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Biomedical
Therapy
J o urnal o f
Integrating Homeopathy
and Conventional Medicine
Chronic
Inflammation
Biomodulation of Osteoarthritis
Lumbosacral Pain Syndrome A Case Study
Contents
I n Fo c u s
Biomodulation of Osteoarthritis . . . . . . . . . . . . . . . . . . . . . . . 4
W h a t E l s e I s N e w ? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8
Specialized Applications
Re f r e s h Yo u r H o m o t ox i c o l o g y
Evidence-Based Homeopathy
More Than Results of Double-Blind Studies! . . . . . . . . . . . . . .16
M a r ke t i n g Yo u r P r a c t i c e
Getting Organized . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18
N e w Pe r s p e c t i v e s
Making of ...
Published by/Verlegt durch: International Academy for Homotoxicology GmbH, Bahnackerstrae 16,
76532 Baden-Baden, Germany, e-mail: journal@iah-online.com
Editor in charge/verantwortlicher Redakteur: Dr. Alta A. Smit
Print/Druck: VVA Konkordia GmbH, Dr.-Rudolf-Eberle-Strae 15, 76534 Baden-Baden, Germany
2008 International Academy for Homotoxicology GmbH, Baden-Baden, Germany
A Holistic Approach
to Chronic Inflammation
Dr. Alta A. Smit
Alta A. Smit, MD
Reference:
1. Edwards T. Inflammation, pain, and chronic
disease: an integrative approach to treatment and prevention. Altern Ther Health Med
2005;11(6):20-27.
)
Journal of Biomedical Therapy 2008 ) Vol. 2, No. 2
) I n Fo c u s
Biomodulation of Osteoarthritis
Introduction
From the homotoxicological perspective, OA falls into the degeneration phase on the Disease Evolution
Table and shares many of the characteristics of degenerative disease
processes, namely, chronic inflammation accompanied by the release
of dangerous free radicals such as
peroxynitrite, disturbance of the
normal cycle of degeneration and
repair, and disturbance of angiogenic balance in the direction of inappropriate vascularization.
Inflammation in osteoarthritis
The effects of subclinical chronic inflammation in OA are now increasingly being recognized.2 The onset
of acute inflammation is generally
sudden, with the above-mentioned
symptoms developing in a matter of
minutes or hours. Neutrophils are
Interleukin-1
Interleukin-6
Tumor Necrosis Factor
Chondrocyte
Bone Morphogenetic
Proteins (Transforming
Growth Factor )
Metalloproteinases
Antimetalloproteinases
Tissu e I nflammation
an d Degradation
(Free radicals)
Tissu e Repai r
Osteoarthritis
Tissue healing
Journal of Biomedical Therapy 2008 ) Vol. 2, No. 2
Matrix
Matrix fragments
Chronic inflammation
Aged Cell
Poor response to growth factors
Degradative pathways stay on
Continued matrix destruction
Osteophytes
Pain
Angiogenesis
VEGF, FGF
abnormal even after the inflammation subsides. In chronic inflammation, the cells that predominate are
macrophages and often lymphocytic
infiltrates. Chronic inflammation can
therefore be seen as a misguided attempt on the part of chondrocytes
and other cells to eliminate damaged
tissue and to effect repair.
Anabolic/catabolic imbalance
Oscillation between degradation
and repair is a normal occurrence in
the matrix. Although the extracellular matrix is the functional unit in
this process, homeostasis is affected
by chondrocytes. Matrix metalloproteinases (MMPs) are stimulated
by inflammatory cytokines and matrix degradation products to induce
degradation of older or damaged
tissues and are counterbalanced by a
number of growth factors, notably
also members of the TGF- family,
Bone Morphogenetic Proteins
) I n Fo c u s
ROS also will induce inflammatory
mediators, such as NF-B, IL-1, and
IL-6. ROS have been implicated in
chondrocyte senescence.6 ROS may
also have a direct influence on the
production of Vascular Endothelial
Growth Factor (VEGF), a powerful
stimulator of angiogenesis and
chronic inflammation.7
Angiogenesis and chronic
inflammation
) I n Fo c u s
15. Heine H, Schmolz M. Induction of the immunological bystander reaction by plant extracts. Biomed Ther 1998;16(3):224-226.
16. Porozov S, Cahalon L, Weiser M, Branski D,
Lider O, Oberbaum M. Inhibition of IL-1
and TNF- secretion from resting and activated human immunocytes by the homeopathic medication Traumeel S. Clin Dev Immunol 2004;11(2):143-149.
17. Lyss G, Knorre A, Schmidt TJ, Pahl HL, Merfort I. The anti-inflammatory sesquiterpene
lactone helenalin inhibits the transcription
factor NF-kappaB by directly targeting p65.
J Biol Chem 1998;273(50):33508-33516.
18. Zell J, Connert W-D, Mau J et al. Treatment of acute sprains of the ankle. Biol Ther
1989;7(1):1-6.
19. Schneider C, Klein P, Stolt P, Oberbaum M.
A homeopathic ointment preparation compared with 1% diclofenac gel for acute symptomatic treatment of tendinopathy. Explore
2005;1(6):446-452.
20. Birnesser H, Oberbaum M, Klein P, Weiser
M. The homeopathic preparation Traumeel
S compared with NSAIDs for symptomatic
treatment of epicondylitis. J Musculosekelet Res
2004;8(2-3):119-128.
21. Singer SR, Amit-Kohn M, Weiss S, Rosenblum J, Lukasiewicz E, Itzchaki M, Oberbaum
M. Efficacy of a homeopathic preparation in
control of post-operative pain A pilot clinical trial. Acute Pain 2007;9(1):7-12.
22. Birnesser H, Stolt P. The homeopathic antiarthritic preparation Zeel comp. N: a review of molecular and clinical data. Explore
2007;3(1):16-22.
23. Mersch-Sundermann V, Kassie F, Bhmer S,
et al. Extract of Toxicodendron quercifolium
caused genotoxicity and antigenotoxicity in
bone marrow cells of CD1 mice. Food Chem
Toxicol 2004;42(10):1611-1617.
24. Stankov M, Bly M, Metelmann HW, et
al. Effects of Zeel comp. on experimental
osteoarthritis in rabbit knee. Rheumatologia
1999;13:101-108.
25. Basini G, Bussolati S, Santini SE, Grasselli
F. Sanguinarine inhibits VEGF-induced angiogenesis in a fibrin gel matrix. Biofactors
2007;29(1):11-18.
26. Basini G, Santini SE, Bussolati S, Grasselli F. Sanguinarine inhibits VEGF-induced
Akt phosphorylation. Ann N Y Acad Sci
2007;1095:371-376.
Myths in medicine
BMJ 2007;335:1288-1289
Mozart as medicine
Not only is Mozarts music beautiful, it also has its uses in the ICU. In
one study, 10 patients on artificial
respiration listened to slow movements from Mozarts piano sonatas
through earphones for one hour on
the first day after surgery, with astonishing effects. In comparison to
the control group, the patients who
received Mozart therapy experienced decreases in heart rate and
blood pressure and required significantly less sedation.
Crit Care Med
2007;35(12):2709-2713
Taciturn or talkative?
Fear increases
sensory acuity
www.giantmicrobes.com
Science 2008;319(5871):1842-1845
F O R P RO F E S S I ONA L U S E ON LY
The information contained in this journal is meant for professional use only, is meant to convey general and/or specific worldwide scientific information relating to the
products or ingredients referred to for informational purposes only, is not intended to be a recommendation with respect to the use of or benefits derived from the
products and/or ingredients (which may be different depending on the regulatory environment in your country), and is not intended to diagnose any illness, nor is it
intended to replace competent medical advice and practice. IAH or anyone connected to, or participating in this publication does not accept nor will it be liable
for any medical or legal responsibility for the reliance upon or the misinterpretation or misuse of the scientific, informational and educational content of the
articles in this journal.
The purpose of the Journal of Biomedical Therapy is to share worldwide scientific information about successful protocols from orthodox and complementary practitioners. The intent of the scientific information contained in this journal is not to dispense recipes but to provide practitioners with practice information for a better
understanding of the possibilities and limits of complementary and integrative therapies.
Some of the products referred to in articles may not be available in all countries in which the journal is made available, with the formulation described in any article or
available for sale with the conditions of use and/or claims indicated in the articles. It is the practitioners responsibility to use this information as applicable
and in a manner that is permitted in his or her respective jurisdiction based on the applicable regulatory environment. We encourage our readers to share
their complementary therapies, as the purpose of the Journal of Biomedical Therapy is to join together like-minded practitioners from around the globe.
Written permission is required to reproduce any of the enclosed material. The articles contained herein are not independently verified for accuracy or truth. They have
been provided to the Journal of Biomedical Therapy by the author and represent the thoughts, views and opinions of the articles author.
) Specialized Applications
By Jan Kersschot, MD
Introduction
Biopuncture is the injection of biotherapeutics into indication or tissue-related zones or points on the
body, as determined through clinical
and functional diagnosis.1 The therapeutic agents may be administered
subcutaneously or injected into
joints, muscles, or ligaments.2 Administering the medications in the
right spots or in the relevant body
zone enhances the clinical effect. Increasing numbers of physicians are
realizing that such injections can expand the scope of their practice.3
Biopuncturists use both antihomotoxic medications and hyaluronic
acid.4,5,6 Lymphomyosot is used for
lymphatic drainage and matrix detoxification and Traumeel is used to
regulate the inflammatory response.
Spascupreel is injected for muscular
) 10
Different steps of
local injections
Lymphomyosot + Traumeel
Lymphomyosot + Traumeel
Lymphomyosot + Traumeel
Lymphomyosot + Spascupreel
Traumeel + dextrose
Traumeel + Zeel
Phase 1 product:
Lymphomyosot
Phase 2 product:
Traumeel
Phase 3 products:
Phase 4 products:
Step 1:
Step 2:
Step 3:
Clinical applications of
biopuncture in treating chronic
inflammatory disorders
inflammatory disorders
) 11
Journal of Biomedical Therapy 2008 ) Vol. 2, No. 2
) Specialized Applications
12
References
1. Kersschot J. Biopuncture A New Clinical
Guide. Aartselaar, Belgium: Inspiration Publishing; in press.
2. Kersschot J. Biopuncture and the Management of Sports Injuries. Albuquerque, NM:
Jaysea Press; 2008.
3. Barkauskas D. Biopuncture in Family Practice. Paper presented at: HSA Congress 2008;
June 8, 2008; Drakensberg Mountains, South
Africa.
4. Smit A, OByrne A, Van Brandt B, Bianchi
I, Kstermann K. Introduction to Bioregulatory
Medicine. Stuttgart, Germany: Thieme Publishers; in press.
) Re f r e s h Yo u r H o m o t ox i c o l o g y
By Alta A. Smit, MD
1. Electrical signals
Szent-Gyrgyi used the term bioenergetics to refer to energy not
confined in biomolecules but emitted or absorbed directly by tissue.
As early as 1941, Szent-Gyrgyi
proposed that electrons can propagate through crystalline structures
both within and between molecules,
forming semiconducting currents
entirely separate from the movement
of ions, previously assumed to be
the only possible basis for bioelec-
13
) Re f r e s h Yo u r H o m o t ox i c o l o g y
Microscopic view of
) 14
rhythm, and normal angiogenic balance. The three pillars of antihomotoxic therapy (detoxification and
drainage, immunomodulation, and
organ regulation) are essential to ensure matrix health.
It can be postulated that many environmental toxins carry electrical or
chemical charges that may disrupt
subtle piezoelectric signals and affect transcription of mediators, thus
affecting plasticity. The example of
the zebra fish tail, which regenerates completely after being severed,
shows that adult zebra fish have the
capacity to regenerate the caudal fin,
a process that is inhibited by exposure to the ubiquitous environmental contaminant 2,3,7,8-tetrachloro
dibenzo-p-dioxin (TCDD). Fin
regeneration is a complex process requiring precise regulation of several
processes including wound healing,
ECM production, revascularization,
innervation, and bone formation.
TCDD, a persistent organic pesticide, directly inhibits this process.15
The practice of advanced supportive
detoxification with subsequent
drainage is thus recommended for
matrix health. Antihomotoxic medicine combined with proper nutrition
can support this process. Medications such as Thyreoidea compositum and Pulsatilla compositum are
especially suitable for supporting
the matrix biorhythm. Immune
modulation that down-regulates inflammatory mediators and secretion
) Re f r e s h Yo u r H o m o t ox i c o l o g y
References
1. Abraham LC, Dice JF, Lee K, Kaplan DL.
Phagocytosis and remodeling of collagen
matrices. Exp Cell Res 2007;313(5):10451055.
2. Langevin HM. Connective tissue: a bodywide signaling network? Med Hypotheses
2006;66(6):1074-1077.
3. Langevin HM, Yandow JA. Relationship of
acupuncture points and meridians to connective tissue planes. Anat Rec 2002;269(6):257265.
4. Swartz MA, Tschumperlin DJ, Kamm RD,
Drazen JM. Mechanical stress is communicated between different cell types to elicit
matrix remodeling. Proc Natl Acad Sci U S A
2001;98(11):6180-6185.
5. Szent-Gyrgyi A. The study of energy-levels
in biochemistry. Nature 1941;148:157-159.
6. Vasishta VG; Kumar RV; Pinto LJ. Rotational
field quantum magnetic resonance (RFQMR)
in treatment of osteoarthritis of the knee
joint. Ind J Aerospace Med 2004;48(2):1-7.
) 15
Evidence-Based Homeopathy
Opening ceremony
16
sessions at the end of each day provided a useful overview of the progress of the conference.
Some highlights of
the conference
Among the many highlights of this
conference, here are a few of special
interest: The first plenary session, on
the Politics, History and Economics of Homeopathy, included Ton
Nicolais talk on the current status
of complementary and alternative
medicine (CAM) in the European
healthcare system and Christian
Boirons Homeopathy is a language.
In another plenary session on Research from proving to doubleblind, Prof. Claudia Witt presented
an important paper on the treatment
of atopic eczema in children. Dr.
Witt is the first person to hold the
Chair for Research in Complementary/Alternative Medicine, recently
endowed by the Karl and Veronica
Carstens Foundation, at the Charit
University Medical Center in Berlin.
17
) M a r k e t i n g Yo u r P r a c t i c e
Getting Organized
) 18
) M a r k e t i n g Yo u r P r a c t i c e
) 19
) Ne w Perspectives
20
ulfur is a non-metal, lemon yellow in color, with atomic number 16 in the periodic table of the
chemical elements. Its symbol is S
and it is situated next to phosphorus
(P, atomic number 15) to its left and
chlorine (Cl, atomic number 17) to
its right. The element immediately
above it is oxygen (O, atomic number 8) and the element immediately
below it is selenium (Se, atomic
number 34).
It is characterized by high electronegativity and consequently gains
electrons more easily than it loses
them. Its oxides are acidic and tend
to form anions and oxyanions in
aqueous solution. Solutions in water
are acidic (pKa1 = 7.00).
The essential amino acid methionine, which is apolar and hydrophobic, contains a sulfur atom in its side
chain. It is converted to homo-
) Ne w Perspectives
21
) Ne w Perspectives
phosphoric acid H3PO4. Proteoglycans and aminoglycans are substances that readily undergo electrolytic
exchange. Their alteration destroys
their capacity to retain water in the
cartilage and extracellular matrix,
changing their state of fluidity to a
state of desiccation or gel formation;
the end result of this alteration is a
loss of the ability of the body to exchange information between different compartments, leading to loss of
the state of systemic equilibrium.
These alterations predispose the patient to chronic conditions such as
diabetes, rheumatic disease, osteoporosis, and arthritis.
What happens in this information
exchange? We do not know exactly,
but can postulate one of the following:
A change in body pH alters the
behavior of the disulfide bonds,
making them more rigid, the result being that the protein chain
loses its capacity to adjust to the
membrane receptor.
An increase in these bonds causes
changes in the three-dimensional
structure of the protein chain.
A loss of the capacity to form
disulfide bonds causes the protein chains to break.
A loss of cohesive strength of the
disulfide bonds makes them
cleave easily.
We do not know exactly how this
destructive process occurs, but we
are familiar with the catastrophic effect of sulfur consumption on the
body. Within a few years, research
will surely reveal to us in detail how
the destructive effect of excessive intake of sulfur on bodily metabolism
occurs.
) 22
References
1. Cooper GM, Hausman RE. La Clula. 4th ed.
Madrid, Spain: Marbn; 2008.
2. Esteller M. Epigenetics in cancer. N Engl J
Med 2008;358(11):1148-1159.
3. Etezad-Razavi M, Mahmoudi M, Hefazi M,
Balali-Mood M. Delayed ocular complications of mustard gas poisoning and the relationship with respiratory and cutaneous
complications. Clin Experiment Ophthalmol
2006;34(4):342-346.
4. Fessenden R, Fessenden J. Qumica Orgnica.
2nd ed. Mexico City, Mexico: Grupo Editorial Iberoamericana; 1984.
5. Foye WO. Principios de Qumica farmacutica.
Barcelona, Spain: Revert; 1984.
6. Ganong WF. Fisiologa mdica. 19th ed. Mexico City, Mexico: Manual Moderno; 2004.
7. Goldsby RA, Kindt TJ, Osborne BA, Kuby J.
Inmunologa. 5th ed. McGraw Hill; 2004.
8. Lodish H, Berk A, Matsudaira P, et al. Biologia Celular Y Molecular. 5th ed. Mxico City,
Mexico: Editorial Medica Panamericana;
2005.
9. Meyers F, Jawetz E, Goldfien A. Farmacologa
Clnica. 3rd ed. Mexico City, Mexico: Manual
Moderno; 1977.
10. Murray RK, Granner DK, Mayes PA, Rodwell
VW. Bioqumica de Harper. 15th ed. Mexico
City, Mexico: Manual Moderno; 2001.
11. Nussey SS, Whitehead SA. Endocrinology: an
integrated approach. Oxford, UK: BIOS Scientific Publishers Ltd; 2001.
12. Reckeweg H-H. Materia Medica Homoeopathia Antihomotoxica. 4th ed. Baden-Baden,
Germany: Aurelia; 2002.
13. Schmid F, Rimpler M, Wemmer U. Medicina
antihomotxica. Vol. I Principios clinica
prctica. Baden-Baden, Germany: Aurelia;
2004:51-88.
14. Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and
Food Contact Materials (AFC) on a request
from the Commission on the results of the
study by McCann et al. (2007) on the effect of some colours and sodium benzoate
on childrens behaviour. The EFSA Journal
2008;660:1-54.
15. Vannier L. Compendio de Materia Mdica Homeoptica. 4th ed. Mxico City, Mexico: Porra, 1998.
16. World Cancer Research Fund/American Institute for Cancer Research. Food, Nutrition,
Physical Activity, and the Prevention of Cancer:
A Global Perspective. Washington, DC: AICR;
2007:35-37.
IAH Abbreviated
Course
An e-learning course leading to
certification in homotoxicology
from the International Academy for
Homotoxicology in just 40 hours.
www.iah-online.com
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24
Lumbosacral Pain
Syndrome
By Dennis van Aswegen, DC
Treatment regimen
Treatment required a combination
of chiropractic and physical therapy.
In addition, several antihomotoxic
medications were prescribed:
Spascupreel was injected twice
weekly into trigger points along
the lumbar vertebrae.
A mixture of Zeel and Discus compositum was injected twice weekly
into the paravertebral muscles to
relieve chronic inflammation and
degeneration of the facet joints
and intervertebral disc.
Colocynthis-Homaccord (which
could also be mixed with Zeel and
Discus compositum) was injected
twice weekly into sites along
the paraspinal muscles to relieve
symptoms of sciatica and neuralgia.
Traumeel tablets were prescribed
for general inflammation and pain
(1 tablet 3 times per day for six
weeks).
The patient reported a 60 percent
improvement in both pain and range
of motion after four weeks of treatment and an additional ten percent
improvement after six weeks. He has
been able to resume his day-to-day
activities and looks forward to taking up some of his previous sporting
and outdoor pursuits again in the
near future.|
) 25
) Making of
Suis-Organ Products in
Antihomotoxic Medicine
he manufacturing of suis-organ
preparations is strictly regulated to ensure their safety. Before production of the mother tincture begins, the identity of the raw material
of animal origin is first confirmed
by a veterinarian. A number of tests
are then performed, including a histological examination. Additional
tests for zoonoses are conducted in
specialized laboratories to ensure
that the animal tissues contain no
pathogens that infect humans. All of
the test results are documented and
archived and must be available before the animal material is processed
further.
Homeopathic extracts
Production of homeopathic extracts
from freshly slaughtered animals or
their organs follows manufacturing
methods 42a or 42b of the German Homeopathic Pharmacopoeia
(HAB).1 In accordance with the
2007 HAB, one part of the animal
ingredient is diluted with nine parts
of 85 percent glycerol (Method
42a). The initial mixture is allowed
to stand for at least five days, after
which the coarsest particles are fil-
) 26
) Making of
) 27
Hans-Heinrich Reckeweg
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