Documente Academic
Documente Profesional
Documente Cultură
2010-2019
Peripheral neuropathy is a syndrome, which is a single or any combination form of
sensory loss, muscle weakness and atrophy, decreased tendon reflex and
vasomotion symptoms. The factors which lead to peripheral neuropathy are that the
damage of single neural limitation is a common cause of trauma, while multiple
single neuropathy occurs secondary to collagen vascular disease; Multiple
neuropathy may be caused by toxins, toxic substances, nutrition deficiency,
metabolic disease and malignant tumors.
Methylcobalamin, derivative of Vitamin B12, is active Vitamin B12 and the
therapeutic drug of peripheral neuropathy. It can promote intraneural nucleic acid,
protein and metabolism, facilitate the synthesis of DNA,RNA as well as the
synthesis of lecithin lipid, which is the main component of myelin sheath, and
accelerate to restore the damaged nerve tissue to improve the transformation of
nerve tissue and the disturbance of metabolism. In addition, it also works on
restraining unusual exciting conduction of nerve tissue.
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Methylcobalamin,. whose trade name is mecobalamin, was developed by Eisai Co.,
Ltd. and put in the market in Japan in the middle of 1980s.In 1996, mecobalamin
entered the Chinese market.
Methylcobalamin developed rapidly after entering China. Its annual sales value
increased from less than 200 million CNY in 2005 to 441 million CNY in 2014, with
CAGR of 12.32%. It had broad market demand in China. Eisai (Suzhou)
Pharmaceutical Co., Ltd, Eisai Co., Ltd. (Japan), Jiangsu Sihuan Bioengineering Co.,
Ltd, Nanjing Hailing Pharmaceutical Co., Ltd. and NCPC occupy large market share,
among which Eisai (Suzhou) Pharmaceutical Co., Ltd occupies most, whose annual
market share of sales value was over 40% in 2014.
It is predicted that in next few years, the incidence of peripheral neuropathy in
China will gradually rise, making the market scale of methylcobalamin continue to
increase.
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Table of Contents:
1 Related Concepts of Methylcobalamin
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