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Key Findings from Irritable Male Syndrome: Understanding and Managing the 4 Key
From Chapter 8
Trauma-spectrum disorders
Although we have known for some time that stress can cause damage to the heart, the
gastrointestinal tract, and other parts of the body, we have recently learned that stress
can actually damage the brain. J. Douglas Bremner, M.D., is Director of Mental Health
“Research in only the past decade or so has shown that extreme stress has effects on
As a result many of those emotional distresses that we have, in the past, viewed as
purely psychological, may be the result of physical damage to the brain. “A group of
stress.”ii
Bremner continues saying that “Trauma-spectrum disorders are those that are
depression, and anxiety.”iii I would include the Irritable Male Syndrome as another one
Trauma-spectrum disorders and Gender: Women Cry and Men Run Away
One of Dr. Bremner’s experiments helps us understand the difference between the
way men and women experience these disorders. He gathered a group of former
depression patients. With their permission, he gave them a beverage that was spiked
with an amino acid that blocks the brain’s ability to absorb serotonin, the
Using the new brain scan techniques he took pictures of the subject’s brains to see if
he could pinpoint the areas that were associated with depression. If we knew the areas
of the brain associated with depression, he reasoned then we could come up with better
medications and treatment approaches. In looking at the color brain scans he was able
to show that a loss of serotonin affects all three major areas of the brain.
What I found even more fascinating were the gender specific differences in the way
men and women reacted to the potion that blocked the effects of the serotonin. Typical
of the males was John, a middle-aged businessman who had fully recovered from a
minutes of drinking the brew, however, "He wanted to escape to a bar across the
street," recalls Bremner. "He didn't express sadness … he didn't really express
anything. He just wanted to go to Larry's Lounge." Contrast John's response with that
of female subjects like Sue, a mother of two in her mid-thirties. After taking the cocktail,
"She began to cry and express her sadness over the loss of her father two years ago,"
So we see a very real contrast in the ways men and women respond to a loss of the
brain chemicals that keep our emotions in a healthy balance. Men tend to withdraw and
go for the alcohol to prevent us from feeling our pain. Women tend to share their
emotions with others. I have found that chronic irritability is one of the principal ways