ADRENOCEPTORS

M1
M2
M3

Nn
Nm

Nerve endings
Heart, some nerve
endings
Effector cells, smooth
muscle, glands,
endothelium
ANS ganglia

G-coupled
G-coupled

Neuromuscular end
plates

Ion channel

G-coupled

Ion channel

Increase IP3
Decrease cAMP,
activates K+ channel
Increase IP3

Depolarizes, evokes
action potential
Depolarizes, evokes
action potential

Alpha1

Effector tissues,
smooth muscle,
glands

G-

Increase IP3

Alpha2

Nerve endings,
some smooth
muscle

G-

Decrease cAMP

Beta1

Cardiac muscle,
kidney

G-

Increase cAMP

Beta2

Lungs, uterus,
heart

G-

Increase cAMP

Beta3

Adipose cells

G-

Increase cAMP

Increase Ca2+,
causes
contraction,
secretion
Decrease
transmitter
release, causes
contraction
Increase heart
rate, force,
increase renin
release
Relax smooth
muscle, increase
glycogenolysis,
increase HR,
force
Increase lipolysis

CHOLINOCEPTORS

NICOTINIC ANTAGONISTS
ORGAN
CNS
EYE
GIT

EFFECTS
Sedation, tremor
Mydriasis and cycloplegia
Marked reduced motility, constipation

GUT

HEART
BLOOD VESSELS
GLANDS

Reduced contractility of the bladder, urinary

hesitancy, impairment of erection and
ejaculation
Vasodilator, antihypertensive, tachycardia
Reduction in arteriolar and venous tone, BP
decrease, orthostatic hypotension
Reduction in salivation, lacrimation, sweating
and gastric secretion