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Inside a Microchip
Cortex
Medulla
Source: Vanders Human Physiology. MCGraw-Hill Higher Education
Filtered
Excreted
Reabsorbed
% Filtered
load reabs.
180
1.5
178.5
99.2
25,200
150
25,050
99.4
720
100
620
86.1
10
530
98.2
Water
b
Na+
b
K+
b
Caa 2+
c540
0.6%
99.2%
98.6%
4
3
2
1
0
100
99
98
97
Fractional Reabsorption (% )
96
Kf = Filtration Coefficient of
glomerular bed
1 sq meter
Aquaporins-2, 3 & 4
Aquaporin-1
is
how
out in
At Whole Kidney
At Whole Kidney
Future Perspectives
Application of principles of operation will provide:
Better understanding of normal kidney function
Newer insights into the disease processes
Rationalization of drug development
Help identify effect of drug interactions based on process flow
Open a new interdisciplinary field to advance knowledge
The End