DRUG STUDY

Generic Name
Brand Name
Classifications

GENERIC NAME:
naloxone
hydrochloride
BRAND NAME:
Narcan, Evzio
Classification:
Opioid antagonist

Prescribed and
Recommended
Dosage,
Frequency, and
route of
Administration
Opioid Overdose:
Initial: 0.4-2mg IV;
may repeat at 2-3 min
intervals if desired
degree of
counteraction and
improvement in
respiratory functions
is not obtained
Opioid Depression:
Initial: 0.1-0.2mg IV
at 2- to 3- min
intervals to the
desired degree of
reversal

Mechanism of
Action

Opioid antagonist;
prevents or reverses
effects of opioids,
including respiratory
depression, sedation,
and hypotension, by
competing for the mu,
kappa, and sigma
opiate receptor sites
in the CNS, with the
greatest affinity for
the mu receptor.

Indication

Contraindication

Known
suspected
narcotic induced
respiratory
depression
including that
cause by
pentazocine and
propoxyphene.

Known
hypersensitivity to
naloxone HCl or to
any of the other
ingredients
contained in the
formulation.

Adverse Reaction

increase or
decrease in
blood pressure,

abnormal heart
rate and

Nursing Responsibilities

Monitor respirator
depth and rate. Be
prepared to provide
O2 ventilation and
resuscitative
measures.

Assess for known

hypersensitivity to the
drug, opioid dependency,
cardiac/hepatic/renal
disease,
pregnancy/nursing
status, and possible drug
interactions.
Monitor for
signs/symptoms of opioid
withdrawal.
Inform that hypotension,
HTN, ventricular
tachycardia and
fibrillation, dyspnea,
pulmonary edema, and
cardiac arrest have
occurred in postoperative
patients.

rhythm,

troubled breathi
ng,

cardiac arrest,

fluid retention

in lungs, and

diarrhea.

DRUG STUDY
Generic Name
Brand Name
Classifications

Prescribed and
Recommended
Dosage,
Frequency, and
route of
Administration

Mechanism of
Action

Indication

Contraindication

Adverse Reaction

Nursing
Responsibilities

Generic name:
Penicillin G
benzathine
Brand name:
penicillin
Classification:
anti-infective,
antibiotic

Minimum Dose Interferes with

300,000 units IM bacterial cell
wall synthesis
during active
Maximum Dose
multiplication,
2.4 million units causing cell
IM weekly for 3
wall death and
weeks
resultant
bactericidal
activity against
Routes
of administrati
on
Intramuscular

susceptible
bacteria

General
Indications
- Severe
infections
caused by
sensitive
organisms
(streptococci)
- URTI
caused by
sensitive
streptococci
- Treatment
of syphilis,
bejel,
congenital
syphilis,
pinta, yaws
- Prophylaxis
of rheumatic
fever and
chorea

Allergies to
penicillins,
cephalosporins,
or other
allergens

CNS:
Lethargy, hallucinations, seizures
GI:
Glossitis, stomatitis, gastritis, sore
mouth, furry tongue, blackhairy
tongue, nausea, vomiting, diarrhea,
abdominal pain, bloody diarrhea,
enterocolitis, pseudomembranous
colitis, nonspecific hepatitis
GU:
Nephritis
Hematologic:
Anemia, thrombocytopenia,
leukopenia, neutropenia, prolonged
bleeding itme
Hypersensitivity:
Rash, fever, wheezing, anaphylaxis
Local:
Pain, phlebitis, thrombosisat
injection site, JarischHerxheimer reaction when used to
treat syphilis
Other:
Super infections, sodium overload
leading to heart failure

- Assess for
hypersensitivity to drug.
- Assess for any
contraindications to the
drug.
- Educate about side
effects of drug.
- Monitor client for at
least 30minutes.
- Arrange for regular
follow up, including
blood tests, to evaluate
effects.
- Instruct to report
difficulty breathing,
rashes, severe pain at
injection site, mouth
sores, unusual bleeding
or bruising.
- Instruct to take
medication as directed
for the full course
of therapy, even if
feeling better.