DRUG STUDY

Drug Data

Generic
Name
biperiden
Trade Name
Akineton

Patients
Dose
2g tab OD PO

Minimum
Dose
6mg/day

Maximum
Dose
16mg/day

Classification
Therapeutic:
Antiparkinson
agents
Pharmacologic
:
Anticholinergics
Pregnancy
Category
C

Mechanism of
Action
Is a tertiary amine
antimuscarinic with
central and
peripheral actions.
It stimulates and
then depresses the
CNS, it also has
antispasmodic
actions on smooth
muscle and
reduces secretions,
esp salivary and
bronchial
secretions.
Pharmacokin
etics
A: Readily
Absorbed from the
GI tract.
D: Unknown

Contents
biperiden

M&E: Extensive
first-pass effect.

Availability
and color
Tablets:
2mg, 4mg,
8mg

Peak
unknown

Routes of
administrati
on

Duration
unknown

PO

Onset
unknown

Drug Half
Life
About 20 hrs.

Indication

General
Indications

Adjunctive
treatment of all
forms of Parkinson
disease, including
drug-induced
extrapyramid
effects and acute
dystonic
reactions.

Patients
Actual
Indication

To prevent drug
induced
extrapyramid
effects and acute
dystonic reactions

Contraindications
Hypersensitivity;
Angleclosure
glaucoma; Bowel
obstruction;
Megacolon;Tardive
dyskinesia.
Precaution
Prostatic
enlargement;
Seizure
disorders;Cardiac
arrhythmias;
OB, Lactation:
Safety not
established;
Geri: Increased risk
of adverse
reactions; lower
doses may be
necessary.
.Drug interaction
-drug to drug
Amantadine May
increase
anticholinergic
adverse reactions.
Digoxin May
increase digoxin
serum levels,
especially with slowdissolution oral
digoxin tablets.
Haloperidol May
worsen
schizophrenic
symptoms; may
decrease
haloperidol serum
levels; tardive
dyskinesia may
develop. May
decrease action of
phenothiazines. May

Adverse Reaction

Nursing Responsibilities

CNS: confusion,
Before
depression,
1. Asses patients
dizziness,
diagnosis.
hallucinations,
2. Assess patients
headache, sedation,
mental status.
weakness.
3. Assess patients
visual acuity.
EENT: blurred vision,
4. Confirm medication
dry eyes, mydriasis.
from doctors orders.
CV: arrhythmias,
5. Assess blood
hypotension,
pressure.
palpitations,
tachycardia.
GI: constipation, dry During
mouth, ileus, nausea.
1. Confirm patients
GU: hesitancy,
identity.
urinary retention.
2. Administer
Misc: decreased
medication at the
sweating.
right prescribed
route.
3. Must administer
medication with food.
4. Practice aseptic
technique.
5. Administer
medication at the
prescribed time.
After
1. Observe proper
documentation of
administered
medication.
2. Ensure that patient
has fully swallowed
oral form of
medication.
3. Observe patients
behavior closely for
atleast 15-30
minutes after
administration.
4. Instruct patient to
move slowly to
prevent dizziness.
5. Encourage patient to

increase incidence
of anticholinergic
adverse reactions.
Source:
Deglin, J. et. Al. 2009. Daviss Drug Guide for Nurses. 12 th ed. F.A. Davis. pp 1320

increase fluid intake

to prevent drying of
mouth.