TCO reagents for Research

Trans-Cyclooctene(TCO) Amine is a carboxyl reactive building block containing a TCO

moiety and is a primary amine group. It is a TCO containing reagent with primary amines
that react with carboxyl groups in the presence of activators forming stable amide bonds.

Highlights of TCO-Amine
The TCO Amine is biocompatible. The click reaction occurs efficiently under mild buffer
conditions. It doesn't require any accessory reagents such as a copper catalyst or reducing
agents like DTT. They are chemo selective. TCO groups do not react or interfere with other
functional groups available in biological samples. However, they conjugate to one another
with efficiency. They provide kinetics which is unprecedented. The inverse electron demand
Diels-Alder chemistry is bio orthogonal ligation which is the fastest.
They work as a short spacer. The 6 carbon atom spacer arm keeps TCO moiety close to
molecules that are tagged. They are also highly stable in aqueous buffered media.

Guide to TCO reagents

There are several types of reagents available in the market. They have various applications in
Click chemistry. TCO Reagents are used for a variety of purposes for concluding different
sorts of reactions. TCO stands for Trans=Cyclooctene. These reagents are used for
Cyclooctene group across various targets. TCO-NHS Ester is a reagent that comes under
TCO reagent. This reagent is generally known as amine reactive TCO reagent. They are also
used for grouping Tetrazine labelled molecules. There is no need of Cu-based catalyst for
reaction under normal temperature. TCO-Amine is perfect TCO reagent.

Facts about TCO Reagents

TCO Reagents are used in Click chemistry. Click chemistry is the branch of biochemistry. It
is extremely useful to our lives. Biochemistry makes use of different types of reagents for
obtaining different varieties of reactions. These reactions help simplify DNA structures. It
helps in analysing DNA easier. DNA analysis helps in finding medicines for a number of
intricate diseases that has genetic makeup. It leads to better understanding of the diseases and
their causes. TAMRA Azide is a reagent that is frequently used as amino group substituted in
DNA structures.

Characteristics of TCO-PEG4-NHS ESTER

TCO-PEG4-NHS ESTER is an amine reactive agent with water solubility enabled by PEG4
spacer. They react efficiently with a primary amine to form a covalent bond at pH 7-9. The
PEG spacer imparts water solubility to the labelled molecule reducing aggregation of labelled
proteins in the solution. The PEG spacer provides a long and flexible connection that
minimizes hindrance involved with ligation to complementary molecules containing
Tetrazine.

Where do you get TCO Reagents?

TCO Reagent is expensive and is available in the market from various companies. You can
even buy them online without any hassle. There are a lot of online providers having all the
desired reagents with quick delivery and effective service. You can buy the best quality with a
little bit of effort by searching on the internet. These TCO Regents help you in research and
for the discovery of advanced medicines to tackle diseases. For more information at
https://www.camperco.co.nz.