift.
Melatonin synthesis directly depends upon
transport of signal of light in the day time and
conversion of serotonin into melatonin depends
upon signals of darkness received at night.
However, its level may differ from individual to
individual. Normal range of melatonin is 0.8-40
ng/ml, its levels increases at midnight and
declines in day time. Night 6-sulfatoxymelatonin
level was found declined as compared to
morning level and this pattern was significant
when
compared night 6-sulfatoxymelatonin
between night (16.71 11.98) vs day shift (22.71
13.25) and morning melatonin level between
night (20.07 14.13) vs day shifts (28.26
14.14) (p<0.001) (Figure 1). 6-sulfatoxy
melatonin level of evening and morning time
during night shift was positively associated with
that of during day shift. Since the pattern of
melatonin secretion was altered in early morning
Anjum et al.,
Anjum et al.,
Anjum et al.,
815
Anjum et al.,
DOI:10.5958/j.2319-5886.2.4.130
Copyright @2013
ISSN: 2319-5886
Accepted: 15th Sep 2013
Background &Aim:Numerous infectious diseases are spread by blood transfusion, particularly viral
infections. The hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus
(HIV) and other pathogenic organisms are transmitted through inappropriate screening of blood product.
These infected blood products are causing fatal, persistent and life frightening disorders. The
predominance of these viruses differs by ethnic group and geography. Scheme of the current study was
to statistical estimation of the incidence of HBV, HCV and HIV along with blood donors. Materials &
Methods: The existing review was approved in Ibn Sina Teaching Hospital, Sirt Region of Libya. A
total of 16,929donors were analyzed by enzyme immune assay (EIA) kits from TaytecInc, Canada, for
the predominance of human immunodeficiency virus, hepatitis B and C virus, over a period of 17
months from January2012 to May 2013.Results: Among the blood donors, 81.40% were unpaid donors
and 18.60% were alternative donors. The total incidence in blood donors was 3.18%. The
seroprevalence of hepatitis B was uppermost (1.98%) followed by hepatitis C (1.20%) and
seroprevalence of HIV was nil among unpaid and surrogate donors. Conclusion: Present study was
emphasized the prevalence rates of HBV and HCV between charitable and alternative blood donors and
the HIVwas not detected in the current study.The prevalence rate was more in male among the blood
donors.
Keywords: Human immunodeficiency virus, Hepatitis B&C virus, Seroprevalence, Blood donors
INTRODUCTION
816
817
RESULTS
A total 16,929 donors were integrated in the
study. Of these, 3152 (18.60%) were replacement
and 13777 (81.40%) were voluntary donors.All
of the samples were collected within transfusion
department not from any other branch of
requirement of blood donation. Males blood
donorsmore than female with16, 862(99.6%)
donations while only 67(0.4%) donors were
females. Among these, most of the donors aged
from 18 to 40 years. Out of the 16,929 blood
donors, 535 were tested positive for donated
healthy blood samples (3.18%).Out of these, 61
were alternative donors. In general, the
predominance of HIV, HBsAg,HCV and total
positivity in blood screening was 0%, 1.98%,
1.2% and 3.18%,in assenting order (fig-1).The
prevalence of HBsAg in total donors was 1.98%
(333 cases). Substitute donors (44 cases) had a
high incidence with low frequency of patients as
compared to the voluntary donors (289 cases).
The seropositivity of HCV in total donors was
1.20% (202 cases). Replacement donors (17
cases) had a low incidence with low frequency of
patients as compared to the voluntary donors
(185 cases). Zero prevalence of HIVwas zero
among all blood donors. The infectivity rate of
male blood is higher than female blood donors.
The agreeing rates for seropositivity were peak
for HBsAg infection followed by HCV infection
in descending order. The co-infection of
transfusion transmitted infectious diseases has
not been studied among blood donors.
1.98% 1.20%
Negative
96.82%
HBsAg Positive
HCV Positive
818
DISCUSSION
Ismail et al.,
to which individuals with risk factors for bloodborn viral infections may have been excluded.
In general, the prevalence rates of hepatitis B and
C were lower among young donors than older
donors. This confirms the results reported earlier
by other investigators22.In contrast, most of the
blood donors in Libya are young men (1840years of age). It is recognized that this age
group is generally arrogant group example of
misusing of drug, insecure sex, and other
misbehavior habits for the transmission of the
virus. This may be explained on the essential of
increased exposure with age and on the fact that
a high awareness of blood born viral infections
has developed and a comprehensive vaccination
program against hepatitis B has been
implemented in Libya. It should be noted that the
carrier rate of HBV was higher than the carrier
rate of HCV in this study and in other studies23.
These data suggested that the mode of
transmission and the efficiency of transmission
of HBV may be different from that of HCV.
The predominance of HBV and HCV between
blood donors was lower than it is in other
countries. The prevalence of hepatitis B among
blood donors was 3.8% in Syria23, 9.8% in
Yemen24, 2.1% in Egypt25, >5.0% in Sudan26,
10.7%in Cameroon27, 8.8% in Tanzania28and
(Africa 5-15%). Similarly, the prevalence of
HCV was 2% in Yemen24, 4.8% in Cameron27,
1.5% in Tanzania28, and high in Egypt 13.6%25.
This was probably due to the compulsory
screening of all emigrants prior to granting
residency in Libya. The other infectious agent of
blood transfusion is HIV causes major health
problem in sub Saharan Africa where the
prevalence of HIV among blood donors ranges
between 2-20% in Kenya29, and 5.9% in
Ethiopia30.However, our results showed no
confirmed HIV in the analyzed blood donors.
Hence, the previous blood donors study in Libya
reported the prevalence rates of HIV was 0.4
%31.The frequency of HBsAg is more compared
to the anti-HCV.There is no way to ignore that
blood donation which is collected in the
Int J Med Res Health Sci. 2013;2(4): 816-822
819
Ismail et al.,
REFERENCES
820
821
Ismail et al.,
822
DOI:10.5958/j.2319-5886.2.4.131
Copyright @2013
ISSN: 2319-5886
Accepted: 19th Sep 2013
Assistant Professor, 3 Professor and Head, 4Associate Professor, Dept of Physiology, MIMSR Medical
College, Latur, Maharashtra, India
2
Professor and Head of Dept, Dept of Physiology, Govt. Medical college, Miraj, Maharashtra, India
* Corresponding author email: bhagwat.shelke@gmail.com, dr.bhagwat@yahoo.co.in
ABSTRACT
Introduction: Noise is one of the causes of preventable sensori-neural loss. The traffic police
personnel(TPP) busy in controlling traffic at heavy traffic junctions suffer from the ill effects of noise
and air pollution. Aim and objectives: The objective of this study was to assess the hearing threshold at
various frequencies of the traffic police persons exposed to the vehicular noise and comparison with
controls not exposed to noise. Material and methods: Thirty TPP and thirty controls were evaluated by
clinical methods and subjected to the Pure Tone Audiometry (PTA) in ENT department. Audiogram
recorded by using conventional techniques in both ears. RESULTS: There was a significant difference
in the hearing thresholds at frequency 2000 Hz, 4000 Hz and 8000 Hz of right and left ear between the
two groups. Conclusion: This study concludes an increased risk of noise induced hearing loss (NIHL)
for the environmental noise exposed subjects.
Keywords: Traffic police personnel, TPP, Hearing threshold, NIHL
INTRODUCTION
Shelke et al.,
823
71.68.66
24.24 2.88
75.537.96
25.1 2.67
> 0.05
> 0.05
824
Table II - Average hearing threshold at different frequencies in study and control groups
Hearing Thresholds Frequencies in Hertz
Study group(n=30) Control group(n=30)
23.835.52
25.57.11
250
R
25.835.26
24.836.08
L
500
23.55.11
23.166.88
R
24.334.49
255.41
L
1000
21.665.14
21.665.62
R
23.54.38
24.165.09
L
2000
17.834.29
214.43
R
17.163.86
21.335.07
L
4000
17.334.86
33.8315.57
R
17.504.50
33.8317.89
L
15.55.62
23.3310.61
8000
R
14.58.02
22.1612.77
L
* Significant R- right ear L- left ear
p value
>0.05
>0.05
>0.05
>0.05
>0.05
>0.05
<0.05*
<0.05*
<0.05*
<0.05*
<0.05*
<0.05*
Shelke et al.,
825
Shelke et al.,
CONCLUSION
Shelke et al.,
827
Int J Med Res Health Sci. 2013; 2(4): 823-827
DOI:10.5958/j.2319-5886.2.4.132
Copyright @2013
ISSN: 2319-5886
Accepted: 21st Sep 2013
Lecturer, 2Assistant professor , 3Professor and Head , Department of Biochemistry, Karpaga Vinayaga
Institute of Medical Sciences, Chinna Kolambakkam, Palayanoor, Madhuranthakam, Tamil Nadu
*Corresponding author email: revathi_3aug@yahoo.co.in
ABSTRACT
Background/Aim: The aim of the present study was to evaluate the lifestyle and metabolic profiles in
normal and obese. Material and Methods: A cross sectional study design was employed. Information
on body weight, height, body fat, food choices, diet and physical activity behavior were collected by a
questionnaire among 100 obese adults aged 18-35 years and compared with healthy individuals as
controls. Blood samples were collected to analyze blood glucose, heamoglobin and total cholesterol.
Result: Mean BMI for obese were 36.25 About 50% reported consuming no fruits or vegetables,
while 80% preferred fried food over other forms of cooked food. The majority (60%) engaged in <40
min of physical activity a day. Significant number of adults had Hb>13mg/dl. Blood glucose levels
(>100) & total cholesterol levels (>200) significantly higher (p<0.05) in obese individuals compared to
control. Conclusions: Dietary and physical activity behaviour of the participants were generally poor.
High blood glucose and cholesterol levels found among obese compared to normal. Innovative ways to
improve consumption of fruits and vegetables and increase physical activity among the obese are
needed.
Keywords: BMI, Waist circumference, Obesity
INTRODUCTION
Revathi et al.,
828
829
Revathi et al.,
RESULT
Table 1: Physical profile of the participants
Variables
Age (years)
BMI (kg/m)
Waist circumference (cm)
Normal (n=100)
29.8 10.3
21.5 2.0
35.5 2.0
Obese (n=100)
29.5 9.8
36.2 5.0
120.2 9.0
P- value
0.04
0.010
Hip (cm)
Waist/hip ratio
45.2 0.72
0.77 0.05
130.0 8.0
0.92 0.03
0.010
Table 1 shows increased BMI & waist/ratio compared to controls (p<0.05).The levels of BMI,
Waist/Hip ratio was significantly higher (p<0.05) in obese compared to normal subjects.
Table.2: Biochemical profile of the participants
Biochemical profile
Normal
(n=100)
Obese (n=100)
Hb (g/dl)
13.2 1.2
14.7 0.9
0.05
87.5 13.3
172.6 19.2
0.02
179.6 22.5
213.4 30.3
0.02
Triglycerides (mg/dl)
120 12.5
170 20.5
0.03
HDL (mg/dl)
60 25.8
35 15.6
0.04
LDL (mg/dl)
95 33.2
145 20.2
0.02
p-value
Table 2 shows increased levels of Heamoglobin in obese compared to normal. Blood glucose and lipid
profile. The levels of Blood glucose and lipid profile was significantly higher (p<0.05) in obese
individuals compared to normal subjects.
DISCUSSION
Revathi et al.,
830
Revathi et al.,
CONCLUSION
831
832
Revathi et al.,
DOI:10.5958/j.2319-5886.2.4.133
Copyright @2013
ISSN: 2319-5886
nd
Accepted: 22 Sep 2013
Assistant Professor, 6Resident, Dept. of Anaesthesia & Intensive Care, Rural Medical College, PIMS
Loni, Maharashtra, India
2
Professor & Head, 3Professor, 4Resident, 5Resident, Dept. of Anaesthesia & Intensive Care GMC,
Rajindra Hospital, Patiala.
*Corresponding author email: tganesh55555@gmail.com
ABSTRACT
Tushar et al.,
Tushar et al.,
RESULT
Table.1: Comparison demography, time of intubation, epistaxis & Spo2
Variables
Group I
Group II
P value
Age [yrs]
36.84 22.28
37.04 21.06
0.9483
Sex [M:F]
9:16
3:22
0.0955
Weight [Kg]
60.2 9.66
59.08 13.9
0.5112
Time req for intub.
69.5237.18
18.2 7.12
<0.0001*
Epistaxis
3[12%]
1[4%]
0.6092
Spo2
98.726.1
99.960.4
0.048*
Table.2: Comparison of haemodynamics FOB vs DLS Group.
Group I
Group II
HR (bpm)
Baseline
Aft. Induct.
At Insertion
Imm. Aft intub.
3min
5 min
10 min
SBP (mmHg)
Baseline
Aft. Induct.
At Insertion
Imm. Aft intub.
3min
5 min
10 min
DBP (mmHg)
Baseline
Aft. Induct.
At Insertion
Imm. Aft intub.
3min
5 min
10 min
MAP(mmHg) Baseline
Aft. Induct.
At Insertion
Imm. Aft intub.
83.1614.7
77.7613.7
88.9615.85
86.0815
83.0414.58
8114.44
79.8414
122.4814.24
108.612.87
127.9615.05
141.416.4
121.3614.54
118.813.61
116.5213.81
7913.65
67.9611.41
82.5614.46
91.2416
78.6414
76.7213
76.613.53
93.513.5
81.511.5
97.714.28
107.9615.72
92.8813.81
90.7512.85
89.9113.3
3min
5 min
10 min
*Significant (P<0.05), values=MeanSD
82.7216.83
76.1213.88
88.5621.99
85.820.39
82.2813.4
80.5212.65
79.412.62
122.0414.67
107.9219.06
14028.67
133.1631.23
116.6421.3
114.1222.8
114.3622.71
79.618.77
68.1619.61
91.9626.28
87.2424.25
75.2421.8
74.4419.73
75.424.8
93.7515.68
81.416.93
107.9724.56
102.5524.69
89.0420.53
87.6718.1
88.3922.8
P value
0.84
0.40
0.88
0.91
0.70
0.80
0.81
0.83
0.76
0.0005*
0.02*
0.07
0.08
0.42
0.79
0.93
0.002*
0.17
0.19
0.33
0.67
0.90
0.96
0.0007*
0.07
0.12
0.17
0.56
835
Tushar et al.,
Tushar et al.,
CONCLUSION
837
Tushar et al.,
ACKNOWLEDGEMENT
Tushar et al.,
839
Tushar et al.,
DOI:10.5958/j.2319-5886.2.4.134
Copyright @2013
ISSN: 2319-5886
Accepted: 24th Sep 2013
Background: Mupirocin is a topical antibiotic used for nasal decolonisation of methicillin resistant
Staphylococcus aureus (MRSA). While resistance to mupirocin has been described it is usually not
tested for in most clinical laboratories. Aim: The present study was carried out to detect the occurrence
of mupirocin resistance in clinical isolates of Staphylococcus aureus in a tertiary care hospital set up in
northern India. Materials and Methods: Staphylococcus aureus isolates obtained from clinical samples
received in the microbiology laboratory over a period of one year were included in this study. Mupirocin
resistance was detected by three phenotypic methods; disk diffusion method using 5g and 200g
mupirocin disk to determine low-level and high-level resistance, broth microdilution method and an agar
dilution method for determining minimum inhibitory concentrations. Methicillin sensitivity was also
determined in the study isolates. Results: Of 250 non-duplicate Staphylococcus aureus isolates
obtained, 5 (2%) were found resistant to mupirocin. All mupirocin resistance isolates were shown to
have high-level resistance (minimum inhibitory concentration > 512g/ml). All mupirocin resistant
isolates were also resistant to methicillin. Results obtained by all three phenotypic methods showed
good correlation. Conclusion: High-level mupirocin resistance is present in the northern Indian
population which may be of major concern to prevent the spread of MRSA in hospitals and community.
Keywords: Mupirocin resistance, MuH, MRSA
INTRODUCTION
Fig.1: Demonstration of high-level mupirocin resistance and mupirocin sensitive phenotypes by disk
diffusion method
Fig.2: Broth microdilution method for determination of MIC of mupirocin in Staphylococcus aureus
isolates
Fig.3: Agar dilution method for determination of MIC of mupirocin in Staphylococcus aureus isolates
Amit et al.,
842
Int J Med Res Health Sci. 2013;2(4): 840-847
RESULTS
Among the 250 non-duplicate Staphylococcus aureus isolates included in study, 133 (53.2%) were
MRSA. Of these, 5 i.e., 3.76% of MRSA were mupirocin resistant Staphylococcus aureus (MupRSA).
Mupirocin resistance was not detected in methicillin sensitive Staphylococcus aureus (MSSA) isolates.
Table.1: MupRSA and MRSH strains among total Staphylococcus aureus isolates in different samples
Samples
S. aureus MRSA (%)
MuH (%) MuL (%) 95% CI
Pus
142
78 (54.93)
2 (1.4)
0.9-6.06
Blood
48
27 (56.25)
3 (6.25)
0.7-22.96
Genitourinary 11
1 (9.09)
specimens
Respiratory
39
23 (58.97)
specimens
Miscellaneous 10
4 (40.0)
TOTAL
0.53-6.99
250
133 (53.2)
5 (2.0)
MRSA= Methicillin resistant Staphylococcus aureus, MuH= High-level mupirocin
MuL= Low-level mupirocin resistance, CI= Confidence Interval, * = Significant
P-value
<0.0001*
<0.0001*
<0.0001*
resistance,
WARDS
MupRSA
(%)
2 (1.73)
0
95% CI
P-value
Surgical
1.06-6.86
<0.0001*
115
69 (60)
54
23(42.59)
General
surgery
21(72.41)
1(3.44)
4.35-13.87
<0.0001*
Orthopaedics 29
20 (62.5)
1(3.12)
4.55-14.55
<0.0001*
Neurosurgical 32
Gynaecology
11
5 (45.45)
0
Paediatrics
0.74-20.74
<0.0001*
67
30 (44.77)
3 (4.47)
Medicine
20
11 (55)
0
OPD
37
23 (62.16)
0
Total
0.53-6.99
<0.0001*
250
133 (53.2)
5 (2.0)
MRSA= Methicillin resistant Staphylococcus aureus, MupRSA=Mupirocin resistance
Staphylococcus aureus, CI= Confidence Interval, * = Significant
Table.3: Antimicrobial sensitivity pattern of MRSA and MupRSA isolates
Antibiotics
Sensitive (%)
Intermediate (%)
MRSA
MupRSA MRSA
MupRSA
Ampicillin
7 (5.26)
7 (5.26) Ciprofloxacin 36 (27.06) 10(7.52) Clindamycin
46 (34.58) 1 (20)
9 (6.77) 1 (20)
Erythromycin 44 (33.08) 1 (20)
6 (4.51) 1 (20)
Linezolid
133 (100) 5 (100)
Septran
44 (33.08) 3 (60)
12(9.02) 1 (20)
Tetracycline
68 (51.13) 3 (60)
9 (6.77) 1 (20)
Vancomycin
133 (100) 5 (100)
MRSA= Methicillin resistance Staphylococcus aureus,
MupRSA= Mupirocin resistance Staphylococcus aureus
Amit et al.,
Resistant (%)
MRSA
119(89.47)
87 (65.41)
78 (58.65)
83 (62.41)
77 (57.89)
56 (42.11)
-
MupRSA
5 (100)
5 (100)
3 (60)
3 (60)
1 (20)
1 (20)
-
843
Int J Med Res Health Sci. 2013;2(4): 840-847
Amit et al.,
Amit et al.,
Amit et al.,
847
Int J Med Res Health Sci. 2013;2(4): 840-847
DOI:10.5958/j.2319-5886.2.4.135
Copyright @2013
ISSN: 2319-5886
th
Accepted: 27 Sep 2013
Student, 2Professor, 3Dean and Head, Department of Physiology, Meenakshi Medical College and
Research Institute, Kanchipuram, Tamilnadu, India
*Corresponding author email: rupanjali1992@gmail.com
ABSTRACT
The most frequently occurring anomaly in the upper extremities has been the Martin Gruber
Anastomoses (MGA) which occurs due to the crossover of nerve fibers from the median nerve to ulnar
nerve. This study was performed to investigate the prevalence of MGA in 100 healthy medical students
as it acts as an etiology to carpal tunnel syndrome and other hand injuries. A nerve conduction study for
median and ulnar nerve was performed by placing the surface electrodes on the Thenar, Hypothenar and
first dorsal interosseus muscle with their Compound Muscle Action Potential (CAMP) and their
amplitudes being evaluated. MGA was found in 23 out of 100 volunteers. This relatively high incidence
demonstrates the necessity for healthcare specialists to factor the MGA into their diagnosis.
Keywords: Martin Gruber Anastomoses, Nerve Conduction study, Compound Muscle Action Potential
INTRODUCTION
Rupanjali et al.,
848
849
Rupanjali et al.,
25
FEMALE(F)
23
MALE(M)
F+ M
20
17
15
11
10
12
0
TYPE I
TYPE II
TYPE III
TOTAL
CONCLUSION
Rupanjali et al.,
851
Rupanjali et al.,
DOI:10.5958/j.2319-5886.2.4.136
Introduction: When a child is in a critical condition, it may not be hundred percent possible to
determine the body weight using weighing scale. Under such a condition, paediatricians estimate weight
using the age of the child. Material and Method: The weight was measured using a weighing scale. In
cases where the babies were too small and unable to stand on the weighing scale alone, the mother was
weighed alone and while carrying the baby and the weight of the baby was determined by subtracting
the weight of the mother from the weight of the mother and the baby. Results: Mean weight for male
children is 10.98kg, Mean foot length for male children is 5.04 inches, R2 = 0.61, F statistics = 7.57,
Probability = 0.0001531, Standard deviation of weight for males is 5.2, Standard deviation of foot length
is 0.009 Conclusion: Base on Foot length, weight of children below two years can be predicted in
emergency condition.
Keywords: Weight, Foot length, Children
INTRODUCTION
RESULT
Table 1: Showing Weight, foot length and Weight Predicted using regression formula for males
Weight
8kg
9kg
9kg
14kg
9kg
Foot length
2.05 inches
3.83 inches
4.46 inches
5.72 inches
6.90 inches
Independent
variable
Weight
Constant
Dependent variable
Coefficient
0.07
77927
t-statistics
2.88
12.47
Standard Error
0.03
6248.207
Probabilities
0.01
0.00
853
Table 3: Showing Weight, Foot length and Weight Predicted using regression formula for Females
Weight
11.5kg
5kg
7kg
12kg
10kg
Foot length
1.09 inches
2.37 inches
3.67 inches
4.21 inches
5.80 inches
Independent
variable
Dependent variable
Coefficient
Standard Error
t-statistics
Probabilities
Weight
0.81
0.05
16.25
0.0000
Constant
2794.7
1183.3
2.36
0.0228
The results in this table suggest that weight has a
linear equation relating foot length to weight was
positive linear relationship with foot length. Thus
y = 2.4x + 1 and y = 1.6x + 1.9 for females. The
an increase in the weight by a unit will increase
average body mass index for males was 15.70
the foot length by 0.81 units. The regression
and for females is 17.28
DISCUSSION
The finding in this present study shows that the
mean weight in males is higher than the mean
weight in females, while the mean foot length in
males is higher than the mean foot length in
females.
Sandeep et al, 8 working with Indian children
under two (2) years found a coefficient of
determination to be 0.88 while James D.K. et al 9
working in Manchester found a correlation
coefficient of 0.95. This work arrived at a
correlation coefficient of 0.62 in males and 0.81
in females. This is quite similar to the above
finding and suggests that all variability in weight
can be explained by a linear regression model.
The average body mass index for females was
17.28 and for males was 15.70, this all falls
within the fifth percentile for children under two
(2) years which is considered as normal (CDC,
2009). This work also gives a regression line
equation for children under two years in Nigeria.
It is our hope that other writers will derive
equations for other parts of Nigeria since this
work x-rays Ethiope East local Government Area
of Delta State in South- South Nigeria.
The importance of this study cannot be
overemphasized, because it provides the
parameters measured for estimation of weight
and thereby estimation of dosage of drugs for
emergency purposes in health cares. The results
have shown some important implications. It
showed that both for females and for males, the
weight plays significant role in influencing the
changes in foot length for both males and
females. The result showed that when the weight
of the females changes by a unit, the foot length
of males increases by 0.86 units. The result also
indicates that when the weight of the females
changes by a unit, the foot length of males will
increase by 0.07 units.
From the equations derived for both males and
females, it shows that if any of the variables are
known, the other can be determined.
856
DOI:10.5958/j.2319-5886.2.4.137
Copyright @2013
ISSN: 2319-5886
Accepted: 29thSep 2013
II Year M.B.B.S., 2Dean, 3Department of Anesthesia, Meenakshi Medical College and Research
Institute, Enathur, Kanchipuram, Tamilnadu, India,
*Corresponding author email: rsri34@gmail.com
ABSTRACT
Occupation is the one in which person not only earn his daily bread but also spend one third of average
adult life. As the number of industries is on the increase, several industries like cement industries,
chemical industries, textile industries etc, serves mainly man for comfortable living. Health hazards
caused due to a particular occupation is yet to gain importance in public health measures. These diseases
are termed occupational hazards. Weavers are constantly exposed to fine cotton dust generated from the
weaving unit. Inhalation of this dust compromises their lung function greatly. Occupational exposure to
cotton dust has been a great threat to the respiratory function. Pulmonary function tests are set of
parameters to assess the lung function. It measures the function of lung capacity and chest wall
mechanics to determine a fault in lung function. Materials & Method: Spirometry is used to determine
airway disorders and is capable of predicting early damage in lung function. This paper discusses about
the lung impairment in female weavers of below age groups, corresponding to minimum 5 years of
exposure to cotton dust. 50 non smoking female weavers of age groups 25-40 years are chosen
respectively. Pulmonary function was assessed using computerized spirometry and compared with same
age, healthy non weavers. Conclusion: The pulmonary function parameters such as FVC, FEV1,
FEV1/FVC, and FEF25-75 were significantly reduced in weavers.
Key words: Pulmonary function tests, Spirometry, Occupational hazards, etc
INTRODUCTION
Rajsri et al.,
Rajsri et al.,
Parameters
Group I
FVC
66.65 4.793
FEV 1
76.24 5.180
FEV 1 / FVC
115.8 2.600
FEF 25 - 75
40.88 4.442
*significant
The mean values of pulmonary function
parameters of weavers are given in above table.
The table depicts the comparative decline in lung
parameters of group I compared with group II.
The FVC, FEV, FEF25-75, FEV1/FVC (as a
percentage of predicted) was seen to significantly
decreased in group I than group II. The Present
study demonstrates that there is altered lung
function in weavers due to chronic exposure.
When compared to the predicted values there
was statistically significant decline in the values
of FVC, FEV, FEF25-75 and FEV1/FVC.
Inhalation of dust is an important cause of
interstitial lung disease in India.6 The present
study demonstrates that there is a significant
decrease in lung function as the years of
exposure to cotton dust increases. The probable
cause for the decrease in pulmonary function test
is the accumulation in peri bronchial lymphoid
and connective tissues along with varying
degrees of wall thickening and remodeling in
terminal and respiratory bronchioles arising from
each pathway. Bronchiolar walls with marked
P Value
83.262.5
86.25 6.292
87.9 10.17
70.64 2.019
< 0.01*
< 0.01*
< 0.01*
< 0.01*
859
Rajsri et al.,
CONCLUSION
1. The
Occupational
Health
Decennial
Supplement published in 1995.
2. Karjalainen A, Kurppa K, Martikainen R,
Klaukka T, Karjalainen J. Work is related to
a substantial portion of adult-onset asthma
incidence in the Finnish population. Am
JRespirCrit Care Med. 2001;164(4):565-8.
3. Asaad Ahmed Nafees. Pattern and predictors
for respiratory illnesses and symptoms and
lung function among textile workers in
Karachi, Pakistan. Occup Environ Med:
2013; 10.1136/oemed-2011-100561; 99-107.
4. Christiani DC, Eisen EA, Wegman DH, Ye
TT, Gong ZC, Lu PL et al., Respiratory
disease in cotton textile workers in the
People's Republic of China. II. Pulmonary
function results, Scand J Work Environ
Health. 1986;12(1):46-50.
5. Boskabady MH, Karimiani EG, Vostacolaei
HA. Respiratory symptoms and pulmonary
function changes among carpet weavers in
Iran.Int J Occup Environ Health. 2007;
13(4):369-75.
6. Jindal SK, Aggarwal AN, Gupta D. Dutinduced intertitial lung diease in the tropics.
Curr Opin Pulm Med.2001; 7: 272-77.
7. Pinkerton KE, Green FHY, Saiki C,
Vallyathan V, Plopper CG, Gopal V et al.
Distribution of particulate matter and tissue
remodeling in human lung. Environ Health
Perspect 2000; 108:10639.
8. Kauffmann F, Drouet D, Lellouch J, Brille D.
Twelve years spirometric changes among
860
Rajsri et al.,
DOI:10.5958/j.2319-5886.2.4.138
Copyright @2013
ISSN: 2319-5886
Accepted: 28th Sep 2013
AND
PREVALENCE
OF
*Sukhmeet Minhas1, Priyanshi Chaudhary2, Harinder Sekhon3, George Koshy4, Vandana Gangadharan5
1
Reader, Dept of Community Medicine, Armed Forces Medical College, Pune, Maharashtra, India
Intern, MH Secunderabad,
3
Psychiatrist, Composite Hospital, Central Reserve Police Force, Jammu, Jammu & Kashmir
4
OIC, Station Health Organisation, INS Rajali, Arakkonam, Tamil Nadu
5
Assistant Professor, Department of Pathology, Meenakshi Medical College & Research Institute,
Enathur, Tamil Nadu
2
Background: Individuals whose Body Mass Index exceeds the age-gender-specific 95th percentile are
overweight; while those with BMI between the 85th and 95th percentiles are at risk of overweight. The
prevalence of obesity is increasing worldwide. Children are becoming overweight at younger age.
Currently 10% of children worldwide are either overweight or obese. The present study was undertaken
to study the anthropometric measurements and determine the prevalence of overweight amongst school
girls in the age group of 5-8 years in a school of Pune. Methods: Anthropometric measurements of the
study subjects were studied by conducting a cross sectional descriptive study. All the 312 girl students,
aged 5 to 8 years enrolled in the school during the study period were studied. Results: 15.4% of the girls
were found to be overweight while 5.4% are at risk of overweight. Conclusion: With increasing age,
more girls become overweight and at risk of overweight. This increase is steady as the age increases
from 5 to 8 years.
Keywords: Anthropometry, overweight, children, urban, girls
INTRODUCTION
Overweight and obesity are by definition,
abnormal or excessive fat accumulation that may
impair health1,2 or simply as a state of excess
adipose tissue3.Another definition says that
obesity is an excessive accumulation of adipose
tissue containing stored fat in the form of
triglycerides4.Limited research has been carried
Minhas et al.,
861
Int J Med Res Health Sci. 2013; 2(4):861-869
Percentile range
Healthy
weight
At risk of
overweight
Overweight
Age
BMI Percentiles
Total
th
th
th
th
th
th
<5
5 - <85
85 - <95
95
1 (16.7)
5 (83.3)
0
0
6 (100)
5
14 (42.4)
15 (45.5)
3 (9.1)
1 (3.0)
33 (100)
6
30 (33.0)
47 (51.6)
9 (9.9)
5 (5.5)
91 (100)
7
30 (16.5)
105 (57.7)
36 (19.8)
11 (6.0)
182 (100)
8
75 (24.0)
172 (55.1)
48 (15.4)
17 (5.4)
312 (100)
Total
2
X = 20.6024, df = 9, p < 0.05
Note: As per CDC 2000 guidelines, percentile of the BMI define Underweight, Healthy weight, At risk
of overweight and Overweight in case of children. The figures in parenthesis refer to the percentages.
Table: 3 Distribution of MUAC Mean Standard Deviation according to age of the subject
Age
(completed years)
5
6
7
8
Minhas et al.,
Observations
Mean SD
6
33
91
142
17.661.40
16.992.07
16.962.55
17.992.47
864
Int J Med Res Health Sci. 2013; 2(4):861-869
35
30
P5
25
P25
20
P50
15
P75
10
P95
5
0
6
7
Age in completed years
P5
P25
110
P50
100
P75
90
P95
Height
(cms)
120
80
5
6
7
8
Age in completed years
BMI
25
20
P5
P25
15
P50
10
P75
P95
5
0
5
6
7
8
Age in completed years
Minhas et al.,
865
Int J Med Res Health Sci. 2013; 2(4):861-869
Age Present
Study
Agarwal
al26
et Rath et al29
Marwaha Vijaya
et al13
Raghavan et al28
CDC23 WHO31
5
117.830.0223 104.9227.38 109.694.84 111
112.243.91
108
110
6
114.760.0639 110.544.34 118.784.65 117
117.735.08
115
115
7
116.700.0633 11542.10
122.994.74 122
122.655.79
122
121
8
124.400.0582 123.835.51 127.796.83 128
127.226.58
128
127
Note: The values in parenthesis correspond to the mean and SD. The values of SD are not available in
respect of the other studies.
Table 5: Comparison of median weight of subjects
Age Present
Agarwal
et Rath et al29 Marwaha Vijaya
al26
et al26
Raghavan et al28
Study
5
20.332.14 15.7711.14
18.722.4 19
18.671.89
6
19.084.21 17.8918.72
21.723.85 21
21.563.44
7
20.154.09 19.3423.40
23.033.49 24
24.454.41
8
23.824.54 22.3422.56
26.396.11 27
25.974.87
Note: The values in parenthesis correspond to the mean and SD. The values of SD
respect of the other studies.
CDC23 WHO31
18
18
20
20
23
22
26
25
are not available in
WHO31
Age
Present Study
5
14.631.32
13
6
14.382.05
13
7
14.722.07
13
8
15.302.13
13
Note: The values in parenthesis correspond to the mean
respect of the other studies.
CDC23
Marwaha et al13
13
12
13
12
13
12
13
13
and SD. The values of SD are not available in
Age
5
6
7
8
Present Study
17.66 1.40
16.99 2.07
16.962.55
17.992.47
Shrivastava et al32
15.3 1.1
15.9 1.3
16.5 1.2
17.2 1.5
Rath et al29
16.34 1.24
17.72 1.71
17.58 1.76
18.57 2.82
DISCUSSION
The comparison of median height of subjects is
as shown in Table4.On comparing with other
studies, it was observed that the median height of
Minhas et al.,
866
Int J Med Res Health Sci. 2013; 2(4):861-869
ACKNOWLEDGEMENT
Minhas et al.,
867
Int J Med Res Health Sci. 2013; 2(4):861-869
CONCLUSION
Minhas et al.,
869
Int J Med Res Health Sci. 2013; 2(4):861-869
DOI:10.5958/j.2319-5886.2.4.139
Professor and Head, 2Assistant Professor, 3Post Graduate, Department of Pathology, Mysore Medical
College and Research Institute, Mysore, Karnataka, India
*Corresponding author email: halingappa@gmail.com
ABSTRACT
Objective: Comprehensive estimates of the incidence of gynecological malignancies reported from
India are very limited due to limitation in record maintenance. Auditing of the results on the incidence
rates provided by the Population Based Cancer Registries has shown variation in the patterns of
gynecologic malignancies. The present study was undertaken to establish the profile of gynecologic
malignancies reported in our centre, with reference to incidence, histological subtypes and frequency of
involvement at various sites. Another objective was also to compare the procured data with those from
other national and international centers. Materials and Methods: In this descriptive study, the records
pertaining to all the pathological specimens categorized as ovarian, uterine corpus and uterine cervical
cancers from January 2003 to December 2012 at our tertiary center were studied and compared with the
available international data. Results: Cervical malignancies were the commonest at our center, as
compared to the uterine malignancies, which were commoner as per the data available from Surveillance
Epidemiology and End Result (SEER) programme of the United States and the European Union.
Keywords: Gynecological malignancy; South India; Cervical Malignancy.
INTRODUCTION
Hemalatha et al.,
870
RESULTS
No. of cases
358
339
%
75.36
71.36
16
3
71
36
7
8
27
24
3
9
8
2
3.36
0.36
14.94
11.78
1.47
1.68
5.68
5.05
0.63
1.89
1.68
0.42
871
Hemalatha et al.,
DISCUSSION
Hemalatha et al.,
REFERENCES
873
Hemalatha et al.,
DOI:10.5958/j.2319-5886.2.4.140
Copyright @2013
ISSN: 2319-5886
Accepted: 29th Sep 2013
Most studies show that objective measures to quantify and determine surgical success in the treatment of
External nasal deformity with /without nasal obstruction do not correlate with subjective improvement
as reported by patients. Aim: To evaluate the subjective& objective improvement in patients undergoing
septorhinoplasty or rhinoplasty Materials and Methods: It is a prospective study in which we evaluate
100 patients who had to undergone septorhinoplasty /rhinoplasty; various angles of nose & face were
evaluated both preoperatively & postoperatively. In cases selected for Septorhinoplasty, the patients
answered a questionnaire preoperatively and 2 months after surgery with questions about the main
symptoms of nasal obstruction (nasal obstruction, coryza, pruritus, sneezing, facial pain, snoring, sleep
disorders, daytime drowsiness), and a score of each. The intensity of symptoms was scored from 1 to 4,
as follows: 1 - absence of symptoms; 2 - mild symptoms; 3 - moderate symptoms; 4 - severe symptoms.
Results: An improvement of all symptoms was observed after surgery, where there was nasal
obstruction associated with external nasal deformity i.e; NOSE (Nasal obstructive symptom evaluation
were 45.010.2 (preoperatively) &10. 04.23 (post-operatively) with p- value < 0.005 whereas NASE
(Nasal appearance surgical evaluation) were 41.811.25 (pre-operatively) &7. 85.29 (postoperatively) with p-value < 0.005 Conclusions: The external nasal appearance as well as symptoms of
nasal obstruction (in c/o =septorhinoplasty) improved.
Keywords: nasal septum, External nasal deformity, NOSE score, NASE
INTRODUCTION
876
877
RESULTS
Table 1: Showing information regarding various parameters among selected cases
Parameter
Sex distribution
Male
Female
Area-wise distribution
Rural areas
Urban areas
Types of cases
Primary cases
Revision cases
Main indications
Saddle nose deformity
Dorsal hump
Supratip depression
Nasal valve area weakness
Type operative procedure Septorhinoplasty
Rhinoplasty only
Type
of
operative Open
approach
Close
Chief complaints
External nasal deformity with nasal obstruction
External nasal deformity
Aetiological factors
Post-traumatic
Developmental
Post-operative
Post-infective
No of patients
67
33
70
30
86
14
20
55
5
20
80
20
55
45
80
20
54
40
5
1
35
5
1
4
878
Only graft
Goldhens tip procedure
Intra & Inter dermal suturing
Table 4: Shows evaluation of operation in terms of pre-operative and post-operative nasal angles
Nasal angles
Nasolabial
Nasofrontal
Nasofacial
Pre-operative
94.2 7.7
134.57.4
32.0 5.2
Post-operative
97.16.8
133.16.9
31.2 4.9
p-Value
1.042
1.058
1.020
Table 5: Shows evaluation of operation success by analysing pre-operative & post-operative NOSE score
and NASE score23,24
Score
NOSE (Nasal obstructive symptom evaluation)
NASE (Nasal appearance surgical evaluation)
879
DISCUSSION
Owing to its central location on the face, the nose
plays an intimate role in all social interactions.
Early surgical correction of nasal deformities
improves psychosocial development and
opportunities for normalized social integration
and removes the stigma of an abnormal
appearance. Pre and intraoperative planning are
essential in order to achieve good results; the
surgeon must carefully examine the nose in order
to determine which pathological condition there
is and which surgical procedure is needed 20.
In the present study 67% of patients were male
vs. 33% female. (Table 1) This agrees with the
study for objective evaluation of a deviated
septum, Erdem & Ozturan 21 reported that the
number of males was more than females, 21 that
may be explained because this study dealt only
with patients seeking functional correction of
deviated septum which is more common in males
due to more exposure to trauma. (Table 4) In
contrast to females, male patients seem to lack a
clear body concept and an in-depth awareness of
their physical appearance. As a result, they often
have difficulty articulating their objectives for
cosmetic surgery.
In the current study there was a statistically
significant difference between pre-operative and
postoperative measurements for nasofacial,
nasolabial & naso frontal angles. (Table 4) This
agrees with Okur, et al.22 who stated that the
angle measurement method may be helpful in
882
DOI:10.5958/j.2319-5886.2.4.141
Copyright @2013
ISSN: 2319-5886
Accepted: 29th Sep 2013
Associate Professor, Dept of Community Medicine, Gujarat Adani Institute of Medical Sciences, Bhuj,
Gujarat, India
2
Assistant professor, Dept of Community medicine, SRTR Medical College and Hospital, Ambajogai,
Maharashtra, India
*Corresponding author email: drkeertijogdand@gmail.com
ABSTRACT
Introduction: In India, the life of the vulnerable and the marginalized working population is at risk as
there is a lack of awareness about occupational safety and environmental hazards. The scissor
manufacturing workers sector is one of the important but unorganized parts of industry of India and
mainly run by private establishments. The scissors manufacturing workers hardly ever benefit from
occupational health and safety provisions. Materials and methods: The present community based,
cross-sectional study was conducted among 218 scissor manufacturing workers of small scale industry
of urban slum area, Malvani in South Mumbai. The study period was from June 2010 to September
2010. Results: In the present study, 52.75% workers were in the age group of 20-30 yrs followed by in
the age group of 30-40 yrs (32.57%). Majority, 92.66% were males. Regarding the history of addiction,
77.52% workers were using tobacco related products. The commonest health problem present in
workers was acute respiratory infection (ARI) (34.86%) followed by musculoskeletal problems in
25.68% workers. Conclusion: As scissor manufacturing workers suffering from various morbidities, it
is necessary to monitor the occupational environment and health status of the workers periodically. It is
also necessary to create awareness regarding the ill effects of industrial hazards.
Key words: Morbidity profile, scissor manufacturing workers
INTRODUCTION
Keerti S et al.,
883
Characteristics
Age (years)
Sex
Religion
Education
Marital status
20-30
30-40
Above 40 yrs
Male
Female
Muslim
Hindu
Illiterate
Literate
Married
Unmarried
No (%)
115 (52.75%)
71 (32.57%)
32 (14.68%)
202 (92.66%)
16 (7.34%)
198 (90.83%)
20 (9.17%)
27 (12.39%)
191 (87.61%)
163 (74.77%)
55 (25.23%)
884
Keerti S et al.,
Diseases
Persistent cough
Asthma
Tuberculosis
COPD
Musculoskeletal problems
Skin diseases
Eye problems
No (%)
76 (34.86%)
51 (23.39%)
18 (8.26%)
6 (2.75%)
56 (25.68%)
35 (16.05%)
23 (10.55%)
DISCUSSION
Keerti S et al.,
CONCLUSION
1.
2.
3.
4.
5.
development.
Geneva
WHO;
1997.
Available from http://www.who.int/peh/
occupational health2.htm
ILO Encyclopedia. Occupational health and
safety 4th ed.1998.pg.89-90.
Goel K, Ahmad S, Goel P, Parashar P,
Maroof KA, Ali AA. Study on social and
health status of scissor manufacturing
workers of Meerut, UP. International J of
Contemporary Medicine 2003;1(1):51-54.
Qurratul A, Shama P, Verma RK.
Prevalence of lung disease in the workers of
scissors manufacturing industries in Meerut
city. The Pharma research. 2009;4(3):57-60.
886
Keerti S et al.,
DOI:10.5958/j.2319-5886.2.4.142
Associate Professor, Department of Pathology, Rohilkhand Medical College & Hospital, Bareilly, U.P.
India
2
Assistant Professor, Department of Dermatology, SRMS Institute of Medical Sciences, Bareilly, U.P.,
*Corresponding author email: drnitesh@gmail.com
ABSTRACT
Background: Leprosy is one of the oldest and chronic infectious diseases known to human being
caused by Mycobacterium leprae. Leprosy is widely prevalent in all parts of India and it presents with
different clinico-pathological forms. However a great variation is seen in interpretation of clinical and
histopathological examination of these lesions. The present research was taken to study the correlations
between the clinical and histological diagnosis and to evaluate the importance of skin biopsy as an
important diagnostic and spectrum defining tool. Methods: A prospective hospital based study was
conducted among patients attending Dermatology OPD of two tertiary care centres in this region over a
period of two years. All clinically suspected new leprosy patients were included in the study. A detailed
clinical history and examination was carried out and skin biopsies were taken from the most active part
of lesions. Sections were stained with Hematoxylin & Eosin stain and Fite-Feracco stain.
Histopathological findings were compared with clinical diagnoses. Results: A total of 190 cases were
studied, out of which 137(72.10%) were males and 53(27.9%) were females. The histopathological
diagnosis of leprosy was established in 99.47% of clinically diagnosed cases. Clinico-histopathological
concordance was seen maximum in LL (97.22%), followed by BT (79.76%), TT (71.43%), BL
(66.67%), BB (66.67%) and least in IL (50.00%). Overall concordance was 56.54% Conclusion:
Clinical diagnoses of Leprosy still pose a significant problem, especially the Intermediate subtypes of
the disease spectrum. Histopathological examination of the active skin lesions should be done in all new
cases to confirm the spectrum of disease and expected duration of therapy.
Keywords: Leprosy, Lepromatous leprosy, Skin biopsy
INTRODUCTION
RESULTS
Table 1: Clinical presentation in various types of leprosy
Clinical diagnosis
Hypopigmented
Erythematous
plaque/ No.of
patch (No. of cases) papule/nodule (No. of cases) cases
06
75
02
10
16
08
09
11
02
16
29
06
15
86
04
26
45
14
7.89
45.26
2.12
13.68
23.68
7.37
888
Histopathological diagnosis
Tuberculoid Leprosy (TT)
Borderline Tuberculoid (BT)
Mid Borderline (BB)
Borderline Lepramatous (BL)
Lepramatous Leprosy (LL)
Intermediate Leprosy (IL)
Total
No. of cases
14
84
03
24
36
28
189
%
7.40
44.44
1.6
12.70
19.05
14.82
100
Type of Leprosy
Percentage
--
--
08
8.42
11
11.58
28
29.47
34
35.79
14
14.73
Total
95
100
Site of Lesion
Number of cases
Percentage
40
21.05
Upper limb
65
34.21
Lower limb
30
15.79
Trunk
25
13.16
Multiple sites
30
15.79
Total
190
100
10
04
BT (84)
03
67
BB (03)
01
02
BL (24)
03
01
LL (36)
IL (28)
02
11
01
Total (189)
15
86
04
BL
LL
IL
Percentage
of
concordance
71.43
10
04
79.76
66.67
16
04
66.67
01
35
97.22
14
26
45
50.00
14
889
Authors
Males (%)
Moorthy et al (2001) 6
65.05
Bhushan et al (2008) 5
Mathur MC et al (2011)
72.34
2
53.8
Gridhar M et al (2012) 3
77.6
72.10
Studies
Kalla G et al 7
Tailor et al
M Giridhar et al
Present Study
Year
Overall Concordance %
2000
60.6
2008
58
2012
60.23
2013
56.54
890
DISCUSSION
In the present study, a total of 190 clinically
diagnosed leprosy patients were examined and
were subjected to clinical and histopathological
examination, which included various aspects of
the lesions, like number and site of lesions, type
of disease.
The studied showed the most common clinical
presentation to be with hypopigmented patch
(61.58%) followed by erythematous plaque or
nodule (38.42%). This correlated well with study
done by M Gridhar et al.3 and Ocampo and
Francisco.4
The sex ratio was heavily skewed towards males
(72.10%). This is similar to other Indian studies
undertaken by Gridhar M et al (77.6%) 3] &
Bhushan et al (72.34%)5. Mathur MC et al.2
however observed 53.8% males in their study
while Moorthy et al. observed 65.05% males.6
In the present study concordance between
clinical and histopathological diagnosis for
individual type of leprosy was found to be TT
(71.43%), BT (79.76%), BB (66.67%), BL
(66.67%), LL (97.22%) and IL (50.00%).
Maximum concordance was observed in LL type
of leprosy, which was similar in studies by
Mathur MC et al.2, Gridhar M et al3 and Moorthy
et al.6 However, concordance differed variably
when compared with other types of Leprosy,
which may be due to more precise diagnostic
criteria laid down in histopathology with
emerging microbiological and immunological
techniques. The observations strongly suggest the
importance of histopathological diagnosis in
these cases, as lesions are easy to diagnose
clinically towards Lepromatous pole of the
disease.4
In our study, histological diagnosis of leprosy
was established in 99.47% cases. One case
(0.53%) was diagnosed as Lupus Vulgaris.
Similar observations have been made by different
authors in their studies, however with lesser
specificity. The discrepancy, whenever seen may
be due to clinical overdiagnosis of leprosy and
891
892
DOI:10.5958/j.2319-5886.2.4.143
Copyright @2013
ISSN: 2319-5886
Accepted: 29th Sep 2013
MD Physiology, 2Asst. Professor, 3Asso. Professor, Dept. of Physiology, Govt. Medical College, Miraj,
Maharashtra, India
* Corresponding author email: dr.deepalijankar@gmail.com
ABSTRACT
Diabetes-related sensorineural hearing impairment affects peoples ability to hear and understand
sounds. We carried out this case control study with the purpose of determining the hearing loss in type II
diabetes mellitus in relation to the age and gender of the patients and duration of the illness using tuning
fork tests and pure tone audiometry. Aim: To study the hearing loss in type II diabetics and controls.
Objectives:1. To study the hearing loss in relation to different age groups in diabetics and controls. 2.
To study the hearing loss in relation to gender in diabetics and controls. 3. To study the hearing loss in
relation to duration of diabetes. Material and Methods: 200 diabetic patients and 200 age and sex
matched controls took part in the study. They were evaluated by Tuning fork tests and Pure Tone
Audiometry. Results: The hearing of diabetics was significantly impaired than the non-diabetic control
group. This hearing impairment was noted in all the frequencies tested. The hearing acuity was not
influenced by the duration of diabetes, age or sex of the subjects. Discussion: The possible mechanisms
underlying the hearing loss in diabetic individuals are microangiopathy, demyelination, hyperglycemia,
etc. Conclusion: Type 2 diabetes causes significant hearing loss in the patients, but it is not affected by
the age and sex of the patient or duration of the illness.
Key words: Audiometry, Diabetes, Sensorineural hearing loss
INTRODUCTION
Diabetes-related
sensorineural
hearing
impairment affects peoples ability to hear and
understand sounds. Although evidence from as
early as the mid-19th century linked diabetes
with hearing loss, a degree of controversy has
surrounded this association.2
Various tests are available for the clinical
assessment of hearing loss. Localization and type
Jankar DS et al.,
893
Sensori-neural deafness
AC > BC
Lateralized to better ear
Reduced
RESULTS
Table 2: mean age of Diabetic and non-diabetic (controls)
Total no.
Mean age (years)
Diabetics
200
50.30 5.78
Non-diabetics
200
50.25 5.69
894
Jankar DS et al.,
Diabetics
Males
60
60
Non-diabetics
Males
Females
60
40
60
40
Females
40
40
79
121
200
Table 5: Comparison of hearing loss in diabetics and non-diabetic controls (chi square test) (Odds
ratio: 2.398)
P value
Hearing Loss
Diabetics
Non-diabetics
Present
absent
Total
p value: 0.0001 (highly significant)
72
128
200
0.0001*
38
162
200
Table 6: Comparison of hearing loss in relation to different age groups in diabetics and non-diabetic
controls (chi square test)
Age
Diabetics
Non-diabetics
41-50 years
29
16
51-60years
43
22
Total
72
38
P value
0.852
-
Table 7: Comparison of hearing loss in relation to sex in diabetics and controls. (chi square test).
Sex
Diabetics
Non-diabetics
Male
42
24
P value
0.6233*
Female
Total
30
72
14
38
Table 8: Comparison of hearing loss in relation to duration of diabetes in diabetics. (chi square test).
Duration
Hearing loss
< 5 yrs
> 5 yrs
Total
25
47
72
54
74
128
0.2999
-
DISCUSSION
Jankar DS et al.,
895
Jankar DS et al.,
896
CONCLUSION
Jankar DS et al.,
897
898
Jankar DS et al.,
DOI:10.5958/j.2319-5886.2.4.144
Copyright @2013
ISSN: 2319-5886
Accepted: 29th Sep 2013
Vedavathi et al.,
899
Vedavathi et al.,
Topic
Day1
Day2
Day3
Day4
Informed consent
Medical negligence
Ethical issues of HIV/ AIDS
Clinical trials
Teaching methodology
Lecture Power point
class
presentation
Group 1 Group2
Group 2 Group 3
Group 3 Group 4
Group 4 Group 1
Case
discussion
Group 3
Group 4
Group 1
Group 2
RESULTS
Table 2: Results of performance based evaluation
Teaching
Method
Lecture
Power point
Case disc#
Film/disc#
MBBS students
Post#
Pre*
14.025
9.65
14.050
9.55
14.55
10.10
14.15
9.20
Nurses
Diff*
4.375
4.5
4.45
4.95
% imp$
21.87
22.50
22.25
24.75
Junior residents/interns
Post* Pre*
Diff *
15.7
12.45 3.25
15.85 12.40 3.45
15.55 12.55 3.00
14.85 11.85 3.00
Lab technicians
% imp*
16.25
17.25
15.00
15.00
Lecture
Power point
Case disc#
Film/disc#
9.00
8.75
9.75
10.25
3.00
3.25
3.75
4.00
15.00
16.25
18.75
20.00
5.62
6.00
4.87
7.75
11.25
13.75
8.75
22.50
6.00
5.50
6.00
6.25
3.37
3.25
3.12
3.25
2.25
2.75
1.75
4.50
Pre*-average pre evaluation score; Post*-average post evaluation score, Diff*-difference between average
pre and post evaluation scores, %imp$-percentage of improvement ; disc#-discussion
901
Vedavathi et al.,
Teaching
method
Preferences
MBBS
Junior
dr
/internees
Nurses
Lab
technicians
Lecture
Power point
Case discussion
1
13
8
2 3 4 1 2 3
12 8 7 8 11 16
8 13 11 8 14 15
4
5
3
9
4
13 8
8 8
10 9 8
20 6 8
14
16
Film-discussion
1
16
18
2
15
09
3
5
7
4
4
6
1
3
6
2
2
9
3
11
5
4
24
20
8
10 12
5
14
13
10
14
4
14
18
13
10
5
6
8
6
Lecture
Score
MBBS
Junior.doctors/interns
Nurses
Lab technicians
All candidates
Power point
%
share
27.75
23.25
25.25
19.00
23.81
111
93
101
76
381
Score
102
107
99
90
398
%
share
25.5
26.75
24.75
22.50
24.87
Case
discussion
Score %
share
123
30.75
119
29.75
87
21.75
114
28.50
443
27.69
Film/discussion
Score
64
81
113
120
378
%
share
16.00
20.25
28.25
30.00
23.63
Sl
no
Category
1
2
3
4
MBBS
Junior.doctors/internees
Nurses
Lab technicians
Choice-evaluation
Case discussion
Case discussion
Film followed by discussion
Film followed by discussion
902
Vedavathi et al.,
Vedavathi et al.,
Vedavathi et al.,
904
DOI:10.5958/j.2319-5886.2.4.145
Copyright @2013
ISSN: 2319-5886
Accepted: 29th Sep 2013
Objectives: Teachers are among the professions reporting highest level of work-related stress, the study
was undertaken to evaluate the levels of stress amongst school teachers in a public school of rural
western Maharashtra Methods: Prospective survey based study was carried out amongst school teachers
of rural western Maharashtra using Copenhagen Psychosocial Questionnaire (COPSOQ).The survey was
carried out on 3 scheduled visits over a period of 2 months after the Institutional Ethical committee
approval. Total 110 Primary and secondary school teachers, satisfying inclusion and exclusion criteria
were randomly selected for the study. All the questions in the Copenhagen Psychosocial Questionnaire
(COPSOQ) were graded according to 1 (Always-0), 2 (Sometimes-25), 3 (Often-50), 4 (Seldom-75) and
5 (Never-100). The scale value was calculated as the simple average. More the average score less the
stress and vice versa Results & Conclusion: Inability to understand the meaning and importance of
work, improper clarity about the job, inability to cope with the problems were found to be the factors
always contributing to stress of teachers.
Keywords: School teacher, Job related stress, COPSOQ, Personal Stressors
INTRODUCTION
Rahul et al.,
905
Rahul et al.,
Study tool:
Psychosocial Questionnaire (COPSOQ): The
scales of the COPSOQ were formed by adding
the points of the individual questions of the
scales by giving equal weights to each question.
In most cases the questions had five response
options.
The Questionnaire was divided into two types:
Job related Questionnaire and Personal
stressor Questionnaire. The scale value was
calculated as the simple average from 0 to 100.
Respondent absent for any one visit were
considered as a drop out
Study conduct: Data was collected in 3
scheduled visits approximately 7 days apart
Table 1: Psychological Questionnaire
Grade
Score
Interpretation
ALWAYS
25
SOMETIMES
50
OFTEN
75
SELDOM
100
NEVER
RESULTS
74.49
52.98
Emotional Demands
37.50
34.44
Influence at Work
32.94
Predictability
Commitment to workplace
27.35
Cognitive Demands
26.81
23.40
11.76
Meaning of Work
0
20
40
60
80
100
907
Rahul et al.,
72.38
COGNITIVE STRESS
61.62
54.67
BEHAVIOURAL STRESS
MENTAL HEALTH
52.18
SENSE OF COHERENCE
47.65
ROLE CONFLICTS
46.50
40.03
GENERAL HEALTH
37.02
SELECTIVE COPING
JOB SATISFACTION
25.99
SOCIAL SUPPORT
23.07
22.68
16.57
ROLE CLARITY
0
20
40
60
80
100
Rahul et al.,
908
Rahul et al.,
910
Rahul et al.,
DOI:10.5958/j.2319-5886.2.4.146
The present study was undertaken to detect the presence of Group B streptococci (GBS) as a coloniser
among women of reproductive age group attending to outpatient clinic in Obstetrics and Gynaecology at
Dr.PSIMS &RF general hospital, Chinnaoutapalli. Methods: Two low vaginal swabs were collected
from 200 women in the age group of 15-45 years and the swabs were subjected to microscopy, culture,
Christie, Atkins and Munch-Peterson test (CAMP) and antibiotic susceptibility testing by Kirby-Bauer
disc diffusion method. Results: Of the total 400 vaginal swabs collected from 200 women 7 were found
to be colonized with Group B streptococci which were mostly susceptible to ceftriaxone and
erythromycin and all were resistant to penicillin except strain 1.Conclusion: Detection of colonization
with GBS and treatment helps in reducing the incidence of neonate acquiring GBS infection.
Keywords: Streptococci, colonization, CAMP test, neonatal meningitis, antibiotic sensitivity
INTRODUCTION
Pradeep et al.,
911
Pradeep et al.,
912
METHODS
After taking informed consent from all the
participants; two vaginal swabs taken from all
subjects and the swabs were immediately
transported to the microbiology laboratory.
Direct Microscopy: One swab was used to
inoculate 5% sheep blood agar and then used for
wet mount and gram staining. Findings of
preliminary microscopic examination were
recorded. The other swab was used for
enrichment culture with Brain Heart Infusion
(BHI) broth with antibiotics (gentamicin-15
mcg/ml and Nalidixic acid-8 mcg/ml) which
after 24hrs incubation was inoculated on to 5%
sheep blood agar. 8
After overnight incubation the growth on plates
were read and suspected colonies on blood agar
were subjected to catalase test and Gram
staining. Gram positive and catalase negative
colonies were subjected to CAMP test and
confirmation was done by Latex agglutination
using latex suspension coated with anti-serum
(Bio-merieux).9 Plates which did not yield
growth of streptococci were further incubated for
24 hours, read and processed similarly for
suspected colonies. The enrichment broth was
subcultured and read and processed similarly.
Specimens yielding group B streptococcus either
on direct inoculation or on subculture of
enrichment medium were recorded as positive.
Antibiotic susceptibility of the isolated group B
streptococci was done by employing Kirby
Bauer disc diffusion method. 8
Pradeep et al.,
Table 1: Standard zone size interpretation chart for the antibiotics tested against GBS 8, 10
Drug
Potency
Penicillin
10U
28
20-27
( )19
Erythromycin
15mcg
21
16-20
( ) 15
Ceftriaxone
30mcg
27
25-26
( )24
Sensitive
Intermediate
Resistant
Pradeep et al.,
914
Pradeep et al.,
CONCLUSION
REFERENCES
916
Pradeep et al.,
DOI:10.5958/j.2319-5886.2.4.147
Coden: IJMRHS
Copyright @2013
th
Revised: 18 Sep 2013
ISSN: 2319-5886
Accepted: 29th Sep 2013
Professor and HOD, Department of Biochemistry, ESIC Medical College, Gulbarga, Karnataka, India
Associate Professor, Department of Psychiatry, Raichur Institute of Medical Sciences, Raichur
3
MBBS Student, Raichur Institute of Medical Sciences, Raichur, Karnataka, India
2
Present cross sectional study was carried out with a view to evaluate the Carbamazepine risk for
coronary heart disease. Lipid profile and Framingham point scores were studied in 60 Epilepsy patients
on Carbamazepine. The epileptic patients were compared with age and sex matched 60 healthy controls.
Framingham Point Scores were estimated by taking into consideration several parameters i.e. Age, Sex,
Systolic blood pressure, HDL levels, Total cholesterol, and smoking history, as per guidelines of the
Framingham Heart Study group We conclude that this drug significantly increases the risk for coronary
heart disease in patients with respect to lipid profile and other parameters as described by the
Framingham study group. Altogether, this drug may be one of the reasons for the high prevalence of
CHD, which is increasing day-by-day due to the globalization.
Keywords: Carbamazepine, Epilepsy, Lipid Profile, Coronary heart disease
INTRODUCTION
Prashant V et al.,
Parameter
Total Cholesterol (mg/dl)
HDL(mg/dl)
LDL(mg/dl)
Triglycerides (mg/dl)
TC/HDL
LDL/HDL
Framingham Risk %
Cases (n=60)
174.15 14.43
43.36 5.26
104.74 13.08
130.18 15.13
4.06 0.51
2.45 0.44
0.45 0.96
Controls (n=60)
164.27 13.19
45.65 6.03
94.52 15.09
120.45 10.76
3.67 0.57
2.12 0.51
0.27 0.76
P Value
<0.001
0.03
<0.001
<0.001
<0.001
<0.001
0.17
918
Prashant V et al.,
Male (n=15)
Female (n=24)
P Value
20-30
161.93 16.49
43.33 4.87
94.76 15.01
119.2 13.54
3.76 0.44
2.21 0.41
Male (n=9)
182.2211.78
45.89 5.08
109.27 13.35
135.33 23.50
4.02 0.58
2.41 0.47
178.29 11.52
42.83 4.94
108.5 10.60
134.79 12.52
4.20 0.45
2.56 0.40
Female (n=12)
175.089.83
42.58 6.45
106.33 8.99
130.83 5.63
4.18 0.55
2.55 0.46
0.003
0.759
0.005
0.001
0.005
0.013
30-40
Total Cholesterol (mg/dl)
HDL (mg/dl)
LDL (mg/dl)
Triglycerides (mg/dl)
TC/HDL (%)
LDL/HDL (%)
10 year Males
% Risk
Total point Cases
scores
<1
<0
8
1
0-4
10
2
5-6
4
3
7
4
8
1
5
9
1
>6
>10
Total
24
(4)
0.199
0.205
0.579
0.588
0.535
0.524
Females
Controls
19
9
1
1
30
Total point
scores
<9
9-12
13-14
15
16
17
>18
Cases
Controls
36
36
30
30
Overall
20-30
Male
1.125 1.26
0.73 0.79
Female
0
0
p-Value
0.000225
0.003
30-40
1.77 1.64
0.011
Prashant V et al.,
Females
DISCUSSION
Prashant V et al.,
29,2010
http://www.framinghamheartstudy.org/
5. Nakken KO, Kornstad S. Do Males 30-50
Years of Age with Chronic Epilepsy and on
Long-Term Anticonvulsant Medication Have
Lower-Than-Expected Risk of Developing
Coronary Heart Disease?, Epilepsia. 1998;
39(3):326-330,
6. Aggarwal A, Kumar M, Faridi MMA. Effect
of Carbamazepine on Serum Lipids and Liver
Function Tests; Indian Pediatrics, 2005;
42:913-918.
7. Nikolaos T, Stylianos G, Chryssoula N, Irini
P,Christos M, Dimitrios T, et al. The effect of
long-term antiepileptic treatment on serum
cholesterol (TC, HDL, LDL) and triglyceride
levels in adult epileptic patients on
monotherepy. Med Sci Monit 2004; 10: 5052.
8. Mintzer S, Skidmore CT, Abidin CJ, Morales
MC, Chervoneva I, Capuzzi DM, Sperling
MR. Effects of antiepileptic drugs on lipids,
homocysteine, and C-reactive protein. Annals
of Neurology. 2009;65: 44856.
9. Zeilthoper S, Doppelbauer A, Tribl G, Leitha
T, Deecke L. Changes in serum lipid pattern
during long term anticonvulsant treatment.
Clin Invest 1993; 71: 574-78.
10. Friedwald WT, Levy RI, Frederickson DS.
Estimation of the concentration of LDL-c in
plasma without use of the preparative
ultracentrifuge. Clin Chem, 1972; 18: 49902.
11. ILAEs 1989 International Classification of
Epilepsies and Epileptic Syndromes,f rom
(1989). Proposal for revised classification of
epilepsies
and
epileptic
syndromes.
Commission
on
Classification
and
Terminology of the International League
Against Epilepsy. Epilepsia.1989;30(4); 38999
12. Granger P, Bilton B, Faure C, Vige X,
Depoortere H, Graham D. et al. Modulation
of the gamma-aminobutyric acid type A
921
Prashant V et al.,
922
Prashant V et al.,
DOI:10.5958/j.2319-5886.2.4.148
Copyright @2013
ISSN: 2319-5886
Accepted: 28th Sep 2013
Background: Healthcare effluent acts as the store house of harmful infectious agents such as the
pathogens and microorganisms possessing multiple drug resistant genes. Potential health risk includes
spreading of diseases by these pathogens and wide dissemination of antimicrobial resistance genes.
Gram-negative bacteria are particularly important for causing most of the hospital and community
acquired infections. Aim: This study was carried out to highlight the incidence of antibiotic resistant
bacteria in hospital generated effluent discharged into municipal sewage system of Sylhet city,
Bangladesh. Methodology: Standard biochemical tests were used to isolate and identify 29 gram
negative bacteria from 6 effluent samples. Antibiotic susceptibility test was assessed by Kirby-Bauer
disc diffusion method. Plasmid isolation and gel electrophoresis were performed using standard
protocols. Results: Antibiogram study showed that the percentage of isolates resistant to amoxicillin,
ceftriaxone, ciprofloxacin, gentamicin, imipenem, azithromycin, andsulphamethoxazole-trimethoprim
were 93.10%, 55.17%, 27.6%, 24.14%, 20.7%, 13.8% and 10.34% respectively. Ten of the isolates
showed resistance to three or more commonly used antibiotics. Plasmid profiles of the multi-drug
resistant isolates showed to harbor two or more plasmids and almost all of them showed a common band
for plasmid DNA size of 24.5kb. Conclusion: Resistance to the bacterial pathogens causing community
acquired infections may, thus, exert a serious public health threat through confining the antibiotic pool.
Hospitals should follow, monitor and regulate proper sanitary measures of hospital generated effluents
to forestall the dissemination of multi drug resistant bacteria transfer from hospital waste to the
environment.
Keywords: multi-drug resistance, hospital effluents, antibiogram, plasmid profiling.
INTRODUCTION
Khan et al.,
923
Khan et al.,
Khan et al.,
RESULTS
925
(A)
(B)
Fig. 1: Antibiogram of two of the isolates- (A) Klebsiella sp. and (B) Pseudomonas sp.
Although, imipenem showed highest sensitivity
pattern to the isolates, both of the two Yersinia
sp. expressed resistance to this antibiotic.
Bacterial isolates resistant to three or more of the
100
90
% of Susceptibility
80
70
Resistant
60
50
40
Moderately
sensitive
30
Sensitive
20
10
0
CTR
AZM
GEN
IPM
CIP
SXT
AMX
Antibiotics
Fig. 2: Comparative antibiogram study of twenty nine isolated bacteria.
Plasmid profiling of ten isolates showed that
eight of the isolates show plasmid DNA of
varying sizes (1.5 kb to 24.5 kb) (Fig. 3and
Table 1). One of the isolates possessed single
band of plasmid while others had more than one
with different sizes as shown in the table. On the
other hand, only two isolates have no plasmid
even though they were resistant to antibiotics.
Khan et al.,
Fig. 3: Agarose gel eletrophoresis of plasmid DNA from ten MDR isolates.
*L= Ladder DNA, P-A=Pseudomonas ATCC, K-A= Klebsiella ATCC
Table: 1. Plasmid profiling and correlation with antibiogram.
Isolates
Antibiotics resistance No. of
pattern
bands
*P-4-5
AMX, CTR, SXT
0
P-1-3
AMX, CTR, CIP, 4
SXT
E-1-4
AMX, CTR, AZM
0
E-3-1
AMX, CTR, CIP
2
S-6-2
AMX, CTR, IPM
1
Y-4-4
AMX, CTR, IPM, CN 2
||
K-1-2
AMX, CTR, CIP, CN 2
K-3-2
AMX, SXT, CN
2
K-2-2
AMX, CTR, CN
2
K-6-4
AMX, CTR, CIP
2
ATCC-Pseudomonas AMX
0
ATCC- Klebsiella
AMX
0
Khan et al.,
927
Khan et al.,
CONCLUSION
Khan et al.,
Khan et al.,
930
DOI:10.5958/j.2319-5886.2.4.149
Copyright @2013
ISSN: 2319-5886
Accepted: 28th Sep 2013
Post Graduate student, Department of Physiology, B.J.Medical College, Ahmedabad, Gujarat, India.
Former Graduate student, Govt. Dental College & Hospital, Ahmedabad, Gujarat, India
Context: The present study evaluated oral hygiene & anomalies of tooth formation and eruption in
adolescents. This was a cross-sectional study, with the primary data was collected from two different
schools in Ahmedabad, Gujarat, India. Aims: Aim of the study was to evaluate oral health that includes
maintenance of oral hygiene and dental anomalies in adolescents of Ahmedabad city. Methods and
Material: In this study, total 500 healthy male and female subjects between 14-16 years of age were
selected for the study and examined for the oral hygiene in the form of cleaning of teeth after all meal,
flossing and regular visit to dentist for check-up. Also they were observed for dental anomalies which
were divided into three types viz. dentitional, occlusal and space anomalies. Comparison of outcome
parameters was calculated with significance test. Results: Awareness of oral hygiene was found
improper in more than half of all adolescents. Occlusal anomalies were found in 48.8% of males &
50.8% of females which were most common among all anomalies. Though all anomalies were more
prevalent in female than male subjects, dentitional anomalies were significantly more in female subject.
Conclusions: Awareness for oral hygiene in adolescent of Ahmedabad city is found to be less. Females
are even less aware than male. Malocclusion is the most common anomaly. All anomalies are more
common in females.
Keywords: Oral hygiene, Anomaly, Mal-occlusion
INTRODUCTION
RESULTS
Table 1: Number of visits to dentist for regular dental check-up
Male subject
Number
Percentage %
169
67.6
55
22
26
10.4
250
Female subject
Number
Percentage %
195
78
46
18.4
9
3.6
250
932
Ankita etal.,
Anomalies
Male
Number
83
122
108
P value
Female
%
33.2
48.8
43.2
Dentitional anomalies
Occlusal anomalies
Space anomalies
*Significant
Awareness of oral hygiene is less in females.
Occlusal anomalies are more predominant among
all anomalies. All anomalies are more prevalent
in females. Dentitional anomalies are
significantly more in females
DISCUSSION
Number
103
128
112
%
41.2
50.8
44.8
< 0.05*
> 0.05
> 0.05
Ankita etal.,
ACKNOWLEDGEMENT
DOI:10.5958/j.2319-5886.2.4.150
Coden: IJMRHS
Copyright @2013
th
Revised: 16 Sep 2013
ISSN: 2319-5886
Accepted: 28th Sep 2013
A hospital based cross sectional study has been conducted in 975 cases to evaluate the prevalence and
pattern of Placental and Umbilical cord abnormalities. All the Placentas with Umbilical cords were
examined for different abnormalities immediately after delivery. Out of 975 specimens, a total of 262
(26.87%) were identified to have various types of abnormalities. Of which, 232 (23.79%) specimens
showed single abnormalities and the remaining 30 (3.07%) specimens were with multiple abnormalities
(more than one abnormalities in each specimen). Prevalence of most of the abnormalities in the present
study is in co ordinance with previous studies and all the abnormalities are distributed among the
specimens in two different forms i.e. specimens with any single abnormally and specimens with multiple
abnormalities.
Keywords: Placental abnormalities, Umbilical Cord abnormalities, IUGR, Circumvallate, Velamentous,
Battledore Placenta
INTRODUCTION
935
RESULTS
Number
abnormalities
(292)
1.12
1.96
3.76
6.5
1.23
1.33
4.1
4.45
1.33
4.45
1.43
4.79
Marginal
Velamentous
Furcate
Single Umbilical Artery
False Knots
True Knots
Uncoiled Cords
Absent Jelly
Short Cords ( 35cm)
Long Cords (75cm)
7.4
0.9
0.7
0.7
4.3
0.2
1.84
0.7
2.46
2.25
24.65
3.08
2.39
2.39
14.38
0.68
6.16
2.39
8.21
7.53
72
9
7
7
42
2
18
7
24
22
936
937
DISCUSSION
CONCLUSION
6. Fernando
Heredia,
Philippee
Jeanty.
Umbilical cord Anomalies (2002). Available
From: http://sonoworld.com/fetus/page.aspx
?id=1149
7. Alain Goriely. Knotted Umbilical cords.
Available
From:
http://math.arizona.
edu/~goriely/Papers/2005-knotbook
(umbilical).pdf
8. Spellacy WN, Graven H, Fish RO. The
Umbilical cord Complications of True Knots,
Nucal coils, Cords around the Boby, Am J
Obstet Gynaecol.1966; 94(8): 1136 42.
9. Balkawade NU, Shinde MA. Study of Length
of Umbilical cord and Fetal outcome: A
Study of 1,000 of 1000 Deliveries. The
Journal of Obstetrics and Gynaecology of
India.2012; 62(5): 520 25.
10. Joan M. Mastrobattista, Eugene CT.
Placenta, Cord and membranes. In: Arthor C.
Fleischer, Eugene C. Toy, Wesley Lee. (7ed).
Sonography in Obstetrics and Gynaecology.
McGraw Hill, New Delhi. 2011:155 84.
11. Rodert D. Harris, Wendy A. Wells, William
C. Black, Jocelyn D. Chertoff, Steven C.
Poplack, Steven K. Sargent, Harte C. Crow.
Accuracy of Prenatal Sonography for
Detecting Circumvallate Placenta. American
Journal of Radiology.1997: 168: 1603-08.
940
DOI:10.5958/j.2319-5886.2.4.151
Copyright @2013
ISSN: 2319-5886
Accepted: 28th Sep 2013
Asst Professor, 2Asst Professor, 3Professor & Head, Dept. of Pediatrics, BLDEUS S. B. M. Patil
Medical College, Bijapur, Karnataka, India
*Corresponding author email: ravikumar8901@gmail.com
ABSTRACT
Baradol etal.,
Baradol etal.,
Table 1: Prevalence of Systolic Hypertension in Rural & Urban Children according to age*.
Table 3: Prevalence of diastolic hypertension in Rural & Urban Children according to age (*)
Baradol etal.,
Table 4: Prevalence of diastolic hypertension in Rural & Urban Children according to sex (*)
Sex
99.1
95.52
92.42
91.12
90
95.8
87.5
80
prevalence (in %)
70
60
Normal
50
PHTN
40
HTN
30
20
10
0.48
0.24
0.45
0.45
10
2.98
11
4.44
4.44
1.5
12
3.74
3.74
13
Age groups (in yrs)
14
2.1 2.1
6.25
15
6.2
16
97.33
95.28
90.7
90
83.46
81.65
75.68
prevalence (in %)
80
70
60
Normal
50
PHTN
40
HTN
30
20
10
0
0.58
0.58
10
1.34
1.33
11
1.72
12
6.76
9.78
10.19
8.26
13 (in yrs)
Age Groups
14
5.23
4.07
15
14.41
9.91
16
Baradol etal.,
DISCUSSION
Baradol etal.,
Baradol etal.,
947
Baradol etal.,
948
Baradol etal.,
DOI:10.5958/j.2319-5886.2.4.152
Copyright @2013
ISSN: 2319-5886
Accepted: 20th Sep 2013
Department of Physiology, Sri Venkateswaraa Medical College Hospital and Research Centre, Pondicherry,
India
2
Department of Physiology, Meenakshi Medical College Hospital and Research Institute, Kanchipuram,
Tamilnadu, India
3
Department of Physiology, Sri Muthukumaran Medical College Hospital and Research Institute, Chennai,
Tamilnadu, India
Background: The prevalence of obesity is increasing globally and in India with lack of sufficient time
for continuous exercise being one of the causes. Performing multiple short bouts of exercise has been
introduced as an alternative method to reduce weight gain. Aim: To determine the effects of different
bouts of supervised exercise accumulated in 30 minutes on weight loss, in overweight Indian female
undergraduate students, without dietary restriction. Methods and Material: Sixty otherwise healthy
overweight female undergraduate medical students aged 18 to 25 years, with a body mass index (BMI)
of 25 to 29.9 kg/m2 were randomly selected and divided into four groups of 15 students each as follows:
Group I: Non-exercising group (controls); Group II: Participants performed one 30 minute bout of
exercise (130 =30min/day); Group III: Participants performed two 15 minute bouts of exercise (215
=30min/day); Group IV: Participants performed three 10 minute bouts of exercise (310=30min/day).
Participants performed moderate intensity exercise using a bicycle ergometer for 16 weeks and their
weight and Body Mass Index were measured before and after the exercise programs and statistically
analyzed. Results: There was a significant weight reduction (p<0.05) in Group II, Group III and Group
IV. Conclusion: Our study revealed that there was significant weight reduction in participants who
performed single or multiple bouts of exercise. The use of accumulated short-bouts of moderate
intensity exercise can therefore be recommended to young overweight females who have difficulty
doing a single long-bout of exercise.
Key words: Exercise; overweight; short-bouts; weight loss.
INTRODUCTION
The prevalence of obesity is increasing globally.
In their review highlighting the Asian Indian
Kavitha etal.,
Kavitha etal.,
METHODS
This study was conducted in the Department of
Physiology of Meenakshi Medical College
Hospital and Research Institute in Kanchipuram
in South India, with the approval of the
Institutional Ethics Committee. Informed consent
was obtained from the all participants.
Sample Size: Sixty otherwise healthy overweight
female undergraduate medical students aged 18
to 25 years, with a body mass index (BMI) of 25
to 29.9 kg/m2 who satisfied the following
inclusion and exclusion criteria were selected
and divided into four groups of 15 students each
by using random sampling method.
Inclusion criteria: Female under graduate
medical students in the age group 18 to 25 years
who were overweight with a BMI of 25 to 29.9
kg/m2 who were staying in the hostel and eating
food provided from the same hostel mess.
Exclusion criteria: Students suffering from
diseases like diabetes mellitus, systemic
hypertension, heart disease, bronchial asthma or
medical problems that could influence heart rate
and/or exercise capacity were excluded from the
study. Students with history of smoking or
alcohol or nicotine intake; or current intake of
any medication; and students following regular
physical exercise or weight reduction programs
were also excluded from the study.
Screening of the participants (consisting of
detailed history including dietary history and
clinical examination) was done. The participants
height was measured by using a calibrated, wallmounted stadiometer while standing straight and
looking forward; weight was measured using a
weighing scale and body mass index was
calculated. Participants were randomly assigned
to the following four groups:
Group I: Non-exercising group (controls)
Group II: Participants performed one 30 minute
bout of exercise per day (130=30 min/day).
Group III: Participants performed two 15 minute
bouts of exercise per day (215 =30 min/day).
951
Kavitha etal.,
Group I
Group II
Group III
Group IV
Age (years)
18 0.98
18 0.75
18 0.12
18 1.22
Height (cm)
158.933.45
158.922.62
158.425.24
157.685.22
Weight(kg)
71.463.09
70.364.6
70.364.6
71.325.00
BMI(kg/m2 )
28.401.08
27.341.22
28.761.02
28.911.03
Group I
Weight (kg)
Pre-training
Post-training
71.463.09
73.634.82
28.41.68
29.022.33
Group II
70.364.60
66.423.4*
27.341.22
25.951.00*
Group III
70.364.60
67.424.54*
28.761.02
27.051.26*
Group IV
71.325.00
67.694.6*
Groups
28.911.09
Data presented as mean standard deviation. *Significant ( p < 0.05 ).
27.750.98*
DISCUSSION
Kavitha etal.,
Kavitha etal.,
954
Kavitha etal.,
DOI:10.5958/j.2319-5886.2.4.153
Copyright @2013
ISSN: 2319-5886
Accepted: 9th Sep 2013
Tutor, 2Professor & Head, Department of Anatomy, Padmashri Dr Vitthalrao Vikhe Patil Medical
College, Ahmednagar, Maharashtra, India
*Corresponding author email: nilesh.rakate19@gmail.com
ABSTRACT
Aim: To compare the differences in the finger print patterns viz., total finger ridge count (TFRC), a-b
ridge count and atd angle in patients with type II diabetes mellitus with non-diabetic as control group
Materials and methods: The study is conducted in 75 type II diabetic patients and 75 non-diabetic
persons as a control group. A sample of 51 male and 24 female patients suffering from type II diabetes
mellitus in the age group of 30 to 60 years has been examined and compared with 75 normal persons (47
males and 28 females) in the same age group to know the difference in fingerprint patterns. We have
also compared total finger ridge count, a-b ridge count and atd angle. For collection of palmar prints
Purvis Smith method has been used. Results: Increase in number of whorls, total finger ridge count, ab ridge count along with wider atd angle in type II diabetes mellitus patients. The result of the present
study is more or less coincides with the observations of the earlier researchers. Conclusion: This
inference may be widely applied clinically for the early diagnosis of type II diabetes mellitus mainly in a
mass screening of a population as an additional diagnostic tool.
Keywords: Type II Diabetes mellitus, Dermatoglyphic patterns, Total finger ridge count, a-b ridge
count, atd angle.
INTRODUCTION
Rakate etal.,
955
Rakate etal.,
RESULT
Pattern
Arch
Plain
Tented arch
Total
Loop
Ulnar
Radial
Total
Plain Whorl
Meet whorl
Whorls Central pocket loop
Double loop
Accidental
Total
Diabetic population
Male
Female
Right
Left
Right
hand
hand
hand
05
10
00
05
06
00
26
00
121
117
69
03
06
01
247
130
79
78
34
07
02
02
22
24
12
12
12
02
01
00
00
347
110
Left
hand
00
00
56
04
43
00
14
03
00
Table 2: Ridge count and atd angle in Diabetic population, Non Diabetic population
Left
hand
74.54
Left
hand
61.89
34.66
35.33
34.42
35.44
35.85
36.78
36.41
36.95
36.19
36.40
37.14
37.75
Diabetic population
Male
Female
Right Left
Right
hand
hand
hand
74.62 73.60
72.70
36
37
atd angle
37.98
39
957
Rakate etal.,
DISCUSSION
2. Diabetes
mellitus
type
2
http://en.wikipedia.org/wiki/Diabetes_mellitu
s_type_2
3. Ravindranath R, Joseph AM, Fluctuating
asymmetry in dermatoglyphics of noninsulin-dependent diabetes mellitus in
Bangalore-based population. Ind J Human
Genetics.2005;11:3: 149-153.
4. Kahn HS, Graff M, Stein AD and Lumey LH.
A fingerprint marker from early gestation
associated with diabetes in middle age. The
Dutch Hunger Winter Families Study.
International Journal of Epidemiology.2009;
38(1):10109.
5. Hirsch W. Dermatoglyphics and creases and
their relationship to clinical syndromes, A
diagnostic criteria in dermatoglyphics an
international perspective. J. Mavalwala
Jamshed.1978; 263282
6. Henry ER. Classification and uses of
fingerprints. London http://www.clpex.com/
Information/ Pioneers/henry-classification.
pdf. 1900.
7. Purvis-Smith SG. Finger and Palm printing
techniques for the clinician. Med J Aust
1969;2:189.
8. Sant SM, Vare AM, Fakruddin S,
Dermatoglyphics in Diabetes Mellitus. J
Anatomical society India. 1983;35(1): 29-32.
9. Knussmann R, Nach ZF, Zwisehen B.
Diabetes Mellitus and Hautleisten system In
Hautleisten and Krankheiten 1971.
10. Barta L, Vari A, Susa E, Dermatoglyphic
patterns of Diabetic children. Acta Paediatric
Acad Sci Hung 1970;11:71-74.
11. Vadgaonkar R, Pai M, Saralaya PL, Vasudha.
Digito-palmar complex in Non-insulin
dependent Diabetes mellitus. Turk J Med Sci
2006;36(6):353-55.
12. Iqbal MA, Sahay BK, Ahuja YR. Finger and
palmar ridge counts in Diabetes mellitus.
Acta Antropogenetica. 1978;2:35-38.
958
Rakate etal.,
959
Rakate etal.,
DOI:10.5958/j.2319-5886.2.4.154
Reader, 2Professor & Head, 3Postgraduate student, Department of Oral Pathology & Microbiology,
School of Dental Sciences, Greater Noida, India
*Corresponding author email: dr.puja.bansal.09@gmail.com
ABSTRACT
Herpes zoster (HZ) is the reactivated form of the Varicella zoster virus (VZV), the same virus
responsible for chickenpox. The condition produces a striking picture, with a blistering, crusting rash
confined to well demarcated areas of the body. Latency is typically life long, and Herpes Zoster is
caused by viral reactivation from the latent state. The survival of Varicella Zoster Virus in human for
several million years attests to its success. Present review provides an overview of the natural history,
epidemiology and possible complications of varicella zoster virus along with diagnosis, prophylaxis and
different treatment modalities.
Keywords: Varicella, Herpes, Shingles
INTRODUCTION
Table.1: Classification, cytopathology, site of latent infection and common associated diseases of human
herpes virus.2,3
Species
Cytopathology
Cytolytic
Site of latent
infection
Neurons
Cytolytic
Neurons
Cytolytic
Neurons
Chickenpox, shingles
Lymphoproliferative
Lymphoid tissues
Infectious mononucleosis
Cytomegalic
Lymphoproliferative
Lymphoid tissues
Lymphoproliferative
Lymphoid tissues
STRUCTURE
Roseola, mononucleosis
syndromes
Currently, no human disease
definitely linked
Suspected association with
Kaposis sarcoma
TREATMENT
Comments
Antivirals reduce both
acute
symptoms
and
subsequent risk of PHN.
Corticosteroids have no
effect on the subsequent
development of PHN and
should be used with
antivirals, never alone;
significant adverse effects
are possible.
*Pain medications
Most will require some type of pain Opioids should be used
*Tramadol
medication.
with caution in elderly
*Oxycodone/acetaminophen
patients.
Prophylactic laxatives and
stool softeners should be
considered when
prescribing opioids.
CONCLUSION
REFERENCES
966
Puja Bansal etal.,
DOI:10.5958/j.2319-5886.2.4.155
Severe Peter plus Syndrome is a rare autosomal recessive condition that is characterized by ocular
anomaly and associated with other systemic major or minor anomalies. Mutations of B3GALTL gene
encoding beta 1,3 glucosyltransferase have been seen in patients with Peter Plus Syndrome.1 We report
a male patient with unusually severe manifestations of Peter Plus Syndrome including prominent
forehead, long area between nose and mouth (philtrum), pronounced double curve of the upper lip,
Anterior Eye Staphyloma (Bilateral), retrognathia, widely spaced nipples and Fallots tetralogy. To our
knowledge Fallot has not been reported previously in Peter plus Syndrome and bilateral anterior
staphyloma, a most severe anterior chamber eye defect i s also apparently rare in this syndrome. Our
patient might represent a new variant of severe Peter plus syndrome w i t h anterior eye Staphyloma and
Fallots tetralogy.
Key words Severe Peter Plus syndrome, Fallots tetralogy, Anterior eye staphyloma, Retrognathia
INTRODUCTION
Dhananjay et al.,
Mutations o f B 3 G A L T L g e n e e n c o d i n g
beta 1,3glucosyltransferase have been seen in
patients with Peter Plus Syndrome4. Less than 70
people with this condition have been reported
worldwide. Patients with this syndrome may also
have shortened upper limbs i.e. rhizomelia and
shortened fingers and toes (brachydactyly)5. It is
Dhananjay et al.,
969
Dhananjay et al.,
DOI:10.5958/j.2319-5886.2.4.156
Copyright @2013
ISSN: 2319-5886
Accepted: 24th Aug 2013
Associate Professor of Surgery, 2 Resident in Surgery, 3Professor & Head, Department of Surgery,
Shri B.M.Patil Medical College, Bijapur, Karnataka, India
*Corresponding author email: babugouda@icloud.com
ABSTRACT
Idiopathic perforation of rectum in newborns is extremely rare. Etiology of spontaneous neonatal rectal
perforation is unknown. We report a case of idiopathic rectal perforation in a neonate who presented
with signs of perforative peritonitis. This case is reported because of its rarity.
Keywords: Rectal perforation, Spontaneous gastrointestinal perforation.
INTRODUCTION
Babu et al.,
conflicts of interest.
Funding Source: Nil
REFERENCES
1. Sharma
SB, Gupta
V, Sharma
V.
Gastrointestinal perforations in neonate with
anorecctal
malformations.
Indian
J
Gastroenterol. 2004;23:107-08.
2. Khan TR et al. Neonatal pnemopertoneum: a
critical appraisal of its causes and subsequent
management from a developing country.
Pediatr Surg Int. 2009;25:1093-97.
3. De Feiter PW, Soeters PB, Dejong CH.
Rectal perforations after barium enema: a
review. Dis Colon Rectum. 2006;49:261-71.
4. Prabhakar G. Spontaneous gastrointestinal
perforation in the neonate. Indian Pediatr.
1991;28:1277-80.
5. Weinberg
G, Kleinhaus
S, Boley SJ.
Ideopathic intestinal perforations in the
newborn: An increasingly common entity. J
Pediatr Surg. 1989;24:1007-08.
971
Babu et al.,
6. Husain
AN, Hong
HY, Gooneratne
S, Muraskas J, Black PR. Segmental absence
of small intestinal musculature. Pediatr
Pathol. 1992;12:407-15.
7. Davies MR, Cywes S, Rode H. Prenatal
perfotion of the extraperitoneal part of the
rectum associated with a developmental
defect
of
the
pelvic
floor.
Z
Kinderchir. 1984;39:271-3.
972
Babu et al.,
DOI:10.5958/j.2319-5886.2.4.157
Post graduate student, 2Professor & Head, 3Associate Professor, Dept of Ophthalmology, Meenakshi
Medical College, Kanchipuram, Tamilnadu, India
4
Associate professor, 5Asst. professor, 6Tutor, 7Professor & HOD, Department of Microbiology,
Meenakshi Medical College, Kanchipuram, Tamilnadu, India
*Corresponding author email: samuelpnrj25@gmail.com
ABSTRACT
The dematiaceous fungi appear to be an increasing cause of human disease. This was a case of a patient
coming with complaints of watering and irritation of right eye following injury to her eye by a stick.
Scrappings from corneal ulcer were sent for gram stain, bacterial and fungal culture. Cladosporium
species of fungus was isolated from a patient who presented with a corneal ulcer not responding to
natamycin drops. Ointment fluconazole was prescribed along with natamycin , moxifloxacin and
atropine drops. The corneal ulcer began to respond and healed completely.
Keywords: Cladosporium, Dematiaceous, Keratomycosis, Conidiophores
INTRODUCTION
CASE REPORT
DISCUSSION
975
DOI:10.5958/j.2319-5886.2.4.158
976
BSA
977
978
proliferative
neurocristic
hamartoma
(neuroectodermal & ectomesenchymal origin15 .
Genetic counseling: It is very important to
reassure the parents of a child with a giant
melanocytic naevus that, the risk of recurrence is
very low in subsequent pregnancies but a few
rare cases have occurred which suggest an
inherited tendency.
Diagnosis &Treatment: MRI scans should be
done in babies with nevi over the cranium or
spine to exclude significant leptomeningeal
melanocytosis.16
Regular
neurological
examination is crucial. The treatment aims at
improving the cosmetic aspect and balancing the
risk of melanoma by excision which may not be
possible in giant melanocytic nevi & periodic
check up to keep an eye out for changes of
malignant transformation. Dermabrasion may
help with a mild reduction in pigmentation.
REFERENCES
Shilpa et al.,
979
Shilpa et al.,
980
DOI: 10.5958/j.2319-5886.2.4.159
Tuberculous meningitis (TBM) is the most common form of central nervous system tuberculosis (TB)
and has very high morbidity and mortality. TBM is a subacute disease with symptoms that may persist
for weeks before diagnosis. Based on the clinical features alone, the diagnosis of TBM can neither be
made nor excluded with certainty. A high clinical suspicion and vigilance is required for early diagnosis
of TBM. The present case report demonstrates a patient with TB meningitis, who presented with clinical
manifestation of isolated left III nerve palsy. Case: A 32 years female was hospitalized with acute onset
of left sided ptosis, diplopia and mild generalized headache. Neurological examination at admission
revealed isolated left III nerve palsy. CT scan and MRI of Brain showed no specific finding. Lumbar
puncture was performed four days later due severe headache, low grade fever and neck rigidity.
Cerebrospinal fluid (CSF) study, raised ESR and positive Montoux Test confirmed the diagnosis of TB
meningitis. Since TB meningitis is a chronic disease, cranial nerve palsies are common manifestations.
This case report suggests that TB meningitis should be considered as a disease of differential diagnosis
for isolated III nerve palsy.
Keywords : III nerve palsy, Tuberculous meningitis, Oculomotor nerve palsy
INTRODUCTION
Laul et al.,
981
CSF study
5th Day
th
14 Day
Cell
count
Protein
Sugar
P/M %
mg/dl
Cloudy
424
Clear
168
Appearance
Initial Pressure
mg/dl
Blood
Sugar
mg/dl
264
16
84
280
112
40
105
146
mm of H2O
21st Day
Clear
46
58
46
108
68
CSF: cerebro-spinal fluid; P: polymorphonuclear leukocytes; M: mononuclear leukocytes.
982
Laul et al.,
Laul et al.,
984
Laul et al.,
DOI:10.5958/j.2319-5886.2.4.160
CASE REPORT
Mehul et al.,
Mehul et al.,
Fig. 2: Genitogram
986
Rectum
Septate Vagina
Urethra
Mehul et al.,
988
Mehul et al.,
DOI:10.5958/j.2319-5886.2.4.161
Copyright @2013
ISSN: 2319-5886
Accepted: 19th Sep 2013
Case report
PRIMARY MALIGNANT MELANOMA OF UTERINE CERVIX: A RARE OCCURRENCE
*Hemalatha AL1, Umarani MK2, Shashikumar SD3
1
Professor & Head, 2Associate Professor, 3Post-graduate student, Department of Pathology, Mysore
Medical College and Research Institute, Irwin Road, Mysore, Karnataka, India
*Corresponding author email: halingappa@gmail.com
ABSTRACT
Primary malignant melanoma of uterine cervix is a rare and aggressive neoplasm. In women, genital
tract is the site of approximately 3%-7%of malignant melanomas. Majority of these occur in vulva or
vagina, but cervix is a rare site. Cervical melanoma is reported in the age range of 19 to 83 years with
peak incidence between 60 to 70years. Malignant melanoma presents with vaginal bleeding or discharge
and appears as exophytic, polypoid, pigmented or colorless cervical mass. Diagnosis is by histopathology which should be confirmed by immunohistochemical staining with S100 protein and HMB45.
Primary cervical melanoma must be differentiated from secondary metastasis of melanoma to the cervix
from other sites in the body. In general, prognosis of primary cervical melanoma is poor, because it is
diagnosed at an advanced stage. No consensus has been established regarding treatment of primary
malignant melanoma of cervix, because of its rarity. Cervical melanoma is incurable in totality with the
currently available therapies and hence it has to be diagnosed early.
A 60 year old woman presented with white discharge per vagina. On examination, there was a bluish
black colored mass arising from the anterior lip of cervix. Following histopathology and other investigations, a diagnosis of primary malignant melanoma of uterine cervix was made. The case is reported for
its rarity.
Keywords: Malignant melanoma, primary, uterine cervix
INTRODUCTION
In 1959, Cid reported the presence of melanocytes in the cervical epithelium of 3.5% of women1 .Since then, in the literature, about 78 cases
of primary malignant melanoma of the uterine
cervix have been reported 2. Primary malignant
melanoma of the cervix is a rare neoplasm. It
constitutes less than 2% of cases of malignant
melanoma of the genital tract3. The diagnosis
may be missed or delayed as it often presents in
Hemalatha et al.,
CASE REPORT
with
prominent
DISCUSSION
Malignant melanomas are generally found in areas of skin exposed to the sun but may also present in nonexposed sites, such as genital tract and
esophagus, among other sites 3. Approximately,
3-7% of malignant melanomas in women develop within genital tract.6 Majority of them occur
in vulva and vagina. Primary cervical melanoma
is a rare entity.
Cervical melanoma arises from melanocytes in
the cervix. The complete spectrum of melanocytic lesions, from benign lentigenes to blue nevi
to melanoma can be seen in the cervical epithelium 3, 4.
Primary malignant melanoma of cervix is very
rare4. A cervical melanoma may be either
melanotic or amelanotic .Diagnosis of
amelanotic melanoma may be missed due to the
990
Hemalatha et al.,
Hemalatha et al.,
CONCLUSION
992
Hemalatha et al.,
DOI:10.5958/j.2319-5886.2.4.162
Visual disturbances have been reported as a consequence of acute severe blood loss. They are related to
hypoperfusion related watershed infarcts in the posterior visual pathway apparatus.
In this case report, we report the clinical course of a young male adult who suffered transient blindness
following an assault in which he sustained deep cuts to the temporal and parietal regions of the scalp. He
was managed in our hospital with copious infusion of intravenous fluid (normal saline) and subsequent
transfusion of 2 pints of whole blood. Blindness persisted from less than one hour following assaut to 96
hours post admission. Blindness resolved completely by the 9th day of admission but was associated
with a homonymous visual field defect.
Keywords: Blindness, cortical, stab wound, blood loss
INTRODUCTION
993
Azonobi et al.,
CASE REPORT
Trauma
Head trauma
Cervical trauma
Iatrogenic
Post cardiac catheterization
Cardiac surgery
Metabolic
Hypoglycemia
Uraemia / Haemodialysis
Acute intermittent porphyria
Miscellaneous
Status epilepticus
Status asthmaticus
Intracranial haemorrhage
Brain tumour
Liver cirrhosis and encephalopathy
Azonobi et al.,
Azonobi et al.,
996
Azonobi et al.,
DOI:10.5958/j.2319-5886.2.4.163
Copyright @2013
ISSN: 2319-5886
Accepted: 22nd Sep 2013
Regauds tumour is a lymphoepithelioma which usually arises in the nasopharynx. Outside the
nasopharynx such lymphoepithelioma like carcinomas are exceedingly rare. Such tumours in the tonsil
are rare. Here we report a 35 year old lady, a case of Regauds tumour involving the Rt. Tonsil.
Tonsillectomy was performed and the patient was subjected to radiotherapy. 2 years follow up showed
no recurrence of tumour.
Keywords: Regauds tumour, Schminkes tumour, Lymphoepithelioma
INTRODUCTION
Muthubabu K et al.,
CASE REPORT
997
Fig.1:
Epithelial
lymphocytes.
islands
surrounded
by
Muthubabu K et al.,
999
Muthubabu K et al.,
DOI:10.5958/j.2319-5886.2.4.164
Copyright @2013
ISSN: 2319-5886
th
Accepted: 29 Sep 2013
Associate Professor, 2Post Graduate, Department of Anatomy, Bangalore Medical College and
Research Institute, Bangalore, Karnataka, India.
*Corresponding author email: rajeshwari.roshan8@gmail.com
ABSTRACT
Brachial plexus is a network of nerves formed at the root of the neck to provide motor and sensory
branches to the upper limb. The major contribution for this plexus is by the anterior primary rami of
C5,6,7,8 and T1. The roots join to form the trunks which in turn divide into anterior and posterior
divisions to form the cords. The knowledge of brachial plexus is important for the anaesthetists while
administering brachial blocks. During routine dissection in a female cadaver aged 65years, the posterior
division of upper trunk fails to fuse with the posterior divisions of the middle and lower trunk and gives
out four branches independently.
Keywords: Brachial plexus, Posterior cord, Radial nerve, Axillary artery.
INTRODUCTION
Rajeshwari et al.,
3.
4.
5.
6.
CONCLUSION
1. Dutta
AK.
Essentials
of
human
Anatomy,superior
and
inferior
Extremities,2nd edition;1995;51-52.
2. Moore KL, Dally AF. Upper limb in
clinically Oriented Anatomy, 5thedition,
Rajeshwari et al.,
1002
Int J Med Res Health Sci. 2013;2(4):1000-1002
DOI:10.5958/j.2319-5886.2.4.165
Rupankar Nath1, Sanju Sharma1, Anshuman Dutta2, Joydeep Roy3, Tulika Singh4
Local anaesthetics are a very important group of drugs in the anaesthetists armamentarium. They have
very widespread use in many branches like surgery, Orthopaedics, ENT, Obstetrics & Gynaecology.
Most popular amide group representative lignocaine is used as its hydrochloride salt at a
concentration of 1 or 2% with or without epinephrine. Though hypersensitivity reactions are rare, they
may occur and varies from life threatening anaphylaxis to less severe delayed type reactions. Here we
are reporting a case of delayed type 4 reaction to lignocaine after supraclavicular brachial plexus block
which was managed conservatively.
Keywords: Lignocaine, Local anaesthetics, Type 4 hypersensitivity, Supraclavicular brachial plexus
block
INTRODUCTION
CASE REPORT
Rupankar et al.,
Rupankar et al.,
They
concluded
that
delayed
type
hypersensitivity to lignocaine may occur more
frequently than previously thought and given its
frequent use, may become widespread.
Duque et al8 described a woman who suffered
eczematous eruption on her face after the
administration of lignocaine and mepivacaine for
dental surgery. Patch test showed delayed type
hypersensitivity to amide local anaesthetics
lignocaine and mepivacaine.
In our case the patient received preservative free
1% lignocaine with adrenaline (1:2, 00,000) for
supraclavicular brachial plexus block.
The
intraoperative and immediate postoperative
period was uneventful. The patient developed
itching and subsequently skin rashes about 16 to
20 hours after administration of Local
anaesthetic. It was diagnosed as urticarial rashes
and the patient was treated conservatively with
anti allergic medications as soon as the rashes
were reported. Patient was advised patch test for
lignocaine for further evaluation; which he
refused. So we could not proceed for further
testing. On clinical grounds it is assumed to be
because of hypersensitivity to lignocaine. We
suspected lignocaine to be the cause because the
preparation was preservative free and no other
drug or sedative were used to supplement the
block. Adrenaline as causative agent was ruled
out because the reaction was localized and also
delayed. On further enquiring it was found that
the patient had no history of exposure to Local
anaesthetics or allergy to any drug or substance.
Moreover he underwent surgery for once only
before this, for putting the implant which he
underwent under general anaesthesia without the
use of local anaesthetic.
After ruling out other probable causes of allergy
we came to conclusion that the reaction was a
true hypersensitivity to lignocaine as the
formulation we used was preservative free. We
finally conclude with a note that allergic
reactions to local anaesthetics though rare can
Rupankar et al.,
REFRENCES
1. Mackley CL, Marks JG, Jr, Anderson BE.
Delayed-Type Hypersensitivity to Lidocaine.
Arch Dermatol. 2003;139(3):343-346.
2. Miller RD, Ed. 7th edn, Anesthesia, Churchill
Livingstone Publisher: 2009; 913-15
3. Giovannitti J, Bennett CR. Assessment of
allergy to local anaesthetics. Journal of
American Dental
Association.
1979;98:701-76.
4. Bircher AJ, Messmer SL, Surber C, Rufli T.
Delayed-type
hypersensitivity
to
subcutaneous lidocaine with tolerance to
articaine: confirmation by in vivo and in vitro
tests. Contact Dermatitis.1996;34:387-89.
5. Whalen JD. Delayed-type hypersensitivity
after subcutaneous administration of amide
anesthetic. Arch Dermatol. 1996;132:125657.
6. Breit S, Rueff F, Przybilla B. Deep impact
contact allergy after subcutaneous injection
of local anesthetics. Contact Dermatitis.
2001;45:296-97.
7. Downs AMR, Lear JT, Wallington TB,
Sansom JE. Contact sensitivity and systemic
reaction to pseudoephedrine and lignocaine.
Contact Dermatitis. 1998;39:33.
8. Duque S, Fernndez L. Delayed-type
hypersensitivity to amide local anesthetics.
Allergol et Immunopathol 2004;32(4):23334.
1005
DOI:10.5958/j.2319-5886.2.4.166
Copyright @2013
ISSN: 2319-5886
Accepted: 28th Sep 2013
Case report
A RARE CASE OF FAMILIAL ADENOMATOUS POLYPOSIS
Saxena D, Akhtar M, *Kundra DN, Zaki M, Rangwala M
Department of Surgery, NKPSIMS & LMH, Nagpur, Maharashtra, India
* Corresponding author email - drdhruvkundra@gmail.com
ABSTRACT
FAP is an autosomal dominant disease characterized by numerous polyps, numbering from hundreds to
thousands, in intestine. It is a very rare condition with incidence ranging from 1 in 6000 to 1 in 12000
births. In absence of surgical intervention, their malignant transformation is inevitable. We report this
case because of its rarity.
Keywords: Familial adenomatous polyposis, Colonoscopy, Adenomatous polyposis coli gene, Ileal
pouch-anal anastomosis
INTRODUCTION
Saxena D et al.,
DISCUSSION
Saxena D et al.,
1008
Saxena D et al.,
DOI:10.5958/j.2319-5886.2.4.167
Resident, 2Assoc. Professor, 3Professor and Head, Department of Pediatrics, Rural Medical College,
Paravara Institute of Medical Sciences, Loni, Maharashtra.
*Corresponding author email: santoshyadav117@gmail.com
ABSTRACT
Ketotic hypoglycemia is the most common form of childhood hypoglycemia. Periods of Hypoglycemic
episodes typically occur during early morning, especially during intercurrent illness when food intake is
limited. The symptoms and signs of hypoglycemia are often overlooked .Because hypoglycemia is a life
threatening event can lead to severe neurological sequel, intravenous administration of glucose is
necessary. These children respond promptly to glucose. We share our experience of four cases of
Ketotic hypoglycemia admitted during last 2 years.
Key words: Hypoglycemia, Ketosis, Ketotic hypoglycemia, Methylcrotonyl-CoAcarboxylase.
INTRODUCTION
Santosh et al.,
Santosh et al.,
DISCUSSION
KH is most commonly seen in early childhood
between 1.5-5years of age. Condition remits
spontaneously by the age of 89 years.
Hypoglycemic episodes typically occur during
periods of intercurrent illness when food intake is
limited. The classic history is of a child, who eats
poorly or completely avoids the evening meal,
who is difficult to arouse from sleep the
following morning, and may have a seizure or be
comatose by early or mid morning. Infants with
this condition do not manifest hypoglycemia due
to frequent breastfeeding.
The etiology of ketotic hypoglycemia may be a
defect in any of the complex steps involved in
protein catabolism, oxidative deamination of
amino acids, transamination, alanine synthesis,
or alanine efflux from muscle. Rarely, inborn
errors of fatty acid metabolism present as ketotic
hypoglycemia, although, typically, fatty acid
1010
oxidation
defects
produce
hypoketotic
1
hypoglycemia . Diet rich in Carbohydrates and
Protein with more frequent feeding is the
recommended
treatment
for
ketotic
hypoglycemia. The appearance of ketone in
urine precedes hypoglycemia by several hours.
Parents are advised to test the child's urine for the
presence of ketones. In the presence of ketonuria,
liquids of high carbohydrate content should be
given. Patient requires hospitalization in case if
oral feeding is not tolerated. During the
intercurrent illness, if frequent estimations and
early detection of urinary ketones done at home,
hypoglycemia can be prevented (as ketones are
detected in urine much before hypoglycemia).
Other causes of hypoglycemia with ketosis
Adrenal insufficiency, Hypopituitarism, Glucose6-phosphatase debrancher defect, Fructose-1, 6diphosphatase defect, Galactosemia, glycogen
storage disease, fatty acid oxidation defects.
Adrenal
insufficiency,
Hypopituitarism,
glycogen storage disease, galactosemia could be
the other cause in children and infants with
seizures, drowinessor coma in the morning.
Glucose-6-phosphatase
debrancher
defect,
Fructose-1,6-diphosphatase defect have moderate
hepatomegaly. Fatty acid oxidation defects
usually do not manifest as ketosis. More
advanced investigations like estimation serum
levels of alanine, insulin, and lactate before and
after deliberate fasting for 24-36 hours are not
done in our cases due to non availability and
economic reasons.
3-Methylcrotonyl-CoA Carboxylase (3-MCC)
Deficiency: 3-Methylcrotonyl-CoA Carboxylase
(3-MCC) deficiency has been recognized since
19847.It is a defect in the degradation of the
amino
acid
leucine
which
is
glucogenicaminoacid7. The clinical presentations
of 3-MCC deficiency range from mild to severe
illness. The age of onset of 3-MethylcrotonylCoA
Carboxylase
(3-MCC)
deficiency
symptoms is between 1-5 years. Clinical
presentation is often with infection, illness, or
after fasting. Most common symptoms are
vomiting, lethargy, hypotonia, apnea, or
Santosh et al.,
CONCLUSION
1011
REFERENCES
1. Mark A.Sperling. Nelson text book of
pediatrics, Elsevier, 19th edition 2012 ; 52830.
2. Mitchell GA, Fu Kao T. Inborn error of
ketone metabolism.In: Scriver CR, Baudet
AL. The Metabolic and Molecular Bases of
Inherited Disease..New York: McGraw-hill
Co. Inc.;2001;2(Chap. 102):2327-35
3. http://www.perkinelmer.com/Industries/Healt
hcare/NewbornTestingServices/ClinicianInformation /3-Methylcrotonyl-CoACarboxylase-Deficiency-(3MCCDeficiency).xhtml
4. Koeberl DD, Millington DS, Smith WE.
Evaluation of 3methylcrotonyl-CoA
carboxylase deficiency detected by tandem
mass spectrometry newborn screening. J
Inherit Metab Dis 2003; 26:25-35.
5. Baumgatner, Baumgatner MR. Molecular
mechanism of dominant expression in 3methylcrotonyl CoA carboxylase deficiency.
J Inherit Metab Dis 2005; 28:301-09
6. Dantas, Dantas MF, Suormala T, Randolph
A. 3-Methylcrotonyl-CoA
carboxylase
deficiency: Mutation analysis in 28 probands,
9 symptomatic and 19 detected by newborn
screening. Hum Mutat 2005; 26:164.
7. Satyanarayan U. Metabolism of amnoacids.
Biochemistry. 2010;15;364-66.
8. William L Nyhan. Abnormalities in
aminoacid metabolism in clinical medicine ;
Appleton-Century-Crofts 1984;chapter 5; 6578
1012
Santosh et al.,
DOI:10.5958/j.2319-5886.2.4.168
1
2
Training Medical officer (Resident), Medicine, Hayatabad Medical Complex, Peshawar, Pakistan
Medical officer, Peshawar Health Clinic, Peshawar, Pakistan
Kikuchi-Fujimoto disease (KFD) is a self-limited pathological entity that is benign in its course. The
main features of this disease are tender regional cervical lymphadenopathy, usually accompanied by
low-grade fever and night sweats. Less frequently patients may report weight loss, nausea, vomiting, and
sore throat. Often referred to as KFD; Kikuchi-Fujimoto disease has a global prevalence with high report
rates from Japan and other Asian regions. That said, it is a very uncommon case to encounter due to its
rare occurrence. A viral causation is suggested keeping in view the clinical presentation, the histology
and immunohistochemical pattern. The recommended procedure to diagnose this disease is an excisional
biopsy of an affected lymph node. This histopathologic analysis is essential for the clinician to
differentiate it from similarly presenting conditions like tuberculous lymphadenitis (scrofula), lupus
(SLE) or malignant lymphoma to state a few. This is especially pertinent in regions where there is a high
index of suspicion for tuberculosis given its high prevalence, like Pakistan and India for example. It is
also essential to inculcate an understanding of this clinically and histopathologically challenging disease
amongst physicians and pathologists alike to decrease the risk of misdiagnosis. Steps to increase
awareness will also help curb the excessive costs and unnecessary interventions that go with wrong
diagnoses. In young patients who present with lymph node enlargement in the posterior cervical chain; a
biopsied node showing cellular and nuclear fragmentation along with features of necrosis should incite
the consideration of KFD amongst other differentials. Once diagnosed; symptomatic treatment with
NSAIDs, analgesics, antipyretics and in some cases corticosteroids is sufficient as the self limited
disease resolves by itself within a period of 1 month in most cases. It is unlikely to stretch beyond 4
months. Patients with KFD are followed for many years nonetheless, since these patients are at a slightly
increased risk of developing systemic lupus erythmatosus later in life than the general population.
The case we report is that of an 18 year old female patient who presented with a month history of low
grade fever, night sweats and cervical lymphadenopathy, which was minimally tender. She was initially
labeled as a case of tuberculous lymphadenitis and put on antituberculous therapy. However, she did not
respond and further diagnostic studies revealed the presence of KFD.
Keywords: Cervical lymphadenopathy, Kikuchi-Fujimoto disease, Self-limiting
1013
Saleem et al.,
CASE REPORT
Saleem et al.,
Saleem et al.,
5.
CONCLUSION
6.
7.
8.
9.
10.
REFERENCES
1.
2.
3.
4.
11.
12.
13.
Saleem et al.,
DOI:10.5958/j.2319-5886.2.4.169
A Meckel's diverticulum, a true congenital diverticulum, a vestigial remnant .It connects the yolk sac to
the small intestine in the early embryonic life. It remains without symptoms. In the children symptoms
occur below 2 years. It may contain heterotopic gastric, pancreatic tissue. Presentation can include
gastrointestinal bleeding, obstruction, perforation, and volvulus. Because of this wide range of clinical
scenarios it is important for a clinician to have a high index of suspicion to prevent significant
complications. Investigations like Ultrasonography, Computed tomography (CT scans) and Technetium
99m pertechnate scan helps in diagnosis Treatment is surgical. We are presenting the management of the
six cases supported by a review of the literature. The five patients presented with complications and
needed emergency operation. This is from the rural set up where the advance facilities are limited. The
knowledge of its anatomical and patho-physiological properties is essential to deal with such
complications.
Keywords: Meckel's Diverticulum, Volvulus, Perforation, Gangreen.
INTRODUCTION
According to Dr Charles Mayo, a Meckel's
diverticulum is frequently suspected, often
sought for and seldom found. 1 An accepted
incident of Meckels diverticulum is 1 to 3
percent. There are many complications related to
Meckel's diverticula . It is difficult to diagnose
Meckels diverticulum clinically and by modern
imaging technique. Depending on the type of the
anomaly patients may be completely symptom
free or may present with the complications with
the chronic abdominal pain. The presentation in
Meena H et al.,
1017
Case report
Case 1: A five year old boy diagnosed as acute
appendicitis. He was taken for emergency
operation. Laparotomy reveled inflamed and
obstructed Meckel's diverticulum. The obstructed
part resected and ileoileal anastomosis was
done. Histopathology confirmed the diagnosis.
Case 2: A 6 years old boy Presented with
chronic pain in abdomen. His ultrasonography
showed inflamed Meckel's diverticulum. He
underwent elective laparotomy. There was a
band extending from the ileum to the umbilicus.
At the umbilicus there was cystic swelling. (Fig.
1) There was no communication between the cyst
and the umbilicus. Resection and anastomosis
with excision of the band and cyst was done. The
postoperative
course
was
uneventful.
Histopathology confirmed the diagnosis.
Case 3: Ten years old boy presented in the
emergency with the signs suggestive peritonitis.
He underwent emergency laparotomy. There was
perforation of Meckel's diverticulum at its base.
(Image no2) .Resection and anastomosis was
done. The postoperative course was uneventful.
Histopathology confirmed the diagnosis. [Fig 2]
Case 4: Thirteen-year-old boy was presented
with intestinal obstruction. Plain x-ray abdomenerect and USG abdomen confirmed the
diagnosis. Except leucocytosis all other blood
report
were
normal.
The laparotomy showed
gangrenous small
bowel around the constricting band of Meckel's
diverticulum. The affected part excised and
anastomosis
was
done.
Histopathology
confirmed the diagnosis.
Case 5: Eighteen year-old boy was presented
with signs and symptoms of intestinal
obstruction in shock. He was operated for acute
appendicitis six months back by the Mac
Burneys incision. He had leucocytosis, decreased
platelet count, Raised blood urea and creatinine.
He was taken for emergency surgery. On
exploring the abdomen, we found the small
bowel volvulus with extensive gangrene due the
band extending from small intestine to the
umbilicus. Resection and anastomosis was
Meena H et al.,
Fig.3: Arrow
sdiverticulum
shows
gangrene
of
meckel
DISCUSSION
1019
Meena H et al.,
1020
Meena H et al.,
DOI:10.5958/j.2319-5886.2.4.170
ISSN: 2319-5886
Accepted: 29th Sep 2013
PG student, 2Professor & Head, 3Professor, Department of Pediatrics, Rural Medical College, PIMS,
Loni, Maharashtra
*Corresponding author email: amityadav1985.ay@gmail.com
ABSTRACT
Vitamin K deficiency bleeding (VKDB) according to recent studies is the preferred term for
hemorrhagic disease of the newborn (HDN). This is due to deficiency of clotting factors as a result of
vitamin K deficiency. VKDB was first described over a hundred years ago but its relationship to vitamin
K was not released until 40 years later. Vitamin K is required for the production of clotting factors II,
VII, IX and X. It is involved in the normal clotting of blood, is present in some plants and is also
synthesized by some E. coli in the gut. Due to low levels of vitamin K all newborn infants are at risk of
developing hemorrhagic disease of the newborn. The body has very limited ability to store the vitamin.
We present an unusual case of Neonatal Hepatitis due to CMV as a rare cause of late onset vitamin kdeficiency bleeding.
Keywords: Cholestatic liver disease, Vitamin K, Vitamin K deficiency bleeding.
INTRODUCTION
AmitYadav et al.,
AmitYadav et al.,
AmitYadav et al.,
DOI:10.5958/j.2319-5886.2.4.171
Copyright @2013
ISSN: 2319-5886
Accepted: 29th Sep 2013
SPERM
GRANULOMA
IN
AN
Epididymal sperm granuloma as a cause of granulomatous epididymitis is rare. Most of the cases are
found post vasectomy as part of the late vasectomy syndrome. These lesions are known to mimic other
conditions including testicular malignancies. We report this interesting case of an epididymal sperm
granuloma which was not only an incidental finding in an orchidectomy specimen of a 55 year old male
with no antecedent history of surgery, trauma or clinical infection but also mimicked a testicular tumor.
Keywords Epididymitis, Sperm granuloma,Vasectomy
INTRODUCTION
Vandana et al.,
CASE REPORT
Vandana et al.,
1026
Vandana et al.,
DOI:10.5958/j.2319-5886.2.4.172
Copyright @2013
ISSN: 2319-5886
Accepted: 29th Sep 2013
Kikuchi disease is a rare benign self limited lymphadenopathy. It is often associated with Systemic
Lupus Erythematosus which can be diagnosed before; at the same time or after a diagnosis of Kikuchi
disease is made. Again SLE is usually associated with APLA syndrome. Furthermore both SLE and
Kikuchi disease can be complicated by HPS. We present a unique case in which Kikuchi disease and
SLE were diagnosed together and disease course was complicated by Hemophagocytic syndrome (HPS).
SLE was also associated with Anti Phospholipid Antibody Syndrome (APS) in this patient.
Keywords: Kikuchi, SLE, APLA, Hemophagocytic syndrome
INTRODUCTION
Kikuchi disease or histiocytic necrotizing
lymphadenitis a rare, benign, self limiting
cervical lymphadenitis of unknown etiology1
mainly affecting young adults with females
outnumbering males.2 Sometimes association
with SLE
has led to the probability of
autoimmune etiology being one of factors
leading to Kikuchi disease. SLE is probably the
most common underlying diseases of APLA
syndrome.3 Hemophagocytic syndrome is a rare
but potentially fatal disease of normal but
overactive histiocytes and lymphocytes often
complicating connective tissue disorder &
haematological malignancies. Kikuchi disease
can independently lead to hemophagocytic
syndrome in rare instances. Kikuchi disease and
SLE with APLA syndrome can coexist rarely &
may be complicated
syndrome.
by
hemophagocytic
Koushik et al.,
CASE REPORT
Koushik et al.,
1028
Koushik et al.,
Koushik et al.,
REFERENCES
1. Kikuchi M. Lymphadenitis showing focal
reticulum cell hyperplasia with nuclear debris
and
phagocytes. Acta
haematologica
Japonica. 1972;35:37980.
2. Fujimoto Y, Kojima Y,. Yamaguchi K.
Cervical
Subacute
necrotizing
lymphadenitits. Naika.1972, 20:92027.
3. Khanna D, Shrivastava A, Malur PR, Kangle
R. Necrotizing lymphadenitis in systemic
lupus erythematosus: is it kikuchi-fujimoto
disease? Journal of Clinical Rheumatology.
2010;16(3):12324
4. Londhey VA, Buche AS, Kini SH,
Rajadhyaksha GC. Kikuchi fujimoto disease
and systemic lupus erythematosusa rare
association, Journal of Association of
Physicians of India. 2010;58(10):64243.
5. Chen HC, Lai JH, Huang GS. Systemic lupus
erythematosus with simultaneous onset of
1030
1031
Koushik et al.,
DOI:10.5958/j.2319-5886.2.4.173
Copyright @2013
ISSN: 2319-5886
Accepted: 20th Sep 2013
Endometriosis affecting the urinary tract is rare and when involved it predominantly affects the bladder,
followed by the ureter. The diagnosis of bladder endometriosis is difficult because of its varied clinical
presentation. Here we report a case of bladder endometriosis, which was suspected pre-operatively and
was confirmed after the histo pathological examination of the excised tissue.
Key words: Extra genital Endometriosis, Bladder Endometriosis, Vesical Endometriosis
INTRODUCTION
CASE REPORT
1032
1033
Ureteric orifice
Fig1: Picture showing bluish nodules around the
ureteric orifice at cystoscopy
An 18years old male patient had undergone surgery for a giant cell tumour upper end of the right radius
in Jan 2007. The tumour recurred within two months. Patient took alternative methods of treatment
including indigenous medicines for the condition; all these failed and the patient was advised an above
elbow amputation. By Sep 2008 the tumour had grown to a 14x11x11 swelling in the forearm
extending to the distal arm with neurovascular involvement. A total resection of the tumour was done;
vascular continuity of the brachial to the ulnar artery was done with a vein graft to salvage the limb. In
2012 tendon transfer was done to restore function to the wrist. Now there is no recurrence of the tumour
and the patient has a fully functional limb.
Keywords: Giant cell tumour; proximal end radius; recurrent; salvage of limb; functional limb
INTRODUCTION
Ravishanker etal.,
1038
Int J Med Res Health Sci. 2013;2(4):1036-1039
REFERENCES
Ravishanker etal.,
1039
Int J Med Res Health Sci. 2013;2(4):1036-1039