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Introduction:
Aspiration of arterial blood during systole with reinfusion during diastole decreased
cardiac work without compromising coronary perfusion Harkin-1960s
Intravascular volume displacement with latex balloons - early 1960s
The Intra-aortic balloon pump (IABP) is a mechanical device that is used to decrease
myocardial oxygen demand, left ventricular systolic work, left ventricular end-diastolic
pressure, and wall tension while at the same time increasing cardiac output. By increasing
cardiac output it also increases coronary blood flow and therefore myocardial oxygen delivery.
The primary goals of IABP treatment are to increase myocardial oxygen supply and
decrease myocardial oxygen demand. Secondary, improvement of cardiac output (CO),
ejection fraction (EF), an increase of coronary perfusion pressure, systemic perfusion and a
decrease of heart rate, systemic vascular resistance occur.
Principles of the IABP
Counterpulsation: A technique that synchronizes the external pumping of blood with the
heart's cycle to assist the circulation and decreasing the work of the heart.
Counterpulsation pumps when the heart is resting to increase blood flow and oxygen to
the heart. Counterpulsation stops pumping when the heart is working to decrease the
heart's workload and lessen oxygen demand.
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INSERTION TECHNIQUES
Since 1979, a percutaneous placement of the IAB via the femoral artery using a modified
Seldinger technique allows an easy and rapid insertion in the majority of situations. After
puncture of the femoral artery a J-shaped guide wire is inserted to the level of the aortic
arch and then the needle is removed. The arterial puncture side is enlarged with the
successive placement of an 8 to 10,5Fr dilator/sheath combination. Only the dilator needs
to be removed.
Continuing, the balloon is threaded over the guide wire into the descending aorta just
below the left subclavian artery. The sheath is gently pulled back to connect with the
leak-proof cuff on the balloon hub, ideally so that the entire sheath is out of the arterial
lumen to minimize risk of ischemic complications to the distal extremity. Recently
sheathless insertion kits are available. Removal of a percutaneously placed IAB may
either be via surgical removal or closed technique. There are alternative routes for
balloon insertion. In patients with extremely severe peripheral vascular disease or in
pediatric patients the ascending aorta or the aortic arch may be entered for balloon
insertion. Other routes of access include subclavian, axillary or iliac arteries
It is inserted into the descending aorta via the femoral artery either percutaneously
or by surgical cut-down.
It should be positioned so that the tip is approximately 1 to 2 cm below the origin of the
left subclavian artery and above the renal arteries.
After correct placement of the IAB in the descending aorta with it`s tip at the distal aortic
arch (below the origin of the left subclavian artery) the balloon is connected to a drive console.
The console itself consists of a pressurized gas reservoir, a monitor for ECG and pressure wave
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recording, adjustments for inflation/deflation timing, triggering selection switches and battery
back-up power sources. The gases used for inflation are either helium or carbon dioxide. The
advantage of helium is its lower density and therefore a better rapid diffusion coefficient.
Whereas carbon dioxide has an increased solubility in blood and thereby reduces the potential
consequences of gas embolization following a balloon rupture.
Correct positioning is critical in order to avoid blocking off the subclavian or renal
arteries. So placement if confirmed by flouroscopy or Chest X-ray. The tip should be visible
between 2nd and 3rd intercostal space.
Table 1: Hemodynamic effects of IABP Therapy
1. Patient Hemodynamics
Heart Rate, Stroke Volume, Mean Arterial Pressure, System Vascular Resistance
2. Intra-Aortic Balloon
IAB in Sheath, IAB Position, Kink in IAB Catheter, IAB Leak, Low Helium
Concentration
3. IABP
Timing, IAB Augmentation Control (Inflation & Deflation)
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Inflation of IABP:
The balloon is inflated during diastole in sync with the closure of the aortic valve.
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The blood in the aortic arch above the level of the balloon is pushed backward providing
increased coronary artery blood flow and increased myocardial oxygen supply.
Inflation of IABP Causes
o Increased coronary perfusion pressure
o Increased systemic perfusion pressure
o Increased O2 supply to both the coronary and peripheral tissue
o Increased baroreceptor response
o Decreased sympathetic stimulation causing decreased Heart Rate, decreased
Systemic Vascular Resistance, and increased Left Ventricular function
Deflation OF IABP
The balloon rapidly deflates just before ventricular systole to reduce Left Ventricular
work helps to decrease afterload.
The space where the balloon was inflated creates an empty space where the blood doesn't
have to flow against any resistance.
Deflation causes
o Deflation creates a "potential space" in the aorta, reducing aortic volume and
pressure
o Afterload reduction and therefore a reduction in myocardial oxygen consumption
(MVO2)
o Reduction in peak systolic pressure, therefore a reduction in LV work
o Increased Cardiac Output
o Improved ejection fraction (The amount of blood pumped out of a ventricle
during each heart beat. The ejection fraction evaluates how well the heart is
pumping; Normally 50 - 70 percent) and forward flow
Preload is defined as the amount of blood volume or pressure in the left ventricle at the end
of diastole (i.e. the resting phase of the heart). Factors affecting preload include:
Aortic insufficiency
Circulating blood volume
Mitral valve disease
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Inflation of the balloon occurs at the onset of diastole. At the beginning of diastole,
maximum aortic blood volume is available for displacement because the left ventricle has
just finished contracting and is beginning to relax, the aortic valve is closed, and the
blood has not had an opportunity to flow systemically.
The pressure wave that is created by inflation forces blood superiorly into the coronary
arteries.This helps perfuse the heart.
Blood is also forced inferiorly increasing perfusion to distal organs (brain, kidneys,
tissues, etc.)
The left ventricle does not have to generate as much pressure to achieve ejection since the
blood has been forced from the aorta.
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This lower ejection pressure reduces the amount of work the heart has to do resulting in
lower myocardial oxygen demand.
The pressure that the LV must generate is less throughout the systolic phase. Therefore,
afterload is reduced which decreases myocardial oxygen demands.
Reduced afterload allows the LV to empty more effectively so SV (stroke volume) is
increased.
Also decreases the amount of blood shunted from left to right in cases of intraventricular
septal defects.
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Schematic representation of coronary blood flow, aortic and left ventricular pressure wave
form with / without IABP. (Effects on DPTI and TTI . Balloon inflation during diastole
augments diastolic pressure and increases coronary perfusion pressure as well as
improving the relationship between myocardial oxygen supply and demand (DPTI:TTI
ratio)
CONTROL OF THE IABP
TRIGGERING
To achieve optimal effect of counterpulsation, inflation and deflation need to be correctly
timed to the patients cardiac cycle. This is accomplished by either using the patients ECG
signal, the patients arterial waveform or an intrinsic pump rate. The most common method of
triggering the IAB is from the R wave of the patients ECG signal. Mainly balloon inflation is set
automatically to start in the middle of the T wave and to deflate prior to the ending QRS
complex. Tachyarrhythmias, cardiac pacemaker function and poor ECG signals may cause
difficulties in obtaining synchronization when the ECG mode is used. In such cases the arterial
waveform for triggering may be used.
TIMING and WEANING
It is important that the inflation of the IAB occurs at the beginning of diastole, noted on the
dicrotic notch on the arterial waveform. Deflation of the balloon should occur immediately prior
to the arterial upstroke. Balloon synchronization starts usually at a beat ratio of 1:2.
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TIMING ERRORS
1. Early Inflation - Inflation of the IAB prior to aortic valve closure
Waveform Characteristics :
Inflation of IAB prior to dicrotic notch.
Diastolic augmentation encroaches onto systole, (may be unable to distinguish).
Physiologic effects:
Potential premature closure of the aortic valve.
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Waveform Characteristics:
Physiologic Effects:
- Sub-optimal coronary artery perfusion
- Sub-optimal diastolic augmentation
3. Early Deflation - Premature deflation of the IAB during the diastolic phase
Waveform Characteristics
Assisted aortic end diastolic pressure may be <= the unassisted aortic end diastolic
pressure.
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Physiologic Effects:
- Sub-optimal coronary perfusion
- Potential for retrograde coronary blood flow
- Angina may occur as a result of retrograde
Waveform Characteristics:
Assisted aortic end diastolic pressure may be equal to the unassisted aortic end diastolic
pressure.
Rate of rise of assisted systole is prolonged.
Physiologic Effects:
Afterload reduction is essentially absent.
Increased MV02 consumption due to the left ventricle ejecting against a greater resistance
IAB may impede left ventricular ejection and increase the afterload
INDICATIONS
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Sheathless insertion with severe obesity, scarring of the groin, or other contraindications
to percutaneous insertion
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