Abegail Ibanez

MLS 3-D

HEMATOLOGY

12/11/14

POIKILOCYTES
Name
Acanthocyte

Synonyms
Spur cell

Illustration

Description

Associated Diseases

irregularly spiculated red

cells in which the ends of
the spicules are bulbous and
rounded

Abetalipoproteinemi
a

Severe hepatic
disease

Myeloproliferative
disorders

MAHA

Neuroacanthocytosis

Syndromes

* certain cases of liver

disease

Blister cell

Burr cell

Echinocyte

containing one or more

vacuoles that resemble a
blister on the skin

This cell has a

significantly thinned area
at the periphery or outer
border of the cell
membrane
irregularly contracted red

indication of
pulmonary emboli in
sickle cell anemia

A variety of anemias
Bleeding gastric ulcers

Abegail Ibanez

MLS 3-D

HEMATOLOGY

12/11/14

cells with prominent

spicules

Crenated
erythrocyte

Echinocyte

Elliptocyte

Elliptocyte

short, scalloped, or spikelike projections that are

regularly distributed
around the cell membrane
projections can vary in
number and appearance
generally narrower
more elongated than
megalocytes
have a rod, cigar, or
sausage shape.
represent a membrane
defect in which
the membrane is radically
affected and suffers a loss
of integrity.

Helmet cell

Schizocyte,
keratocyte

usually the larger scooped

out part of the cell
cell part that remains
after the rupturing of a

Gastric carcinoma
Peptic
Renal insufficiency
Pyruvate kinase defi
ciency
Uremia
Result from osmotic
imbalance
Dse-none

iron deficiency
anemia
myelofibrosis
megaloblastic
anemia
sickle cell anemia
hereditary
elliptocytosis
anemias associated
with malignancy
hemoglobin (Hb) C
disease
Hemolytic
anemias(occasionally)
pernicious anemia
sickle cell trait
thalassemia

Abegail Ibanez

MLS 3-D

HEMATOLOGY

Normal
erythrocyte
Oval macrocyte

Discocyte

Ovalocyte

Ovalocyte

Pyknocyte

Megalocyte

12/11/14

blister cell
formed as a result of the
physical process of
fragmentation
formed in the spleen and
intravascular fibrin clots

have an oval or egglike appearance

similar in
appearance to
elliptocytes,
megalocytes are
macrocytic and
have a fuller and
rounder appearance
have an oval or egg-like
appearance (Fig. 6.13).
Although these cells are
similar in
appearance to elliptocytes,
megalocytes are macrocytic
and
have a fuller and rounder
appearance. In contrast,
elliptocytes
tend to have a normal cellsize volume
distorted, contracted
erythrocytes
that are similar to burr cells

Abegail Ibanez
Schistocyte

MLS 3-D
Schizocyte

HEMATOLOGY

Sickle cell

Drepanocyte,
meniscocyte

Spiculated
erythrocyte

Spherocyte

burr cells,
crenated cells,
pyknocytes,
spur cells,
acanthocytes,
and
echinocytes
Spherocyte

12/11/14

fragments of erythrocytes
small and irregularly
shaped.
produced as the result of
the breaking apart of an
erythrocytes
about half the size of a
normal erythrocyte
may have a deeper red
appearance
resemble a crescent
At least one of the ends of
the cell must be pointed
the membrane is smooth
and the cell stains
uniformly throughout
irregularly contracted
erythrocytes

nearly spherical
erythrocytes, in
contradistinction to
normal biconcave disks.
diameter is smaller than
normal
lack the central pale area
or have a smaller, often
eccentric, pale area
(because the cell is

Hemolytic anemias
related to burns or
prosthetic implants
Renal transplant
rejection

Sickle cell anemia

Hereditary
spherocytosis

Certain hemolytic
anemias

Severe burns

Abegail Ibanez

MLS 3-D

HEMATOLOGY

12/11/14

thicker and can come to

rest somewhat tilted
instead of perfectly
flattened on the slide)
Stomatocyte

Stomatocyte

Target cell

Codocyte

Teardrop

Keratocyte

Dacryocyte

bull's-eye morphology
erythrocytes that are
thinner than normal
(leptocytes)
peripheral rim of
hemoglobin (Hb),
dark, central, Hbcontaining area

shaped like a teardrop

with a projection
extending from one end
partially deformed
but not cut

Hemoglobinopathies
(e.g., sickle cell
disease)

hypochromic
anemia

Certain thalassemias

Iron deficiency anemia

Splenectomy

Severe liver disease

obstructive jaundice

Myelofibrosis with
myeloid metaplasia
(MMM)
Disseminated (diffuse)
intravascular
coagulation (DIC)

Abegail Ibanez

MLS 3-D

HEMATOLOGY

Knizocyte

Leptocyte

12/11/14

spicules,resembling two
horns, result from a
ruptured vacuole
Usually the cell appears
like a half-moon or spindle
resemble a pinched bottle

resemble target cells

(codocytes)
but the inner, central
portion is not completely
detached from the outer
membrane

hemolytic anemias :
hereditary
spherocytosis
hepatic disorders
iron deficiency
anemia
thalassemia

Abegail Ibanez

MLS 3-D

HEMATOLOGY

12/11/14

Abegail Ibanez

MLS 3-D

HEMATOLOGY

12/11/14