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have taken the unusual step of advising their citizens to delay pregnancy
until more is known about the virus and its impact on fetal development.[15]
Contents [hide]
1
Epidemiology
1.1
Transmission
1.2
1.3
GuillainBarr syndrome
2.1
Diagnosis
2.2
Americas
2.3
International
2.4
Responses
2.5
Controversies
See also
References
External links
Epidemiology[edit]
Cases in the Americas[16]
[show]Country
as of 31 March 2016
Autochthonous cases
Deaths
The Zika virus was first isolated in 1947, in a rhesus monkey in a forest near
Entebbe, Uganda.[64] Although serologic evidence indicated additional
human exposure during subsequent decades in parts of Africa and Asia,[65]
before the 2007 Yap Islands Zika virus outbreak, only 14 cases of human Zika
virus disease had been documented.[64]
The specific event that brought the virus to Brazil was uncertain until March
2016. Brazilian researchers have suggested that the Zika virus arrived during
the 2014 FIFA World Cup tournament.[66] French researchers speculated the
virus arrived shortly afterwards, in August 2014, when canoeing teams from
French Polynesia, New Caledonia, Easter Island, and the Cook Islands, which
had been or were experiencing Zika outbreaks, attended the Va'a World
Sprint Championships in Rio de Janeiro.[61][67] However, the outbreak in
French Polynesia is known to have peaked and declined precipitously by
February 2014, lending doubt to the suggestion the virus arrived later that
year in Brazil with spectators and competitors.[70] A study published in
Science, which developed a "molecular clock" based on the count of virus
mutations in a relatively small sample, suggested Zika virus arrived in the
Americas (most likely in Brazil) from French Polynesia between May and
December 2013, well before the World Cup and Va'a Championships.[70] In
the Science article, Faria and colleagues managed to trace the origins of the
virus strain that is circulating in Brazil and found out that this strain has few
genetic variability when compared to the strain of French Polynesia; after
relating the number of travellers arriving in Brazil from French Polynesia with
the cases reported and the events happening in that year, the team was able
to prove that the virus arrived in Brazil on 2014 during the Confederation
Cup, when Tahiti's team played against other teams in a few brazilians cities,
which attracted a lot of tourists from both places.[71] Zika virus usually has
very mild, or no symptoms, so it took almost a year for Brazil to confirm the
first case of the disease. By then the outbreak was already widespread..
Factors associated with the rapid spread of Zika virus in Brazil include the
non-immune population, high population density, tropical climate and
inadequate control of Aedes mosquitoes in the country.[72]
Confirmed cases have now been reported in most of South and Central
America, and the Caribbean.[73] Cases have also been reported that were
imported from South America into Europe,[74] Canada,[75] United States,[76]
China,[77] and Australia.[78]
Transmission[edit]
See also: Zika virus Transmission
The Aedes aegypti mosquito usually bites in the morning and afternoon
hours, and can be identified by the white stripes on its legs.[80] The mosquito
species (Aedes aegypti, mainly, and Aedes albopictus) that can spread Zika
virus can also spread dengue, chikungunya, and yellow fever.[81]
There have been two reports of possible Zika virus transmission via sexual
intercourse from infected males to their partners.[6][8][82] On 23 February
2016, the CDC announced that it is investigating 14 additional cases of
possible sexual transmission.[9][10]
A baby with microcephaly (left) compared to a baby with a typical head size
As of March 2016, public health officials strongly suspect that Zika infection
during pregnancy can cause a number of grave outcomes, including
microcephaly and loss of pregnancy.[6][85] Following the initial Zika outbreak
in Northeastern Brazil, physicians observed a very large surge of reports of
infants born with microcephaly, with 20 times the number of expected cases.
[86][87] Many of these cases have since been confirmed, leading WHO
officials to project that approximately 2,500 infants will be found to have born
in Brazil with Zika-related microcephaly.[88][89] On 10 March 2016, a
research group from the Faculty of Medicine, University of Ljubljana
(Slovenia), led by young researcher Jernej Mlakar, M.D., published an article
in The New England Journal of Medicine, connecting the Zika virus to
microcephaly.[84]
Proving that Zika causes these effects is difficult and complex for several
reasons.[90][91] For example, the effects on an infant might not be seen until
months after the mother's initial infection, long after the time when Zika is
easily detected in the body.[90] In addition, research is also needed to
Since the initial outbreak, studies that use several different methods have
found evidence of a link, leading public health officials to conclude that it
appears increasingly likely the virus is linked to microcephaly and
miscarriage.[92][93] On 1 February 2016, the World Health Organization
declared recently reported clusters of microcephaly and other neurological
disorders a Public Health Emergency of International Concern (PHEIC).[85] On
8 March 2016, the WHO Committee reconfirmed that the association between
Zika and neurological disorders is of global concern.[92]
The Zika virus was first linked with newborn microcephaly during the Brazil
Zika virus outbreak. In 2015, there were 2,782 suspected cases of
microcephaly compared with 147 in 2014 and 167 in 2013.[86] Confirmation
of many of the recent cases is pending,[94] and it is difficult to estimate how
many cases went unreported before the recent awareness of the risk of virus
infections.[95]
In November 2015, the Zika virus was isolated in a newborn baby from the
northeastern state of Cear, Brazil, with microcephaly and other congenital
disorders. The Lancet medical journal reported in January 2016 that the
Brazilian Ministry of Health had confirmed 134 cases of microcephaly
"believed to be associated with Zika virus infection" with an additional 2,165
cases in 549 counties in 20 states remaining under investigation.[6][98] An
analysis of 574 cases of microcephaly in Brazil during 2015 and the first week
of 2016, reported in March 2016, found an association with maternal illness
involving rash and fever during the first trimester of pregnancy.[99] During
this period, 12 Brazilian states reported increases of at least 3 standard
deviations (SDs) in cases of microcephaly compared with 200014, with the
northeastern states of Bahia, Paraba and Pernambuco reporting increases of
more than 20 SDs.[99]
In January 2016, a baby in Oahu, Hawaii, was born with microcephaly, the
first case in the United States of brain damage linked to the virus. The baby
and mother tested positive for a past Zika virus infection. The mother, who
had probably acquired the virus while traveling in Brazil in May 2015 during
the early stages of her pregnancy, had reported her bout of Zika. She
recovered before relocating to Hawaii. Her pregnancy had progressed
normally, and the baby's condition was not known until birth.[100]
In March 2016, first solid evidence was reported on how the virus affects the
development of the brain. It appears to preferentially kill developing brain
cells.[101] The first cases of birth defects linked to Zika in Colombia[102] and
in Panama were reported in March 2016.[103]
Ocular disorders in newborns have also been linked to Zika virus infection.
[104] In one study in Pernambuco state in Brazil, about 40 percent of babies
with Zika-related microcephaly also had scarring of the retina with spots, or
pigment alteration.[105]
GuillainBarr syndrome[edit]
A high incidence of the autoimmune disease GuillainBarr syndrome (GBS),
noted in the French Polynesia outbreak, has also been found in the outbreak
that began in Brazil.[98] Laboratory analysis found Zika infections in some
patients with GBS in Brazil, El Salvador, Suriname and Venezuela,[111] and
the WHO declared on 22 March 2016 that Zika appeared to be "implicated" in
GBS infection, and that if the pattern was confirmed it would represent a
global public health crisis.[112]
Americas[edit]
Several countries, including Colombia, Ecuador, El Salvador, and Jamaica,
advised women to postpone getting pregnant until more was known about
symptoms of microcephaly
Symptoms of microcephaly, linked to mothers infected by Zika virus.[113]
Because of the "growing evidence of a link between Zika and microcephaly"
the CDC issued a travel warning on 15 January 2016 advising pregnant
women to consider postponing travel to Brazil as well as the following
countries and territories where Zika fever had been reported: Colombia, El
Salvador, French Guiana, Guatemala, Haiti, Honduras, Martinique, Mexico,
Panama, Paraguay, Suriname, Venezuela, and the Commonwealth of Puerto
Rico.[120] On 20 January, the Ministry of Health of Chile published a health
notice.[121] On 22 January, eight more countries and territories were added
to the list of those affected: Barbados, Bolivia, Ecuador, Guadeloupe, Saint
Martin, Guyana, Cape Verde, and Samoa.[122] On 1 February, Costa Rica and
Nicaragua were added to the list, bringing the number of countries and
territories affected to 28.[123]
The agency issued additional guidelines and suggested that women thinking
about becoming pregnant consult with their physicians before traveling.[124]
Canada issued a similar travel advisory.[118][125]
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International[edit]
To prevent the transmission of the Zika virus, WHO recommends using insect
repellent, wearing long-sleeved clothes to cover the body, and using screens
and mosquito nets to exclude flying insects from dwellings or sleeping areas.
It is also vital to eliminate any standing water near homes to minimize
breeding areas for mosquitoes. Authorities can treat larger water containers
with recommended larvicides.[80][136] Furthermore, the Centers for Disease
Control and Prevention (CDC) recommends that containers holding water
near homes either be sealed or scrubbed once per week, because mosquito
eggs can stick to them.[81]
Responses[edit]
See also: Mosquito control
The Brazilian Army has sent more than 200,000 troops to go "house to house"
in the campaign against Zika-carrying mosquitoes.
On 1 February 2016, the WHO declared the current Zika virus outbreak an
international public health emergency,[5][144] and the Brazilian President
released a decree that increased local and federal pest control agents' access
to private property required by mobilization actions for the prevention and
elimination of Aedes mosquito outbreaks in the country.[145]
Some experts have proposed combatting the spread of the Zika virus by
breeding and releasing mosquitoes that have either been genetically
modified to prevent them from transmitting pathogens or that have been
infected with the Wolbachia bacterium, thought to inhibit the spread of
viruses.[146][147] Another proposed technique consists of using radiation to
sterilize male larvae so that when they mate, they produce no progeny.[148]
Male mosquitoes do not bite or spread disease.[149]
A joint statement on the sharing of data and results on the Zika outbreak in
the Americas and future public health emergencies was issued on 10
February 2016 by a group of more than 30 global health bodies.[151] The
statement reinforces a similar consensus statement issued by WHO in
September 2015.[152] The statement calls for free access to all data as
rapidly and widely as possible.[153]
In February 2016, Google announced that they were donating $1 million via
UNICEF to fight the spread of the Zika virus and offering professional
personnel to help to determine where it will hit next.[154]
Controversies[edit]
Some efforts to contain the spread of Zika virus have been controversial.
Oxitec, the company behind the "self-limiting" mosquitoes released in Brazil,
has faced criticism from environmental groups, who fear that releasing a new
mosquito strain into the wild will damage the ecosystem. In the short term,
the concern is that a drop in the mosquito population could affect the
populations of other species. Supporters claim that the environmental impact
of the "self-limiting" mosquitoes will be minimal, since only one species of
mosquito is being targeted and the genetically-modified mosquitoes are still
safe for predators to eat. Oxitec Product Development Manager Derric Nimmo
likened the process to "going in with a scalpel and taking away Aedes
aegypti, leaving everything untouched."[155] Since Aedes aegypti is an
imported invasive species in Brazil, some experts expect that its eradication
will have little impact on the environment. However, other environmentalists
emphasize that the long-term consequences of eliminating an entire species
cannot be predicted.[156]
On 5 February 2016, the UN High Commissioner for Human Rights urged Latin
American governments to consider repealing their policies regarding
contraception and abortion, emphasizing that "upholding human rights is
essential to an effective public health response."[160] On 16 February 2016,
the Vatican condemned the UN for its call to action, deeming it "an
illegitimate response" to the Zika crisis and emphasizing that "a diagnosis of
microcephaly in a child should not warrant a death sentence."[161]
On 18 February 2016, after a trip to Latin America, Pope Francis stated that
"avoiding pregnancy is not an absolute evil" in cases such as the Zika virus
outbreak. His comments sparked speculation that the use of contraception
may be morally permissible in the fight against the Zika virus.[162]
See also[edit]
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