Components of the

immune system

Contents
Cells and organs of the immune system
Overview of leukocyte migration

Adhesion molecules on leukocytes and

endothelial cells
Chemokines and their receptors
Leukocytes-Endothelial interactions and
leukocyte recruitment into tissue
Migration of phagocytes to sites of
infection and tissue injury
Migration and recirculation of T cells

Reference

Lymphoid organs
Lymph nodes
Spleen

Mucosal lymphoid tissues

Morphology of a lymph node and segregation

of B cells and T cells

Morphology of the spleen

Mucosal immune system

Receptors of innate and adaptive immunity

Innate

Adaptive

Principal cells of the immune system

Phagocytes
Neutrophil
Eosinophil
Monocyte, macrophage
Antigen presenting cells
Dendritic cell
Follicular dendritic cell
Monocyte, macrophage
B cell
Lymphocytes
T cell, B cell
Treg, gd T cell
NK cells, NKT cells

Granulocytes
Mast cell

Basophil
Eosinophil
Involvement in immune response to
helminthes and allergic reaction

Characteristics of nave, effector, and memory

lymphocytes

Properties of Nave, effector and memory lymphocytes

Adhesion molecules on
leukocytes and endothelial cells
involved in leukocyte recruitment

Adhesion molecules on leukocytes and endothelial cells

Seletins and selectin ligands

Integrin and integrin ligands
Chemokines and chemokine receptors

 Seletins and selectin ligands

Plasma membrane carbohydrate-binding
adhesion molecule
Mediate an initial step of low affinity
adhesion of leukocyte to endothelial cells
Integrin and integrin ligands

Heterodimeric cells surface proteins

Mediate adhesion of cells or to
extracellular matrix

Chemokines
Stimulate leukocyte movement
regulate the migration of
leukocytes from blood to tissue

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Acute inflammation response

Migration of T cells

Migration of T cells

http://multimedia.mcb.harvard.edu/flash/extravasation.swf

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