Mosquitoe

s
(Mansonia
mosquitoe
s)

3rd stage
larvae
present
in
proboseis
of fly

3rd stage
larvae travel
to proboseis
of mosquito

Microfilariae
develop into 1st
stage larvae then
eventually to 3rd
stage larvae

Brugia malayi

3rd stage
(infective
stage)
larvae enter
bite wound

3rd stage larva

travel in the
circulation until
reach lymphat
vessels

Microfilariae travel to
the proventiculus of
mosquito then
penetrate the midgut

during blood
feeding in the
day/night,
mosquitoes
bite infected
host (infected
w/
microfilariae)

infected
flies bite
host
during
night
time

MICROFILARI
AE travel to
the
lymphatic
vessels and
into the
circulation

Adults
copulate in
lymph nodes
and females
produce
MICROFILARI
AE
(diagnostic
stage)

3rd stage
larvae settle
in lymph
nodes and
become adults

Chryso
ps fly
3rd stage
larvae travel
to proboseis
of chrysops
fly

Microfilariae
develop into 1st
stage larvae
then eventually
to 3rd stage
larvae

3rd stage
larvae
present
in
proboseis
of fly

Loa loa

Microfilariae
travel to the
midgut of
chrysops fly
during
blood
feeding in
the day,
chrysops fly
bite
infected
host
(infected w/
microfilaria
e)

infected
flies bite
host
during
night
time

3rd stage
(infective
stage)
larvae enter
bite wound

3rd stage larva

travel in the
circulation until
subcutaneous tiss

MICROFILARI
AE travel to
the
lymphatic
vessels and
into the
circulation

Adults
copulate in
subcutaneou
s and
females
produce
MICROFILARI
AE
(diagnostic
stage)

3rd stage
larvae settle
in
subcutaneous
tissues and
become adults

Simulia
n fly
3rd stage
larvae travel
to proboseis
of fly

Microfilariae
develop into 1st
stage larvae then
eventually to 3rd
stage larvae

3rd stage
larvae
present in
proboseis
of fly

Onchocerca
volvulus

Microfilariae
travel to the
midgut of
Simulian fly
during blood
feeding in
the day,
Simulian fly
bite infected
host
(infected w/
microfilariae
)

infected
flies bite
host
during
night
time

3rd stage
(infective
stage) larvae
enter bite
wound

3rd stage larvae

travel in the
circulation until the
subcutaneous tissues

MICROFILARIA
E reside in
subcutaneous
tissue

Adults
copulate in
subcutaneous
and female
produce
MICROFILARIA
E (diagnostic
stage)

3rd stage
larvae settle
in
subcutaneou
s tissues and
become
adults