ASPIRIN

Brand Names: Aspilet, Scheeprin, Bayer

Classification: Antithrombotic/ NSAIDs
PNDF Section:
*Medicine for Acute Coronary Syndrome: Antithrombotics
*Post-myocardial infarction maintenance medicines
* Medicine for Peripheral Artery Occlusive Disease
* Medicine Affecting the Blood
Typical Dosage:
Pedia:
> Juvenile rheumatoid arthritis:
- weighing more than 25 kg (55 lb): 2.4 to 3.6 g P.O. daily
in divided doses.
- weighing 25 kg or less: 60 to 130 mg/kg daily P.O. in
divided doses.
Increase by 10 mg/kg daily at no more than weekly
intervals. Maintenance dosages usually range from 80 to
100 mg/kg daily; up to 130 mg/kg daily.
> Mild Pain or Fever:
- Children ages 2 to 11: 10 to 15 mg/kg/dose P.O. or P.R.
every 4 hours up to 80 mg/kg
Adult Dose: As Antithrombotic agent: 30 mg to 80 mg,
once daily.
Pregnant: should only take aspirin if clearly needed.
Dialysis: Detailed information concerning the removal of
aspirin by hemodialysis is not available. Some
investigators have suggested that aspirin and/or
salicylate may be removed by hemodialysis and that
aspirin dosing should follow dialysis sessions
Route: Most commonly oral, also rectal.

Indications for use:

It is used to treat pain, and reduce fever or inflammation.
Aspirin is sometimes used to treat or prevent heart
attacks, strokes, and chest pain (angina). Aspirin should
be used for cardiovascular conditions only under the
supervision of a doctor.
Administration:
Take immediately after meals. Take each dose of aspirin
with a full glass of water unless patient is fluid restricted.
The tablet must be swallowed whole with a glass of water.
Do not chew, crush or bite the tablet since this may cause
inappropriate release and absorption of the drug.
Mode of Action: Inhibits synthesis of prostaglandin by cyclooxygenase;
inhibits platelet aggregation; has antipyretic and analgesic activity.
Mode of Elimination: Salicylic acid plasma halflife is
approximately 6 h, but may exceed 20 h in higher doses.
The halflife is approximately 15 to 20min for aspirin.
Elimination follows zero-order kinetics. Renal elimination
of unchanged drug depends on urine pH. A pH of more
than 6.5 increases renal Cl of free salicylate from less
than 5% to more than 80%.
Common Side Effects:
rash, gastrointestinal ulcerations, abdominal pain, upset
stomach, heartburn, drowsiness, headache, cramping,
nausea, gastritis, and bleeding.
3 Important Issues I Would Counsel Patients with:

3 Drugs which significantly interact with this class

and state what action I would take:
1.) Ibuprofen decreases effects of aspirin. Possible serious
or life-threatening interaction. Ibuprofen decreases the
antiplatelet effects of low-dose aspirin by blocking the
active site of platelet cyclooxygenase.
Corrective Action: Let your healthcare professionals
(e.g. doctor or pharmacist) know that you are using these
products together. Your doctor may want to change your
medicine. Taking ibuprofen 8 hours before or 30 minutes
after the aspirin may help avoid the problem. Take other
NSAIDs at least two hours after your aspirin. Your
healthcare professionals may already be aware of this
interaction and may be monitoring you for it. Do not start,
stop, or change the dosage of any medicine before
checking with them first.
2.) Anticoagulants may increase risk of bleeding.
Corrective Action: Use with extreme caution if must be
used together.
3.) Antacids decrease aspirin concentration leading to
decrease aspirin action or no action.
Corrective Action: Watch for decreased aspirin effect.

http://www.webmd.com/drugs/2/drug-1082-3/aspirinoral/aspirin-oral/details/list-interaction-details/dmid1627/dmtitle-aspirin-ibuprofen/intrtype-drug