MCQ Series Practice Test UG-S2

MCQ Series Practice Test-2
Basic Sciences
Author Email: sidharta123@yahoo.com

Total Marks: 25 | Pass Mark: 15
PHARMACOLOGY
Read the instructions at the begining carefully. Subjects inlude Pharmacology &
Clinical Pharmacology. Answer sheets are provided separately.
Please Note: There is a Negative Marking of (-1) for each incorrect response. There
may be more than one correct answer(s).
Multiple Choice Questions (MCQ)
Total time for test = 30 minutes
QUESTION 1. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Regarding dicarboxylic acids correct statements are:
1. Oxaloacetic acid is an aromatic dicarboxylic acid
2. Phthalic acid is an unsaturated dicarboxylic acid
3. Maleic acid is a linear saturated dicarboxylic acid
4. oxalic acid is a linear saturated dicarboxylic acid
QUESTION 2. Choose the CORRECT options (A-E) listed below, MULTIPLE options may be
correct.
Regarding induction of hepatic isoenzymes P450 CYP
A) chronic alcohol consumption induces CYP2B1
B) Isoniazid induces CYP3A
C) phenobarbitone induces CYP2B1
D) chronic alcohol consumption induces CYP2E1
E) phenytoin induce CYP3A
All of the following drugs are specific inhibits of organic anion transporter (OAT3) in the human
kidney except:
A) chlorpropamide
B) mefenamic acid
C) ornidazole
D) demeclocycline
E) artesunate
Regarding mechanism of action of glibenclamide
A) inhibition of glucagon-induced elevation of cAMP
B) suppresses hepatic gluconeogenesis

C) decreases absorption of glucose from the g.i. tract
D) stimulates insulin release
E) increases better utilization of glucose
Catalase-negative bacteria/organisms include:
A) Enterococcus faecalis
B) Corynebacterium diphtheriae
C) Staphylococcus aureus
D) Shigella dysenteriae
E) E. coli
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Side effects of phenytoin includes:
1. interstitial nephritis
2. arthralgia
3. gout
4. peripheral neuropathy
An anthelmintic drug used to treat tapeworm infection
A) Ivermectin
B) Albendazole
C) Antimycin A
D) Mebendazole
E) Niclosamide
Co-trimoxazole is not effective against:
A) Yersinia enterocolitica
B) Staphylococcus aureus
C) Streptococcus pyogenes
D) Chryseobacterium meningosepticum
E) Francisella tularensis
Which of the following drugs do not belong to morphinan class?
A) codeine
B) butorphanol
C) dextromethorphan
D) oxycodone
E) pentazocine
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Which of the following statements regarding opioids is/are correct?
1. Dextrorphan is a glycine receptor agonist
2. naloxone is used to block the effects of opioid overdose
3. Dextromethorphan is a drug of benzomorphan class
4. dihydrocodeine is a semi-synthetic opioid analgesic
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
All of the following are substrates for organic anion transporter (OAT1) in the basolateral membrane
of the kidney except:
1. PAH
2. folate
3. aciclovir
4. penciclovir
correct.
Which of the following TCAs causes marked hypotension and cardiac arrhythmias?
A) imipramine
B) mirtazepine
C) citalopram
D) bupropion
E) duloxetine
A semisynthetic opioid derivative of thebaine:
A) levopropoxyphene
B) codeine
C) buprenorphine
D) bupropion
E) dihydromorphinone
correct.
Classify the antibiotics according to their correct origin and groups that they belong to:
A) Azithromycin is a macrolide antibiotic
B) Trimethoprim belongs to diaminopyrimidines group of antimicrobial drugs
C) Neomycin is a macrolide antibiotic
D) Colistin is a polyene antibiotic
E) Amphotericin B is a glycopeptide antibiotic

B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Drugs that decreases the plasma levels of digoxin include:
1. spironolactone
2. verapamil
3. amiodarone
4. domperidone
All of the following produce penicillinase except:
A) S. typhi
B) E. coli
C) H. influenzae
D) Staphylococci
E) B. subtilis
correct.
Which of the following statements regarding drug interactions is/are correct?
A) Ethanol predisposes to metformin-related lactic acidosis
B) corticosteroids antagonize the hypoglycaemic effects of sulphonylureas
C) lithium reabsorption is reduced by loop diuretics
D) tetracyclines reduces the aborption of calcium and iron in the stomach in presence of food
E) erythromycin cause accumulation of warfarin
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Spot the correct statements regarding drugs considered to be safe during pregnancy:
1. erythromycin is considered to be safe during pregnancy
2. cephalexin is not contraindicated in pregnancy
3. LMW heparin considered to be safe in pregnancy
4. Methyldopa is not contraindicated during pregnancy
Which of the following antibiotics are susceptible to degradation by gram -ve beta-lactamase
enzymes?
A) sulbactam
B) piperacillin
C) carbenicillin
D) carbapenem
E) clavulanic acid
The agent most commonly implicated to cause drug-induced hepatitis:
A) Co-trimoxazole
B) Streptomycin
C) Pyrazinamide
D) Nitrofurantoin
E) Ethionamide
All of the following drugs increases the plasma levels of digoxin except:
A) verapmil
B) diltazem
C) quinidine
D) metoclopramide
E) amiodarone
correct.
Spot the correct statements regarding the mechanism of action of the following antibiotics:
A) Polymyxins function by causing leakage from cell menbranes
B) Chloramphenicol acts by inhibiting cell wall synthesis
C) Erythromycin acts by inhibiting protein synthesis
D) Bacitracin acts by interfering with intermediary metabolism
E) Pyrimethamine acts by interfere with intermediary metabolism
Catalase-positive organisms include:
A) Clostridium perfringens
B) Corynebacterium diphtheriae
C) Streptococcus pyogenes
D) Enterococcus faecalis
E) Streptococcus viridans
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Side effects of pyrazinamide includes:
1. peripheral neuropathy
2. nystagmus
3. folate deficiency
4. interstitial nephritis
Stevens-Johnson syndrome is caused by
A) Erythromycin
B) Cyclophosphamide
C) Doxycycline
D) Lamotrigine
E) Cyclosporin
ANSWERS
QUESTION 1. Correct answer = C
QUESTION 2. Correct answer = D
QUESTION 3. Correct answer = A
QUESTION 4. Correct answer = B
QUESTION 5. Correct answers: A= F, B = T, C = T, D = T, E = T.
Essentials of Medical Pharmacology, Tripathy, KD
QUESTION 8. Correct answer = E
BRS Pharmacology
QUESTION 12. Correct answers: A= F, B = T, C = T, D = F, E = F.
QUESTION 15. Correct answers: A= T, B = F, C = T, D = T, E = F.
Essentials of Medical Pharmacology, Tripathy, KD
QUESTION 19. Correct answers: A= T, B = T, C = T, D = F, E = F.
QUESTION 21. Correct answers: A= T, B = F, C = F, D = F, E = T.
KD Tripathy Essentail of Medical Pharmacology

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Author Email: sidharta123@yahoo.com

B) suppresses hepatic gluconeogenesis

E) Amphotericin B is a glycopeptide antibiotic

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