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MOA of AEDs
Antidepressants
Antipsychotics
(asenapine, olanzapine,
quetiapine)
MOA of AP
Prophylactic, to avoid
cycling of episodes
Bipolar depression
ANXIOLYTICS
Acting via amino acid
MOA of AEDs
transmission
Anxiety disorders
(benzodiazepines, AEDs)
TMI. Everything with
panic, anxiety and phobia
Acting via monoaminergic
MOA of ADs
on their nomenclature are
NTs
ADs
(antidepressants TCA,
MAOI, SSRI, SNRI, NaSSA)
Antipsychotics
MOA of APs
LEGEND: *Reuptake inhibitors | -Enzyme inhibitors | + Mixed receptor blockers
EJBC A2019
*SNRI
(venlafaxine, duloxetine)
Blocks 5HT2&
noradrenaline reuptake
*NDRI
(bupropion)
Blocks norepinephrine
and dopamine reuptake,
similar cascade as SSRI
Reversible inhibitor of
MAO (2 weeks) &
destroy its function
Increased 5HT2, NE and
D
Blocks alpha 2
autoreceptors on
epinephrine and
heteroreceptors on
serotonin neurons
Increases 5HT2 and NE
-MAOI
(isocarboxazid, phenelzine,
tranylcypromine)
- RIMA
(moclobemide)
+NaSSA
(mirtazapine, mianserin)
+SARI
(trazodone, nefazodone)
Lithium carbonate
Inositol phosphate
metabolism modulation;
inhibition of IMPase:
modulates PKC signaling
activity
Decreases intracellular
NA; attenuates
fluctuation in CAMP;
neuroprotection
EJBC A2019
Depressive disorders
DMDD, MDD,
Premenstrual dysphoric
d/o, substance induced
depressive d/o
Bulimia, electrolyte
imbalance
Diet w tyramine
MOOD STABILIERS
Bipolar and related d/o
Bipolar I & II, cyclothymic
d/o, substance induced
bipolar, etc.
Amelioration of affective
and psychotic symptoms
during manic phase
Improvement in
depression
DRUG
MOA
PSYCHOPHARMACOLOGIC AGENTS
INDICATIONS
CONTRAINDICATIONS
ANTIPSYCHOTICS
Depressed sensorium,
parkinsonism,
pregnant, respiratory
depression, geriatric
Psychotic
patients
(schizophrenia,
schizoaffective,
schizophreniform,
psychosis, manic phase of
bipolar, delusional
disorders)
Non-Psychotic
(Alzheimers, Gilles dela
Tourette, tetanus,
antiemetic, cingultus,
preoperative medications,
antishistaminic)
Typical Antipsychotics
- Phenothiazines
(chlorpromazine,
thioridazine,
trifluoroperazine)
- Butyrophenones
(haloperidol)
- Thioxanthenes
(thiothixene)
Atypical Antipsychotics
- Tight D2 binding
(ziprazidone, loxapine,
clozapine, risperidone,
paliperidone, sertindole,
olanzapine, sulpride,
amisulpride)
- Readily D2 dissociating
(quetiapine)
- Partial D2 agonist
(aripiprazole)
D2 blockade/ D2
antagonist
*Tricyclic antidepressants
3o amines
(amitypltyline, imipramine,
deoxepine)
2o amines
(nortriptyline, desipramine)
*SSRI
(cilatopram, escilatopram,
parozetine, fliozetine,
sertraline)
MDD, augmentation in
bipolar, premenstrual
dysphoric d/o, anxiety d/o
*NARI
(reboxetine)
Blocks noradrenaline
reuptake
EJBC A2019
D2&5HT2 antagonist
ANTIDEPRESSANTS
Depressive disorders
DMDD, MDD,
Premenstrual dysphoric
d/o, substance induced
depressive d/o
SIDE EFFECTS
COMMENTS
Prior
EPS + tardive dyskinesia, negative
symptoms, cognition
Current
Weight gain, CVD, hyperglycemia,
hyperlipidemia, akathisia, diabetes,
dizziness,
Clozapine agranulocytosis, seizure