Numrul total de ore (pe semestru) din

planul de nvmnt
(40 SEM.I)

FIA DISCIPLINEI

Denumirea disciplinei
Anul de studiu

PHYSIOPATHOLOGY
III

II Tipul de evaluare final (E / V / C)

Semestrul *

Regimul disciplinei (Ob obligatorie, Op opional, F - facultativ)

Total ore din planul de nvmnt
Titularul disciplinei

44

Total ore de studiu

individual

Ob

Numrul de credite

100

Total ore pe
semestru

44

Prof. Dr. Magda Bdescu

* Dac disciplina are mai multe semestre de studiu, se completeaz cte o fi pentru
fiecare semestru
Facultatea
Catedra

Medicine
Total

44
Profilul
Specializarea

C**

20

24

Medicine
General Medicine

** C curs, L activiti de laborator, P proiect

sau lucrri practice

Obiectivele disciplinei
1. Understand how the normal regulation and integration of physiological systems are altered
by diseases.
2. In-depth knowledge of specific mechanisms that lead to the alterated functions in
cardiovascular, lung, renal, digestive, and blood diseases.
3. Develop skills in laboratory techniques that are integral to the study of pathophysiology.
4. Develop skills in the analysis of data and presentation of results through written reports.
Coninutul disciplinei

Nr. ore

Curs (20 ore)

GENERAL PATHOPHYSIOLOGY
1. PATHOHYSIOLOGY OF CARBOHYDRATE METABOLISM
Diabetes mellitus (DM)
Hypoglycemia

E1

2. PATHOHYSIOLOGY OF ACID-BASE, FLUID AND

ELECTROLYTES BALANCE
Pathophysiology of ECF volume depletion and exces
Pathophysiology of of sodium, potassiumand calcium metabolism
PATHOHYSIOLOGY OF ACID-BASE BALANCE
Metabolic and respiratory acidosis
Metabolic and respiratory alkalosis
3. PATHOHYSIOLOGY OF CANCEROGENESIS AND TUMORAL
PROGRESSION
- Cancer etiology
- Hypotheses of the origin of cancer (viral, genetic, epigenetic,
immunologic)
- Multiple step evolution of cancer
II. PATHOPHYSIOLOGY OF BODY SYSTEMS

4. PATHOPHYSIOLOGY OF BLOOD CELLS

Pathophysiology of anemias
Pathophysiology of polyglobulia
5. PATHOPHYSIOLOGY OF HEMOSTASIS
PATHOPHYSIOLOGY OF PRIMARY HEMOSTASIS
Vascular and platelet bleeding syndromes
PATHOPHYSIOLOGY OF SECONDARY HEMOSTASIS
Hereditary and acquired coagulation disorders
6. PATHOPHYSIOLOGY OF GASTROINTESTINAL SYSTEM
Pathophysiology of oral cavity and esophagus
Pathophysiology of gastritis
Pathophysiology of gastro-duodenal ulcer
Pathophysiology of intestinal diseases and malabsorbtion
7. PATHOPHYSIOLOGY OF EXOCRINE PANCREAS AND LIVER
Pathophysiology of pancreatitis
Pathophysiology of liver failure
8. PATHOPHYSIOLOGY OF NEFRONS
Pathological changes of glomerular filtration and tubular functions
Pathophysiology of nephrotic syndrome
9. PATHOPHYSIOLOGY OF RENAL FAILURE
Pathophysiology of acute renal failure
Pathophysiology of chronic renal failure
10. PATHOPHYSIOLOGY OF ENDOCRINE SYSTEM
Mecanisms of endocrine control
General aspects of altered endocrine functions
TOTAL CURSURI

20

Lucrari practice (24 ore)

1. Red blood cell disorders screening tests

2. Red blood cell disorders analytical tests

3. Primary hemostasis diagnostic tests in vascular and platelet bleedings

4. Secondary hemostasis- diagnostic tests in coagulation disorders

5. Esophageal and gastric disorders - diagnostic tests

6. Intestinal and pancreatic disorders diagnostic tests

7. Liver and biliary tract disorders diagnostic tests

8. Renal disorders I - static tests

9. Renal disorders II dynamic tests

10. Hidroelectrolytic and acid-base metabolism disorders diagnostic tests

11. Carbohydrate metabolism disorders diagnostic tests

12. Endocrine disorders diagnostic tests

2
TOTAL LUCRARI PRACTICE

24

Ponderea n notare exprimat n

procente
(Total = 100%)

La stabilirea notei finale se iau n considerare

- rspunsurile la examen / colocviu (evaluarea final):

50%

- rspunsurile finale la lucrrile practice de laborator

35%

- testarea periodic prin lucrri de control

15%

- activitile gen teme / referate / eseuri / traduceri /

proiecte etc.

- alte activiti (PRECIZAI) : colocviu

Descriei modalitatea practic de evaluare final E/V (de exemplu: lucrare scris (descriptiv i
/ sau test gril i / sau probleme etc.), examinare oral, colocviu individual ori n grup, proiect,
etc.)
- Asignments (3) and midterm test
- Final examination: practical and written (60 MCQ) examination
Estimai timpul total (ore pe semestru) al activitilor de studiu individual pretinse
studentului
(completai cu 0 activitile care nu sunt cerute)
10
1. Descifrarea i studiul notielor de curs
8. Pregtire prezentri orale
0
2. Studiu dup manual, suport de curs

20

9. Pregtire examinare final

10

3. Studiul bibliografiei minimale indicate

4. Documentare suplimentar n
bibliotec
5. Activitate specific de pregtire
SEMINAR i / sau LABORATOR
6. Realizare teme, referate, eseuri,
traduceri, etc.
7. Pregtire lucrri de control

10

10. Consultaii

10

11. Documentare pe teren

10

12. Documentare pe Internet

10

13. Alte activiti ....

10

14. Alte activiti ....

TOTAL ore studiu individual (pe

semestru) = 165

References for the study of Pathophysiology

Required references
1. Colev Luca V., Mocanu V., Vornicu M., Musta G.T., Pathophysiology course,
Litografia UMF Iai, 2000
2. Colev Luca V., Mocanu V., Vornicu M., Musta G.T., Handbook of practical
pathophysiology, Litografia UMF Iai, 1999
Recommended references
1. Kumar V., Abbas A.K., Fausto N., Robbins & Cotran Pathologic Basis of Disease,
7th edition, Elsevier Health Sciences, 2004
2. Porth Carol Marttsen, Matfin Glenn, Essentials in pathophysiology: concepts of
altered health states, Philadelphia: Lippincott Williams & Wilkins, 2007
3. Porth Carol Marttsen, Matfin Glenn, Pathophysiology: concepts of altered health
states, 8th edition, New York: Wolters Kluwer, 2009
4. Riede U.N., Werner M., Color atlas of pathology, Stuttgart - New York,Thieme, 2004
5. Silbernagl S., Lang F., Color atlas of pathophysiology, Stuttgart - New York, Thieme,
2000
6. CHETA D.M. Preventing Diabetes: Theory, Practice and New Approaches, John
Wiley & Sons, Chichester, UK, 1999 (187 p.)

Data completrii: 2012

Coordonator of Patophysiology Department,

Prof. Dr. Magda Badescu