Documente Academic
Documente Profesional
Documente Cultură
BIOLOGI
MOLEKULER
Riandini Aisyah
Molecular Biology & Immunology
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If we can reveal the exact form of our genetic blueprint we shall have
taken a giant step toward understanding the many complex set of
interconnected chemical reactions in an organism
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One gene
one protein
DNA
RNA
Protein
(Central Dogma)
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Central Dogma
Gene
Genome
Transcription
Transcriptome
Protein
Translation
Proteome
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NUCLEAR GENOME
* 23 pairs of chromosomes 2 X ( 3 X 109
b.p) 2 meters DNA / Cell
* 2 X ( 3 X 1012 ) meters DNA in human
body 8,000 X (earth to moon)
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MtDNA
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Nucleotides:
A - T
G - C
Sugar:
De oxy ribose
Ribose
Phosphate
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Protein (a.a)
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one protein
DNA
RNA
Protein
(Central Dogma)
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RNA -
m RNA
t RNA
r RNA
Fungsi RNA
m RNA
t
RNA
r RNA
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GENOME :
Mus musulus :
Homo sapiens
mammalia
3.109 bp DNA
3.5 109 bp
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DNA / Genes
* existence
* multicopy
* rearrangement
* mutation
* structural / sequence changes
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RNA :
* gene expression
* level of expression
* degradation time
* gene function
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Therapy in the future, drug discovery
today
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