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Acetazolamide
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
250-375 mg/day
250-1000 mg 24
hrly
8-30 mg/kg/day
Acetylcysteine
(Fluimucil)
600mg/200mg
Acetylsalicylic
acid
(Aspirin)
325 mg/tab or 80
mg/tab
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
the drug forces the
kidneys to excrete
bicarbonate, the
conjugate base of
carbonic acid. By
increasing the amount of
bicarbonate excreted in
the urine, the blood
becomes more acidic.
Acidifying the blood
stimulates ventilation,
which increases the
amount of oxygen in the
blood
Exerts mucolytic action
through its free
sulfylhydryl group which
opens up the disulfide
bonds in the
mucoproteins thus
lowering mucous
viscosity.
Antithrombotic,
analgesic/antipyretic
Inhibits prostaglandin
synthesis, resulting in
analgesia, antiinflammatory activity
and platelet aggregation
inhibition; reduces fever
by aacting on the brains
heat-regulating canter to
promote vasodilation
and sweating.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Hypersensitivity to
sulphonamides; sodium
or potassium depletion,
hepatic insufficiency;
hepatic cirrhosis;
hyperchloraemic
acidosis; severe renal
impairment; severe
pulmonary obstruction;
chronic noncongestive
angle-closure glaucoma;
adrenocortical
insufficiency. Pregnancy,
lactation
Phenylketonurics
Drowsiness, paraesthesia,
ataxia, dizziness, thirst,
anorexia, headache; confusion,
malaise, depression; GI
distress, metabolic acidosis,
polyuria, hyperuricaemia, renal
calculi, nephrotoxicity, hepatic
dysfunction.
Potentially Fatal: Rarely, skin
reactions or blood dyscrasias.
Gastric hemorrhage,
hypersensitivity and
thrombocytopenia may occur
Prophylaxis of
thromboembolic disorder;
prevention of MI & stroke
Rarely, urticaria,
bronchospasm, nausea and
vomiting.
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Allopurinol
(Allomaron,
Allurase,
Alpurase, Elavil,
Llanol, Lopric,
Lopurine,
Loricid,
Purinase)
300mg / tab
Adult 2-10 mg/kg
BW/day.
Mild 100-200 mg
daily.
Moderately
severe 300-600
mg daily
Almitrine
30mg/tab q8
Ambroxol
Cap: 75mg
1cap TID
Susp: 30mg/5ml
0.5~5ml TID
Ambroxol
30mg/5ml
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Absorption of most oral
penicillins is impaired by
food (except amoxicillin),
and should be
administered 1-2 hours
before a meal.
Intravenous route is
preferred because of
irritation and local pian
produced by the
intramuscular injection
of large doses. Penicillin
is rapidly excreted by the
kidney into the urine,
small amounts excreted
via other routes
Almitrine is a peripheral
chemoreceptor agonist
that is used as a
respiratory stimulant in
acute respiratory failure
such as COPD. It is
believed to improve
oxygenation by
enhancing the
ventilation perfusion
mismatch.
Causes the formation of
qualitatively different
mucus of lower viscosity
by the mucus-secreting
cells and thus leads to a
liquefaction of the mucus
in the lumen of the
respiratory tract
a secreolytic. It causes
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Rash or hypersensitivity
reactions (discontinue). Acute
attack of gouty arthritis in early
stages of therapy. GI
disturbance. Blood & lymphatic
system disorders. Fever,
general malaise, headache,
vertigo, ataxia.
Minor age-related
neurological disorders.
Some visual disorders
related to the circulation.
Some disorders of the inner
ear related to the
circulation
Concurrent
administration with
MAOIs.
Abdominal discomfort,
epigastric distress, peptic
ulceration, headache, nausea,
peripheral angioedema,
tinnitus, edema.
1st trimester of
pregnancy
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
(Mucosolvan)
Amlodipine
(Amvasc)
(Norvasc)
5mg/tab OD
Amino acids
(Dipeptiven)
1.5-2ml/kg
BW/day, max 3
wk
Amoclav
Clavulanic acid Amoxicillin
1 g tab once a
day
Amoxicillin
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
the formation of the
qualitative different
mucus of the lower
mucus-secreting cells
and thus leads to the
liquefication of the
mucus in the lumenof
the respiratory tract.
Inhibits Ca++ ions from
the entering the slow
channels of select
voltage-sensitive areas
of vascular smooth
muscle and myocardium
during depolarization,
producing relaxation of
coronary vascular
smooth muscle and
coronary vasodilation;
increases myocardial
oxygen delivery in
patients with vasospastic
angina.
As a supplement to
amino acid solutions or
an amino acid-containing
infusion regimen in
parenteral nutrition for
hypercatabolic or
hypermetabolic patients
Inhibit cell wall
synthesis. Beta
lactamase inhibitor and
protect hydrolysable
penicillins from
inactivation.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
allergic reactions
reactions
Hypertension, Angina,
myocardial ischemia.
Reduce the risk of coronary
revascularization.
Known sensitivity to
dihydropyridines
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Ampicillin
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
synthesis. Beta
lactamase inhibitor and
protect hydrolysable
penicillins from
inactivation.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Ampicillin acts as a
competitive inhibitor of
the enzyme
transpeptidase.
Transpeptidase is needed
by bacteria to make their
cell walls
Asparaginase
(Elspar,
Oncaspar,
Erwinase)
Adults and
children:
200 IU/KG
intravenously
daily for 28 days
Asparaginase interferes
with malignant cell
growth by breaking down
asparagine to aspartic
acid and ammonia as
leukemic cells are unable
to synthesise asparagine
and depends on
exogenous source of
asparagine for survival.
It acts on the G1 phase of
the cell cycle.
Induction of remissions in
acute lymphoblastic
leukaemia
Hypersenstivity.
Pregnancy: Use only if
potential benefit justifies
risk to the fetus
Breast Feeding:
Discontinue nursing or
the drug
Atenolol
250mg/tab
Competitively and
selectively blocks
stimulation of beta1adrenergic receptor
within vascular smooth
muscle to produce
negative chronotropic
and positive inotropic
Hypertension, angina
pectoris, cardiac
arrhythmia, MI, prophylaxis
of migraine.
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Atorvastatin Ca
Lipitor
10 mg/tab
Atropine
1amp q3min
Atropine sulfate
1 drop 3 times a
day at left eye
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
activity. It also decreases
RAAS at high doses and
inhibits beta2-receptors
in brochial system at
higher doses.
Inhibitor of HMG-CoA
reductase, the rate
limiting enzyme in
cholesterol synthesis,
result in compensatory
increase in expression of
LDL receptors on
hepatocyte membranes
& stimulation of LDL
catabolism
Blocks the action of
acetylcholine at
parasympathetic sites in
smooth muscle,
secretory glands and the
CN; Increases cardiac
output, dries secretions,
antagonizes histamine
and seotonin
mechanism of action
involves blocking the
contraction of the
circular pupillary
sphincter muscle, which
is normally stimulated by
acetylcholine release,
thereby allowing the
radial pupillary dilator
muscle to contract and
dilate the pupil
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Prostate enlargement,
paralytic ileus, pyloric
stenosis, angle-closure
glaucoma & narrow
angle between iris &
cornea. Childrn with high
ambient temp.
Primary glaucoma or a
tendency toward
glaucoma.
Hypersensitivity.
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
500mg/250mg
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Inhibits RNA-dependent
protein synthesis at the
chain elongation step;
binds to the 50s
ribosomal unit resulting
in blockage of
transpeptidation.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Hypersensitivity to
erythromycin and other
macrolide antibiotics.
Azithromycin
(Zithromax)
500mg/tab OD
hypersensitivity
GI disturbances,
hypersensitivity, angioedema,
anaphylaxis, hearing
impairment, abnormal liver
function, dizziness, vertigo,
reduced cell counts
Bacillus clausal
(Erceflora)
2billion/5ml
Adult : 2~3
vials/day,
children :
1~2vials/day
N/A
N/A
Betahistine
diHCl
Pheochromocytoma,
bronchial asthma, history
of peptic ulcer
Azithromycin
dihydrate
Bethanecol
Chloride
(Uriflow)
Anti-histamine with
specific cellular
receptors located ont the
surface membrane
Stimulates muscarinic
acetylcholine receptors
directly; mimics effects
of parasympathetic
system stimulation;
stimulates gastric
motility, micturition;
increases lower
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
esophageal sphincter
pressure
Stimulates enteric
nerves to cause colonic
mass movements
Bisacodyl
(Dulcolax)
Brimonidine
tartrate 2.0
mg/mL and
Timolol 5.0
mg/mL eye
drops
(COMBIGAN)
1 drop every 12
hours
Bromazepam
( Lexotan )
Benzodiazepine:
Potentiates the action of
GABA by increasing the
frequency of opening of
the chloride channel
complexed with the
GABA A receptor.
Binds to stereo specific
benzodiazepine
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Constipation. Preparation
for radiography,
antepartum, postpartum
care, preparation for
sigmoidoscopy or
protoscopy or colonoscopy,
hemorrhoids and anal
fissures
for the reduction of
elevated intraocular
pressure in patients with
open angle glaucoma or
ocular hypertension not
adequately responding to
monotherapy.
Ileus, intestinal
obstruction, acute
surgical abdominal
conditions, severe
dehydration
in patients with
hypersensitivity to any
component of this
medication, in patients
receiving monoamine
oxidase (MAO) inhibitor
therapy, in patients with
bronchospasm, bronchial
asthma or patients with
a history of bronchial
asthma, or severe
chronic obstructive
pulmonary disease, in
patients with sinus
bradycardia, second or
third degree
atrioventricular block,
overt cardiac failure or
cardiogenic shock.
Early pregnancy,
lactation, Myasthenia
Gravis, Hypersensitivity
Emotional disturbances,
functional disturbances in
the cardiovascular and
respiratory systems,
psychosomatic disorder,
emotional reactions to
chronic organic disease.
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Bromhexine
16 mg/ capsule
Budesonide MDI
64 mcg MDI
Budesonide +
Formoterol
fumarate
(Symbicort)
320/9 mcg
160/4.5 mcg
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
receptors on the post
synaptic GABA neuron at
the several sites within
the CNS. Enhancement
of the inhibitory effect of
GABA on neuronal
excitability results by
increased neuronal
membrane permeability
to chloride ions.
Secretolytic therapy in
acute and chronic
bronchopulmonary
disease associated with
abnormal mucus
secretion and impared
mucus transport
Glucocorticosteroid with
a high local antiinflammatory effect.
Budesonide: Antiinflammatory
corticosteroid, has
potent glucocorticoid
activity and weak
mineralocorticoid
activity.
Formeterol: Long acting
beta 2 adrenergic
agonist, local
bronchodilator,
stimulates IC adenylyl
cyclase, which results in
increased cyclic
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Secretolytic therapy in
acute & chronic
bronchopulmonary disease
associated with abnormal
mucus secretion &
impaired mucus transport
GI ulcerations
Bronchial asthma.
Seasonal allergic &
allergic/non-allergic
perennial rhinitis.
Treatment & prevention of
nasal polyps after
polypectomy
Asthma
COPD
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Calcium
polystyrene
sulfonate
(Kalimate)
Candesartan
5g sachet
Captopril
(Capotec)
25mg/tab
Carbimazole
15mg/day PO
divided q8hr
initially
Carbocisteine
( Solmux )
16 mg once daily.
total daily doses
ranging from 8-32
mg.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
adenosine
monophosphate levels,
causing relaxation of
bronchial smooth muscle
and inhibition of release
of mast cell mediators.
Is a calcium-type resin
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Hyperkalemia resulting
from acute or chronic renal
failure.
Angiotensin II is formed
from angiotensin I in a
reaction catalyzed by
angiotensin-converting
enzyme (ACE), kininase
II.
Blocks the
vasoconstrictor and
aldosterone secreting
effects of angiotensin II;
selectively blocks the
binding of angiotensin II
to the AT1 receptor
found in the tissues.
Is an ACE-inhibitor which
converts angiotensin I to
angiotensin II.
Hypertension
Heart failure
Careful administration in
patients with
hyperparathyroidism and
multiple myeloma.
Hypersensitivity
Severe hepatic
impairment and/or
cholestasis.
Discontinue
breastfeeding or drug
due to potential risk to
breastfeeding infants,
Pregnancy. Severe or
end-stage renal
impairment, children
GI symptoms
Inhibits synthesis of
thyroid hormone by
blocking oxidation of
iodine in thyroid gland;
blocks synthesis of
thyroxine (T4) and
triiodothyronine (T3)
Reduces the viscosity of
bronchial secretions anf
Hyperthyroidism, graves
disease, thyrotoxic crisis
Patients with
hypersensitivity to the
drug and who
experienced angioedema
during ACE drug therapy.
Hypersensitivity,
breastfeeding
For treatment of
hypertension, CHF.
Hypotension, tachycardia,
palpitation, angina pectoris,
myocardial infarction.
Nausea, abdominal pain,
diarrhea, dyspepsia, vomiting,
anorexia, gastroenteritis,
stomach discomfort, epigastric
pain, stomatitis.
Epistaxis, neutropenia,
leukopenia, agranulocytosis,
leukocytosis, eosinophilia,
anemia.
Agranulocytosis, alopecia,
aplastic anemia, dermatologic
reaction, hepatotoxicity,
leukocytoclastic vasculitis,
neuritis, polyarthritis
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Carvedilol
(Dilatrend)
Cefaclor
Cefalexin
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
facilitates excretion
Is a multiple action
neurohormonal
antagonist consisting of
nonselective beta and
alpha blockade, and
antioxidant properties.
>1mth:
20mg/kg/day PO
divided TID
>6mth:
20mg/kg/day PO
once daily or 15
mg/kg/day PO
divided BID
500mg/cap
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
carbocisteine
skin rash
Hypersensitivity to
cephalosporins or
penicillins
fever, headache,lethargy,
paresthesia, syncope, seizures,
edema,
hypotension,vasodilation,
palpitations, chest pain,
hearing loss, nausea, vomiting,
diarrhea, abdominal cramps,
oral candidiasis,
pseudomembranous colitis
vaginal candidiasis
nephrotoxicity, lymphocytosis,
eosinophilia, bleeding
tendency, hemolytic anemia,
neutropenia,
thrombocytopenia,
Inhibit mucopeptide
synthesis in the bacterial
cell wal. Broad spectrum
& b-lactamase-resistant;
used for infections by
gm-ve bacilli.
Cephalexin, like the
penicillins, is a betalactam antibiotic. By
binding to specific
penicillin-binding
proteins (PBPs) located
inside the bacterial cell
wall, it inhibits the third
and last stage of
bacterial cell wall
synthesis. Cell lysis is
then mediated by
bacterial cell wall
autolytic enzymes such
as autolysins; it is
Hypersensitivity reaction
(urticaria, pruritus, rash, severe
reactions eg anaphylaxis can
occur); GI effects (diarrhea,
N/V, rarely antibioticassociated diarrhea
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Cefazolin
0.5~1gram every
5~12 hours
Max 6g/day
Cefixime
(Tergecef)
200mg/cap
Cefoxitin
sodium
(Monowel)
1g IV every 8
hours
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
possible that cephalexin
interferes with an
autolysin inhibitor.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Hypersensitivity to
penicillins
Shock, hypersensitivity
reaction, granulocytopenia,
eosinophilia,
thrombocytopenia, GI
disturbance, convulsion, HA,
dizziness, malaise
Shock, anaphylactoid
symptoms, agranulocytosis,
vomiting, diarrhea, abdominal
pain
Hypotension, phlebitis,
thrombophlebitis,
pseudomembranous colitis,
nausea, vomiting, diarrhea,
acute renal failure, transient
neutropenia, dyspnea,
maculopapular and
erythematous rash, urticaria,
hypersensitivity reactions,
serum sickness, anaphylaxis,
fever
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Ceftazidime
(Tazidem)
1 gm vial
Ceftriaxone
1~2 g once a
daily
Cefuroxime
500mg every 12
hours
IV, oral
Cefuroxime
750 mg 3 times
daily by IM or IV
injection, may be
increased to 1.5 g
3 times daily IV in
severe infections.
30-60 mg/kg/day,
may be increased
to 100 mg/kg/day
given as 3 or 4
divided doses, if
necessary.
Celecoxib
(Celebrex)
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
selected.
Bactericidal in action by
inhibitng bacterial cell
wall synthesis.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Treatment of single or
multiple infections caused
by susceptible organisms.
Cephalosporin (2nd
generation); binds to
essential target proteins
and the resultant
inhibition of cell-wall
synthesis.
Treatment of susceptible
infections which include
bone and joint infections,
bronchitis (and other lower
respiratory tract
infections), gonorrhea,
meningitis (although
treatment failures have
been reported in H.
influenzae meningitis),
otitis media, peritonitis,
pharyngitis, sinusitis, skin
infections (including soft
tissue infections) and
urinary tract infections.
Injection: Prophylaxis for
surgical infection.
Treatment of signs and
symptoms of osteoarthritis
hypersensitive to the
drug or other
nitroimidazole
derivatives and in
patients in 1st trimester
of pregnancy
Hypersensitivity to
cephalosporin
antibiotics.
Hypersensitivity reaction,
urticaria, eosinophilia, serum
sickness-like fever,
anaphylaxis, neutropenia,
thrombocytopenia, ATN, acute
intestinal nephritis
GI disturbances, occasionally
pseudomembranous colitis;
hypersensitivity reactions.
Eosinophilia. Headache.
Superinfection or eythema
multiforme, Stevens-Johnson
syndrome, toxic epidermal
necrolysis
Transient pain at the site of IM
injection which is more likely to
occur with higher doses.
Skin rashes (maculopapular
and urticaria),
Diarrhea and nausea.
Pseudomembranous colitis
Decreased hemoglobin
concentration and/or
eosinophilia, leukopenia and
neutropenia
Transient rise in serum glutamic
oxaloacetic transaminase
(SGOT) and serum glutamic
pyruvic transaminase (SGPT)
and bilirubin may occur.
Abdominal pain, diarrhea,
dyspepsia, flatulence, nausea,
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
(NSAID) that exhibits
anti-inflammatory,
analgesic and antipyretic
activities due to
inhibition of
prostaglandin synthesis.
Chamomile
extract +
Methyl
salicylate +
Peppermint +
sage oil + anise
oil + pine
needle oil +
bergamot oil +
Cineol
(Kamillosan-M)
Chlorphenamine
maleate
(Antamin)
Cinnarizine
25mg/tab q12
Inhibits contractions of
vascular smooth muscle
cells by blocking calcium
channels. In addition to
this deformability and
derdirect calcium
antagonism, cinnarizine
decreases the contractile
activity of vasoactive
substances. It may
further improve deficient
microcirculation by
increasing erythrocyte
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Inflammation affections of
the buccal and pharyngeal
cavity, parodontosis, acute
gingivitis, pain after tooth
extraction and during
second dentition, mucosal
irritation caused by dental
plates, tonsillary angina,
canker sores, bad breath
Allergy, allergic rhinitis,
bronchial asthma,
vasomotor rhinitis,
dermatoses of allergic
etiology, urticaria, drug
sensitization, serum
sickness, anaphylactic
shock, insect bites
Maintenance therapy of
labyrinthine disorders,
cerebrovascular origin,
migraine. Prophylaxis of
motion sickness,
maintenance therapy for
symptoms of peripheral
circulation disorders.
Hypersensitivity
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Ciprofloxacin
(Ciprobay)
500mg/tab q12 x
7 days
Ciprofloxacin
HCl
Prozine
500mg / tab
Cystic fibrosis
20mg/kg, max
750mg BID
Gonorrhea
500mg OD
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
deformability and
decreasing blood
viscosity. Cellular
resistance to hypoxia is
increased. Cinnarizine
inhibits stimulation of
the vestibular system
which results in
suppression of
nystagmus and other
autonomic disturbances.
Acute episodes of vertigo
can be prevented or
reduced by cinnarizine.
Blocks bacterial DNA
synthesis by inhibiting
bacterial topoisomerase
II (DNA gyrase) and
topoisomerase IV
Inhibits DNA-gyrase in
susceptible organism;
inhibit relaxation of
supercoiled DNA and
promotes breakage of
double-stranded DNA
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Hypersensitivity
Pregnancy and lactation
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Citicoline Na
500mg/cap
Citicholine;
cytidine 5'diphosphocholin
e
200-600 mg for
head injury
Cerebrovascular
disorders
Adult: 200-600
mg daily in
divided doses.
Oral
Parkinsonism
Adult: 200-600
mg daily in
divided doses.
Parenteral
7.5 mg/kg bid up
to a max 500 mg
bid. Usual
duration: 5-10
days
Clarithromycin
(Klaricid)
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
A derivative of choline
and cytidineinvolved in
the synthesis of lecithin.
It is claimed to increase
blood flow and oxygen
consumption in the
brain.
Citicoline increases blood
flow and O2
consumption in the
brain. It is also involved
in the biosynthesis of
lecithin
Clarithromycin prevents
bacteria from growing by
interfering with their
protein synthesis.
Clarithromycin binds to
the subunit 50S of the
bacterial ribosome and
thus inhibits the
translation of peptides.
Clarithromycin has
similar antimicrobial
spectrum as
erythromycin but is more
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
gonorrhea, legionnaires
disease, otitis media &
externa, peritonitis, Q
fever, lower respiratory
tract infection
Cerebrovascular disorder
including ischemic stroke,
parkinsonism, and head
injury
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
thrombocytopenia, hemolytic
anemia or agranulocytosis.
Transient increase in serum
creatinine or BUN
Parasympathetic
hypertonia
Head injury
Cerebrovascular disorders
Parkinsonism
Cerebrovascular disorders
hypersensitivity reaction
Parasympathetic
hypertonia.
Known hypersensitivity
to macrolides.
Concomitant use of
clarithromycin w/
astemizole, cisapride,
pimozide, terfenadine &
ergotamine or
dihydroergotamine.
Patients receiving
terfenadine therapy w/
preexisting cardiac
abnormalities or
electrolyte disturbances
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Clindamycin
150-300 mg 6
hourly
Clonidine
(Catapres)
Oral: 0.1,0.2,0.3
mg tablets
Patche: release
0.1,0.2,0.3 mg/24
hrs
Clopidogrel
75 mg OD
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
effective against certain
gram-negative bacteria,
particularly Legionella
pneumophila. Besides
this bacteriostatic effect,
clarithromycin also has
bactericidal effect on
certain strains such as
Haemophilus influenzae,
Streptococcus
pneumoniae and
Neisseria gonorrhoeae..
Partial alpha-2
antagonist. Decrease
preganglionic
sympathetic outflow
from brain resulting in
decrease in blood
pressure
Inhibits platelet
aggregation by
irreversibly blocking the
ADP receptor on
platelets.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Treatment of anaerobic,
staphylococcal &
strepcoccal infections & in
the prophylaxis of
endocarditis; it is also used
in the treatment of acne &
protozoal infections such as
Pneumocytis carnii
pneumonia or
toxoplasmosis.
Diarrhea. Pseudomembranous
colitis may develop.
Hypersensitivity reactions
including skin rashes, uticaria &
very rare anaphylaxis. Transient
leucopenia occasionally
agranulocytosis, eosinophilia,
thrombocytopenia, erythema
multiforme polyarthritis &
abnormalities in the liver
function tests. Jaundice &
hepatic damage. Local irritation
& contact dermatitis.
Orthostatic hypotension, rash,
drowsiness, dry mouth,
constipation, headache,
impaired ejaculation
GI bleeding, mucocutaneous
bleeding, intracranial and
ocular hemorrhage, abdominal
pain, dyspepsia, rash, pruritus.
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Cloxacillin Na
(oxacillin)
500mg tab q4
It acts as a competitive
inhibitor of the enzyme
transpeptidase.
Transpeptidase is needed
by bacteria to make their
cell walls
Co-Amoxiclav
1 g tab once a
day
Co-amoxiclav
(Augmentin)
625mg / cap
BID or TID
Colchicine
Taken at first
sign of flares
0.6mg PO OD or
BID; do not
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
coronary syndrome,
patients undergoing stent
placement following PTCI in
combination with ASA for
thrombolysis.
Treatment of infections due
to staphylococci resistant
to benzylpenicillin including
infection of skin & soft
tissue, bones & joints, resp
& urinary tacts, otitis
media, endocarditis,
septicemia, & meningitis
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Hypersensitivity to
penicillins
Gi disturbances
Contraindicated in
patients with penicillin
hypersensitivity.
Superinfections involving
pseudomonas or
candida. Pregnancy and
lactation
Hypersensitivity to
penicillins and
cephalosphorins or other
allergen, possible cross
sensitivity with other lactams. History of
penicillin-associated
cholestatic jaundicehepatic dysfunction.
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
exceed 1.2
mg/day
Combivent
Nebules
16 mg/capsule
8 mg/5 mL syrup
4mg/ 5mL syrup
8mg/tablet
Cotrimoxazole
160mg/tabBID
Dexamethasone
5mg IV
Dexketoprofen
12.5 mg every 4
6 hours, or 25 mg
every 8 hours;
max 75 mg daily.
Elderly: initially
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
and monocytes that
mediates activation of
interleukin-1B; disruption
of cytoskeletal functions
through inhibition of Btubulin polymeration into
microtubules which
prevents activation,
degranulation, and
migration of neutrophils
thought to mediate some
gout symptoms
Secretolytic therapy in
acute and chronic
bronchopulmonary
disease associated with
abnormal mucus
secretion and impared
mucus transport
SMZ inhibits formation of
dihydrofolic acid from
PABA, TMP inhibits
dihydrofolate reductase
blocking the synthesis of
tetrahydro folic acid
Decreases inflammation
by suppression of
migration of PMN
leukocytes and reversal
of increased capillary
permeability ;
suppresses normal
immune response
It works by blocking the
action of a substance in
the body called cyclooxygenase. Cyclooxygenase is involved in
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
GI ulcerations
Liver damage,pregnancy
Short-term treatment of
mild to moderate pain,
including dysmenorrhoea.
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
max 50 mg daily.
Child: not
recommended
Dexlansoprazole
60mg OD
Dextromethorp
han HBr
Guafenesin
(Robitussin DM)
TID
Diazepam
5-20 mg OD
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
the production of
chemicals in the body
called prostaglandins.
Prostaglandins are
produced in response to
injury or certain diseases
and would otherwise go
on to cause swelling,
inflammation and pain.
By blocking cyclooxygenase,
dexketoprofen prevents
the production of
prostaglandins and
therefore reduces
inflammation and pain.
Along with Peripheral
analgesic action it
possesses central
analgesic action
Proton pump inhibitor. Binds to
H+/K+ exchanging ATP in gastric
parietal cells resulting to blockage
of acid secretion
Controls cough by
depressing the medullary
cough center
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
class,Asthma or history
of asthma, Bleeding
disorders, Bleeding from
the stomach or intestines
Hypersensitivity
Cough suppressant.
Patients at risk of
developing resp failure.
During an acute attack.
Patients receiving MAOI
or for 2 wk after
discontinuing them.
Persistent or chronic
cough.
Dependence on other
substances like alcohol
except in management
of acute withdrawal
reactions.Severe chronic
hypercapnia.
Dizziness, GI disturbances.
Symptomatic relief of
anxiety, agitation and
tension, as adjunct in
organic neuropsychotic
states and reflex muscle
spasm due to local trauma.
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Diclofenac K
(Cataflam)
50~150mg /day
Nonsteroidal
Anti0inflammatory Drugs
Digoxin
(Lanoxin)
0.25mg/tab
Diltiazem HCl
Dilzem
90 mg/ tab OD
Digoxin is a cardiac
glycoside which has
positive inotropic activity
characterized by an
increase in the force of
myocardial contraction.
It also reduces the
conductivity of the heart
through the
atrioventricular (AV)
node. Digoxin also exerts
direct action on vascular
smooth muscle and
indirect effects mediated
primarily by the
autonomic nervous
system and an increase
in vagal activity.
Calcium antagonist
Inhibits movement of
calcium ions across cell
membrane in systemic
and coronary vascular
smooth muscle; slows
calcium ion movement
across cell membranes in
both cardiac muscle and
cardiac pacemaker cells,
decreasing sinoatrial and
atrioventricular
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Known hypersensitivity
to diclofenac or other
NSAIDs, gastric or
intestinal ulcer
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Digitalis toxicity,
ventricular
tachycardia/fibrillation,
obstructive
cardiomyopathy.
Arrhythmias due to
accessory pathways (e.g.
Wolff-Parkinson-White
syndrome).
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Diphenhydrami
ne
(Benadryl)
50mg/mL for
injection
Dobutamine
2.5-40
mcg/kg/min IV
infusion
Domperidone
(Motilium)
10mg, 1mg/ml
1tab TID
Dopamine
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
conduction
H1 receptor antagonist /
Antihistamine
Competes with histamine
for H1-receptor sites on
effector cells in the
gastrointestinal tract,
blood vessels, and
respiratory tract
Directly stimulates beta
1 receptors to increase
myocardial contractility
and stroke volume.
Decrease vascular
resistance, reduces
ventricular filing
pressure and facilitate
AV node conduction
Peripheral dopamine
receptor blocking
properties. It increase
esophageal peristalsis
and increase lower
esophageal sphincter
pressure, increase
gastric motility and
peristalsis and enhances
gastroduodenal
coordination, therefore,
facilitating gastric
emptying and decrease
small bowel transit time
Endogenous
catecholamine; acts on
both dopaminergic and
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
GIT ulceration or
inflammation
GI disturbances, bleeding,
drowsiness, dizziness
Obstructive
cardiomyopathy
Dyspeptic symptom
complex associated with
delayed gastric emptying,
GERD, esophagitis eg
epigastric sense of fullness,
early satiety, feeling of
abdominal distention,
upper abdominal pain;
bloating, erucation,
flatulence; heartburn w/ or
w/o regurgitations of
gastric contents in the
mouth. Nausea & vomiting
of functional, organic,
infectious or dietetic origin
or induced by radio or drug
therapy
Hypotension, low cardiac
output, poor perfusion of
vital organs, used to
GI hemorrhage,
mechanical obstruction
or perforation; in
patients w/ prolactinreleasing pituitary tumor
(prolactinoma). Known
intolerance to the drug.
Hypersensitivity to
dopamine,
pheochromocytoma,
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
15 mcg/kg/min
High dose: 20-50
mcg/kg/min
Dopamine HCl
Doxofylline
(Ansinar)
400mg tablet
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
adrenergic neurons. Low
dose stimulates mainly
dopaminergic receptors,
produces renal and
mesenteric vasodilation.
Higher dose stimulates
both beta 1 and
dopaminergic receptors,
produces cardiac
stimulation and renal
vasodilation. Large dose
stimulates alphaadrenergic receptors.
A myocardial inotropic
agent which may
increase mesenteric and
renal blood flow plus
urinary output
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
ventricular
fibrillation/tachyarrhythm
ias
Correction of hemodynamic
imbalances present in the
shock sndrome due to MI,
trauma, endotoxic
septicemia, open heart
surgery, renal failure &
chronic cardiac
decompensation as in CHF,
hypotension
Bronchodilator xathine
that differes from
theophylline for the
presence of a dioxolane
group in position.
Particularly effective in
both decreasing the daily
asthma attack rate as
Treatment of chronic
respiratory disease
Patients w/
pheochromocytoma,
presence of uncorrected
tachyarrthmias or
ventricular fibrillation.
Those w known allergy to
corn & corn products &
sulfite sensitivie
patients. IV soln may
cause fluid overloading
leading to dilution of
secrum electrolyte conc,
overhydration,
congested states of
pulmonary edema.
Excess administration of
K-free soln
Hypersensitivity to the
components
Patients with acute MI
and hypotension.
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Doxorubicin
(Adriblastina,
Adrim, Axibin,
Caelyx,
Dactorubin,
Rubidox)
IV 60-75 mg/m2
as single dose at
21 day interval
Doxycycline
100mg/tab
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
well as the beta2-agonist
consumption.
Doxorubicin prevents
DNA replication. The
exact mechanism is still
being studied, but it may
be a "topoisomerase
inhibitor".
Topoisomerases are
enzymes that
temporarily cut one
strand of DNA during
replication to help
unwind the double helix..
Doxorubicin prevents the
topoisomerase from
reattaching the cut ends
inhibition of protein
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Allergy to penicillin
Allergy to penicillin Secondary syphilis,
Anthrax
Anthrax;
Prophylaxis
Bacterial infectious
disease,
Chlamydial
infection
Cholera,
Epididymo-orchitis, acute
Gonorrhea, Uncomplicated
Granuloma inguinale
Prophylaxis
Nongonococcal urethritis ,
Pelvic inflammatory
disease
Postexposure;
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Close observation is
required esp during
initial treatment. Monitor
cardiac function.
Myelosuppression &
immunosuppression.
Hepatic impairment,
obesity & extravasation
Cardiotoxicity. GI &
dermatologic disturbances.
Myelosuppression &
leucopenia. Dehydration &
facial flushing
Pregnancy,
breastfeeding and in
children less than 8
years of age
Dermatologic:
Photosensitivity
Gastrointestinal: Druginduced gastrointestinal
disturbance
Renal: Serum blood
urea nitrogen raised
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Duxaril
Tab BID
Dydrogesterone
(Duphaston)
10mg/tab
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Avoid concurrent
adminstration of
almitrine-raubasine w/
MAOIs
Breakthrough bleeding
(prevented by increasing the
dosage). Altered liver function
w/ asthenia or malaise,
jaundice & abdominal pain.
Allergic rash, pruritus, urticaria
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Enoxaparin
sodium
(Clexane)
Ensure
250kCal
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
ovariectomised animals
after they have been
primed with oestrogens
(cf. the Clauberg test).
The oral progestogenic
potency of
dydrogesterone is 20
times higher than that of
progesterone. The
progestational efficacy
and potency of
dydrogesterone was
confirmed by standard
test (i.e. delay of menses
and induction of
withdrawal bleeding).
The benefits of
oestrogen or other target
organs are not
compromised by
dydrogesterone
Causes higher anti-factor
Xa to antithrombin
activities (anti-factor IIa)
ration than heparin,
which may prevent
thrombosis
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
dysfunctional uterine
bleeding and postmenopausal complaints
where endogenous
progesterone deficiency is
implicated
Prophylaxis of venous
thromboembolitic disease.
Treatment of deep vein
thrombosis, unstable
angina and non-Q wave
myocardial infarction.
Patients requiring
supplementation,
convalescence, early or
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Epinephrine Hcl
1amp q3
Epoietin
50-100units/kg
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
uncomplicated carcinoma,
coma, pre-op prep, post-op
care, bowel prep, moderate
protein-caloric malnutrition,
nutritional support of
chronically ill or elderly
patients
Cardiac stimulant in case of
collapse, shock & anesth
accidents. Hemostatic in
hemorrhages. Prolongs
action of infiltration anesth
agent. Urticaria.
Treatment of anemia
associated with renal
insufficiency or CRF
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Cardiac arrhythmia,
tachycardia >140 bpm,
severe HTN, narrow
angle glaucoma, anesth
w/ halogenated
hydrocarbon f
cyclopropane, w/ local
anesth of finger or toe,
woman in labor, cardiac
dilation & coronary
insufficiency
Hypersensitivity
Hypertension, seizures,
arthralgia, asthenia, chest pain,
diarrhea, edema, headache,
nausea, vomiting, tachycardia
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
enhancing RBC
production
Synthetic erythropoeitin
needed for RBC
production
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Epoetin
(Renogen)
Treatment of anemia
associated with chronic
renal failure, HIV-infected
patients, cancer patients
on chemotherapy,
Reduction of allogenic
blood transfusion in
surgery patients
Hypersensitivity to
mammalian cell-derived
products
Hypersensitivity to
albumin (human)
Uncontrolled
hypertension
Erceflora
Bacillus clausal
Susp: 2billion/5ml
Adult : 2~3
vials/day,
children :
1~2vials/day
Antidiarrheal
N/A
N/A
Ercefuryl
Nifuroxazide
Cap: 200mg
1cap QID
Susp: 220mg/5ml
5mlTID, 10ml
divide by 3/d
Antidiarrheal
N/A
N/A
Esomeprazole
(Nexium)
40 mg/tab OD
Headache, abdominal
pain,diarrhea,flatulence,nausea
, and vomiting
Eterocoxib
(Arcoxia)
120mg/tab OD
Asthenia/fatigue, dizziness,
lower extremity edema,
hypertension, dyspepsia,
heartburn, nausea, increased
ALT & AST
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Febuxostat
80 mg/ tablet
Felodipine
5 mg/tab
OD
Treatment of chronic
hyperuricemia in
conditions where urate
deposition has already
occurred (including a
history or presence of
tophus and or gouty
arthritis
Dihydropiridine
derivative, calcium
antagonist; interfere with
voltage- dependent Ltype calcium channels in
membranes of smooth
muscle cells
Treatment of hypertension
and angina pectoris
Pregnancy, unstable
angina, significant aortic
Ferrous Sulfate
1 tablet/day
Flenax forte
Flunarizine
(Sibelium)
Migraine
prophylaxis:
<65 yr 10 mg at
night, >65 yr 5
inhibitors
Pregnancy and lactation.
Ischemic heart disease
or CHF. Acute gouty
attacks, xanthine
deposition, altered tyroid
function.
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Abdominal discomfort,
epigastric distress, GI reaction,
peptic ulceration, HA, nausea,
peripheral edema
Generic/ Brand
Acarbose
(Glucobay)
Folart
(Folic Acid)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
mg at night.
Maintenance if
patient is
responding
satisfactorily
and if a
maintenance
treatment is
needed,
decrease dose
to 5 days
treatment at
the same daily
dose w/ 2
successive drug
free days every
week
Adult & childn >1
yr 5 mg daily for
4 mth.
Maintenance: 5
mg every 1-7
days depending
on underlying
disease. Childn up
to 1 yr 500
mcg/kg daily.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Megaloblastic anemia
secondary to vit B12
deficiency. Folic acid
administration may
produce hematologic
remission while
neurologic damage
progresses.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
due to a diagnosed
functional disorder of
the vestibular system
other extrapyramidal
disorders. Driving or
operating machinery
Folic acid
(pteroylmonoglutamic acid)
in its reduced form of
tetrahydrofolate, serves as
an important mediator of
many reactions involving 1carbon transfers. Important
reactions involve the
conversion of
homocysteine to
methionine and of
deoxyuridylate to
thymidylate, an important
step in DNA synthesis. It is
also implicated in the
conversion of some amino
acids, and in the synthesis
and utilization of formate.
The deficiency of folic acid
can lead to megaloblastic
anemia, which develops
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Fondaparinux
Na
(Arixtra)
2.5-7.5mg
Fucidin
ointment
Furosemide
(Fremid, Fretic,
Frusema,
Furoscan,
Fusimex, Lasix)
Initially 20-40 mg
IV/IM. If diuretic
effect is not
satisfactory, dose
may be increased
stepwise, at 2hrly interval by 20
mg each time
until satisfactory
diuresis is
obtained, the
dose should then
Furosemide primarily
inhibits sodium and
chloride absorption in
the thick ascending limb
of the loop of Henle
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Clinically significant
bleeding, acute bacterial
endocarditis
None
Hypotension, latent or
manifest diabetes
mellitus, gout,
obstruction of urinary
passages; hepatic
cirrhosis w/ concomitant
renal insufficiency;
hypoproteinaemia;
premature infant.
Pregnancy, lactation
Rarely hypersensitivity
Symptomatic hypotension,
dehydration,
hemoconcentration;
hypokalemia, hyponatremia,
metabolic acidosis; increase of
blood lipid levels, urea, uric
acid; reduced glucose
tolerance; hearing disorders,
tinnitus; pancreatitis, GI
symptoms; fever, vasculitis,
interstitial nephritis; hemolytic
or aplastic anemia,
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
be given once-bid
Furosemide
40mg, KCL
600mg
(Diumide K)
Gabapentin
300 mg/tab OD
Gatifloxacin
(Zymar)
Gentamycin
1~1.7mg/kg
every 8 hours
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Cardiac, pulmonary,
hepatic, renal and
peripheral edema of
various etiologies
Gabapentin is
structurally related to
the neurotransmitter
GABA but is neither a
GABA agonist nor
antagonist. Gabapentinbinding sites have been
identified throughout the
brain tissues e.g.
neocortex and
hippocampus. However,
the exact mechanism of
action is still unknown.
antibiotic of the fourthgeneration
fluoroquinolone family,
that like other members
of that family, inhibits
the bacterial enzymes
DNA gyrase and
topoisomerase IV
Aminoglycoside
Treatment of partial
seizures with or without
secondary generalization ,
neuropathic pain.
Adjunctive therapy in
patients unresponsive to or
intolerant of standard
anticonvulsant.
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Hyperkalemia,
precomatose states
associated with liver
cirrhosis, addisonss
disease, concomitant
administration of Ksparing diuretics,
prostatic hypertrophy,
impairment of
micturition, latent
diabetes
Absence seizure.
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
leukocytopenia,
agranulocytosis,
thrombocytopenia
Allergic reaction,
hyperurecemia, bone marrow
depression
Treatment of bacterial
conjunctivitis caused by
susceptible strains of both
gm+ve & gm-ve
microorganisms.
Diabetes
Conjunctival irritation,
increased lacrimation, keratitis
& papillary conjunctivitis.
Hypersensitivity to
amynoglycosides
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Gliclazide
(Diamicron MR)
30 mg tab OD
Inhibiting ATP-sensitive
potassium channels in
pancreatic beta cells.
This inhibition causes
cell membrane
depolarization, which
causs voltage-dependent
calcium channels to
open, which causes an
increase in intracellular
calcium in the beta cell,
which stimulates insulin
release.
Gliclazide
(Diamicron)
60mg tablet
Sulfonylurea which
stimulates insulin
secretion by the
pancreas. Its action on
insulin secretion is
mainly due to the
restoration of the early
hase, resulting in a
physiological release of
insulin. This, gliclazide
restores glycemic control
throughout 24 hours. It
normalizes fasting and
postprandial blood sugar.
Glimepiride
1-4 mg daily
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Hypoglycemic manifestations,
skin reactions, GI disorders
Non-insulin dependent
diabetes mellitus (Type 2)
Hypoglycemia. Temporary
visual impairment. GI
symptoms. Elevated liver
enzymes, impairment of liver
function, hepatitis, liver failure.
Thrombopenia, hemolytic
anemia, erythrocytopenia,
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Glipizide
(Minidiab)
5mg/tab OD
Godex DS
Carnitine
orotate 300mg
17-AA 25mg
Adenine HCL
5mg
Vit B6 50mg
Vit B2 1mg
Vit B12 250mcg
Hexetidine
(Bactidol)
gargle
Humulin 70/30
56 'u' SQ prebreakfast
28 'u' pre-dinner
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Stimulates insulin
release from the
pancreatic beta cells,
reduces glucose output
from the liver; insulin
sensitivity is increased at
peripheral target sites.
Carnitine orotate have
synergistic effect for
solubility and absorption.
Orotic acid prohibits
necrosis of injured cells
by normalizing cell
proliferation process,
hepatic enzymatic
system and normal
hepatic function.
Vit B12 and adenine HCL
act synergistically for the
treatment of hepatic
disease.
disruption of bacterial
cell membrane.
Contains isophane
human insulin of
recombinant DNA origin.
It is an intermediatedacting preparation; onset
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
IDDM, keto-acidosis,
diabetic coma, gangrene,
severe trauma, infection
or febrile status
Hypersensitivity to any
of the components of
Godex DS. Severe renal
dysfunction (serum
creatinine >3 mg/100
mL).
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
leucopenia, agranulocytosis,
pancytopenia. Allergic or
pseudoallergic reactions
including shock, allergic
vasculitis. Hypersensitivity to
light. Decreased serum Na.
Leukopenia, agranulocytosis,
thrombocytopenia, hemolytic
anemia,pancytopenia.
Gastrointestinal disturbances
eg, nausea, vomiting, diarrhea
and abdominal cramps have
been reported after the daily
use of large doses of levocarnitine. Body odor has also
been noticed in some patients,
possibly due to the formation of
the metabolite trimethylamine.
Lypodystrophy, insulin
resistance and hypersensitivity
reactions have been associated
with insulin therapy, but the
incidence and severity of these
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Hydrocortisone
sodium
succinate
(Solu-cortef)
100mg IV every 8
hours
Hydroxyurea
(Hydab,
Krabinex,
Litalir)
Myeloproliferative
disorders 20-30
mg/kg daily. Acute
leukemia 50-75
mg/kg
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
of action is
approximately 1 hour,
with a duration of about
14 hours and peak
activity at 2-8 hours
Corticosteroids enter the
cell and bind to cytosolic
receptors that transport
the steoid into the
nucleus. The steroidreceptor complex alters
gene expression by
binding to glucocorticoid
response elements
(GREs) or
mineralocorticoidspecific elements.
Tissue-specific responses
to steroids are made
possible by the presence
in each tissue of different
protein regulators that
control the interaction
between the hormonereceptor complex and
particular response
elements
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
hyperglycemic coma
Corticosteroids may
mask some signs of
infection, and new
infections may appear
during their use. There
may be decreased
resistance and inability
to localize infection when
corticosteroids are used.
Prolonged use of
corticosteroids may
produce posterior
subcapsular cataracts,
glaucoma with possible
damage to the optic
nerves, and may
enhance the
establishment of
secondary ocular
infections
Corticosteroids should be
used cautiously in
patients with ocular
herpes simplex for fear
of corneal perforation.
Monitor hematological
parameters during
treatment. Chickenpox or
herpes infection, active
infection or dental
disease, marked renal
dysfunction, gout or
Anemia, neutropenia,
leukopenia, thrombocytopenia;
burning, redness or pain at site
of radiation therapy; erythema,
maculopapular rash, sore
mouth or lips, skin rash; fever
or chills, cough or sore throat;
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
psoriasis. The S-phasespecifec action of
hydroxyrea can deplete
bone marrow precurso
cells associated with
megaloblastic changes
Reversible .blockade of
the actions of
cholinomimetics at
muscarinic receptors
Hyoscine-Nbutylbromide
(Buscopan)
10mg/tab,
20mg/amp
1~2 tab / amp IV
several times
Hydroxyzine Hcl
(Iterax)
10mg/tab
May be caused by
suppression of activity in
subcortical areas of CNS.
Ibuprofen
200mg cap :
1cap Q4~6hr
100mg/5ml susp:
5~15ml Q6~8hr
Itopride HCl
(Ganaton)
50 mg/tab
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
nephrolithiasis, patients
who have received
radiation or cytotoxic
therapy causing
myelosuppression
constipation or diarrhea;
stomatitis; difficulty in
micturition, nausea, vomiting,
low back pain, fatigue,
hyperuricemia
Xerostomia, tachycardia,
urinary retention, allergic
reactions, skin reactions
Precaution to pregnant
and lactating mothers.
CARDIOVASCULAR: Chest
tightness. CNS: Transitory
drowsiness; involuntary motor
activity, including tremor and
convulsions. GI: Dry mouth.
RESPIRATORY: Hypersensitivity
reactions (eg, wheezing,
shortness of breath).
Last trimester of
pregnancy, lactation
Special precaution :
severe allergic reaction
to aspirin
Treatment of GI symptoms
of functional, non-ulcer
dyspepsia ie feeling of
Known hypersensitivity,
GI hemorrhage,
mechanical obstruction
Leucopenia and
thrombocytopenia. Dizziness,
headache, tremors. Diarrhea,
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
antagonizing activity and
acetylcholinesterase
inhibitory activity.
Immuzinc
Zn sulfate
(syrup
55mg/5ml =
20mg)
Syrup 55mg/5ml,
5ml once a day
Pediatric mineral
Insulin
(Humulin R)
The dosage
should be
determined
according to the
individual
requirements of
the patient.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
abdominal bloatedness,
upper abdominal pain,
heartburn, nausea and
vomiting.
Help stimulate the
activities of many
enzymes, promoting
normal biochemical
reactions in the body.
Adequate daily zinc
supplementation helps
strengthen the immune
system. Supports normal
growth & development.
Also helps in the
management of acute
diarrhea in infants &
children
Treatment of patients
with diabetes mellitus for
the control of
hyperglycemia.
or perforation.
None
None
Lipodystrophy, insulin
resistance and hypersensitivity
reactions have been associated
with insulin therapy, but the
incidence and severity of these
unwanted effects is minimal
with monocomponent insulin.
Common Problems of Diabetes:
Hypoglycemia (Insulin
Reaction): Hypoglycemia (too
little glucose in the blood) is
one of the most frequent
adverse events experienced by
insulin users. It can be brought
about by: Taking too much
insulin; missing or delaying
meals; exercising or working
more than usual; an infection or
illness (especially with diarrhea
or vomiting); a change in the
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
2.5ml vial
Isoniazid
10-15mg/kg
Isosorbide-5mononitrate
(Imdur)
325 mg/tab or 80
mg/tab
Inhibits prostaglandin
synthesis, resulting in
analgesia, antiinflammatory activity
and platelet aggregation
inhibition; reduces fever
by acting on the brains
heat-regulating canter to
promote vasodilation
and sweating
Management of revesible
bronchospasm associated
with obstructive airway
disease in patients who
require more than a single
bronchodilator
Prophylactic treatment of
angina pectoris. Treatment
of post-myocardial
infarction anginal attacks.
Hypertrophic obstructive
cardiomyopathy or
tachycarrhythmia.
History of
hypersensitivity to soya
lecithin or related food
products
Convylsive disorders,
history of psychosis,
hepatic or renal
impairment
Patients prone to
dyspepsia or known to
have a lesion of the
gastric mucosa. Do not
administer to patients
with hemophilia and is
not recommended to
infants <1 year. Caution
is necessary when renal
or hepatic function is
impaired and particularly
Generic/ Brand
Acarbose
(Glucobay)
Isoxsuprine HCl
(Duvadilan)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
10mg/tab
Isoxsuprine HCl
(Isoxilan)
Itopride HCl
(Ganaton)
Ivabradine
50 mg/tab
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
a -adrenoceptor agonist
with selectivity of action
for the smooth muscles
of the blood vessels,
particularly the cerebral
vessels and the deeper
vessels of the limbs. In
higher doses, isoxsuprine
has a relaxant action on
the smooth muscles of
the uterus. Isoxsuprine
also has a beneficial
effect on blood viscosity.
Isoxsuprine, a adrenoceptor agonist, is
an orally and
perenterally active
peripheral vasodilator. It
has a strong relaxing
action on arteries and to
a certain extent, also on
cutaneous blood vessels.
In addition to this, it had
a direct relaxant effect
on the smooth muscle
tissue of the uteru
Treatment of circulatory
disorders & uterine
hypermotility.
Activates GI propulsive
motility due to its
dopamine D2
antagonizing activity and
acetylcholinesterase
inhibitory activity.
Treatment of GI symptoms
of functional, non-ulcer
dyspepsia ie feeling of
abdominal bloatedness,
upper abdominal pain,
heartburn, nausea and
vomiting.
Symptomatic treatment of
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Recent arterial
hemorrhage, heart
disease, severe anemia.
Parenterally,
hypotension,
tachycardia, premature
rupture of membranes or
immediately post partum
Known hypersensitivity,
GI hemorrhage,
mechanical obstruction
or perforation.
Hypersensitivity to said
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Generic/ Brand
Acarbose
(Glucobay)
Ivabradine
(Coralan)
Kalium
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Usual
recommended
initial dose: 5 mg
bid. Increase if
necessary to 7.5
mg bid after 3-4
weeks. Titrate
downward to 2.55 mg bid if
patient
develops bradyca
rdia symptoms
(e.g. dizziness,
fatigue) or resting
heart rate is
persistently <50
beats/min).
Elderly: 75 yr
old: Initiate
treatment at 2.5
mg bid. Titrate up
if necessary.
Renal
impairment: Cau
tion in patients
with CrCl <15
ml/min.
750 mg durule
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
lowering agent acting by
selective and specific
inhibition of the cardiac
pacemaker.
Ivabradine is a heart rate
lowering agent that
works through selective
and specific inhibition of
the cardiac
pacemaker If current. If c
urrent controls the
spontaneous diastolic
depolarisation in the
sinus node and regulate
heart rate.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Pregnancy, lactation,
resting heart rate <60
beats/min prior to
treatment, cardiogenic
shock, acute myocardial
infarction, severe
hypotension (<90/50
mmHg), severe hepatic
insufficiency, sick sinus
syndrome, sino-atrial
block, heart failure
patients with NYHA class
III-IV, pacemaker
dependent, unstable
angina, 3rd degree AVblock, concurrent use
with potent CYP3A4
inhibitors.
Luminous phenomena
(phosphena), blurred vision,
bradycardia, 1st degree AVblock, ventricular extrasystole,
supraventricular extrasystoles,
palpitations, headache,
dizziness, nausea, constipation,
diarrhoea, vertigo, dyspnoea,
muscle cramps,
hyperuricaemia, eosinophilia,
elevated blood-creatinine.
Hypokalemia, prophylaxis
during treatment with
diuretics
Renal insufficiency,
hyperkalemia, untreated
Addisons disease,
constriction of the
esophagus &/or
Hyperkalemia.
Generic/ Brand
Acarbose
(Glucobay)
Ketoprofen
(Orudis)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
maintenance
100-300 mg IV
daily for a max of
48 hrs
30 mg IV TID
Analgesic
Lactulose
(Duphalac)
3.3g/5ml
Starting
Adult : 15~45ml
Child :5~15ml
Maintenance
Adult : 10~25ml
Child :5~20ml
Lansoprazole
Peptic ulcer
Adult: 30 mg
once daily in the
morning given for
4 wk (duodenal
ulcer) or for 8 wk
(gastric ulcer).
Hypersecretory
conditions
Adult: Initially,
60 mg daily and
adjust as
required. Daily
doses >120 mg
should be given in
Ketorolac
trometamol
(Toradol)
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
obstructive changes in
the GIT.
Renal impairment
Constipation associated
with ped problems, postop; pregnancy & postnatal
period; bedridden &
geriatric patients; surgical
procedures; painful rectal &
anal conditions; laxative
dependence; barium x-ray
investigation; drug-induced
constipation
Peptic ulcer
Hypersecretory conditions
Acid-related dyspepsia
Gastro-oesophageal
reflux disease
NSAID-associated
ulceration
Prophylaxis of NSAIDinduced ulcers
H.pylori infection
Erosive oesophagitis
Special Precautions: in
patients with impaired
renal function. History of
GIT disease,
anaphylactoid reactions,
elderly, coagulation
disorders. Avoid driving
and operating machinery
Galactosemia, bowel
obstruction,
hypersensitivity
Special concerns in
lactose intolerance
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
GI disorders, headache,
drowsiness, dizziness, edema,
bullous dermatoses
GI reactions, nausea,
dyspepsia, drowsiness,
headache, sweating edema,
bradycardia, palpitation,
hypotension, chest pain
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
2 divided doses.
Acid-related
dyspepsia
Adult: 15-30 mg
once daily in the
morning for 2-4
wk.
Gastrooesophageal
reflux disease
Adult: 30 mg
once daily in the
morning for 4-8
wk. Maintenance:
15-30 mg once
daily according to
response.
NSAIDassociated
ulceration
Adult: 15-30 mg
daily for 4-8 wk.
Prophylaxis of
NSAID-induced
ulcers
Adult: 15-30 mg
daily for 4-8 wk.l
H.pylori infectio
n
Adult: 1-wk triple
therapy: 30 mg
bid combined
with
clarithromycin
500 mg bid and
either amoxicillin
1 g bid or
metronidazole
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Generic/ Brand
Acarbose
(Glucobay)
Levetiracetam
(Keppra)
Levocetirizine
and
Montelukast
(Co-altria)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
400 mg bid.
Erosive
oesophagitis
Adult: 30 mg
over 30 minutes
daily for up to 7
days
500-1500mg BID
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
q HS
Montelukast: The
cysteinyl leukotrienes
(LTC4, LTD4 and LTE4)
are potent inflammatory
eicosanoids released
from various cells
including mast cells and
eosinophils. These
important mediators
bind to cysteinyl
leukotriene receptors.
Cysteinyl leukotrienes
have been correlated
with the pathophysiology
of asthma and allergic
rhinitis. In asthma,
leukotriene-mediated
effects include
bronchoconstriction,
mucous secretion,
vascular permeability
and eosinophil
recruitment. In allergic
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Hypersensitivity.
Pregnancy and lactation
Relief of symptoms
associated with seasonal
and perennial allergic
rhinitis.
Asthenia, somnolence.
Amnesia, ataxia, convulsion,
dizziness, headache,
hyperkinesia, tremor, agitation,
depression, emotional lability,
hostility, insomnia,
nervousness, personality and
mental disorders
Dyspepsia, Dizziness, Nasal
congestion, Rash, Somnolence,
Dry mouth, fatigue, agitation,
convulsion
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Levofloxacin
250mg, 500mg
tablets, 5mg/ml x
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
rhinitis, cysteinyl
leukotrienes are released
from the nasal mucosa
after allergen exposure
during both early- and
late-phase reactions and
are associated with
symptoms of allergic
rhinitis. Intranasal
challenge with cysteinyl
leukotrienes has been
shown to increase nasal
airway resistance and
symptoms of nasal
obstruction. Montelukast
is an orally active
compound which binds
with high affinity and
selectivity to the
cysteinyl leukotriene
type 1 receptor thereby
preventing cysteinyl
leukotrienes from
exerting their effects.
Levocetirizine: The
active enantiomer of
cetirizine is an
antihistamine. Its
principal effects are
mediated via selective
inhibition of H1 receptors.
The antihistamine
activity of levocetirizine
has been documented in
a variety of animal and
human models
Semi-synthetic
antibacterial agent that
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Age<19 y/o,
hypersensitivity,
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
100 ml
Linagliptin
(Trajenta)
5 mg once daily.
Loperamide
(Diatabs,
Imodium)
2mg/cap,
2cap followed by
1cap after
unformed stool
Loratadine
Adult: syrup
5mg/5ml
Tablet 10mg
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
inhibits bacterial DNA
gyrase, necessary for
supercoiling of the DNA,
thereby preventing DNA
replication in susceptible
bacteria
Linagliptin is an inhibitor
of the enzyme DPP-4 (EC
3.4.14.5), an enzyme
which is involved in the
inactivation of the
incretin hormones
glucagon-like peptide-1
(GLP-1) and glucosedependent insulinotropic
polypeptide (GIP).
Directly acts on intestinal
muscles to inhibit
peristalsis and prolongs
transit time enhancing
fluid & electrolyte
movement through
intestinal mucosa;
reduces fecal volume,
increase viscosity &
diminishes fluid and
electrolyte loss;
demonstrates
antisecretory activity;
exhibits peripheral action
Long-acting tricyclic
antihistamine with
selective peripheral
histamine h1-receptor
antagonistic activity
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
For type II DM
to improve glycemic control
in conjunction with diet and
exercise, or as add-on to
metformin, sulfonylureas,
thiazolidinediones, insulin
(with or without metformin
and/or pioglitazone and/or
sulfonylurea) or metformin
plus sulfonylureas.
Anti-diarrheal
Symptomatic control of
acute & chronic diarrhea,
ileostomy
Hypersensitivity to
linagliptin or any of the
excipients of Trajenta.
Trajenta should not be
used in patients with
type 1 diabetes or for the
treatment of diabetic
ketoacidosis.
Hypoglycemia
Constipation, acute
ulcerative,
pseudomembranous
colitis, acute dysentery
Hypersensitivity, hepatic
and renal impairment
Headache, somnolence,
fatigue, nervousness, dry
mouth, hyperkinesia,
conjunctivitis, drowsiness
Generic/ Brand
Acarbose
(Glucobay)
Losartan
(Cozaar)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
50mg/tab
100mg/tab
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Losartan is a selective,
competitive Angiotensin
II receptor type 1 (AT1)
receptor antagonist,
reducing the end organ
responses to angiotensin
II. Losartan
administration results in
a decrease in total
peripheral resistance
(afterload) and cardiac
venous return (preload)
All of the physiological
effects of angiotensin II,
including stimulation of
release of aldosterone,
are antagonized in the
presence of losartan
Antacids, antireflux &
antiulcerants agents
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Dizziness, dose-related
orthostatic effects, rash,
asthenia/fatigue, vertigo,
hypotension & hyperkalemia,
hypersensitivity, GI, CV,
hematologic, musculoskeletal,
nervous, psychiatric, resp &
dermatologic effects; vomiting,
dysgeusia & erythroderma.
Maalox
Al(OH)3 200mg,
Mg(OH)2 200mg
Mannitol
Chewtab 2~4
Susp 2~4tsp
QID
150cc/TSS
Symptomatic relief of
hyperacidity
Severe debilitation,
kidney failure
Rarely, GI disturbance
Severe impairment of
renal function, excessive
loss of electrolyte,
osmotic nephrosis,
Mebendazole
100mg/tab
None
none
Enterobiasis, ascariasis,
hookworm infections,
trichomoniasis, roundworm
Mefenamic acid
Inhibits prostaglandin
synthesis by decreasing
GIT ulceration or
inflammation
GI disturbances, bleeding,
drowsiness, dizziness
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Meloxicam
15mg/tab OD
Memantine HCl
(Zimerz)
5-20mg
Menadione
10mg/tab q8
Meperidine
(Demerol)
50 to 150 mg
every three hours
Meropenem
500mg IV q6
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
the activity of the
enzyme,
cyclooxygenase, which
results in decrease
formation of the
protaglandin precursor
Selective COX-2 inhibitor,
thus, preventing
prostaglandin synthesis
and inflammation
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Moderate to severe
Alzheimers disease
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Cross sensitivity to
Aspirin and other
NSAIDs, history of
stroke, heart attack,
uncontrolled
hypertension,
pregnancy
Hypersensitivity
Hemolytic anemia,
hyperbilirubinemia & kernicterus
in newborns especially in
premature babies.
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
(Meronem)
Metformin HCl
500mg/tab BID
Methylergometr
ine hydrogen
maleate
(Methergin)
125~250mg
orally TID
Methylergonovi
ne
(Syntocinon)
Methylprednisol
40 mg/tab
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
antibiotic for parenteral
use that is relatively
stable to human
dehydropeptidase-1.
Decreases hepatic
glucose production,
decreasing intestinal
absorption of glucose
and improves insulin
sensitivity
Similar smooth muscle
actions as seen with
ergotamine; however,
affects primarily uterine
smooth muscle
producing sustained
contractions and thereby
shorten the third stage
of labor
Produces rhythmic
uterine contractions and
can stimulate the gravid
uterus; has vasopressive
and antidiuretic effects;
can control postpartum
bleeding or hemorrhage
by increasing
postpartum myometrial
tonus
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
meropenem
of injection site
Abnormal presentation,
before delivery of child
is completed & in
multiple birth not before
the last child has bee
delivered.
Is a synthetic steroid
Documented
hypersensitivity;
pregnant patients with
severe toxemia,
unfavorable fetal
positions, and a
contracting uterus with
hypertonic or
hyperactive patterns;
labor in which vaginal
delivery should be
avoided, such as
invasive cervical
carcinoma, cord
presentation or
prolapse, active herpes
genitalis, total placenta
previa, and vasa previa
Gastric and duodenal
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
one
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
which is easily absorbed
from the GIT. It has an
antiallergenic, antitoxic,
antipyretic and
immunosuppressive
properties.
Methotrexate
(Biomedis
Methotrexate
soln, Emthexate
vial, Methobax
vial, Pfizer
Methotrexate
vial)
Induction 3.3
mg/m2 w/
prednisolone 60
mg/m2 daily.
Maintenance
therapy 30
mg/m2 IM twice
wkly or 2.5 mg/kg
IV every 14 days
Metoclopramide
HCl
(Reglan, Plasil)
10mg/tab,
5mg/5ml susp.
10-15mg QID, 30
minutes before
food intak IV, Tab,
Syrup
Metoclopramide
stimulates motility of the
upper GIT without
stimulating gastric,
biliary or pancreatic
secretions. Its mode of
action is unclear. It
seems to sensitize
tissues to the action of
acetylcholine. The effect
of metoclopramide on
motility is not dependent
on intact vagal
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
pericarditis, idiopathic,
postmyocardial infarction.
Preexisting liver
damage or impaired
hepatic function.
Malignant disease w/
preexisting bone
marrow aplasia,
leucopenia,
thrombocytopenia or
anaemia. Infection,
peptic ulcer, ulcerative
colitis, debility &
extreme youth & old
age. Monitor renal
function & serum levels
when giving high dose;
give Ca folinate,
hydration & urine
alkalinisation
GI hemorrhage,
mechanical obstruction
or perforation,
pheochromocytoma,
epileptics
Dermatological &
hypersensitivity reactions. Bone
marrow depression, leucopenia,
neutropenia, thrombocytopenia,
decreased serum albumin,
anemia, pancytopenia,
hypogammaglobulinemia.
Mucositis, anorexia, nausea,
vomiting, diarrhea, abdominal
distress, hematemesis, melena,
Renal failure, azotemia, cystitis,
hematuria, urogenital or
menstrual dysfunction
Antiemetic, prokinetic
agent
Disturbances of GI motility
including GERD & diabetic
gastroparesis. Nausea &
vomiting of central &
peripheral origin associated
with surgery, metabolic
disease, infectious disease,
migraine headache or
drugs including cancer
chemotherapy. Facilitate
small bowel intubation &
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
In approximately 10%
restlessness, drowsiness, fatigue
and lassitude. Less frequently,
insomnia, headache, dizziness,
nausea or bowel disturbances
may occur
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Metoprolol
(Neobloc)
Metronidazole
500mg every 8
hours
IV, Oral
Metronidazole
500 mg,
nystatin
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
innervation, but it can be
abolished by
anticholinesterase.
Blocks dopamine and
serotonin in the CTZ of
the CNS, which is
responsible for its
antiemetic action. Also
increases LES tone
The -blocking activity
primarily affects the
cardiovascular system
(decreases heart rate,
decreases contractility,
decreases BP) and lungs
(promotes
bronchospasm)
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
A direct acting
trichomonacide and
amebecide that works at
both intestinal and
extraintestinal sites.
Thought to enter the
cells of microorganisms
that contain
nitroreductase. Unstable
compounds are then
formed that bind to DNA
and inhibit synthesis,
causing cell death
Metronidazole is
converted to reduction
products that interact
Amoebiasis, giardiasis,
urethritis & vaginitis due to
trichomonas, aerobic
infection
Hypersensitive to the
drug or other
nitroimidazole
derivatives and in
patients in 1st trimester
of pregnancy
Digitalis toxicity,
ventricular
tachycardia/fibrillation,
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
radiological procedure of
GIT
Lactation: excreted in
breast milk; Children:
safety and efficacy not
established;
Anaphylaxis: Deaths
have occurred;
aggressive therapy may
be required; AV block,
slows AV conduction
and may cause heart
block; Bradycardia
Local irritation
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
100,000 IU.
(Flagystatin)
MgSO4
4grams, slow IV
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
with DNA to cause
destruction of helical
DNA structure and strand
leading to a protein
synthesis inhibition and
cell death in susceptible
organisms. It is effective
against a wide range of
organisms including E.
histolytica, T. vaginalis,
Giardia, anaerobes e.g.
Bacterioides sp,
Fusobacterium sp,
Clostridium sp,
Peptococcus sp and
Peptostreptococcus sp,
and moderately active
against Gardnerella sp
and Campylobacter sp
Nystatin, a polyene
antifungal, binds to
ergosterol in the fungal
cell membrane. This
binding affects the cell
wall permeability
allowing leakage of
cellular contents.
Magnesium prevents or
controls convulsions by
blocking neuromuscular
transmission and
decreasing the amount
of acetylcholine liberated
at the end plate by the
motor nerve impulse.
Magnesium is said to
have a depressant effect
on the CNS, but it does
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
fungal infections.
obstructive
cardiomyopathy.
Arrhythmias due to
accessory pathways
(e.g. Wolff-ParkinsonWhite syndrome).
For eclampsia or
preeclampsia; For
replacement therapy in
magnesium deficiency,
especially in acute
hypomagnesemia
accompanied by signs of
tetany similar to those
observed in hypocalcemia
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Generic/ Brand
Acarbose
(Glucobay)
Midazolam
(Dormicum)
Montelukast
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
tablet initially
then tablet
every 2 hours
prior to operation
10mg PO
qEvening (use
10mg tablet)
Morphine
sulfate
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
not adversely affect the
mother, fetus or neonate
when used as directed in
eclampsia or preeclampsia.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Blocks binding of
leukotriene D4 to its
receptor
Analgesic and for
sedation
Hypersensitivity
Prolonged relief of
moderate to severe pain
Antibiotic / Quinolone
Moxifloxacin
(Avelox)
Moxifloxacin
HCl
(Vigamox)
Mupirocin
ointment
Apply up to TID
for 10 days
Myrin
(Ethambutol
HCl, Rifampicin,
300/150/75 mg
tab once a day
Oral chemotherapeutic
agent which is specially
effective against actively
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Treatment of
bacterial conjunctivitis.
Hypersensitivity to
moxifloxacin or to other
quinolones.
Hypersensitivity
Generic/ Brand
Acarbose
(Glucobay)
Isoniazid)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
growing microorganisms
of the genus
Mycobacterium
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Generic/ Brand
Acarbose
(Glucobay)
Nalbuphine
(Nubain)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
5 mg IM 0.15-0.2
mg/kg BW
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Opioid Analgesic
Apirin intolerance,
advanced renal failure,
active peptic ulcer
5mg/day PO
Competitive and
selective beta 1-receptor
antagonist; has little or
no effect on beta 2
receptors at doses
<10mg; possesses mild
vasodilating properties;
reduces systemic
Hypertension
Hypersensitivity, severe
hepatic impairment,
cardiogenic shock,
uncontrolled heart
failure, bradycardia,
hypotension, COPD
Naproxen Na
(Flanax Forte)
Nasatapp
(Tab/syrup/drop
):
Bromphenirami
ne Maleate
12/4/2mg,
Phenylpropanol
amine HCL
15/12.5/6.25mg
Nebivolol
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Nicardipine HCl
(Cardepine)
Oral: 20,30 mg
Parenteral: 2.5
mg/mL
Nifedipine
(Adalat,
Calibloc,
Calchek,
Nelapine,
Nifelan)
10mg TID or
30mg OD
(Extended release
tablets) max 120180mg/day
Nitroglycerine
Norgesic tab
Orphenadrine
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
vascular resistance
Potent peripheral
vasodilator. Little
depression of nodes.
Causes reflex increase in
heart rate and output
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Hypertensive emergencies
or urgencies, periop &
post-op HTN, hypertensive
states of NPO patients
Nitroglycerin causes a
relaxation of vascular
smooth muscle thereby
inducing a
vasodilatation. Both
peripheral arteries and
veins are relaxed by
nitroglycerin. The latter
effect promotes venous
pooling of blood and
decreases venous return
to the heart, thereby
reducing ventricular enddiastolic pressure and
volume (preload).
Orphenadrine: Muscular
Prophylaxis of angina
pectoris. Long-term
treatment of CHD.
Treatment of chronic heart
failure in combination w/
digitalis &/or diuretics
Glaucoma; myasthenia
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
citrate 35 mg,
paracetamol 450
mg.
Ofloxacin
(Inoflox)
200mg IV every 8
hours
Olmesartan
(Olmetec)
10-40 mg once
daily, adjusted
according to
patient need.
Olmesartan
medoxomil
(Olmetec)
20mg-40mg
OD
Omeprazole
(Losec,
20mg OD
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
analgesic combination;
not clearly identified.
May be related to its
analgesic properties;
possesses anticholinergic
actions.
Blocks bacterial DNA
synthesis by inhibiting
bacterial topoisomerase
II (DNA gyrase) and
topoisomerase IV
Olmesartan is a selective
and competitive
angiotensin II Type 1
(AT1) receptor antagonist
that blocks the
vasoconstrictor and
aldosterone-secreting
effects of angiotensin II.
As a result, olmesartan
relaxes blood vessels,
hence lowering BP and
increases blood supply
and oxygen to the heart.
Blocks the
vasoconstrictor and
aldosterone secreting
effects of angiotensin II
by selectively blocking
the binding of the
angiotensin II to the
angiotensin I receptor in
the vascular smooth
muscle.
Suppresses gastric acid
secretion by inhibiting
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
gravis; prostatic
hypertrophy or bladder
neck obstruction. Childn
<12 yr.
Hypersensitivity to
quinolones, Pregnancy
and lactation. Children.
GI effects, neurological
reactions, superinfection,
tendenitis
Hypersensitivity to the
drug.
Use of drugs that act
directly on the reninangiotensin system
administered during the
2nd and 3rd trimesters
of pregnancy has been
associated with fetal
injury and even death.
Dizziness
Peripheral edema, headache,
cough, abdominal pain, nausea,
vomiting, diarrhea,
anaphylactic reaction, rash,
pruritus, angioedema, acute
renal failure, increased hepatic
enzymes and blood creatinine,
hyperkalemia, myalgia and
asthenic conditions eg,
asthenia, fatigue, lethargy,
malaise.
Treatment of essential
hypertension
Hypersensitivity
Hepatic impairment
Severe renal impairment
Primary aldosteronism
Pregnancy & lactation
Biliary obstruction
Children & adolescents
up to 18yrs of age
Duodenal ulcer,prevention
of relapse of duodenal
Presence of significant
unintentional weight
Headache, diarrhea,
constipation, abdominal pain,
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mepracid,Hoviz
ol)
OMX Probiotics
Probiotics 12+
Professional
Formula
Orofar
(Benzoxonium
Cl 0.5 mg,
lidocaine HCl
0.5 mg)
Soln After
morning &
evening meals,
gargle or rinse
mouth for 30-60
sec w/ 1 tbsp of
undiluted soln (do
not swallow). If
continued
treatment is
indicated, the
soln may be used
more often or
may be replaced
by loz during the
day. Childn >4 yr
Dose should be
reduced. Max: 6
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
the parietal cell H+/K+
ATP pump
Normalizes the micro
flora (lactic acid
bacteria) in the intestinal
tract, Reestablishes the
colon's optimum pH level
and Probiotics 12 plus,
Suppresses the growth of
bad bacteria, stimulates
the immune system,
fortifies the body's ability
to absorb nutrients,
provides complex B
vitamins, antioxidants,
minerals & amino acids.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Generic/ Brand
Acarbose
(Glucobay)
Orphenadrine
citrate+
Paracetamol
(Norgesic Forte)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
loz/day. Use only
1 tsp of soln to
rinse or gargle
50mg/
650mg/
tab
1-2tab TID
Oxytetracycline
(Terramycin)
Oxytocin
(Syntocinon)
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Glaucoma, myasthenia
gravis, prostatic
hyperthropy, bladder
neck obstruction
Prophylaxis of opthalmia
neonatorum; treatment of
superficial ocular infection
due to susceptible
organism;
Ophthalmic use is
contraindicated in
epithelial herpes simplex
keratitis, fungal disease
of ocular structure and
after removal of corneal
compound
Produces rhythmic
uterine contractions and
can stimulate the gravid
uterus; has vasopressive
and antidiuretic effects;
can control postpartum
bleeding or hemorrhage
by increasing
postpartum myometrial
tonus
Documented
hypersensitivity;
pregnant patients with
severe toxemia,
unfavorable fetal
positions, and a
contracting uterus with
hypertonic or
hyperactive patterns;
labor in which vaginal
delivery should be
avoided, such as
invasive cervical
carcinoma, cord
presentation or prolapse,
active herpes genitalis,
total placenta previa,
vasa previa
Xerostomia, tachycardia,
urinary retention, allergic
reactions, skin reactions
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Pankreatoflat
(Pancreatin,
dimethicone)
170/80 mg tab
OD
Pantoprazole
(Ulcepraz,
Pantoloc)
20-40mg 1x a day
Paracetamol
500mg/tab,
250mg/5ml
250~500mg
every 3~6hrs
Paracetamol
(Aeknil)
150mg/ml
2~3ml every 4
hours for adult
1~2ml every 4
hours for child
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Paracetamol
(Biogesic)
500mg/tab,
250mg/5ml
250~500mg
every 3~6hrs
Perindopril
(Coversyl)
2, 8 mg/tab
Pethidine HCl
(Demerol)
25 mg IV
Pethidine or
meperidine
(Demerol)
50 to 150 mg
every three hours
Piracetam
4.8-6gm/day
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Essential hypertension,
CHF. Prevention of stroke
recurrence, history of CVD
Hypersensitivity,
pregnancy and lactation
Respiratory depression,
circulatory depression, resp.
arrest, shock, cardiac arrest, GI
disturbance. Dizziness,
sedation, headache, dysphoria,
tremor, agitation, hallucination,
disorientation
constipation, dry mouth,
lightheadedness, twitchiness,
muscular twitches, and nausea
Nervousness, agitation,
irritability, anxiety, sleep
Generic/ Brand
Acarbose
(Glucobay)
Pinaverium
chloride
( Eldicet )
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
500 mg/
tab TID
Polynerve
Potassium
citrate
(Acalka)
supplementation
1080 mg / Tablet
TID
Prednisone
Prednisolone
acetate
(PREDFORTE )
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
origin, dementia,
alcoholism, vertigo, CVA,
behavioral disorders in
children, after trauma or
surgery.
Anti- spasmodic
Inhibitor of
crystallization; used in
treatment of patients
with renal lithiasis and
hypocitraturia, chronic
formers of calcium
oxalate, phosphate
calculi; uric acid lithiasis
alone or accompanied by
calcium lithiasis, and
renal tubular acidosis
with calcium
nephrolithiasis.
Is a synthetic steroid
which is easily absorbed
from the GIT. It has an
antiallergenic, antitoxic,
antipyretic and
immunosuppressive
properties.
Decreases inflammation
by suppression of PMNs
and reversal of increased
capillary permeability
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
manifestations of CVA or
cerebral atherosclerosis,
post-traumatic syndromes
disturbances.
Spasmodic digestive
disorders, functional
colonopathies, preparation
for radiologic exams,
Prevention & treatment of
deficiency disorders
following poor dietary
intake .
Treatment of patients with
renal lithiasis &
hypocitraturia, chornic
formers of Ca oxalate,
phosphate calculi. Uric acid
lithiasis alone alone or
accompanied by Ca
lithiasis. Renal tubular
acidosis with Ca
nephrolithiasis.
Steroid responsive
inflammation of the
palpebral and bulbar,
cornea and anterior
Acute, untreated
purulent occular
infections. Acute
superficial herpes
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Pregabalin
(Lyrica)
Propanolol
40mg PO q12hr
initially,
increasing every
33-7 days;
maintenance: 80240mg PO q8q12hr; not to
exceed 640
mg/day
500mg / tab
Cystic fibrosis
20mg/kg, max
750mg BID
Gonorrhea
500mg OD
Prozine
Ciprofloxacin
HCl
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Precise mechanism of
action unknown but is a
GABA analogue that
binds to a subunit of
voltage-gated calcium
channels in cns; does not
affect sodium channels,
opiate receptors, or
cyclo-oxyenase enzyme
activity; interactions with
descending
noradrenergic and
serotonergic pathways
originating from the
brain stem appear to
reduce neuropathic pain
transmission from spinal
cord
Non selective beta
adrenergic receptor
block; competitive
inhibition results in
decreases in heart rate,
myocardial contractility,
myocardial oxygen
demand, and blood
pressure
Inhibits DNA-gyrase in
susceptible organism;
inhibit relaxation of
supercoiled DNA and
promotes breakage of
double-stranded DNA
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
segment
Hypertension, migraine,
angina,
pheochromocytoma,
supraventricular
arrhythmia
Aggravated CHF,
bradyarrhythmia, hypotension,
decreased exercise tolerance,
Raynaud phenomenon,
potential increase in insulin
resistance, depression, fatigue,
insomnia, paresthesia,
psychotic disorders
Dizziness, somnolence.
Appetite increase, euphoric
mood, confusion, decreased
libido, irritability. Blurred vision,
diplopia, vertigo, dry mouth,
constipation, vomiting,
flatulence, erectile dysfunction,
fatigue, peripheral edema,
feeling drunk, edema, gait
abnormality, wt increase.
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Polynerve
PTU
Pyrazinamide
Racecadotril
(Hidrasec)
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
supplementation
300-450 mg/day
PO divided q8hr
initially
Maintenance:
100-150 mg/day
divided q8fr
15-30mg/kg
100-mg cap
1.5 mg/kg per
dose, with 1 initial
dose and 3 doses
spread over the
day. Children >9
years (approx
>27 kg): 2
sachets/dose; 30
months - 9
years (approx
Inhibits synthesis of
thyroid hormone by
blocking oxidation of
iodine in thyroid gland;
blocks synthesis of T4
and T3
Its metabolic derivative,
pyrazinoic acid, has
specific antimicrobial
activity against M.
tuberculosis & lowers the
pH of the environment
below the level required
for mycobacterial
growth.
Hidrasec is an inhibitor of
enkephalinase, the
enzyme responsible for
breaking down
enkephalins. It is a
selective but reversible
inhibitor and protects
endogenous enkephalins
which are physiologically
active in the digestive
tract.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Hypersensitivity
Agranulocytosis, aplastic
anemia, dermatologic
reactions, hepatitis, drowsiness,
fever, headache, vertigo,
alopecia
Renal insufficiency
Known hypersensitivity to
racecadotril. Renal or
hepatic impairment.
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
13-27 kg): 1
sachet/dose; 9-30
months (approx
9-13 kg): 2
sachets/dose; 1-9
months: 1
sachet.dose.
Rebamipide
Ranitidine
(Ulcin / Zantac)
Renogen
2,000 u/ml
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Hidrasec has a pure
intestinal antisecretory
agent which has been
shown to have no effect
on GI motility. It reduces
intestinal hypersecretion
of water and electrolytes
caused by cholera toxin
or inflammation without
affecting basal secretion.
There is therefore no
effect in the normal
intestine.
Rebamipide is a mucosal
protective agent and is
postulated to increase
gastric blood flow,
prostaglandin
biosynthesis and
decrease free oxygen
radicals.
Inhibits action of
histamine at the H2
receptor site located
primarily in the gastric
parietal cells
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Hypersensitivity to
mammalian cell-derived
products & to albumin,
uncontrolled
hypertension
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Lactation.
Histamine H2 Antagonist,
Antiulcer
Renal impairment,
hepatic impairment,
pregnancy, lactation, or
children
Hypertension, partial or
complete clotting at the
site of vascular access,
seizures, increased
potassium, BUN,
creatinine, arthralgia,
asthenia, chest pain,
diarrhea, edema,
headache, nausea,
tachycardia, vomiting
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
10-20mg/kg
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Inhibits transcription by
blocking DNA-dependent
RNA polymerase
Rofecoxib
(Vioxx)
Roxithromycin
(Ruthison)
Adult: 150 mg
bid or 300 mg
once daily for 510 days in
susceptible
infections.
Rifampicin
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Contraindicated in
patients hypersensitive
to drug or its
components and in those
who have experienced
asthma, urticaria,
allergic reactions after
taking aspirin or other
NSAIDs. Also
contraindicated in
patients with advanced
renal disease or
moderate or severe
hepatic insufficiency and
in pregnant women
because it may cause
ductus arteriosus to
close prematurely
Treatment of infections
caused by susceptible
strains of gm+ve & gm-ve
microorganisms.
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
GI disturbances, increase in
liver enzyme values, hepatitis,
rash, headache, dizziness,
weakness, changes in CBC
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
spectrum as
erythromycin, but is
more effective against
certain gram-negative
bacteria, particular
Legionella pneumonia.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Rosuvastatin
(Crestor)
10-40 mg orally
once a day.
Rosuvastatin is a
selective, potent and
competitive inhibitor of
HMG-CoA reductase, the
rate-limiting enzyme that
converts 3-hydroxy-3methylglutaryl coenzyme A to mevalonate,
a precursor of
cholesterol.
Patients with
hypersensitivity to any
component of Crestor.
Patients with active liver
disease.
Crestor is contraindicated
during pregnancy, while
breastfeeding and in
women of childbearing
potential not using
appropriate contraceptive
measures.
Salbutamol
(Asmalin)
2mg/tab,
2mg/5ml susp.
1tab TID, 2.5 ~
5ml TID
Relaxes bronchial
smooth muscle by action
on B2-receptors with
little effect on heart rate
Asthma
Prevention & relief from
bronchospasm associated
with reversible obstructive
airway disease eg bronchial
asthma
Salbutamol
(Ventolin)
Inhalant: 40
micrograms/puff
aerosol
Oral: 2,4 mg
tablets; 2 mg/mL
syrup
Special precaution :
coronary insufficiency,
cardiac arrhythmias,
hypertension, convulsive
disorder,
hyperthyroidism,
diabetes mellitus;
pregnancy, lactation.
Threatened abortion
during 1st or 2nf
trimesters of pregnancy.
Toxaemia of pregnancy,
antepartum
haemorrhage, placenta
praevia.
Senna
(Senokot)
187mg/tab,
374mg/tab,
stimulation of colonic
motility, resulting in
Functional constipation of
hospitalized patient, O & G
Thyrotoxicosis, inhaled
salbutamol prep are not
appropriate for managing
premature labour. Pregnancy,
lactation. Acute severe asthma.
Monitor fluid balance,
cardiorespiratory function &
ECG
Mild abdominal discomfort;
diarrhea w/ excessive loss of
Generic/ Brand
Acarbose
(Glucobay)
Simethicone
(Disflatyl )
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
40 to 125 Mg
1-2 tab after
meals, for prep
for x-ray, give
2-3 days before
exam
Sinupret
Gentianae
radix (gentian
root),
Primulae
flos (primrose
flowers with
calyx),
Rumicus
herba (common
sorrel herb),
Sambuci
flos (elder
flowers),
Verbenae
Adult:
2 dragees.
Children of
school age:
1 dragee.
To be taken tid.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
augmented propulsion
and accelerated colonic
transit, reducing the
opportunity for fluid
absorption from the
faeces. It also influences
fluid and electrolyte
absorption and secretion
by the colon, resulting in
a net fluid secretion. The
mucilage inhibits fluid
absorption, enhancing
the laxative effec
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
patient, post-surgical,
prenatal, postpartum,
geriatric patient, functional
constipation due to intake
of certain drugs, ped
patient.
vomiting or symptoms of
appendicitis; intestinal
hemorrhage or
obstruction, persistent
diarrhea.
Accumulation of gas in
GIT, sensation of
pressure and fullness in
the epigastrium,
temporary meteorism,
post-op meteorism,
gastrocardiac
syndrome, prep for xray exam and before
gastroscopy
Acute & chronic
inflammations of the
sinuses & the resp tract;
supplementary measure in
antibacterial therapy.
allergic to Simethicone.
Hypersensitivity to the
drug or any of its
contents
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
herba (shop
vervain wort).
Simvastatin
(Vidastat,
Zocor)
10~80mg tab OD
Sitagliptin
50mg tablet
Sitagliptin
phosphate
monohydrate,
metformin HCl
(Velmetia)
50mg/500mg/tabl
et BID
Sodium Chloride
(Muconase)
Spirinolactone
(Aldactone)
25 mg, 50 mg
tabblets
Antagonizes aldosterone
in the distal tubules,
increasing sodium and
water excretion
Sulbactam-
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Renal disease or
dysfuctin, acute or
chronic metabolic
acidosis including
diabetic ketoacidosis
with or without coma.
Lactic acidosis.
None
None
Overgrowth of non-
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Ampicillin
(Unasyn)
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
synthesis
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Phenoxymethylpenicillin
(penicillin V) is a natural
penicillin which kills
bacteria by interfering
with the synthesis of the
bacterial cell wall. It
binds to penicillinbinding proteins on the
bacterial cell wall and
blocks peptidoglycan
synthesis.
Treatment of respiratory
tract infections,
genitourinary tract
infections, skin and soft
tissue infections, oral and
dental infections, and
surgical infections caused
by susceptible organisms.
Prevention and treatment
of secondary bacterial
infections in measles,
mumps, chickenpox,
influenza, and other viral
infections. Also useful in
preventing bacterial
endocarditis after
tonsillectomy or tooth
extraction in patients with
history of rheumatic fever.
Sumapen
Adults: 250-500
mg every 6 hrs.
Children:
Suggested dosage
for infants and
children is 50
mg/kg body
weight/day in 4
divided doses.
Systane Ultra
Tazobactam
2g/250mg + 10ml
diluent, 4g/500mg
+10ml diluent
Telmisartan
40mg OD
Angiotensin receptor
Temporary relief of
burning and irritation
due to dryness of the
eyes
Treatment of systemic &/or
local bacterial infections
caused by susceptible
organisms.
Esssential hypertension.
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
susceptible organism.
Check periodically for
organ system
dysfunction during
prolonged therapy
hypersensitivity to
penicillins.
History of allergic
reactions to any
penicillins,
cephalosporins, or betalactamase inhibitors.
Hypersensitivity,
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
blocker.
Inhibits vasoconstriction
and aldosteronesecreting effects of
angiotensin II.
Angiotensin receptor
blocker + thiazide
diuretic
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Prevention of CV morbidity
and mortality in patients
>55 at high risk of CV
disease.
pregnancy, bilateral
renal stenosis
Esssential hypertension
Hypersensitivity.
Pregnancy, lactation.
Biliary obstructive
disorders.
Cholestasis & obstructive
disorders. Severe
hepatic and renal
impairment (CrCl <30
mL/min). Refractory
hypokalemia,
hypercalcemia.
Pregnancy & Lactation
IgA deficiency and
concurrent presence of
antibodies to IgA
Diarrhea, angioedema
Hypersensitivity
reactions
Telmisartan +
Hydrochlorothia
zide
(Micardis)
Telmisartan +
HCTZ
(Micardis plus)
40mg + 12.5
mg/tab OD
40mg + 12.5mg
tablet
Angiotensin II antagonist,
antihypertensive,
thiazide diuretic
Treatment of essential
hypertension for patients in
whom combination therapy
is appropriate
Tetagam
(Human Tetanus
Ig,
pasteurizaed)
Tetanus toxoid
(Adsorbed)
TOBRANYCIN +
Tobramycin binds
For steroid-responsive
Bronchitis, pharyngitis,
sinusitis, hypokalemia,
hyponatremia, hyperuricemia,
anxiety, depression,
exacerbation or activation of
SLE, dizziness, depression,
syncope/fain, paresthsia
Generic/ Brand
Acarbose
(Glucobay)
DEXAMETHSON
E (TOBRADEX)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
a day
Tramadol
(Dolotral,
Silverol, TDL,
Tradonal,
Trama)
50-100mg every
4-6 hours, not to
exceed
400mg/day
Tramadol HCl
and
paracetamol
(Dolcet)
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
irreversibly to one of two
aminoglycoside binding
sites on the 30 S
ribosomal subunit,
inhibiting bacterial
protein synthesis.
Tobramycin may also
destabilize bacterial
memebrane by binding
to 16 S 16 S r-RNA. An
active transport
mechanism for
aminoglycoside uptake is
necessary in the bacteria
in order to attain a
significant intracellular
concentration of
tobramycin.
Binds to Mu Opiate
receptors in the brain
and spinal cord, which
alters sensation and
response to pain. Also
inhibits reuptake of
serotonin and
norepinephrine, which
also results in alteration
in pain signal
transmission
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
inflammatory ocular
conditions for which a
corticosteroid is indicated
& where bacterial infection
or risk of bacterial ocular
infection exists
keratitis (dendritic
keratitis), vaccinia,
varicella & many other
viral diseases of the
cornea & conjunctiva.
Mycobacterial eye
infection. Fungal
diseases of ocular
structures. After
uncomplicated removal
of a corneal foreign body
Hypersensitivity to
tramadol or any
component of the tablets
or Ampoule solution.
Patients intoxicated with
alcohol or other sedating
drugs
Use with extreme
precaution among
patients taking other
CNS drugs particularly
sedatives or CNS
depressants
Acute intoxication w/
alcohol, hypnotics,
narcotics, centrallyacting analgesics,
opioids or psychotropic
drugs. Hypersensitivity.
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Tranexamic Acid
250-500mg/cap
1-2 cap TID/QID
250-500mg IV
slow push
Trimetazidine
20 mg/tablet
35 mg/tablet
3 tabs daily in 3
divided doses
Trimetazadine
hydrochloride
As conventional
tab: 40-60 mg
daily in divided
doses.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
(7)5 nicotinic
acetylcholine receptor
antagonist, and M1 and
M3 muscarinic
acetylcholine receptor
antagonis
Competitively inhibits
activation of
plasminogen to plasmin,
which inhibits
fibrinolysis. Also inhibits
plasmin proteolytic
activity
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Menorrhagea,
Metrorrhagea, valvular
heart surgery, GI
hemorrhage, Hereditary
angioneurotic edema
A metabolic agent, a
specific ad selective
inhibitor of an enzyme of
the fatty acids beta
oxidation: 3-ketoacyl
CoA. This inhibition of
beta oxidant allows a
recoupling of glycolysis
and an increase in
glucose oxidation for
better energy production
under ischemic
conditions.
Trimetazidine is a cellular
acting anti-ischaemic
agent. It has 3 main
properties by which it
acts as a cytoprotective
agent. It inhibits the
anaerobic glycolysis and
fatty acid metabolism,
Hypersensitivity.
Pregnancy and lactation.
GI disturbances, vomiting,
nausea.
Angina pectoris,
Meniere's disease
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Ursodeoxycholic
acid
(Ursofalk)
10 mg/kg body
weight/day
equivalent to: Up
to 60 kg: 2 caps;
up to 80 kg: 3
caps; up to 100
kg: 4 caps; >100
kg: 5 caps.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
thus allowing only
aerobic glycolysis. This
action helps to restore
the energy balance in
the cell. It inhibits
acidosis and free radical
accumulation in the cell.
All these action help the
cell to restore the normal
ionic and metabolic
balance.
Each capsule also
contains maize starch,
colloidal anhydrous
silica, magnesium
stearate, gelatin titanium
dioxide (E171) and
sodium dodecyl sulfate
as inactive ingredients.
class of bile acids
Valdecoxib
(Bextra)
Inhibition of
cyclooxygenase-2 (COX2) pathway
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Treatment of cholestatic
liver disease. Dissolution of
cholesterol gallstone in the
gallbladder. The gallstones
should not show up on xray and should not be >15
mm. The gallbladder must
be functioning despite of
(a) gallstone(s).
Treatment of biliary reflux
gastritis.
Symptomatic treatment of
primary biliary cirrhosis
provided no
decompensated liver
cirrhosis is present
Acute inflammation of
the gallbladder and bile
ducts; obstruction of the
biliary tract (common
bile duct or cystic duct),
inflammation disorders
of the large and small
intestine, pregnancy.
Ursofalk should not be
taken when the
gallbladder cannot be
visualized at x-ray, in
patients with calcified
gallstones, disturbed
contractility of the
gallbladder or frequent
biliary colic
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Valproic acid,
Divalproex Na
(Depakene)
Valsartan
(Diovan)
80 or 160 mg
once daily,
40 mg twice
daily002E
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Hypertension.
Heart Failure: Treatment of
heart failure (NYHA class IIIV) in patients receiving
standard therapy eg,
diuretics, digitalis and
either angiotensinconverting enzyme (ACE)
inhibitors or -blockers but
not both; presence of all
these standard therapies is
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Hypersensitivity.
In pregnancy,
2nd and 3rd trimesters
has been reported to
cause injury and death
to the developing fetus.
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Vandol
Cream/ointment
None
Verapamil
(Isoptin)l
240mg OD
Vincristine
(Alcavixin,
Biomedis
Vincristine,
Nevexitin,
Pfizer
Vincristine)
Adult 0.4-1.4
mg/m2 BSA.
Childn 1.5-2
mg/m2 BSA, <10
kg or BSA <1 m2
0.05 mg/kg wkly
Vitamin A
Retinol
25,000iu
A calcium antagonist
that inhibits the
transmembrane influx of
calcium ions into the
heart and vascular
smooth muscles.
vincristine and other
vinca alkaloids exert
their cytotoxic effects by
binding to tubulin, the
protein subunit of the
microtubles that form
the mitotic spindle. The
formation of vincristinetublin complexes prevent
the polymerization of the
tubulin subunits into
microtublues and
induces
depolymerization of
microtubules resulting in
inhibition of microtubule
assembly and cellular
metaphase arrest. In
high concentrations, the
drug also exerts complex
effects on nucleic acid
and protein synthesis.
Vincristine exerts some
immunosuppressive
activity
Supplementation
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
not mandatory.
Post-Myocardial Infarction
Emollients
None
Chronic coronary
insufficiency, long term
treatment of angina
pectoris, coronary spasms.
Hypertesnion. Tachycardia.
Cardiovascular shock,
complicated acute MI,
severe conduction
disorders and sick sinus
syndrome.
Biliary obstruction,
preexisting neuropathies,
liver dysfunction or
jaundice & elderly.
Extravasation,
nephrotoxicity, hepatic
impairment. Pregnancy,
lactation. Fatal if given
intrathecally
Treatment of vit A
deficiency
Special precaution in
pregnancy. Excessive
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
palmitate
Vitamin B
Complex
(Neurobion)
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.
Supplementation
Vitamin E
DI-a-tocopheryl
acetate
(Mira E )
300iu, 400iu
an allithiamine that
boosts Advanced
Glycation Endproduct
(AGE)-inhibiting thiamine
pyrophosphate and cellshielding transketolase
activity.
Supplementation
Vitamin K
0.5mg IM
Warfarin
(Coumadin)
2-5 mg/day
2-10 mg daily
Vitamin B
Complex with C
(BNC)
Neuritis, neuralgias,
shoulder-arm syndrome,
facial paresis, pregnancy
neuritis, drug-induced &
alcoholic neuropathy,
diabetic neuropathy,
sciatica, lumbagolumbalgia, intercoastal
neuralgia, trigeminal
neuralgia, herpes zoster,
optic neuritis, numbness of
the extremities,
hyperemesis gravidarum,
vit B deficiency, CVA
Increased requirement of
these vit as in pregnancy,
lactation, periods of rapid
growth & development,
infection, physical &
mental strain.
Maintains healthy skin &
eyes. Protects against
artherosclerosis & CV
disorders. Improves nerve
functions & prevents onset
of neuromuscular
degenerative diseases
Prophylaxis and therapy of
hemorrhagic disease of the
newborn
Prophylaxis and/or
treatment of venous
thrombosis and its
extension, pulmonary
embolism, thromboembolic
Hypersentivity
Coumarin and
indanedione derivatives
Hemorrhage
Embryopathy
Generic/ Brand
Acarbose
(Glucobay)
Dosage
1 tablet of
Glucobay 50 mg
three times a day
or tablet of
Glucobay 100 mg
three times a day
up to 2 tablets of
Glucobay 50 mg
three times a day
or 1 tablet of
Glucobay 100 mg
three times a day.
Mode of Action
The action of acarbose is
based on inhibition of the
intestinal enzymes (glucosidases) involved in
the degradation of
disaccharides,
oligosaccharides and
polysaccharides. This
leads to a dosedependent delay in the
digestion of these
carbohydrates.
dependent coagulation
factors.
Indications
Additional therapy in
association with diet in
patients with diabetes
mellitus.
Prevention of onset of type
2 diabetes
complications associated
with atrial fibrillation,
cardiac valve replacement
and as an adjunct in the
prophylaxis of systemic
embolism after myocardial
infarction.
Contraindications
Hypersensitivity to
acarbose and/or to
inactive constituents.
Chronic intestinal
disorders associated with
distinct disturbances of
digestion and absorption.
severe renal impairment
Adverse Effects
Flatulence. Common: Diarrhea,
gastrointestinal and abdominal
pain. Uncommon: Nausea,
vomiting, dyspepsia. Not
Known: Subileus/ileus,
pneumatosis cystoidis
intestinalis.