ERA : Endometrial Receptivity Array

P+0= First day of progesterone intake

LH+0= The day of the LH surge
P+0= Primer da de la toma de progesterona LH+0= Da del Pico de LH

HRT

P+0

(120 hrs)

Menstruation
Menstruacin

P+5

label it
etiquetar

NATURAL

LH+0

LH+7
Sample extraction
Extraccin de la muestra

(168 hrs)

endometrial biopsy
biopsia endometrial

The ERA indicates the window of

implantation (WOI), increasing your
chances of a successful transfer.
ERA localiza la ventana de
implantacin (WOI), incrementando
tus posibilidades de xito en la
transferencia.

>4 hrs
refrigerator (4 to 8C)
minimum 4 hrs
nevera (4 a 8C)
mnimo 4 hrs

avoid temperatures
over 35 C
evitar temperaturas
superiores a 35C

Never prerform the biopsy in a

Controlled Ovarian Stimulated (COS)
Nunca realizar la biopsia en ciclo
estimulado (COS).

to:

shipment at room temperature

envo a temperatura ambiente

ERA reccomends that the ERA

biopsy be performed in a HRT cycle.
ERA recomienda realizar la biopsia
en HRT.

secondary receptacle
recipiente secundario

embryo transfer
transferencia
de embriones

receptive
receptivo

results in
10 working days
resultados en
10 das laborables

ERA cryotube
criotubo ERA

HRT

next cycle
siguiente ciclo

non receptive
no receptivo

NATURAL

NATURAL

* RIF: Recurrent Implantation Failure.

* FI: Fallos de Implantacin.
** EPA: Expression Profile Analysis. To identify a possible displacement of the WOI.
** APE: Anlisis del Perfil de Expresin. Para identificar un posible desplazamiento de la ventana de implantacin (WOI).

2nd biopsy at the

recommended day
2 biopsia en
da recomendado

In the case of non receptive results, ERA will

indicate the day on which a second biopsy
should be performed in order to validate a
displacement of the WOI:
Pre-receptive patients, after the first biopsy.
Post-receptive patientss, before the first biopsy.
En resultados no receptivos, ERA indicar el
momento en el que se debe realizar una
segunda biopsia para validar un
desplazamiento de la WOI:
Prerreceptivos, despus de la primera biopsia.
Postrreceptivos, antes de la primera biopsia.

P+0

P+5

LH+0

HRT

**EPA
**APE

LH+7

The transfer of a blastocyst should be

performed in the day in which a receptive result
has been obtained. The transfer of a day-3
embryo should be performed two days earlier
than the receptive day.
La transferencia de embriones se realizar en
el mismo da en el que se ha obtenido el
resultado receptivo. La transferencia de
embriones de da 3 se realizar dos das antes
del da en que se ha obtenido el resultado
receptivo.

P+0

LH+0

P+3

P+7

LH+5

LH+9

Menstruation
Menstruacin

26% of RIF* patients are non receptive.

EL 26% son no receptivos en FI*.
More than 2,500 cases were analyzed, and in
99.1% the WOI was found.
Ms de 2.500 casos analizados. Para el 99,1% se
encontr la WOI.

Action Protocol Protocolo de Actuacin

HRT
o
NATURAL

Select the cycle type (HRT or

Natural) in which the ERA
should be performed.
Establecer el tipo de ciclo
(sustituido o natural) en el que
se va a realizar el ERA.

Take a biopsy of the uterine

fundus during the Window of
Implantation:
During Hormone
Replacement Therapy after 5
days of progesterone
impregnation.
In the natural cycle at LH +7.
Tomar la biopsia del fondo
uterino en la ventana de
implantacin:
En ciclo sustituido tras 5 das
completos de impregnacin
de progesterona.

Place the biopsy in the ERA

cryotube attached.

Label the cryotube. Shake it

vigorously for a few seconds.

Introducir la biopsia en el
criotubo ERA que se adjunta.

Etiquetar el cryotubo. Agitar

vigorosamente durante unos
segundos.

>4 hrs
(4 to 8C)

Immediatly store in the

refrigerator for a minimum of 4
hours and until shipping
(maximum 1 month).
Inmediatamente conservar en
la nevera durante un mnimo
de 4 horas y hasta el
momento del envo (mximo 1

to:

Send the sample at room

temperature in a padded
envelope or similar with the
secondary container inside.
Attach the documentation. Do
not send at temperatures above
35 C.
Realizar el envo a temperatura
ambiente en un sobre
acolchado o similar con el
recipiente secundario. Adjuntar
la documentacin. No enviar a

Send an e-mail to confirm

shipping.
EU, LATAM, e-mail to:
support@igenomix.com;
USA e-mail to:
support@ivigen.com;
INDIA e-mail to:
info.india@iviomics.com
Enviar un e-mail avisando del envo.

For clinical questions, send an

e-mail:
EU, e-mail to:
era@igenomix.com;
USA e-mail to: era@ivigen.com;
LATAM, e-mail to:
era.latam@igenomix.com;
INDIA e-mail to:
era.india@iviomics.com

EU, LATAM, enviar a:

Para consultas clnicas, enviar un email:

support@igenomix.com;

EU, enviar a: era@iigenomix.com;

USA enviar a: support@ivigen.com;

USA enviar a: era@ivigen.com;

INDIA enviar a:

LATAM, enviar a:

info.india@iviomics.com

era.latam@igenomix.com;
INDIA enviar a: era.india@iviomics.com