RAJAN H. NAIK, Ph.D.

Ex-Head, National Repository of Molecules (NRM),

Ex-Principal Senior Scientist (R & D)
Division of Organic Chemistry
National Chemical Laboratory [NCL], Pune, INDIA
Director (New Projects)

Ross Lifescience Pvt. Ltd.

Plot No 96, Sector no 10, Bhosari, Pune 411026
Near Times of India Building, Vishweshwar Chowk
Tel.: +91 20 66357725 ; Mobile: +91 9822561757
http://www.rosslife.net

Home Address :
Dr. Rajan H. Naik
C-6 , Mayurban Co- Op Soc, Model
Colony, Shivaji Nagar, Pune 411016
Home :(91)-020-25655157
Mobile # 9665044114
E-mail: rajan@rosslife.net
rajan.naik3@gmail.com

HIGHLIGHTS

Forty years of rich experience in Research and New Product Development in Synthetic
Organic Chemistry of commercially important agrochemicals, metalloporphyrins, drugs
and drug intermediates, medical and veterinary disinfectants and variety of household and
Industrial formulations.

Visiting Assistant Professor, at University of South Florida, Tampa, Florida, USA

(August 2002 to May 2003).

Principal Investigator (Project Leader) in several projects involving design, development,

process optimization and commercialization. My responsibilities include selection and
planning of the projects, scale-up and transfer of technologies to chemical industries.
Well-versed in the preparation of Project profiles, Funding proposals, Feasibility reports,
Designing and conducting Training courses etc.

Innovated novel and commercially feasible, non-MIC, non-Phosgene (eco-friendly)

synthetic route for Carbamate Pesticides, post Bhopal tragedy due to MIC .

Designed and synthesized new class of HIV-Protease inhibitors (anti-AIDS compounds)

at NIH, Maryland USA, using state-of-the-art techniques such as molecular modeling.
(With Prof. John W. Erickson, Director and inventor of AIDS virus X ray structure)

Recognized research guide for M.Sc., M.Phil. & Ph.D. for Pune University, Shivaji
University, Singhania University, NIMS University and YCMOU and visiting faculty.

Associated with eminent Scientists: Dr. S. Rajappa (Ex-Head, Organic Chemistry

Division, NCL), Dr. K. N. Ganesh (Director, IISER and Ex- Head, Organic Chemistry
Division, NCL) and Dr. John W. Erickson (Director, SBP, National Cancer Institute,
USA).

Published 35 research papers in International journals of repute. Filed 25 Indian patents

with 9 US / European patents.
AWARDS

Visiting Assistant Professor at University of South Florida (USF), Tampa, Florida,

USA (August 2002 May 2003).

Recipient of Silver Medal Award by DG- CSIR, India, for U.S. Patent (1998).

Recipient of Silver Medal Award by NCL Research Foundation.

Raman Research Fellow (Council of Scientific & Industrial Research, New Delhi,
India) at National Cancer Institute, Frederick, MD, USA (April 1993 January 1994)

Visiting Scientist at NCI, Frederick, MD, USA ( February 1994 August 1994)

Felicitated by Mayor, Pune Municipal Corporation, Pune, for the development of

innovative process for Carbamate pesticides (August 15, 1992).

Recipient of Certificates of Commendation by Director General, CSIR, India, for

U.S. and European Patents (1992-93).

Felicitated by Chairman, Shikshan Prasarak Mandali (S. P. College, Pune), for

outstanding contributions in research (July 1991).

EDUCATION
Degree /
Fellowship
Post Doctoral :
Raman Research
Fellow (CSIR)
Post Doctoral :
Visiting Scientist

Institution / University

Year

Subject

April 1993
January 1994

Molecular Modeling /
Development of HIVProtease Inhibitors
Development of HIVProtease Inhibitors

Ph.D.

National Cancer Institute (NCI),

Frederick Cancer R & D
Center, Frederick, MD, USA
National Cancer Institute (NCI),
Frederick Cancer R & D
Center, Frederick, MD, USA
University of Pune / NCL

M.Sc.

University of Pune (Ist Class)

1974

Synthetic Studies in
Pyrethroids
Organic Chemistry

B.Sc.

University of Pune (Ist Class)

1972

Chemistry

February 1994
January 1995
1985

CURRENT ACTIVITIES
1. Director (New Projects): (wef July 2011)
Ross Lifescience Pvt. Ltd., Pune, India: [A CRO company]
Main activities involve business development with various National / Multinational companies in
connection with New Product Development, involving Custom Synthesis of diverse classes of
molecules and Variety of Formulations in the Niche areas of Pharma, Medical and Animal
Disinfectants, Veterinary, Health and Body care, Energy Drinks, Pesticides and Biopesticides,
Agrochemicals, Herbals, Nutraceuticals and Nano / Microencapsulation technology based
insecticide formulations etc.
2. Scientific Advisor to CROs like Florentis Pharmaceuticals, Pune; Kanashi Biotech, Bhosari,
Pune; National Agriculture and Food Analysis Research Institute (NAFARI) etc
3. Research Guide:

For M.Sc. / M. Phil. / Ph.D. (Pune University, Shivaji University, Singhania University, NIMS
University and YCMOU University):
4. Visiting Faculty:
Teaching Instrumental techniques in Food Analysis, such as TLC, Column Chromatography, GC,
HPLC, GC-MS, LC-MS, AAS, Spectroscopic Techniques ( UV-Vis, AAS) and Multiple
Extraction methods etc at collaborative course of National Agriculture and Food Analysis
Research Institute (NAFARI) and Ferguson College ( Life Sciences) entitled Food Analytics
in Food Processing and Safety Management. a bi-yearly Course. Visiting professor: Bharati
Vidyapeeths CAREERVERSITY for PGDFM course.
5. Chemical Consultant and Technology Angel of TePP programme of DSIR / DST.
ACCOMPLISHED RESEARCH WORK
Project Leader / Principal Senior Scientist
Division of Organic Chemistry (Synthesis)

1988 - 2011

National Chemical Laboratory, Pune, India

o Head - National Repository of Molecules (NRM) (April 2005 June 2011):

NRM is the centralized facility of CSIR focused on the building and cataloguing the
library of diversified compounds of small molecules along with research data. The main
objective of this central NRM facility is to establish a molecular repository of the
international standard to cater the needs of research laboratories and pharma industries

doing drug discovery research.

o Co-research Guide for Ph.D. (Pune University):
Thesis Title: Investigations of TiO2, ZnO and Metalloporphyrins Nanoparticles
inside the Mesoporous Silica MCM-41

We investigated the interaction of zinc tetra phenyl porphyrin and CdSe nanoparticles. It
was shown that the porphyrin nanoparticles and CdSe nanoparticles conjugate to each
other producing striking spectral changes in the fluorescence spectra.

Synthesis, Immobilization of Metalloporphyrin nanoparticles in mesoporous MCM-41

and its conjugates with inorganic salts and their applications in the photovoltaic.

Synthesis of various Porphyrins and Metalloporphyrins using 2+2 synthetic approach

with Zn, Fe, Co, Mn, Ni, as central metal atoms and converting them in to their Nano
particles using Host-Guest solvent technique at laboratory scale.

Successfully accomplished the project entitled Design, Synthesis, Immobilization and

Applications of potent Metalloporphyrins and Transition metal complexes funded by
Department of Science and Technology (DST), India (2002- 2005) (Principal
Investigator).

Evaluated the efficacy of the Herbal mosquito repellent as per the international standards
in our Entomology department. (External consultancy project) (Project Leader)

Synthesized N-Boc-2, 5-di (trimethylsilyl) Pyrrolidone, an important intermediate for

Epibatidine, a potent analgesic (Team Leader, Contract Research for USA based

company)
Successfully completed NCL - S. C. Johnson (USA) collaborative research project
entitled Development of new household insecticides, cleaners and disinfectants for
Indian market, (October 2001- September 2002) (Principal Coordinator).

Synthesized -thio (6, 7-Dihydroxynaphthyl)-N- (O-carboxyl methyl) acetanilide.

(Contract Research, Yamanouchi, JAPAN).

Developed a new and cost-effective one-pot synthetic route for Chaetomellic Acid A, a
potent anti-cancer agent using elegant strategy (Co-Principal Investigator).

Developed the commercially feasible process for 2-Phosphono Butane 1, 2, 4Tricarboxylic Acid (PBTC), a sequestering agent, corrosion inhibitor, etc. The know-how
(on 1 Kg. scale) was sold to the chemical industry (Principal Investigator).

Designed and developed a novel, innovative process for important Carbamate pesticides
like Carbaryl (Sevin), Carbofuran, Baygon, B.P.M.C., M.I.P.C., etc. by a non-MIC, nonPhosgene and even non-Carbon monoxide route involving a contra-thermodynamic
transesterification of alkyl N-alkylcarbamates by a counter-attack strategy. The process
know-how was released to few Indian industries (Project Leader).

Designed and developed an environmentally safe, economical and commercially feasible

process for methyl N-methylcarbamate , (MMC) a synthon for carbamate insecticides by

two different novel routes. The process know-how was released to the industry (Project
Leader).

Accomplished the synthesis of 8-chlorotheophylline, a key drug intermediate. The

process know-how (on 1 Kg. scale) was released to the industry (Project Leader).

Designed and developed the total synthetic route for commercially important plant
growth regulator and fungicide viz. Paclobutrazole. The process knowhow was sold to
Maharashtra Agro Industries (Project Leader).

A one-step synthesis for 1, 2, 4-Triazole, an important intermediate for biologically active

compounds has been developed (Project Leader).
Raman Research Fellow and Visiting Scientist
at National Cancer Institute (NCI), Frederick Cancer April 1993 to August 1994
Research & Development Center, Frederick, MD, USA

Designed and developed a novel, achiral, non-peptidic C2 symmetry based HIV- Protease
inhibitors (Drug candidates for AIDS) having potent antiviral activity with the help of
molecular modeling. (With Prof. John W. Erickson, Director and inventor of AIDS virus
X ray structure at SBP, NCI, USA and his group).

Research Scientist at NCL

1975 - 1987

Involved in the development of Alphamethrin and Deltamethrin (potent pyrethroids) from

(+)-3-Carene (Team Member).

Designed and developed the total synthetic route to commercially important drugs viz.
Theophylline, Aminophylline (anti-asthmatic and diuretic) and Caffeine (stimulant). The
multi-step process (on 1 Kg. scale) was sold to 3 Indian industries (Team Member)

Developed the two synthetic routes for (+)-cis-DV-acid (key intermediate for synthetic
pyrethroids (Co-Investigator).

Synthetic routes for insecticidally active (+)-1R-cis-and 1R-trans-chrysanthemates

possessing substituted styryl side chain on cyclopropane ring from (+)-3-Carene were
developed (Co-Investigator).

Designed and developed total synthetic routes for chlorinated insecticides like
Chlordane (on 1 Kg. scale) and Heptachlor and the processes were sold to industries
(Co-Investigator).

Developed the process for Carboxin (Vita wax), a systemic fungicide on 1 Kg. scale. The
process is commercialized (Co-Investigator).

Standardized the process for Diethyl oxalate (Plasticizer) (Co-Investigator).

Highlights of Doctoral Research at NCL

1981 - 1984

under Pune University

Several esters of (+) cis DV acid with p-substituted benzyl and -RS-cyano p-substituted
benzyl alcohols and substituted phenols have been synthesized. Many of the above esters
have shown promising insecticidal activity.

Synthetic routes for some modified pyrethroids in which the conventional gem-dimethyl
groups at C2 position of cyclopropane is replaced by a functionalized Spiro fused cycloalkyl
ring.

Methyl esters with long chain substituent on cyclopropane were prepared from (+)-3-Carene
to study the effect of long chain substituent on miticidal activity.

1R cis Caronaldehyde, an important intermediate for photostable pyrethroids like

Deltamethrin, Cyahalothrin and NRDC 182 has been obtained from (+)-3-Carene.

Synthesis and biological evaluation of 1R trans and 1R cis chrysanthemate derivatives was
carried out, resulting into potent pyrethroids.
LIFE MEMBERSHIP OF ACADEMIC SOCIETIES

Indian Chemical Society

Indian Society of Bio-Organic Chemists

YCMOU membership

Chemical Research Society of India

PERSONAL

Born on June 10, 1951, Married.

RESEARCH PUBLICATIONS
1. Standardization of preservation techniques of natural leaves for dry flower arrangements
Saima Mir, M M Jana1 and Rajan Naik
Current Horticulture 1(1): 0710, JanuaryJune 2013
2. Confinement of zinc oxide nanoparticles in ordered mesoporous silica MCM-4.
N. B. Lihitkar, Samuel Violet, Mandar Shirolkar, Jai Singh, O. N. Shrivastava, R. H. Naik and S.
K. Kulkarni
Journal of Material Chemistry and Physics. 133 (2012) 850 856
3. RESIDUE OF d-TRANS ALLETHRIN ON DIFFERENT SUBSTRATE AFTER COMPLETE
BURNING OF MOSQUITO COILS MANUFACTURED FROM DIFFERENT INERT
MATERIAL
Deepak Phal, Sagar Patil, Kedar Deobhankar, Rajan Naik, Swati Vitonde, Nitin Ghatpande
International Journal of Institutional Pharmacy and Life Sciences 2(5): September-October
2012
4. Water Quality of Evaluation From District Nashik Maharastra (River Darana)
Dilip Dube and Rajan Naik.
International Journal Golden Research thought ISSN-2231-5063 July 2012.
5. Environmental Studies of the River Darna With Reference To Water Quality evaluation From
District Nashik- Maharashtra
Dube Dilip Karbhar and Dr.Rajan Naik
Indian Streams Research Journal, Volume 2, Issue. 6, July 2012
6. Laboratory Evaluation of Herbal Mosquito Coils against Aedes aegypti mosquito.
Volume 1 [10] September 2012: 16 - 20
Deepak Phal* Rajan Naik, Kedar Deobhankar, Swati Vitonde and Nitin Ghatpande
Bulletin of Environment, Pharmacology and Life Sciences (BEPLS) ISSN 2277 1808
7. Residue of d-trans allethrin on different substrate after complete burning of mosquito coils
manufactured from different inert material

International Journal of Institutional Pharmacy and Life Sciences (IJIPLS); 2(5):

September-October 2012 6-13
Deepak Phal, Sagar Patil, Kedar Deobhankar, Rajan Naik, Swati Vitonde, Nitin Ghatpande
8. To identify the source of heavy metal elements present in the mosquito coils and to reduce
their contents by choosing appropriate raw materials.
Deepak Phal and Dr. Rajan Naik
International Journal of Pharmaceutical Research and Bioscience IJPRBS, 2012; Volume
1(4):268-281 (ISSN: 2277-8713).
8. Concentration of d-trans allethrin in air after complete smouldering of mosquito repellent coil
manufactured using different fillers.
PHAL D, PATIL S, NAIK R, DEOBHANKAR K, VITONDE S & GHATPANDE N.
International Journal of biology, Pharmacy & Allied Sciences (IJBPAS) ISSN: 22774998
IJBPAS, October, 2012, 1(9): 1312-1321
10. Leaves to Flowers: An Aesthetic Transformation
Saima Rashid .M.M.Jana and R.H.Naik
Horticulture World (July-September) 2012, 40 - 41
11. What Dry Flowers Can Offer?
Saima Rashid .M.M.Jana and R.H.Naik
Horticulture World (January-March) 2012, 11-12
12. Skeleton Roses to Create A Lasting Beauty
Saima Rashid .M.M.Jana and R.H.Naik
Souvenir, The Rose Society of Pune, 2012, 41-42
13. Rose making with processed leaves.
Saima Rashid .M.M.Jana and R.H.Naik
The Indian Rose Federation (The Indian Rose Annual xxviii, (January 2012), 71-77
14. The art and craft of making roses from natural leaves skeletons.
Saima Rashid .M.M.Jana and R.H.Naik
Abstract Book of International Conference on Business Opportunities in Life Sciences,
(January 2012), 33
15. Preparative studies of leaves vein skeleton by fermentation under various condition
Saima Rashid .M.M.Jana; R.H.Naik

The Indian Horticulture World (submitted)

16.

Optical investigations of interaction between zinc tetra phenylporphyrin and CdSe

nanoparticles.
N. B. Lihitkar, S. B. Singh, R. H. Naik and S.K. Kulkarni
Chemical Physics Letters, 2009, 483, 227-232
17. Encapsulation of Metalloporphyrins in mesoporous silica MCM-41 and its optical
investigations.
N. B. Lihitkar, S. B. Singh, R. H. Naik and S.K. Kulkarni
18. Optical Investigations of the Thermally Stable CdS Doped Silica Aerogel.
N. B. Lihitkar, S. B. Singh, R. H. Naik and S.K. Kulkarni
19. Polystyrene encapsulation of Manganese porphyrins: highly efficient catalysts for oxidation
of olefins.
Rajan Naik, Padmakar Joshi, Shubhangi Umbarkar and Rajesh K. Deshpande
Catalysis Communications, 2005, 6,125-129
20. Polystyrene Immobilization of Metalloporphyrins: Efficient catalysts for aerobic oxidation of
alcohols.
Rajan Naik, Padmakar Joshi, and Rajesh K. Deshpande
J. Mol. Catalysis A: Chemical, 23, 2005, 46-50
21. Polymer encapsulation of Metallophthalocynines : Efficient catalysts for aerobic oxidation
of alcohols.
Rajan Naik, Padmakar Joshi, and Rajesh K. Deshpande
Catalysis Communications, 2004, 5,195-198
22. Facile synthesis of meso-substituted dipyrromethanes and porphyrins using cation
exchange resins
Rajan Naik, Padmakar Joshi, Sharada P.Kaiwar (nee Vakil) and Rajesh K. Deshpande
Tetrahedron, 2003, 59, 2207-2213
23. Synthesis of Chaetomellic Acid A:A potent inhibitor of Ras Farnesyl-Protein Transferase
N.P.Argade and Rajan H.Naik
Bioorganic & Medicinal Chem. 1996, 4(6), 881-883.
24. Structure-based Design of Achiral Anthranilamides as P2/P2 surrogates for

Symmetry-based HIV Protease Inhibitors: Design, Synthesis and X-ray structure, Enzyme
Inhibition and Antiviral Activity.
R.S.Randad, Rajan H.Naik, L.Lubkowska, S.V.Gulnik, Betty Yu, Abelardo Silva and John
W.Erickson
Bioorganic & Medicinal Chemistry Letters, 1995, 5(21), 2557-2562.
25. Symmetry-based HIV Protease Inhibitors: Synthesis of HIV Protease Inhibitors containing
Symmetric Hydroxy Bis-Urea Isostere.
R.S.Randad, Rajan H.Naik and John W. Erickson
Bioorganic & Medicinal Chemistry Letters, 1994, 19, 2343-2346.
26. Toxicity of newly synthesized pyrethroids against mosquito larvae, Aedes aegypti (Diptera
cuticidae).
R.H.Naik, D.G.Panse, D.S.Hebbalkar, G.D.Hebbalkar and R.N.Sharma
Indian J. Of Experimental Biology, 1994, 32, 132-134.
27. A novel non-MIC route to Carbamates: Scope of the irreversible transesterification reaction
of methyl N-methylcarbamate with phenolic substrates possessing addition functional groups.
R.H.Naik, G.Kumaran and G.H.Kulkarni
Indian J.Chemistry, 1993, 32B, 893.
28. Contra-thermodynamic transesterification of Carbamates by counter-attack strategy: a viable
non-phosgene, non-MIC route to Carbamate Pesticides.
R.H.Naik, G.H.Kulkarni and S.Rajappa
Tetrahedron, 1991, 47(7), 1249-56.
29. Synthesis of (+) cis and (+) trans Ethyl/Isopropyl/3-phenoxybenzyl/Cyano -3phenoxybenzyl-2-alkyl/aryl-4-oxo/hydroxy/acetoxy spiro [2,5] octane and spiro [2,4]heptane-1carboxylates.
R.H.Naik, A.A.Arbale and G.H.Kulkarni
Indian J. Chemistry, 1990, 29B, 568-571.
30. Synthesis of Methyl 1S cis-2, 2-dimethyl-3n-alkyl cyclopropane methanols from (+)-3Carene
R.H.Naik, A.A.Arbale, G.H.Kulkarni and R.B.Mitra
Indian J. Chemistry, 1988, 27B, 253-256.

31. Stereo specific synthesis of optically active cis 3R (3,3-dihalo-2-propenyl)-2,2-dimethyl

1S hydroxymethyl cyclopropane and corresponding cyclopropane carboxylic acids
R.H.Naik, G.S.Joshi and G.H.Kulkarni
Current Science, 1987, 56, 409-411.
32. Synthesis and reactions of 4--Acetoxy-2-ene.
R.H.Naik and G.H.Kulkarni
Indian J. Chemistry, 1986, 22B, 306-307.
33. Synthesis of 3-Phenoxybenzyl 1R trans-2, 2-dimethyl-3-(2-phenyl/p-substituted phenylprop1-enyl) cyclopropane carboxylates from (+)-3-Carene.
R.H.Naik and G.H.Kulkarni
Indian J. Chemistry, 1985, 22B, 154-158.
34. Synthesis of Methyl 1R (-) cis (+) cis-2,2-dimethyl-3-(2-oxopropyl) cyclopropane
carboxylates from (+)-3-Carene.
R.H.Naik and G.H.Kulkarni
Indian J.Chemistry, 1983, 22B, 1209-1212.
35. Synthesis of Methyl (+) cis chrysanthemates and (+) cis homochrysanthemates from (+) 3Carene.
R.H.Naik and G.H.Kulkarni ,
Indian J.Chemistry, 1983, 22B, 859-763.
PATENTS
Foreign Patents:
1. US patent Application No 11 / 331,358 - A process for the preparation of encapsulated
Metalloporphyrin catalyst and a process for oxidation of alcohols
R. H. Naik and P.L. Joshi
2. US patent No. US 6,852,864 (2005)- Process for the synthesis of Dipyrromethanes
R. H. Naik and P.L. Joshi
3. U.S. Patent is filed: An improved process for the preparation of Aryl Nesters (Mrs.) S.R.Deshpande and R.H.Naik
4. U.S. Patent No.: US 5,750,757 (1998)- Pesticidal Ester preparation
A.R.A.S.Deshmukh, R.H.Naik, S.K.Tandel and S.Rajappa

alkylcarbamate

5. U.S. Patent No.: US 5621132

(1997)-A process for making alkyl-N-alkyl or N-aryl

thiocarbamates
R.H.Naik, A.R.A.S.Deshmukh, S.K.Tandel and S.Rajappa
6. European Patent No. 446514 (1990)- An improved process for the preparation of aryl-nalkylcarbamates
R.H.Naik, G.H.Kulkarni and S.Rajappa
7. U.S. Patent No. US 5066819 (1990) -An improved process for the preparation of aryl-nalkylcarbamates
R.H.Naik, G.H.Kulkarni and S.Rajappa
Indian patents:
1. Herbal formulation as insect repellant and process for preparation thereof.
Indian Patent Application Number: 2675 /MUM/2012
Rajan Naik, Kedar Deobhankar, Nitin Ghatpande, Deepak Phal and Swati Vitonde
2. A Novel Synergistic Bactericidal composition, dressings using the said composition and
method of treatment of wounds
Indian Patent Application No. 2509/Mum/2012
Rajan Naik, Kedar Deobhankar, Nitin Ghatpande, Deepak Phal and Swati Vitonde
3. A process for the preparation of encapsulated Metalloporphyrin catalyst and a process for
oxidation of alcohols
Indian Patent Application No. 799/DEL/2005
R. H. Naik and P.L. Joshi
4. An improved process for the preparation of meso- substituted Dipyrromethanes.
R. H. Naik and P.L. Joshi
Indian Patent Number 370 / DEL / 2002
5. An improved process for the preparation of Aryl N-alkylcarbamate esters
(Mrs.) S.R.Deshpande and R.H.Naik
Indian Patent No. 186426 (2002).
6. A process for the preparation of 3-Tetradecyl 2-oxo-3H-imidazo [1,2-a] pyridinium bromide:
An important intermediate for the synthesis of Chaetomellic Acid A Anhydride
N.P.Argade and R.H.Naik

Indian Patent No.184878 (2001)

7. A process for the preparation of Chaetomellic Acid A Anhydride: A potent inhibitor of Ras
Farnesyl-Protein Transferase
N.P.Argade and R.H.Naik
Indian Patent No. 184694 (2001)
8. A process for the preparation of N-(2-pyridyl)- -bromopalmitamide: A key intermediate for
the preparation of Chaetomellic Acid A Anhydride
N.P.Argade and R.H.Naik`
Indian Patent No.183338 (2000)
9. An improved process for the preparation of N-haloacetamides
R.H.Naik, V.S.Dalavoy and (Mrs.) S.R.Deshpande
Indian Patent Application No. NF/157/97
10. A novel process for the conversion of dithiocarbamates into alkyl/aryl/N-alkyl/aryl
carbamates
R.H.Naik, S.K.Tandel and S.Rajappa
Indian Patent No. 175790 (1996).
11. A process for the preparation of -RS cyano p-substituted benzyl (+) cis-2, 2-dimethyl-3(2,2-dichlorovinyl)cyclopropane carboxylates, highly potent insecticides belonging to the
synthetic pyrethroids group
R.H.Naik, D.G.Panse and G.H.Kulkarni
Indian Patent No.175850 (1996).
12. Improved process for the preparation of Aryl N-alkyl carbamate esters
R.H.Naik, G.H.Kulkarni and S.Rajappa
Indian Patent No.173865 (1995).
13.

process

for

the

dimethyl-3-(2,2-dichlorovinyl)
insecticides

belonging

preparation

of

cyclopropane
to

the

p-substituted
carboxylates,
synthetic

R.H.Naik, D.G.Panse and G.H.Kulkarni

Indian Patent No.172965 (1994).
14. An improved process for the preparation of aryl-n-alkylcarbamates

benzyl

(+)

cis-2,2-

highly

potent

pyrethroids

group

R.H.Naik, G.H.Kulkarni and S.Rajappa

Indian Patent No. 170908 (1993).
15. An improved process for aryl substituted aryl/alkyl substituted alkyl ester of n-alkyl/aryl
carbamic acid.
R.H.Naik, G.H.Kulkarni and S.Rajappa
Indian Patent No.179735 (1990)
16. An improved process for the preparation of alkyl esters of n-methylcarbamothoic acid (Oalkylthiocarbamates into the corresponding S-alkyl analogues)
R.H.Naik, A.R.A.S.Deshmukh, S.K.Tandel and S.Rajappa.
Indian Patent No.175790 (1990)

Research students under the guidance for their Ph. D.

programmes:
Sr.
Name
N
of
o. student
1 Prashant
N.
Lihitkar
2 Dilip K.
Dube
3

Dipak
Budguja
r

Saima
Rashid
Mir

Deepak
Phal

Nitin
Ghatpan
de

Univers
ity

Status

Project title

Pune
Universit
y
Singhani
a
Universit
y
Singhani
a
Universit
y
Singhani
a
Universit
y
Singhani
a
Universit
y

Awarded
(2010)

Thesis
submitte
d

Investigations of TiO2, ZnO and

Metalloporphyrins Nanoparticles
inside the Mesoporous Silica MCM-41
Environmental Studies of the River
Darna With Reference To Water
Quality evaluation From District NasikMaharashtra
Impact assessment of sugarcane
factory effluent on soil and water in
Jalana district of Maharashtra

Awarded
( July
2014)

THE ART AND CRAFT OF DRY

FLOWERS: PREPARATION,
PRESERVATION AND DECORATION

Awarded
(April
2014)

Shivaji
Universit
y

Work in
progress

DEVELOPMENT OF NEW MOSQUITO

COIL FORMULATION HAVING
IMPROVED PERFORMANCE
PARAMETERS WITH SPECIAL
EMPHASIS ON MINIMISING HEALTH
HAZARD
Susceptibility status of Anopheles
culicifacies to synthetic pyrethroids
and its underlying mechanisms in
conjunction with susceptibility of

Awarded
( March
2014)

Satish
Yadav

NIMS
Universit
y

Work in
progress

Yatin
Mokel

NEHRU
GRAMIN
Universit
y

Work in
progress

Anand
kale
( M.Phil
degree)

YCMOU

Plasmodium falciparum to drugs in

geographical locations of Maharashtra
DEVELOPMENT OF FOGGING /
MISTING CONCENTRATE USING
SYNTHETIC PYRETHROIDS FOR
INDOOR AND OUTDOOR MOSQUITO
CONTROL.

DEVELOPMENT OF NANOENCAPSULATED HREBO-BOTANICAL

AEROSOL FORMULATION FOR THE
CONTROL OF HOUSEHOLD AND
GARDEN PESTS
AwardedChemical and microbiological estimation of water
(2005) portability at selected sectors in Mumbai region.

M.Sc. PROJECT DISSERTATIONS: (As a Research Guide- University of Pune)

Sr.
Project title
N
o.
1 Polystyrene supported metallophthalocyanines: Efficient catalysts for aerobic
2

oxidation of alcohols (May 2006).

Polymer Supported Metalloporphyrins: Synthesis, Characterization and

Applications (May 2006).

Synthesis of water soluble Porphyrins (July 2005)

Synthesis of chemical nucleases and its comparative study with biological

nucleases (April 2005)

Metallation and sulphonation studies of Porphyrins (July 2005)

Synthesis, Immobilization and Applications of Metalloporphyrins (April 2004)

Synthesis, Immobilization and Applications of Metalloporphyrins (April 2004)

Encapsulation of Metallophthalocynines: Efficient catalysts for

aerobic oxidation of alcohols (April 2004).
Synthesis of meso-substituted tetrarylporphyrins by microwave irradiation and

mixed porphyrins via dipyrromethanes. (April 2002)

10

Part 1- Esterification reactions of benzoic acid and its derivatives using cation
exchange resins Part 2- Identification of synthetic pyrethroids from mosquito

11

repellent coil and liquid vaporizer by gas chromatography. (April 2002).

Synthesis of meso-substituted tetraryl porphyrins and metalloporphyrins via

12

dipyrromethanes. (April 2001)

Synthetic Metalloporphyrines. (April 2000)

13

A novel method for the Carbamate Esters. (April 1999)

Significant Presentations

The poster entitled Synthesis and optical study of tetra phenyl porphyrin nanoparticles was
presented at 4th ICMAT (International Conference on Materials for Advance Technology), held
at Singapore from 1 to 6 July 2007.

A talk on Synthesis of Metalloporphyrins as versatile oxidation catalysts was presented at

Department of Chemistry, University of South Florida, Tampa, USA on May 2, 2002.

A paper entitled Structure-based design of achiral anthranilamides as a P2/P2 ligands for

symmetry based HIV-Protease Inhibitors was presented at Indo-German Symposium on
Organic Synthesis: Growing Interface with Adjacent Sciences on September 27-28, 1996, held
at Hyderabad, India.

A paper entitled Symmetry-based HIV-Protease Inhibitors containing symmetric hydroxy Bisurea Isostere was presented at the 10th ICOS Conference (IUPAC Symposium) held at
Bangalore, India, in December 1994.

A Novel Technology for Carbamate Pesticides presented at Pesticides: Future Scenario

Symposium at New Delhi, India, in April 1993.

A talk on Recent Advances in Pesticides was presented at S.P. College, Pune, India, in 1991.

Contra-thermodynamic transesterification of Carbamates by counter-attack strategy presented

at National Seminar on Recent Advances in Synthetic Organic Chemistry held at the
Department of Chemistry, Bharathiyar University, Coimbatore, India, on June 9-10, 1990.

A paper entitled NCL develops a non-phosgene, non-MIC route for carbamate pesticides was
presented at National Symposium on Pest Management without Environment Pollution on
September 18-19, 1990, at NCL, Pune, India.

Significant Conferences / Workshops attended

Attended 3 day workshop on Advanced Patent Drafting arranged by N.C.L. Venture Center at
NCL innovation park on 26-28 September 2013

Attended Patent awareness workshop arranged in Maharashtra State of Cultivation of Science

(ARI), Pune on May 17th 2000.

Attended one-day workshop on Pesticide Manufacturing & Formulation Association on 27th July
2000 at NCL.

Attended fifth IUPAC International symposium on Bioorganic Chemistry (ISBOC-5) at NCL

from 30th January to 4th February 2000.

Attended WIPO CSIR National Roving workshop on Drafting, Interpretation & Examination
of patent documentations at NCL on 21st & 22nd April 1997.
Extra Work
Developed variety of following products / Formulations for reputed Indian / MNC
clients

Powder and Liquid range of Laundry Detergents, Fabric Softeners of International

standards.
Medical disinfectants such as Sterilium, Cutasept, Cidex type: Operation Theatre
Instrument sterilizer, Betadine scrubbers, solutions of different strengths and douche.
(Formulations sold to client for its sale through TTK Healthcare)
Wound management formulation ( Beta- Tulle with its patent and copyright)
ECG jelly, Sonography (ultrasound Gel) Jelly.
Poultry, Hatchery, Fishery disinfectants
Energy Drinks like Red Bull and Mountain Dew
Health Drinks, Isotonic drinks
Herbal Mosquito repellent giving 8 hrs protection ( Patented)
Housekeeping and Janitorial Chemicals such as Floor cleaners, Window and Glass
cleaners, Toilet and Bathroom cleaners, Air Fresheners, Car Fresheners and
Bathroom Fresheners, Mat and Sofa cleaners, Marble cleaners, Hand Sanitizers
(Gel and Liquid form)

Novel Toilet, Bathroom disinfectants (Liquid, Tablets), Vegetable, Fruits washing

with killing pathogenic bacteria, fungi, mould and pesticide removal solutions.
Gold / Silver polish chemicals
Cockroach Gel
Pest control agents, both Chemical and Herbal based
3 in 1
Screen printing coating and de -coating solutions
Veterinary pour on and spot on formulations for MNC
Car coolants (For Castrol) etc ---------------